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Design, Quality Control and Normalization of Biosensor Chips

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Optical Sensors

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 1))

Abstract

With the completion of the human genome project biochip technologies have boosted and revolutionized automated genomic and proteomic analysis (www.microarrays.org; www.gene-chips.com) [1–7]. Based on conventional biomolecular techniques such as Southern and Northern blotting, sample preparation and assay was miniaturized by micromachining and microbiochemistry implemented efficiently by automated processes. To use biochip technologies for high throughput applications the system was adapted for high levels of parallelization. The potential of biochips lies in the parallel analysis of a huge number of probes, measured at once instead of one probe after the other. Such a technique speeds up biomolecular analysis tremendously. DNA chips have been widely used for gene expression, functional analysis, gene mapping and genotyping. Measuring RNA levels, however, might not give a complete or accurate description of a biological system. Because proteins mediate nearly all cellular activities, biochips have also been applied at the protein level (“proteomics”) [8, 9].

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  1. Claudia Preininger
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  2. Ursula Sauer
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Preininger, C., Sauer, U. (2004). Design, Quality Control and Normalization of Biosensor Chips. In: Optical Sensors. Springer Series on Chemical Sensors and Biosensors, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09111-1_4

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  • DOI: https://doi.org/10.1007/978-3-662-09111-1_4

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