Translation optimization in bacteria: statistical models
Growth rate, in bacteria, is supposed to depend largely on the optimization of the machinery for the synthesis of proteins. A crucial step is the translation from messenger RNA to the protein chain. This phase in bacteria is a highly coordinated and multistep process, being coupled also with the transcription process (). It begins with the interactions of a ribosome with a sequence of the messenger RNA called translation initiation region. This region is characterized by a start triplet, mostly AUG, and normally an upstream Shine- Dalgarno sequence.
KeywordsSynonymous Codon Translation Time Synonymous Mutation Rare Codon tRNA Molecule
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