Skip to main content
SpringerLink
Log in

Thrombozyten und Gerinnung

  • Chapter
Pädiatrie

  • 14 Accesses

Zusammenfassung

An den Aufgaben der Hämostase, die Fließfähigkeit des Blutes optimal zu erhalten, dabei jedoch Blutverluste nach Verletzungen zu verhindern, sind im wesentlichen 3 Systeme beteiligt:

  • das Gefäßsystem selbst, ausgekleidet mit Endothel, das den Durchtritt von Wasser, Ionen, Sauerstoff, CO2, Nährstoffen, Stoffwechselprodukten, Proteinen und zellulären Komponenten ermöglichen, auf der anderen Seite jedoch den Austritt von Blut verhindern soll,

  • die Blutplättchen oder Thrombozyten und

  • die plasmatische Gerinnung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L (1992) Maturation of the hemostatic system during childhood. Blood 80: 1998–2005

    PubMed  CAS  Google Scholar 

  • Aschka I, Aumann V, Bergmann F et al. (1996) Prevalence of factor V Leiden in children with thrombo-embolism. Eur J Pediatr 155:1009–1014

    Article  PubMed  CAS  Google Scholar 

  • Aster RH (1995) Heparin-induced thrombocytopenia and thrombosis. N Engl J Med 332:1374–1376

    Article  PubMed  CAS  Google Scholar 

  • Bertina RM (1998) The prothrombin 20210 G to A variation and thrombosis. Curr Opin Hematol 5: 339–342

    Article  PubMed  CAS  Google Scholar 

  • Bertina RM, Koeleman BP, Koster T et al. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C [see comments]. Nature 369: 64–67

    Article  PubMed  CAS  Google Scholar 

  • Bick RL (1998) Disseminated intravascular coagulation: pathophysiological mechanisms and manifestations. Semin Thromb Hemost 24:3–18

    Article  PubMed  CAS  Google Scholar 

  • Brenner B, Sanchez-Vega B, Wu SM, Lanir N, Stafford DW, Solera J (1998) A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors. Blood 92:4554–4559

    PubMed  CAS  Google Scholar 

  • Broze GJ Jr (1995) Tissue factor pathway inhibitor. Thromb Haemost 74: 90–93

    PubMed  CAS  Google Scholar 

  • Cooper DN, Millar DS, Wacey A, Banner DW, Tuddenham EG (1997) Inherited factor VII deficiency: molecular genetics and pathophysiology. Thromb Haemost 78:151–160

    PubMed  CAS  Google Scholar 

  • Cooper DN, Millar DS, Wacey A, Pemberton S, Tuddenham EG (1997) Inherited factor X deficiency: molecular genetics and pathophysiology. Thromb Haemost 78:161–172

    PubMed  CAS  Google Scholar 

  • Dahlback B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofac-tor to activated protein C [see comments], Proc Natl Acad Sci U S A 90: 1004–1008

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • David M, Andrew M (1993) Venous thromboembolic complications in children. J Pediatr 123: 337–346

    Article  PubMed  CAS  Google Scholar 

  • David M, Manco-Johnson M, Andrew M (1995) Diagnosis and treatment of venous thromboembolism in children and adolescents. On behalf of the Subcommittee on Perinatal Haemostasis of the Scientific and Standardization Committee of the ISTH. Thromb Haemost 74: 791–792

    PubMed  CAS  Google Scholar 

  • Engesser L, Broekmans AW, Briet E, Brommer EJP, Bertina RM (1987) Hereditary protein S deficiency: clinical manifestations. Ann Intern Med 106: 677–682

    Article  PubMed  CAS  Google Scholar 

  • Fisher S, Rikover M, Naor S (1966) Factor 13 deficiency with severe hemorrhagic diathesis. Blood 28: 34–39

    PubMed  CAS  Google Scholar 

  • Furie B, Furie BC (1990) Molecular basis of vitamin K-dependent gamma- carboxylation. Blood 75:1753–1762

    PubMed  CAS  Google Scholar 

  • George JN, Woolf SH, Raskob GE et al. (1996) Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology [see comments]. Blood 88:3–40

