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Nematode Antigens

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Parasite Antigens in Protection, Diagnosis and Escape

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 120))

Abstract

Nematodes form a large diverse phylum living in a range of habitats both free living and parasitic more varied than any other animals except arthropods. Their life cycle is divided into five stages separated by four moults. There are no gross structural alterations between the newborn L1 and mature adult L5 and so all preadult stages can be described as larval (Chitwood and Chitwood 1974). Most nematodes are bisexual; the female fertilises her eggs with sperm deposited within her by the males. The female may then release fertile ova or hatched larvae depending on the species. Nematodes may be parasitic for all or part of their life cycle. Some, like filarial worms, pass through two hosts during their lives. The study of nematodes is important because within their numbers are species which cause some of the most widespread and debilitating diseases of man. In addition, economic losses arising from parasitosis of crops and domestic animals make nematodes a major drain of human resources, especially in developing countries.

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References

  • Ali NMH, Behnke JM (1983) Nematospiroides dubius factors affecting the primary response to SRBC in infected mice. J Helminthol 57:343–353

    PubMed  CAS  Google Scholar 

  • Ali NMH, Behnke JM (1984) Non-specific immunodepression by larval and adult Nematospiroides dubius. Parasitology 88:153–162

    PubMed  Google Scholar 

  • Ambler J, Miller JN, Orr TSC (1974) Some properties of Ascaris suum allergen A. Int Arch Allergy Appl Immunol 46:427–437

    PubMed  CAS  Google Scholar 

  • Ambroise-Thomas P (1974) Immunological diagnosis of human filariases: present possibilities, difficulties and limitations. Acta Trop (Basel) 31:108–128

    CAS  Google Scholar 

  • Ambroise-Thomas P (1980) In: Houba V (ed) Immunological investigation of tropical parasitic diseases. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Anders RF, Howard RJ, Mitchell GF (1982) Parasite antigens and methods of analysis. In: Cohen S, Warren KS (eds) Immunology of parasitic diseases, 2nd ed Blackwell Scientific, Oxford

    Google Scholar 

  • Anya AO (1966) The structure and chemical composition of the nematode cuticle. Observations on some axyurids and Ascaris. Parasitology 56:179–198

    PubMed  CAS  Google Scholar 

  • Askonas BA (1984) Interference in general immune function by parasite infections. African trypanosomiasis as a model system. Parasitology 88:633–638

    PubMed  Google Scholar 

  • Au ACS, Denham DA, Draper CC (1982) Detection of antibodies in Brugia pahangi-infected cats by counter immunoelectrophoresis, indirect fluorescent antibody test and enzyme-linked immunosorbent assay. Z Parasitenkd 68:313–320

    PubMed  CAS  Google Scholar 

  • Behnke JM, Parish HA (1980) Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum. Parasite Immunol 1:13–26

    Google Scholar 

  • Behnke JM, Parish HA (1981) Transfer of immunity to Nematospiroides dubius: co-operation between lymphoid cells and antibodies in mediating worm expulsion. Parasite Immunol 3:249–259

    PubMed  CAS  Google Scholar 

  • Behnke JM, Hannah J, Pritchard DI (1983) Nematospiroides dubius in the mouse: evidence that adult worms depress the expression of homologous immunity. Parasite Immunol 5:397–408

    PubMed  CAS  Google Scholar 

  • Berrens L (1971) In: The chemistry of atopic allergens. Monographs in allergy, vol 7. Karger, Basel Bird AF (1980) The nematode cuticle and its surface. In: Zuckerman BM (ed) Nematodes as biological models, vol 2. Academic, New York pp 213–236

    Google Scholar 

  • Bloch KJ (1967) The anaphylactic antibodies of mammals including man. Progr Allergy 10:84–150

    Google Scholar 

  • Bradbury SM, Percy DH, Strejan GH (1974) Immunology of Ascaris suum infection. I. Production of reaginic antibodies to worm components in rats. Int Arch Allergy Appl Immunol 46:498–511

    PubMed  CAS  Google Scholar 

  • Buys J, Weyer R, van Stigt R, Ruitenberg EJ (1981) The killing of newborn larvae of Trichinella spiralis by eosinophil peroxidase in vitro. Eur J Immunol 11:843–845

    PubMed  CAS  Google Scholar 

  • Canlas M, Wadee A, Lamontagne L, Piessens WF (1984) A monoclonal antibody to surface antigens on microfilariae of Brugia malayi reduces microfilaraemia in infected jirds. Am J Trop Med Hyg 33:420–424

    PubMed  CAS  Google Scholar 

  • Capo V, Despommier DD, Silberstein DS (1985) The site of exclysis of the L1 larva of Trichinella spiralis. J Parasitol 70:992–994

