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Parasite Antigens in Protection, Diagnosis and Escape: Plasmodium

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Parasite Antigens in Protection, Diagnosis and Escape

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 120))

Abstract

In the hundred years since Laveran first described the malaria parasite as the cause of intermittent fevers, the basic biological questions posed at the end of his paper have been answered. The pathology of acute or chronic malaria infection is however still far from being fully understood and despite the accumulated knowledge of a century, the disease persists as one of the world’s major health problems. Optimism about worldwide eradication by organised vector control and chemotherapy was maintained up until the early 1960s. Since this time there has been a resurgence of malaria in many areas of the world due to a number of factors many of which are outside the scope of this discussion. Deterioration in control of malaria has however been associated with a rapid spread of both insecticide resistance among mosquitos and drug resistance of the parasites. Such chemical weapons remain as the major means of controlling malaria so that for the reasons outlined above, research in recent years has begun to focus on possible means of immunoprophylaxis. This chapter will be devoted mainly to work which has attempted to define and characterise parasite antigens important in the induction of protective immunity, and evasion of the host’s immune response.

D’ou viennent les elements parasitaires qui se trouvent dans le sang des malades attients de fievre palustre? Par quelle voie s’introduisentils dans l’economie? Comment provoquentils la fievre intremittente et les autres manifestations de l’impaludisme? On ne peut encore poser ces importantes questions.1

Laveran 1880

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  1. Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, OX3 9DU, UK

    C. I. Newbold

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  1. National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    R. M. E. Parkhouse MD

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Newbold, C.I. (1985). Parasite Antigens in Protection, Diagnosis and Escape: Plasmodium . In: Parkhouse, R.M.E. (eds) Parasite Antigens in Protection, Diagnosis and Escape. Current Topics in Microbiology and Immunology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09197-5_5

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