Translation optimization in bacteria: statistical models

  • F. Bagnoli
  • G. Guasti
  • P. Liò
Conference paper
Part of the Centre de Physique des Houches book series (LHWINTER, volume 2)


Growth rate, in bacteria, is supposed to depend largely on the optimization of the machinery for the synthesis of proteins. A crucial step is the translation from messenger RNA to the protein chain. This phase in bacteria is a highly coordinated and multistep process, being coupled also with the transcription process ([1]). It begins with the interactions of a ribosome with a sequence of the messenger RNA called translation initiation region. This region is characterized by a start triplet, mostly AUG, and normally an upstream Shine- Dalgarno sequence.


Synonymous Codon Translation Time Synonymous Mutation Rare Codon tRNA Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • F. Bagnoli
    • 1
  • G. Guasti
    • 2
  • P. Liò
    • 3
  1. 1.Dipto. di Matematica ApplicataUniv. di FirenzeFirenzeItaly
  2. 2.Dipto. di FisicaUniv. di FirenzeFirenzeItaly
  3. 3.Dipto. di Biologia Animale e GeneticaUniv. di FirenzeFirenzeItaly

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