Additional Medications

Abstract

Calcitonin is a polypeptide hormone produced by the parafollicular C cells of the thyroid. It inhibits the osteoclasts by binding to specific receptors on the cell surface. Calcitonin can be given as a subcutaneous injection or in a nasal spray. However use of calcitonin is limited because of its side effects such as feelings of heat as well as nausea, and mucosal irritation with use of the nasal spray. The most valid indication for calcitonin today is the intractable pain caused by a vertebral fracture, although even here its use is limited because of the superior results of intravenous bisphosphonates. On the other hand, the calcitonins are physiological peptides which can be metabolised and therefore are not retained in the body. Toxic effects have not been reported. Calcitonins are therefore suitable for children and in pregnancy and during breast feeding.