    Google Scholar 

  • Capron A, Dessaint JP (1981) IgE: a molecule in search of a function. Ann Immunol 132C:3–8

    CAS  Google Scholar 

  • Chen SN, Howells RE (1979) The uptake of dyes, monosaccharides and amino acids by the filarial worm Brugia pahangi. Parasitology 78:343–354

    PubMed  CAS  Google Scholar 

  • Chitwood BG, Chitwood MB (1974) Introduction to nematology. University Press, Baltimore, pp 1–7

    Google Scholar 

  • Clark NWT, Philipp M, Parkhouse RME (1982) Non-covalent interactions result in aggregation of surface antigens of the parasitic nematode Trichinella spiralis. Biochem J 206:27–32

    PubMed  CAS  Google Scholar 

  • Clegg JA, Smith MA (1978) Prospects for the development of dead vaccines against helminths. Adv Parasitol 16:165–218

    PubMed  CAS  Google Scholar 

  • Dalesandro DA, Klei TR (1976) Evidence for immunodepression of Syrian hamsters and Mongolian jirds by Dipetalonema viteae infections. Trans R Soc Trop Med Hyg 70:534–535

    PubMed  CAS  Google Scholar 

  • Dandeu JP, Lux M (1978) Purification and characterisation of two proteins from Ascaris suum extract, antigenically different but bearing common allergenic epitopes. Immunol Commun 7:393–415

    PubMed  CAS  Google Scholar 

  • Davis A (1983) The importance of Parasitic Disease. In: Warren K, Bowers JZ (eds) Parasitology, a global perspective. Springer, Berlin Heidelberg New York

    Google Scholar 

  • de Savigny D, Voller A, Woodruff AW (1979) Toxocariasis serological diagnosis by enzyme immunoassay. J Clin Pathol 32:284–288

    PubMed  Google Scholar 

  • des Moutis I, Ouassi A, Grzych JM, Yarzabal L, Haque A, Capron A (1983) Onchocerca volvulus: detection of circulating antigen by monoclonal antibodies in human onchocerciasis. Am J Trop Med Hyg 32:533–542

    Google Scholar 

  • Despommier DD (1975) Adaptive changes in muscle fibres infected with Trichinella spiralis. Am J Pathol 78:477–496

    PubMed  CAS  Google Scholar 

  • Despommier DD, Campbell WC, Blair LS (1977) The in vivo and in vitro analysis of immunity to Trichinella spiralis in mice and rats. Parasitology 74:109–119

    PubMed  CAS  Google Scholar 

  • Dessein AJ, Parker WL, James SL, David JR (1981) IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection. J Exp Med 153:423–436

    PubMed  CAS  Google Scholar 

  • Dissanayake S, Ismail MM (1980) Antigens of Setaria digitata: cross reactions with surface antigens of Wuchereria bancrofti microfilariae and serum antibodies of W. bancrofti infected subjects. Bull WHO 58:644–654

    Google Scholar 

  • Dissanayake S, Galahitiyawa SC, Ismail MM (1982) Immune complexes in Wuchereria bancrofti infection in man. Bull WHO 60:919–927

    PubMed  CAS  Google Scholar 

  • Edwards AJ, Burt JS, Ogilvie BM (1971) The effect of immunity upon some enzymes of the parasitic nematode, Nippostrongylus brasiliensis. Parasitology 62:339–347

    PubMed  CAS  Google Scholar 

  • Faubert GM (1976) Depression of the plaque forming cells to sheep red blood cells by the newborn larvae of Trichinella spiralis. Immunology 30:485–489

    PubMed  CAS  Google Scholar 

  • Faubert GM (1982) The reversal of the immuno-depression phenomenon in trichinellosis and its effect on the life cycle of the parasite. Parasite Immunol 4:13–20

    PubMed  CAS  Google Scholar 

  • Forsyth KP, Copeman DB, Abbot AP, Anders RF, Mitchell GF (1981a) Identification of radioiodinated cuticular proteins and antigens of Onchocerca gibsoni microfilariae. Acta Trop (Basel) 38:329–342

    CAS  Google Scholar 

  • Forsyth KP, Copeman DB, Anders RF, Mitchell GF (1981b) The major radioiodinated cuticular antigens of Onchocerca gibsoni microfilariae are neither species nor onchocera specific. Acta Trop (Basel) 38:343–352

    CAS  Google Scholar 

  • Forsyth KP, Copeman DB, Mitchell GF (1984) Differences in the surface radioiodinated proteins of skin and uteric microfilariae of Onchocerca gibsoni. Mol Biochem Parasitol 10:217–229

    PubMed  CAS  Google Scholar 

  • Fujita K, Tsukidate S (1981) Preparation of a highly purified allergen from Dirofilaria immitis. Reaginic antibody formation in mice. Immunology 42:363–370

    PubMed  CAS  Google Scholar 

  • Fujita K, Ikeda T, Tsukidate S (1979) Immunological and physico-chemical properties of a highly purified allergen from Dirofilaria immitis. Int Arch Allergy Appl Immunol 60:121–131

    PubMed  CAS  Google Scholar 

  • Furman S, Ash LR (1983) Analysis of Brugia pahangi microfilariae surface carbohydrates: comparison of the binding of a panel of fluoresceinated lectins to mature in vivo derived and immature in utero derived microfilariae. Acta Trop (Basel) 40:45–51

    CAS  Google Scholar 

  • Gajana A, Bheema Rao US, Manomani LM (1982) Preliminary study on circulating immune complexes in bancroftian filariasis. Indian J Med Res 76:146–149

    Google Scholar 

  • Godson GN, Ellis J, Lupski JR, Ozaki LS, Svec P (1984) Structure and organisation of genes for sporozoite surface antigens. Philos Trans R Soc Lond 307:129–139

    CAS  Google Scholar 

  • Greene BM, Taylor HR, Aikawa M (1981) Cellular killing of microfilariae of Onchocerca volvulus: eosinophil and neutrophil mediated immune serum-dependent destruction. J Immunol 127:1611–1618

    PubMed  CAS  Google Scholar 

  • Grove DI, Davis RS (1978) Serological diagnosis of bancroftian and malayan filariasis. Am J Trop Med Hyg 27:508–513

    PubMed  CAS  Google Scholar 

  • Grzych JM, Capron M, Bazin H, Capron A (1982) In vitro and in vivo effector function of rat IgG2a monoclonal anti-S. mansoni antibodies. J Immunol 129:2739–2743

    PubMed  CAS  Google Scholar 

  • Hague A, Joseph M, Ouassi MA, Capron M, Capron A (1980) IgE antibody-mediated cytotoxicity of rat macrophages against microfilariae of Dipetalonema viteae in vitro. Clin Exp Immunol 40:487–495

    Google Scholar 

  • Hogarth-Scott RS (1967) The molecular weight range of nematode allergens. Immunology 13:535–537

    PubMed  CAS  Google Scholar 

  • Horowitz S, Tarrab-Hazdai R, Eshhar Z, Arnon R (1983) Anti-schistosome monoclonal antibodies of different isotypes: correlation with cytotoxicity. EMBO J 2:193–198

    PubMed  CAS  Google Scholar 

  • Howells RE, Chen SN (1981) Brugia pahangi: feeding and nutrient uptake in vitro and in vivo. Exp Parasitol 51:42–58

    PubMed  CAS  Google Scholar 

  • Hussain R, Ottesen EA (1983) IgE responses in human filariasis. II. Quantitative characterisation of filaria specific IgE. J Immunol 131:1516–1521

    PubMed  CAS  Google Scholar 

  • Hussain R, Bradbury SM, Strejan G (1973) Hypersensitivity to Ascaris antigens. VIII. Characterisation of a highly purified allergen. J Immunol 111:260–268

    PubMed  CAS  Google Scholar 

  • Ishizaka K (1983) IgE-Binding factors from rat T lymphocytes. In: Pick E (ed) Lymphokines, vol 8. Academic, New York pp 41–80

    Google Scholar 

  • Ishizaka T, Ishizaka K (1975) Biology of immunoglobulin E. Prog Allergy 19:101–105

    Google Scholar 

  • Jarrett EE (1978) Stimuli for the production and control of IgE in rats. Immunol Rev 41:52–76

    PubMed  CAS  Google Scholar 

  • Jarrett EE, Bazin H (1974) Elevation of total serum IgE following helminth parasite infection. Nature 251:613–614

    PubMed  CAS  Google Scholar 

  • Jenkins SN, Behnke JM (1977) Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Parasitology 75:71–78

    PubMed  CAS  Google Scholar 

  • Jenkins DC, Phillipson RF (1972) Increased establishment and longevity of Nippostrongylus brasiliensis in immune rats given repeated small infections. Int J Parasitol 2:105–111

    PubMed  CAS  Google Scholar 

  • Johnson P, Mackenzie CD, Suswillo RR, Denham DA (1981) Serum mediated adherence of feline granulocytes to microfilariae of Brugia pahangi in vitro: variations with parasite maturation. Parasite Immunol 3 :69–80

    PubMed  CAS  Google Scholar 

  • Jones VE, Ogilvie BM (1972) Protective immunity to Nippostrongylus brasiliensis in the ratt. (iii) Modulation of worm’s acetyl cholinesterase by antibodies. Immunology 22:119–129

