Skip to main content

Psychoendokrine Aspekte neuropsychologischer Funktionen: Die Hypothalamus-Hypophysen-Nebennierenrinden-Achse

  • Chapter
Neuropsychologie psychischer Störungen

Zusammenfassung

Der Patient P. leidet an einem Cushing-Syndrom. Sein Leben hat sich dramatisch verändert, seit aufgrund eines Tumors in seiner Hypophyse übermäßige Mengen der Stresshormone Kortikotropin und Kortisol freigesetzt werden. Äußerlich ist aus dem einst schlanken Mann ein fettleibiger Mensch geworden. Schlimmer für den Patienten P. sind die psychischen Auswirkungen der Hormonstörung. Seit Beginn der Krankheit ist er gereizt und leidet immer wieder unter depressiven Verstimmungen. Bei der Arbeit kann er sich nur mit Mühe konzentrieren, und sein Gedächtnis lässt ihn immer wieder im Stich. Erst seitdem sich der Patient P. einer Operation unterzogen hat, bei der der Tumor entfernt werden konnte, haben sich seine Hormonspiegel im Blut wieder normalisiert, und die psychischen Symptome haben sich deutlich gebessert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abdel-Malek ZA (2001) Melanocortin receptors: their functions and regulation by physiological agonists and antagonists. Cell Mol Life Sci 58: 434–441

    Article  PubMed  CAS  Google Scholar 

  • al’Absi M, Hugdahl K, Lovallo WR (2002) Adrenocortical stress responses and altered working memory performance. Psychophysiology 39: 95–99

    Article  PubMed  Google Scholar 

  • Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB (1999) The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 160: 1–12

    Article  PubMed  CAS  Google Scholar 

  • Barden N, Reul JM, Holsboer F (1995) Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 18: 6–11

    Article  PubMed  CAS  Google Scholar 

  • Born J, Fehm HL, Voigt KH (1986) ACTH and attention in humans: a review. Neuropsychobiology 15: 165–186.

    Article  PubMed  CAS  Google Scholar 

  • Born J, Brauninger W, Fehm-Wolfsdorf G, Voigt KH, Pauschinger P, Fehm HL (1987) Dose-dependent influences on electrophysiological signs of attention in humans after neuropeptide ACTH4_10. Exp Brain Res 67: 85–92

    Article  PubMed  CAS  Google Scholar 

  • Born J, Hitzler V, Pietrowsky R, Pauschinger P, Fehm HL (1988) Influences of cortisol on auditory evoked potentials ( AEPs) and mood in humans. Neuropsychobiology 20: 145–151

    Google Scholar 

  • Born J, Bathelt B, Pietrowsky R, Pauschinger P, Fehm HL (1990) Influences of peripheral adrenocorticotropin 1–39 (ACTH) and human corticotropin releasing hormone (h-CRH) on human auditory evoked potentials ( AEP ). Psychopharmacology (Berl) 101: 34–38

    Google Scholar 

  • Born J, Pietrowsky R, Fehm HL (1992) Differenzierung pharmakopsychologischer Wirkungen von Hormonen durch späte Komponenten des reizevozierten Potentials. In: Oldigs-Kerber J, Leonard JP (Hrsg) Pharmakopsychologie: Experimentelle und klinische Aspekte. Fischer, Jena, S 305–320

    Google Scholar 

  • Born J, Pietrowsky R, Fehm HL (1998) Neuropsychological effects of vasopressin in healthy humans. Prog Brain Res 119: 619–643

    Article  PubMed  CAS  Google Scholar 

  • Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL (2002) Sniffing neuropeptides–a transnasal approach to the human brain. Nat Neurosci 5: 514–516

    Article  PubMed  CAS  Google Scholar 

  • Boyer P (2000) Do anxiety and depression have a common pathophysiological mechanism? Acta Psychiatr Scand Suppl 406: 24–29

    Article  PubMed  Google Scholar 

  • Buchanan TW, Lovallo WR (2001) Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology 26: 307–317

    Article  PubMed  CAS  Google Scholar 

  • Calvo N, Volosin, M (2001) Glucocorticoid and mineralocorticoid receptors are involved in the facilitation of anxiety-like response induced by restraint. Neuroendocrinology 73: 261–271

    Article  PubMed  CAS  Google Scholar 

  • Dautzenberg FM, Kilpatrick GJ, Hauger RL, Moreau J (2001) Molecular biology of the CRH receptors–in the mood. Peptides 22: 753–760

    Article  PubMed  CAS  Google Scholar 

  • de Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19: 269–301.

