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Novel Approaches to Treatment of Osteoporosis pp 179–198Cite as

The Regulation of Gene Expression in Bone by Mechanical Loading

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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 25))

Abstract

In the search for therapies to increase bone mass, it is not surprising that much attention has focused on studies of the effects of mechanical loading on the skeleton. Historical comments on the stronger skeletons of individuals with active lifestyles are attributed to Galileo, but serious studies of the relationships between bone mass and loading were not made until the late 1800s, when Culmann, von Meyer, Roux and Wolff initiated what has now become the idea of functional adaptation in the skeleton. Since then, studies have been predominantly phenomenological, cataloguing the changes in bone mass in response to exercise, disuse and applied loading. That is not to say that the data have not had important applications. For example, studies which have determined the numbers, rates and magnitudes of loads which influence bone mass have been useful in order to develop appropriate exercise regimens for improvement of bone mass. In addition it has become clear from clinical studies that exercise which fails to increase bone mass may still reduce the risk of fractures in osteoporotic individuals. This is because the increased muscle power and coordination which accompany increased fitness reduce the risk of falling, and therefore incidence of fracture.

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Authors
  1. T. M. Skerry
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Editors and Affiliations

  1. Human Metabolism and Clinical Biochemistry, Sheffield University Medical School, Beech Hill Road, S 10 2RX, Sheffield, UK

    R. Graham G. Russell

  2. Department of Biology, University of York, PO Box 373, YO1 5YW, York, UK

    Timothy M. Skerry

  3. FC/HT Research, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    Uwe Kollenkirchen

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© 1998 Springer-Verlag Berlin Heidelberg

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Skerry, T.M. (1998). The Regulation of Gene Expression in Bone by Mechanical Loading. In: Russell, R.G.G., Skerry, T.M., Kollenkirchen, U. (eds) Novel Approaches to Treatment of Osteoporosis. Ernst Schering Research Foundation Workshop, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09007-7_8

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  • DOI: https://doi.org/10.1007/978-3-662-09007-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09009-1

  • Online ISBN: 978-3-662-09007-7

  • eBook Packages: Springer Book Archive

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