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Agonistic Effects of MIF (MSH-Release Inhibiting Factor) in Levodopa-Treated Parkinsonian Patients

  • E. Schneider
  • P.-A. Fischer
  • P. Jacobi
  • W. Reeh
Conference paper
Part of the Verhandlungen der Deutschen Gesellschaft für Neurologie book series (VDGNEUROLOGIE, volume 1)

Abstract

The use of Pro-Leu-Gly-NH2 (PLG) synthezised by NAIR et al (9) and considered as MSH-release inhibiting factor (MIF-I) in the treatment of parkinsonism is based on clinical and experimental findings. It could be shown that the application of MSH leads to an aggravation of the parkinsonian symptomatology. In animal studies it was shown that PLG (MIF-I) is able to potentiate the effects of levodopa and to antagonize the effects of reserpine and oxotremorine (for review see 8, 3). The positive effects of PLG (MIF-I) on the parkinsonian symptomatology, first shown by KASTIN and BARBEAU (2) using doses of 20-40 mg , soon were confirmed by CHASE et al (4) and FISCHER et al (6) who, in addition, could demonstrate mood elevating properties of PLG (MIF-I). This latter finding was confirmed also with larger doses of PLG in parkinsonian patients (7) and patients with endo-geneous depression (5). In the present study an analysis of the levodopa potentiating effect on motor performances, mood and drive was carried out.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • E. Schneider
  • P.-A. Fischer
  • P. Jacobi
  • W. Reeh

There are no affiliations available

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