    Article  PubMed  Google Scholar 

  • de Quervain DJ, Roozendaal B, McGaugh JL (1998) Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 394: 787–790

    Article  PubMed  Google Scholar 

  • de Quervain DJ, Roozendaal B, Nitsch RM, McGaugh JL, Hock C (2000) Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nat Neurosci 3: 313–314

    Article  PubMed  Google Scholar 

  • de Wied D, van Ree JM (1989) Neuropeptides: animal behaviour and human psychopathology. Eur Arch Psychiatry Neu rol Sci 238: 323–331

    Article  Google Scholar 

  • Diorio D, Viau V, Meaney MJ (1993) The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J Neurosci 13: 3839–3847

    PubMed  CAS  Google Scholar 

  • Dornbush RL, Nikolovski 0 (1976) ACTH4_10 and short-term memory. Pharmacol Biochem Behav 5: 69–72

    Article  PubMed  CAS  Google Scholar 

  • Dugbartey AT (1998) Neurocognitive aspects of hypothyroidism. Arch Intern Med 158: 1413–1418

    Article  PubMed  CAS  Google Scholar 

  • Dunn AJ, Berridge CW (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Brain Res Rev 15: 71–100

    Article  PubMed  CAS  Google Scholar 

  • Eichenbaum H (2000) A cortical-hippocampal system for declarative memory. Nat Rev Neurosci 1: 41–50

    Article  PubMed  CAS  Google Scholar 

  • File SE, Vellucci SV, Wendlandt S (1979) Corticosterone–an anxiogenic or an anxiolytic agent? J Pharm Pharmacol 31: 300–305

    Article  PubMed  CAS  Google Scholar 

  • Fink G, Sumner BE, McQueen JK, Wilson H, Rosie R (1998) Sex steroid control of mood, mental state and memory. Clin Exp Pharmacol Physiol 25: 764–775

    Article  PubMed  CAS  Google Scholar 

  • Gais S, Plihal W, Wagner U, Born J (2000) Early sleep triggers memory for early visual discrimination skills. Nat Neurosci 3: 1335–1339

    Article  PubMed  CAS  Google Scholar 

  • Greven HM, de Wied D (1977) Influence of peptides structurally related to ACTH and MSH on active avoidance behaviour in rats. A structure-activity relationship study. Front Horm Res 4: 140–152

    PubMed  CAS  Google Scholar 

  • Habib KE, Weld KP, Rice KC et al. (2000) Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A 97: 6079–6084

    Article  PubMed  CAS  Google Scholar 

  • Heilig M, Koob GF, Ekman R, Britton KT (1994) Corticotropinreleasing factor and neuropeptide Y: role in emotional integration. Trends Neurosci 17: 80–85.

    Article  PubMed  CAS  Google Scholar 

  • Heinrichs SC, Pich EM, Miczek KA, Britton KT, Koob GF (1992) Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res 581: 190–197

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F (2001) Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. J Affect Disord 62: 77–91.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson L, Sapolsky R (1991) The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 12: 118–134

    Article  PubMed  CAS  Google Scholar 

  • Janke W, Debus G (1978) Die Eigenschaftswörterliste EWL. Eine mehrdimensionale Methode zur Beschreibung von Aspekten des Befindens. Hogrefe, Göttingen

    Google Scholar 

  • Keck ME, Holsboer F (2001) Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides 22: 835–844

    Article  PubMed  CAS  Google Scholar 

  • Kern W, Peters A, Fruehwald-Schultes B, Deininger E, Born J, Fehm HL (2001) Improving influence of insulin on cognitive functions in humans. Neuroendocrinology 74: 270280

    Google Scholar 

  • Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH (1996) Stress-and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci 58: 1475–1483

    Article  PubMed  CAS  Google Scholar 

  • Lang PJ, Öhman A, Vaitl D (1988) The International Affective Picture System (photographic slides). The Center for Research in Psychophysiology, University of Florida, Gainesville/FL

    Google Scholar 

  • Lautenbacher S, Roscher S, Krieg 1C (2002) Aufmerksamkeit und Befindlichkeit unter hormonell simuliertem Stress: Die Wirkung von Corticotropin-Releasing-Hormon. Z Neuropsychol 13: 59–67

    Google Scholar 

  • Lupien SJ, McEwen BS (1997) The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Res Brain Res Rev 24: 1–27.