    PubMed  CAS  Google Scholar 

  • Jungery M, Ogilvie BM (1982) Antibody response to stage specific Trichinella spiralis surface antigens in strong and weak responder mouse strains. J Immunol 129:839–843

    PubMed  CAS  Google Scholar 

  • Jungery M, Clark NWT, Parkhouse RME (1983) A major change in surface antigens during the maturation of newborn larvae of Trichinella spiralis. Mol Biochem Parasitol 7:101–109

    PubMed  CAS  Google Scholar 

  • Kagan IG (1963) A review of immunologic methods for the diagnosis of filariasis. J Parasitol 49:773–779

    PubMed  CAS  Google Scholar 

  • Katz SP, Lammie PJ (1984) Effect of cyclophosphamide on the immune responsiveness of jirds infected with Brugia pahangi. Infect Immun 43:753–755

    PubMed  CAS  Google Scholar 

  • Kaushal NA, Hussain R, Ottesen EA (1984) Excretory-secretory and somatic antigens in the diagnosis of human filariasis. Clin Exp Immunol 56:567–576

    PubMed  CAS  Google Scholar 

  • Kawanishi H, Saltzman LE, Strober W (1982) Characteristics and regulatory function of murine ConA-induced cloned T cells obtained from Peyer’s patches and spleen: mechanical regulating isotypespecific immunoglobulin production by Peyer’s Patch B cells. J Immunol 129:475–483

    PubMed  CAS  Google Scholar 

  • Kazura JW, Meshnick SR (1984) Scavenger enzymes and resistance to oxygen mediated damage in Trichinella spiralis. Mol Biochem Parasitol 10:1–10

    PubMed  CAS  Google Scholar 

  • Kemp DJ, Coppel RL, Cowman AF, Saint RB, Brown GV, Anders RF (1983) Expression of Plasmodium falciparum blood stage antigens in Escherichia coli: detection with antibodies from immune humans. Proc Natl Acad Sci USA 80:3787–3791

    PubMed  CAS  Google Scholar 

  • Kennedy MW (1976) Kinetics of establishment and rejection of the enteral phase of a primary infection of Trichinella spiralis in the NIH strain mouse. Trans R Soc Trop Med Hyg 70:285

    Google Scholar 

  • Kiyono H, McGhee JR, Mosteller LM, Elridge JH, Koopman WJ, Kearny JF, Michalek SM (1982) Murine Peyer’s Patch T cell clones. Characterisation of antigen-specific helper T cells for immunoglobulin A responses. J Exp Med 156:1115–1130

    PubMed  CAS  Google Scholar 

  • Klenk A, Geyer E, Zahner M (1984) Serodiagnosis of human onchocerciasis. Evalution of sensitivity and specificity of a purified Litomosoides carinii adult worm antigen. Tropenmed Parasitol 35:81–84

    PubMed  CAS  Google Scholar 

  • Kwa BK, Mak JK (1980) Specific depression of cell-mediated immunity in Malayan filariasis. Trans R Soc Trop Med Hyg 74:522–527

    PubMed  CAS  Google Scholar 

  • Lammie PJ, Katz SP (1983a) Immunoregulation in experimental filariasis. I. In vitro suppression of mitogen-induced blastogenesis by adherent cells from jirds chronically infected with Brugia pahangi. J Immunol 130:1381–1385

    PubMed  CAS  Google Scholar 

  • Lammie PJ, Katz SP (1983b) Immunoregulation in experimental filariasis. II. Responses to parasite and non-parasite antigens in jirds with Brugia pahangi. J Immunol 130:1386–1389

    PubMed  CAS  Google Scholar 

  • Larsh JE, Weatherly NF (1975) Cell mediated immunity against certain parasitic worms. Adv Parasitol 13:183–222

    PubMed  CAS  Google Scholar 

  • Lee DL (1972) Structure of the helminth cuticle. Adv Parasitol 10:347

    PubMed  CAS  Google Scholar 

  • Lee DL, Wright KA, Shivers RR (1984) A freeze-fracture study of the surface of the infective stage larva of the nematode Trichinella. Tissue and Cell 16:819–828

    PubMed  CAS  Google Scholar 

  • Lichtenfels JR, Murrell KD, Pilitt PA (1984) Comparison of three subspecies of Trichinella spiralis by scanning electron microscopy. J Parasitol 69:1131–1140

    Google Scholar 

  • Lumsden DL (1975) Surface ultrastructure and cytochemistry of parasitic helminths. Exp Parasitol 37:267–339

    PubMed  CAS  Google Scholar 

  • Mackenzie CD, Preston PM, Ogilvie BM (1978) Immunological properties of the surface of parasitic nematodes. Nature 276:826–828

    PubMed  CAS  Google Scholar 

  • Mackenzie CD, Jungery M, Taylor PM, Ogilvie BM (1980) Activation of complement, the induction of antibodies to the surface of nematodes and the effect of these factors and cells on worm survival in vitro. Eur J Immunol 10:594–601

    PubMed  CAS  Google Scholar 

  • Maizels RM, Meghji M, Ogilvie BM (1983a) Restricted sets of parasite antigens for the surface of different stages and sexes of the nematode parasite Nippostrongylus brasiliensis. Immunology 48:107–121

    PubMed  CAS  Google Scholar 

  • Maizels RM, Partono F, Oemijati S, Denham DA, Ogilvie BM (1983b) Cross-reactive surface antigens on three stages of Brugia malayi, B. pahangi and B. timori. Parasitology 87:249–263

    PubMed  CAS  Google Scholar 

  • Maizels RM, Partono F, Oemijati S, Ogilvie BM (1983c) Antigenic analysis of Brugia timori, a filarial nematode of man: initial characterisation by surface radioiodination and evaluation of diagnostic potential. Clin Exp Immunol 51:269–277

    PubMed  CAS  Google Scholar 

  • Maizels RM, de Savigny D, Ogilvie BM (1984a) Characterisation of surface and exretory-secretory antigens of Toxocara canis infective larvae. Parasite Immunol 6:23–37

    PubMed  CAS  Google Scholar 

  • Maizels RM, Philipp M, Dasgupta A, Partono F (1984b) Human serum albumin is a major component on the surface of microfilariae of Wuchereria bancrofti. Parasite Immunol 6:185–190

    PubMed  CAS  Google Scholar 

  • Malhotra A, Harinath BC (1984) Detection and monitoring of microfilarial ES antigen levels by inhibition of ELISA during DEC therapy. Indian J Med Res 79:194–198

    PubMed  CAS  Google Scholar 

  • Manning DD, Manning JK, Reed ND (1976) Suppression of reaginic antibody (IgE) formation in mice by treatment with anti-u antiserum. J Exp Med 144:288–292

    PubMed  CAS  Google Scholar 

  • Martinz-Palomo A (1978) Ultrastructural characterisation of the cuticle of Onchocerca volvulus microfilaria. J Parasitol 64:127–136

    Google Scholar 

  • McLaren DJ (1984) Disguise as an evasive strategem of parasitic organism. Parasitology 88:597–611

    PubMed  Google Scholar 

  • Moloney A, Denham DA (1979) Effects of immune serum and cells on newborn larvae of Trichinella spiralis. Parasite Immunol 1:3–11

    PubMed  CAS  Google Scholar 

  • O’Donnell IJ, Mitchell GF (1978) An investigation of the allergens of Ascaris using a radioallergosorbent test (RAST) and sera of naturally infected humans: comparison with an allergen for mice identified by passive cutaneous anaphylaxis test. Aust J Biol Sci 31:459–487

    PubMed  Google Scholar 

  • Ogilvie BM, Philipp M, Jungery M, Maizels RM, Worms MJ, Parkhouse RME (1980) The surface of nematodes and the immune response of the host. In: van der Bossche H (ed) The host invader interplay. Elsevier Amsterdam, pp 99–104

    Google Scholar 

  • Ortega-Pierres G, Chayen A, Clark NWT, Parkhouse RME (1984a) The occurrence of antibodies to hidden and exposed determinants of surface antigens of Trichinella spiralis. Parasitology 88:359–369

    PubMed  Google Scholar 

  • Ortega-Pierres G, Mackenzie CD, Parkhouse RME (1984b) Protection against Trichinella spiralis induced by a monoclonal antibody that promotes killing of newborn larvae by granulocytes. Parasite Immunol 6:275–284

    PubMed  CAS  Google Scholar 

  • Ortega-Pierres G, Clark NWT, Parkhouse RME (1985) Regional specialisation of the surface of a parasitic nematode. Parasite Immunol (in press)

    Google Scholar 

  • Ottesen EA, Weller PF, Heck L (1977) Specific cellular immune unresponsiveness in human filariasis. Immunology 33:413–421

    PubMed  CAS  Google Scholar 

  • Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaver MA (1979) Specific allergic sensitisation to filarial antigens in tropical eosinophilia syndrome. Lancet ii:1158–1160

    Google Scholar 

  • Ouassi A, Kouemeni LE, Haque A, Ridd PR, Andre PS, Capron A (1981) Detection of circulating antigens in onchocerciasis. Am J Trop Med Hyg 30:1211–1218

    Google Scholar 

  • Paganelli R, Ngu NL, Levinsky RJ (1980) Circulating immune complexes in onchocerciasis. Clin Exp Immunol 39:570–575

    PubMed  CAS  Google Scholar 

  • Parkhouse RME, Clark NWT (1983) Stage specific secreted and somatic antigens of Trichinella spiralis. Mol Biochem Parasitol 9:319–327

    PubMed  CAS  Google Scholar 

  • Parkhouse RME, Cooper MD (1977) A model for the differentiation of B lymphocytes with implications for the biological role of IgD. Immunol Rev 37:105–126

    PubMed  CAS  Google Scholar 

  • Parkhouse RME, Philipp M, Ogilvie BM (1981) Characterisation of surface antigens of Trichinella spiralis infective larvae. Parasite Immunol 3:339–352

    PubMed  CAS  Google Scholar 

  • Parkhouse RME, Bofill M, Gomez-Priego A, Janossy G (1985) Human macrophages and T-lymphocyte subsets infiltrating nodules of Onchocerca volvulus. Parasite Immunol (in press)

    Google Scholar 

  • Pery P, Luffau G (1979) Antigens of helminths. In: Sela M (ed) The Antigens, vol 5. Academic, New York, pp 83–172

    Google Scholar 

  • Petit A, Pery P, Luffau G (1980) Purification of an allergen from culture fluids of Nippostrongylus brasiliensis. Mol Immunol 17:1341–1349

    PubMed  CAS  Google Scholar 

  • Philipp M (1984) Acetylcholinesterone secreted by intestinal nematodes: a reinterpretation of its putative role of a “biochemical holdfast”. Trans R Soc Trop Med Hyg 78:138–139

    PubMed  CAS  Google Scholar 

  • Philipp M, Parkhouse RME, Ogilvie BM (1980) Changing proteins on the surface of a parasitic nematode. Nature 287:538–540

    PubMed  CAS  Google Scholar 

  • Philipp M, Taylor PM, Parkhouse RME, Ogilvie BM (1981) Immune response to stage specific surface antigens of the parasitic nematode Trichinella spiralis. J Exp Med 154:210–215

    PubMed  CAS  Google Scholar 

  • Philipp M, Gomez-Priego A, Parkhouse RME, Davies ML, Clark NWT, Ogilvie BM, Beltran-Hernandez F (1984a) Identification of an antigen of Onchocerca volvulus of possible diagnostic use. Parasitology 84:295–310

    Google Scholar 

  • Philipp M, Worms MJ, McLaren DJ, Ogilvie BM, Parkhouse RME, Taylor PM (1984b) Surface proteins of a filarial nematode: a major soluble antigen and a host component on the cuticle of Litomosoides carinii. Parasite Immunol 6:63–82

    PubMed  CAS  Google Scholar 

  • Philipp M, Worms MJ, Maizels RM, Ogilvie BM (1984c) Rodent Models of Filariasis. In: Marchalonis JJ (ed) Contemporary Topics in Immunobiology vol 12. Plenum New York, pp 275–321

    Google Scholar 

  • Piessens WF, McGreevy PB, Piessens PW, McGreevy M, Koiman I, Saroso JS, Dennis DT (1980a) Immune responses in human infections with Brugia malayi. Specific cellular unresponsiveness to filarial antigens. J Clin Invest 65:172–179

    PubMed  CAS  Google Scholar 

  • Piessens WF, McGreevy PB, Ratiwayanto S, McGreevy M, Piessens PW, Koiman I, Saroso JS, Dennis DT (1980b) Immune responses in human infections with Brugia malayi: correlation of cellular and humoral reactions to microfilarial antigens with clinical status. Am J Trop Med Hyg 29:563–570

    PubMed  CAS  Google Scholar 

  • Piessens WF, Ratiwayanto S, Tuti S, Palmieri JH, Piessens P, Koiman I, Dennis DT (1980c) Antigenspecific suppressor cells and suppressor factors in human filariasis with Brugia malayi. N Engl J Med 302:833–837

    PubMed  CAS  Google Scholar 

  • Piessens WF, Partono F, Hoffman SL, Ratiwayanto S, Piessens PW, Palmieri JR, Koiman I, Dennis DT, Carney WP (1982) Antigen-specific suppressor-T-lymphocytes in human lymphatic filariasis. N Engl J Med 307:144–148

    PubMed  CAS  Google Scholar 

  • Ponundurai T, Denham DA, Nelson GS, Rogers R (1974) Studies with Brugia pahangi. Antibodies against adult and microfilarial stages. J Helminthol 48:107–111

    Google Scholar 

  • Prasad GBK, Kharat I, Harinath BC (1983a) Detection of anti-filarial ES antigen-antibody in immune complex in Bancroftian filariasis by enzyme immunoassay. Trans R Soc Trop Med Hyg 77:771–772

    PubMed  CAS  Google Scholar 

  • Prasad GBK, Reddy MVR, Hariath BC (1983b) Detection of filarial antigen in immune complexes in Bancroftian filariasis by ELISA. Indian J Med Res 78:780–783