    PubMed  CAS  Google Scholar 

  • Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (1981) Deficiency of protein C in congenital thrombotic disease. J Clin Invest 68:1370–1373

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Ingram GIC (1997) The history of haemophilia. Haemophilia 3 (Suppl 1): 5–15

    Google Scholar 

  • Lillicrap D (1998) The molecular basis of haemophilia B. Haemophilia 4: 350–357

    Article  PubMed  CAS  Google Scholar 

  • Mammen EF (1983) Factor V deficiency. Semin Thromb Hemost 9:1–72

    Article  PubMed  CAS  Google Scholar 

  • Mannucci PM (1998) Hemostatic drugs. N Engl J Med 339: 245–253

    Article  PubMed  CAS  Google Scholar 

  • Mannucci PM (1998) Haemophilia treatment protocols around the world: towards a consensus. Haemophilia 4: 421

    Article  PubMed  CAS  Google Scholar 

  • Mannucci PM (1998) Treatment of von Willebrand disease. Haemophilia 4: 661–664

    Article  PubMed  CAS  Google Scholar 

  • McDonagh J, Carrell N, Lee MH (1994) Dysfibrinogenemia and other disorders of fibrinogen structure and function. In: Colman RW, Hirsh J, Marder VJ, Salzman JB (eds) Hemostasis and thrombosis: basic principles and clinical practice, 3rd edn. Lippincott, Philadelphia, pp 314–334

    Google Scholar 

  • Peake I (1998) The molecular basis of haemophilia A. Haemophilia 4: 346–349

    Article  PubMed  CAS  Google Scholar 

  • Ragni MV, Sinha D, Seaman F, Lewis JH, Spero JA, Walsh PN (1985) Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindreds. Blood 65: 719–724

    PubMed  CAS  Google Scholar 

  • Remond-O’Donnell E, Rosen FS, Kenney DM (1996) Defects in Wiskott-Aldrich syndrome blood cells. Blood 87: 2621–2631

    Google Scholar 

  • Ruggeri ZM (1991) Structure and function of von Willebrand factor: relationship to von Willebrand’s disease. Mayo Clin Proc 66: 847–861

    Article  PubMed  CAS  Google Scholar 

  • Schneppenheim R, Thomas KB, Sutor AH (1995) Von Willebrand disease in childhood. Semin Thromb Hemost 21: 261–275

    Article  PubMed  CAS  Google Scholar 

  • Sutor AH (1995) Thrombocytosis in childhood. Semin Thromb He-most 21: 330–339

    Article  CAS  Google Scholar 

  • Triplett DA (1998) Many faces of lupus anticoagulants. Lupus 7 (Suppl 2): 18–22

    Article  Google Scholar 

  • Tuddenham EG, Pemberton S, Cooper DN (1995) Inherited factor VII deficiency: genetics and molecular pathology. Thromb Haemost 74: 313–321

    PubMed  CAS  Google Scholar 

  • Wood AJJ (1998) Thrombopoietin. N Engl J Med 339: 746–754

    Article  Google Scholar 

  • Zimmerman TS, Ratnoff OD, Powell AE (1971) Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand’s dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor. J Clin Invest 50:244–254

    Article  PubMed  CAS  PubMed Central  Google Scholar 

Download references

Authors
  1. R. Schneppenheim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Bergmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitäts-Kinderklinik, Adenauerallee 119, 53113, Bonn, Deutschland

    Michael J. Lentze

  2. Universitäts-Kinderklinik, Martinistr. 52, 20246, Hamburg, Deutschland

    Franz J. Schulte

  3. Universitäts-Kinderklinik, Schwanenweg 20, 24105, Kiel, Deutschland

    Jürgen Schaub

  4. Universitäts-Kinderklinik, Langenbeckstr. 1, 55101, Mainz, Deutschland

    Jürgen Spranger

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schneppenheim, R., Bergmann, F. (2003). Thrombozyten und Gerinnung. In: Lentze, M.J., Schulte, F.J., Schaub, J., Spranger, J. (eds) Pädiatrie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09176-0_169

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-09176-0_169

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09177-7

  • Online ISBN: 978-3-662-09176-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation