Abstract
Osteoporosis is one of the leading causes of morbidity and mortality in the elderly. Osteoporosis affects 20 million Americans and leads to approximately 1.5 million fractures each year (Finkelstein 1995). The annual cost of health care and lost productivity attributed to osteoporosis exceeds $10 billion in the United States. During the course of their lifetimes, women lose about 50% of their trabecular bone and 30% of the cortical bone while men lose about 30% of their trabecular bone and 20% of their cortical bone. Thus, even though osteoporosis is less common in men than in women, one fifth of all hip fractures occur in men and by the age of 90 one of every six men will have fractured his hip.
This chapter has been published previously in the Proceedings of the Second International Congress on Androgens and has been reproduced with the permission of John Wiley & Sons, Inc.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bonjour J-P, Theintz G, Buchs B, Slosman D, Rizzoli R (1991) Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 73: 555–563
Finkelstein JS (1995) Osteoporosis. In: Bennett JC, Plum F (eds) Cecil textbook of medicine. Saunders, Philadelphia (in press)
Finkelstein JS, Klibanski A, Neer RM, Greenspan SL, Rosenthal DI, Crowley WF (1987) Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Ann Intern Med 106: 354–461
Finkelstein JS, Klibanski A, Neer RM, Doppelt SH, Rosenthal DI, Segre GV, Crowley WF (1989) Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 69: 776–783
Finkelstein JS, Neer RM, Biller BMK, Crawford JD, Klibanski A (1992) Osteopenia in adult men with histories of delayed puberty. N Engl J Med 326: 600–604
Finkelstein JS, Klibanski A, Schaefer EH, Hornstein MD, Schiff I, Neer RM (1994) Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. N Engl J Med 331: 1618–1623
Francis RM, Peacock M, Aaron JE, Selby PL, Taylor GA, Thompson J, Marshall DH, Horsman A (1986) Osteoporosis in hypogonadal men: role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone formation. Bone 7: 261–268
Goldray D, Weisman Y, Jaccard N, Merdler C, Chen J, Matzkin H (1993) Decreased bone density in elderly men treated with the gonadotropin-releasing hormone agonist decapeptyl (D-Trp6-GnRH). J Clin Endocrinol Metab 76: 288–290
Greenspan SL, Neer RM, Ridgway EC, Klibanski A (1986) Osteoporosis in men with hyperprolactinemic hypogonadism. Ann Intern Med 104: 777–782
Greenspan SL, Oppenheim DS, Klibanski A (1989) Importance of gonadal steroids to bone mass in men with hyperprolactinemic hypogonadism. Ann Intern Med 110: 526–531
Kasperk CH, Wergedal JE, Farley JR, Linkhart TA, Turner RT, Baylink DJ (1989) Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology 124: 1576–1578
Katznelson L, Finkelstein J, Baressi C, Klibanski A (1994) Increase in trabecular bone density and altered body composition in androgen replaced hypogonadal men. Endocrine Society, 76th annual meeting 581 (abstract 1524)
Krabbe S, Christiansen C (1984) Longitudinal study of calcium metabolism in male puberty. I. Bone mineral content, and serum levels of alkaline phosphatase, phosphate, and calcium. Acta Paediatr Scand 73: 745–749
Matzkin H, Chen J, Welsman Y, Goldray D, Pappas F, Jaccard N, Braf Z (1992) Prolonged treatment with finasteride (a 5a-reductase inhibitor) does not affect bone density and metabolism. Clin Endocrinol (Oxf) 37: 432–436
Seeman E, Melton LJ, O’Fallon WM, Riggs BL (1983) Risk factors for spinal osteoporosis in men. Am J Med 75: 977–983
Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331: 1056–1061
Stepan JJ, Lachman M, Zverina J, Pacovsky V, Baylink DJ (1989) Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab 69: 523–527
Tenover JS (1992) Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 75: 1092–1098
Young NR, Baker HWG, Liu G, Seeman E (1993) Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception. J Clin Endocrinol Metab 77: 1028–1032
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Finkelstein, J.S. (1995). Androgen Action on the Bone. In: Baird, D.T., Schütz, G., Krattenmacher, R. (eds) Organ-Selective Actions of Steroid Hormones. Ernst Schering Research Foundation Workshop, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09153-1_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-09153-1_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-09155-5
Online ISBN: 978-3-662-09153-1
eBook Packages: Springer Book Archive