    PubMed  CAS  Google Scholar 

  • Premaratne VN, Parkhouse RME, Denham DA (1984) The use of anti-cat immunoglobulin monoclonals in detecting immune responses of cats to Brugia pahangi. Parasitology 89: ixvii

    Google Scholar 

  • Pritchard DI, Williams DJL, Behnke JM, Lee TDG (1983) The role of IgG1 hypergammaglobulinaemia in immunity to the gastrointestinal nematode Nematospiroides dubius. The immunochemical purification, antigen specificity and in vivo anti-parasite effect of IgG1 from immune serum. Immunology 49:353–363

    PubMed  CAS  Google Scholar 

  • Pritchard DI, Ali NMH, Behnke JM (1984) Analysis of the mechanism of immunodepression following heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius. Immunology 51:633–642

    PubMed  CAS  Google Scholar 

  • Purkerson M, Despommier D (1974) Fine structure of the muscle phase of Trichinella spiralis in the mouse. In: Kim C (ed) Trichinellosis. Intext, New York

    Google Scholar 

  • Rhoads ML (1983) Trichinella spiralis: identification and purification of superoxide dismutase. Exp Parasitol 56:41–54

    PubMed  CAS  Google Scholar 

  • Ridley DS, Hedge EC (1977) Immunofluorescent reactions with microfilariae 2. Bearing on host-parasite relations. Trans R Soc Trop Med Hyg 71:522–525

    Google Scholar 

  • Rivera-Ortiz C, Nessenzweig R (1976) Trichinella spiralis: anaphylactic antibody formation and susceptibility in strains of inbred mice. Exp Parasitol 39:7–17

    PubMed  CAS  Google Scholar 

  • Rothwell TLW, Prichard RK, Love RJ (1974) Studies on the role of histamine and 5 hydroxytryptamine in immunity against the nematodes Trichostrongylus colubriforms. I. In vivo and in vitro effects of the amines. Int Arch Allergy Appl Immunol 46:1–13

    PubMed  CAS  Google Scholar 

  • Ruitenberg EJ, Ljungstrom I, Steerenberg PA, Buys J (1975) Application of immunofluorescence and immunoenzyme methods in the serodiagnosis of Trichinella spiralis infection. Ann NY Acad Sci 254:296–303

    PubMed  CAS  Google Scholar 

  • Sanderson BM, Jenkins DC, Phillipson RF (1972) Nippostrongylus brasiliensis: relation between immune damage and acetyl cholinesterase levels. Int J Parasitol 2:227–232

    PubMed  CAS  Google Scholar 

  • Scher I (1982) The CBA/N mouse strain: An experimental model illustrating the influence of the X-chromosome on immunity. Adv Immunol 33:1–71

    PubMed  CAS  Google Scholar 

  • Silberstein DS, Despommier DD (1984) Antigens from Trichinella spiralis that induce a protective response in the mouse. J Immunol 132:898–904

    PubMed  CAS  Google Scholar 

  • Smith HV, Quinn R, Kusel JR, Girdwood RWA (1981) The effect of temperature and anti-metabolites on antibody binding to the outer surface of second stage Toxocara canis larvae. Mol Biochem Parasitol 4:183–193

    PubMed  CAS  Google Scholar 

  • Stahl HD, Coppel RL, Brown GV, Saint R, Lingelbach K, Cowman AF, Anders RF, Kemp DJ (1984) Differential antibody screening of cloned Plasmodium falciparam sequences expressed in Escherichia coli: procedure for isolation of defined antigens and analysis of human antisera. Proc Natl Acad Sci USA 81:2456–2460

    PubMed  CAS  Google Scholar 

  • Suemara M, Ishizaka J (1979) Potentiation of IgE response in vitro by T cells from rats infected with Nippostrongylus brasiliensis. J Immunol 123:918–924

    Google Scholar 

  • Suemara M, Yodoi J, Hirashima M, Ishizaka K (1980) Regulatory role of IgE-binding factors from rat T-lymphocytes. I. Mechanism of enhancement of IgE response by IgE-potentiating factor. J Immunol 125:148–154

    Google Scholar 

  • Sutanto I (1983) A study on the Antigenicity of surface components of adult Brugia pahangi and their stage specificity. M Phil Thesis. University of Brunel

    Google Scholar 

  • Svet-Moldaysky GJ, Shadhijan GS, Chernyakhoiskaya IY; Mkheidze DM, Litovchenko TA, Ozeretskovskaya NN, Kadaghidze ZG (1970) Inhibition of skin allograft rejection in Trichinella infected mice. Transplantation 9:69–71

