Multi-functional Biochip for Medical Diagnostics and Pathogen Detection

  • Tuan Vo-Dinh
  • Guy Griffin
  • David L. Stokes
  • Dimitra N. Stratis-Cullum
  • Minoo Askari
  • Alan Wintenberg
Part of the Springer Series on Chemical Sensors and Biosensors book series (SSSENSORS, volume 1)


There is an urgent need to develop monitoring devices capable of screening multiple medical diseases and detecting multiple infectious pathogens simultaneously. A critical factor in biomedical diagnostics involves selectivity and sensitivity for detection of a wide variety of biochemical substances (e.g., proteins, metabolites, nucleic acids), biological species or living systems (bacteria, virus or related components) at trace levels in complex biological samples (e.g., tissues, blood, other body fluids, and environmental biosamples). Biosensors are diagnostic devices that employ the powerful molecular recognition capability of bioreceptors such as antibodies, DNA, enzymes and cellular components of living systems. The operating principle of a biosensor involves detection of this molecular recognition and transforming it into another type of signal using a transducer that may produce either an optical signal (i.e., optical biosensors) or an electrochemical signal (i.e., electrochemical biosensors). A biosensor that involves the use of a microchip system for detection is often referred to as a bio-chip.


Medical Diagnostics Bacillus Anthracis Pathogen Detection FHIT Gene FHIT Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Fodor SPA, Read JL, Pirrung MC, Stryer LT, Lu A, Solas D (1991) Science 251: 767CrossRefGoogle Scholar
  2. 2.
    Anderson RC, McGall G, Lipshutz RJ (1997) Polynucleotide arrays for genetic sequence analysis. In: Manz A, Becker H (eds) Microsystem technology in chemistry and life science. Springer Verlag, Berlin, p 117Google Scholar
  3. 3.
    Schena M, Shalon D, Davis RW, Brown PO (1995) Science 270: 467CrossRefGoogle Scholar
  4. 4.
    Piunno PAE, Krull UJ, Hudson RHE, Damha MJ, Cohen H (1995) Anal Chim Acta 228: 205Google Scholar
  5. 5.
    Vo-Dinh T, Tromberg BJ, Griffin GD, Ambrose KR, Sepaniak MJ, Gardenhire EM (1987) Appl Spectrosc 41: 735CrossRefGoogle Scholar
  6. 6.
    Vo-Dinh T, Griffin GD, Sepaniak MJ (1991) Fiberoptic immunosensors. In: Wolfbeis OS (ed) Fiber optic chemical sensors and biosensors, vol 2. CRC Press, Boca Raton, Florida, P 217Google Scholar
  7. 7.
    Kumar P, Wilson RC, Valdes JJ, Chambers JP (1994) Mat Sci Eng C1: 187Google Scholar
  8. 8.
    Eggers M, Hogan M, Reich RK, Lamture J, Ehrlich D, Hollis M, Kosicki B, Powdrill T, Beattie K, Smith S, Varma R, Gangadharam R, Mallik A, Burke R, Wallace D (1994) Biotechniques 17: 516Google Scholar
  9. 9.
    Wolfbeis OS (ed) (1991) Fiber optic chemical sensors and biosensors. CRC Press, Boca Raton, FloridaGoogle Scholar
  10. 10.
    Vo-Dinh T, Isola NR, Alarie JP, Landis D, Griffin GD, Allison S (1998) Instrum Sci Technol 26: 503CrossRefGoogle Scholar
  11. 11.
    Vo-Dinh T (1998) Sens Actuators B 51: 52CrossRefGoogle Scholar
  12. 12.
    Vo-Dinh T, Alarie JP, Isola NR, Landis D, Wintenberg AL, Ericson MN (1999) Anal Chem 71: 358CrossRefGoogle Scholar
  13. 13.
    Vo-Dinh T (2003) Biodrugs (in press)Google Scholar
  14. 14.
    Allain LR, Askari M, Stokes DL,Vo-Dinh T (2001) Fresenius’ J Anal Chem 371: 146CrossRefGoogle Scholar
  15. 15.
    Stokes DL, Griffin GD,Vo-Dinh T (2001) Fresenius’ J Anal Chem 369: 295CrossRefGoogle Scholar
  16. 16.
    Vo-Dinh T, Askari M (2001) Cur Genomics 2: 399CrossRefGoogle Scholar
  17. 17.
    Patra G, Sylvestre P, Ramisse V, Therasse J, Guesdon JL (1996) FEMS Immunol Med Mic 15: 223CrossRefGoogle Scholar
  18. 18.
    Gopel G, Hesse J, Zemel JN (eds) (1992) Sensors, vol. 3. VCH, New York, NY, 1991Google Scholar
  19. 19.
    Tromberg BJ, Sepaniak MJ,Vo-Dinh T, Griffin GD (1987) Anal Chem 59: 1226CrossRefGoogle Scholar
  20. 20.
    Rowe CR, Scruggs SB, Feldstein MF, Golden JP, Ligler FS (1999) Anal Chem 71: 433CrossRefGoogle Scholar
  21. 21.
    Huebner K, Garrison PN, Barnes LD, Croce CM (1998) Ann Rev Genet 32: 7CrossRefGoogle Scholar
  22. 22.
    Ingvarsson S, Agnarsson BA, Sigbjornsdottir BI, Kononen J, Kallioniemi OP, Barkardottir RB, Kovatich A], Schwarting R, Hauk WW, Huebner K, McCue PA (1999) Cancer Res 59: 2682Google Scholar
  23. 23.
    Huiping C, Jonasson JG, Angarsson BA, Sigbjornsdottir BI, Huebner K, Ingvarsson S (2000) Eur J Cancer 36: 1552CrossRefGoogle Scholar
  24. 24.
    Mangray S, King TC (1998) Front Biosci 3: D1148Google Scholar
  25. 25.
    Mueller J, Werner M, Siewert JR (2000) Recent Results Cancer Res 155: 29CrossRefGoogle Scholar
  26. 26.
    Gartenhaus RB (1997) Oncogene 14: 375CrossRefGoogle Scholar
  27. 27.
    Sozzi G, Pastorino U, Moiraghi L, Tagliabue E, Pezzella F, Ghirelli C, Tornielli S, Sard L, Huebner K, Pierotti MA, Croce CM, Pilotti S (1998) Cancer Res 58: 5032Google Scholar
  28. 28.
    Mori M, Mimori K, Shiraishi T, Alder H, Inoue H, Tanaka Y, Sugimachi K, Huebner K, Croce CM (2000) Cancer Res 60: 1177Google Scholar
  29. 29.
    Sozzi G, Musso K, Ratcliffe C, Goldstraw P, Pierotti MA, Pastorino U (1999) Clin Cancer Res 5: 2689Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Tuan Vo-Dinh
  • Guy Griffin
  • David L. Stokes
  • Dimitra N. Stratis-Cullum
  • Minoo Askari
  • Alan Wintenberg

There are no affiliations available

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