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Multi-functional Biochip for Medical Diagnostics and Pathogen Detection

  • Tuan Vo-Dinh
  • Guy Griffin
  • David L. Stokes
  • Dimitra N. Stratis-Cullum
  • Minoo Askari
  • Alan Wintenberg
Chapter
Part of the Springer Series on Chemical Sensors and Biosensors book series (SSSENSORS, volume 1)

Abstract

There is an urgent need to develop monitoring devices capable of screening multiple medical diseases and detecting multiple infectious pathogens simultaneously. A critical factor in biomedical diagnostics involves selectivity and sensitivity for detection of a wide variety of biochemical substances (e.g., proteins, metabolites, nucleic acids), biological species or living systems (bacteria, virus or related components) at trace levels in complex biological samples (e.g., tissues, blood, other body fluids, and environmental biosamples). Biosensors are diagnostic devices that employ the powerful molecular recognition capability of bioreceptors such as antibodies, DNA, enzymes and cellular components of living systems. The operating principle of a biosensor involves detection of this molecular recognition and transforming it into another type of signal using a transducer that may produce either an optical signal (i.e., optical biosensors) or an electrochemical signal (i.e., electrochemical biosensors). A biosensor that involves the use of a microchip system for detection is often referred to as a bio-chip.

Keywords

Medical Diagnostics Bacillus Anthracis Pathogen Detection FHIT Gene FHIT Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Tuan Vo-Dinh
  • Guy Griffin
  • David L. Stokes
  • Dimitra N. Stratis-Cullum
  • Minoo Askari
  • Alan Wintenberg

There are no affiliations available

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