    Google Scholar 

  • Thompson JR, Crandall RB, Crandall CA, Neilson JJ (1979) Clearance of microfilariae of Dipetalonema viteae in CBA/N and CBA/H mice. J Parasitol 65:966–968

    PubMed  CAS  Google Scholar 

  • Thompson JR, Crandall RB, Crandall CA, Neilson JJ (1981) Microfilaraemia and antibody responses in CBA/H and CBA/N mice following injection of microfilariae of Brugia malayi. J Parasitol 67:728–730

    PubMed  CAS  Google Scholar 

  • Unanue ER (1981) The regulatory role of the macrophage in antigenic stimulation. II Symbiotic relationship between the lymphocyte and macrophage. Adv Immunol 31:1–136

    PubMed  CAS  Google Scholar 

  • van Knapen F, Franchimont JH, Ruitenberg EJ, Baldelli B, Bradley J, Gibson TE, Gottal C, Henrikson SA, Kohler G, Skorgaard N, Soula N, Taylor SM (1980) Comparison of the enzyme-linked immunosorbent assay (ELISA) with three other methods for the detection of Trichinella spiralis infections in pigs. Vet Parasitol 7:109–121

    Google Scholar 

  • Wakelin D (1978) Genetic control of susceptibility and resistance to parasitic infection. Adv Parasitol 16:219–308

    PubMed  CAS  Google Scholar 

  • Wakelin D, Donachie A (1981) Genetic control of immunity to Trichinella spiralis. Donor bone marrow cells determine responses to infection in mouse radiation chimaeras. Immunology 43:787

    PubMed  CAS  Google Scholar 

  • Wassom DL, Wakelin D, Brooks BO, Krco KJ, David CS (1984) Genetic control of immunity to Trichinella spiralis infections in mice: hypothesis to explain the role of H-2 genes in primary and challenge infections. Immunology 51:625–631

    PubMed  CAS  Google Scholar 

  • Wegerhof PM, Wenk P (1979) Studies of acquired resistance of the cotton rat against microfilariae of Litomosoides carinii. I. Effects of single and repeated injections of microfilariae. Z Parasitenkd 60:50–64

    Google Scholar 

  • Weiss N (1978) Dipetalonema viteae: in vitro blastogenesis of hamster spleen and lymph node cells to phytohaemaglutinin and filarial antigens. Exp Parasitol 46:283–299

    PubMed  CAS  Google Scholar 

  • Weiss N, Tanner M (1979) Studies on Dipetalonema vitaea (Filaroidea) 3. Antibody dependent cell mediated destruction of microfilariae in vivo. Tropenmed Parasitol 30:73–80

    PubMed  CAS  Google Scholar 

  • Weiss N, Gualzat M, Wyss T, Betschart B (1982a) Detection of IgE-binding Onchocerca volvulus antigens after electrophoretic and immuno-enzyme reaction. Acta Trop (Basel) 39:373–377

    CAS  Google Scholar 

  • Weiss N, Huassain R, Ottesen EA (1982b) IgE antibodies are more species specific than IgE antibodies in human onchocerciasis and lymphatic filariasis. Immunology 45:129–137

    PubMed  CAS  Google Scholar 

  • Weller PF (1978) Cell-mediated immunity in experimental filariasis: lymphocyte reactivity of filarial stagespecific antigens and to bound T cell mitogens during acute and chronic infection. Cell Immunol 37:369–382

    PubMed  CAS  Google Scholar 

  • Williams DJ, Behnke JH (1983) Host protective antibodies and serum immunoglobulin isotypes in mice chronically infected or repeatedly immunised with the nematode parasite Nematospiroides dubius. Immunology 48:37–47

    PubMed  CAS  Google Scholar 

  • Wong MM, Guest MF (1969) Filarial antibodies and eosinophilia in human subjects in an endemic area. Trans R Soc Trop Med Hyg 63:796–800

    PubMed  CAS  Google Scholar 

  • Wong MM, Suter PF (1979) Indirect fluorescent antibody test in occult dirofilariasis. Am J Vet Res 40:414–420

    PubMed  CAS  Google Scholar 

  • World Health Organisation Memorandum (1975) Parasite antigens. Bull WHO 52:237–249

    Google Scholar 

  • Wright KA (1979) Trichinella spiralis: an intracellular parasite in the intestinal phase. J Parasitol 65:441–445

    PubMed  CAS  Google Scholar 

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  1. Division of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    N. M. Almond & R. M. E. Parkhouse

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  1. N. M. Almond
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    R. M. E. Parkhouse MD

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Almond, N.M., Parkhouse, R.M.E. (1985). Nematode Antigens. In: Parkhouse, R.M.E. (eds) Parasite Antigens in Protection, Diagnosis and Escape. Current Topics in Microbiology and Immunology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09197-5_9

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