    Article  PubMed  CAS  Google Scholar 

  • Lupien SJ, Gaudreau S, Tchiteya BM et al. (1997) Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity. J Clin Endocrinol Metab 82: 2070–2075

    Article  PubMed  CAS  Google Scholar 

  • Lupien SJ, de Leon M, de Santi S et al. (1998) Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci 1: 69–73

    Article  PubMed  CAS  Google Scholar 

  • Lupien SJ, Gillin CJ, Hauger RL (1999) Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav Neurosci 113: 420–430

    Article  PubMed  CAS  Google Scholar 

  • McGaugh JL (2000) Memory–a century of consolidation. Science 287: 248–251

    Article  PubMed  CAS  Google Scholar 

  • Mölle M, Albrecht C, Marshall L, Fehm HL, Born J ( 1997 a) Adrenocorticotropin widens the focus of attention in humans. A nonlinear electroencephalographic analysis. Psychosom Med 59: 497–502

    Google Scholar 

  • Mölle M, Pietrowsky R, Fehm HL, Born J (1997 b) Regulation of human thought by neuropeptide ACTH4_10: an analysis of the EEG’s dimensional complexity. Neuroreport 8: 2715–2720

    Google Scholar 

  • Nemeroff CB, Widerlov E, Bissette G et al. (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226: 1342–1344

    Article  PubMed  CAS  Google Scholar 

  • Newcomer 1W, Craft S, Hershey T, Askins K, Bardgett ME (1994) Glucocorticoid-induced impairment in declarative memory performance in adult humans. J Neurosci 14: 20472053

    Google Scholar 

  • Newcomer JW, Selke G, Melson AK, Hershey T, Craft S, Richards K, Alderson A L (1999) Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Arch Gen Psychiatry 56: 527–533

    Article  PubMed  CAS  Google Scholar 

  • Oitzl MS, de Kloet ER (1992) Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behav Neurosci 106: 62–71

    Article  PubMed  CAS  Google Scholar 

  • Pietrowsky R, Krug R, Fehm HL, Born J (1992) Der Einfluss von »Streßhormonen« auf die emotionale Befindlichkeit. Z Exp Angew Psycho) 39: 278–298

    CAS  Google Scholar 

  • Plihal W, Born J (1997) Effects of early and late nocturnal sleep on declarative and procedural memory. J Cogn Neurosci 9: 534–547

    Article  Google Scholar 

  • Plihal W, Born J (1999 a) Memory consolidation in human sleep depends on inhibition of glucocorticoid release. Neuro-report 10: 2741–2747

    Google Scholar 

  • Plihal W, Born J (1999 b) Effects of early and late nocturnal sleep on priming and spatial memory. Psychophysiology 36: 571–582

    Google Scholar 

  • Plihal W, Krug R, Pietrowsky R, Fehm HL, Born J (1996) Corticosteroid receptor mediated effects on mood in humans. Psychoneuroendocrinology 21: 515–523

    Article  PubMed  CAS  Google Scholar 

  • Plihal W, Pietrowsky R, Born J (1999) Dexamethasone blocks sleep induced improvement of declarative memory. Psychoneuroendocrinology 24: 313–331

    Article  PubMed  CAS  Google Scholar 

  • Rockstroh B, Elbert T, Lutzenberger W, Birbaumer N, Voigt KH, Fehm HL (1983) Distractability under the influence of an ACTH 4–9 derivative. Int J Neurosci 22: 21–36

    Article  PubMed  CAS  Google Scholar 

  • Roozendaal B (2000) Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology 25: 213–238.

    Article  PubMed  CAS  Google Scholar 

  • Sanchez MM, Young U, Plotsky PM, Insel TR (2000) Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci 20: 4657–4668

    PubMed  CAS  Google Scholar 

  • Sapolsky RM (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57: 925–935

    Article  PubMed  CAS  Google Scholar 

  • Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21: 55–89

    Article  PubMed  CAS  Google Scholar 

  • Schmidt LA, Fox NA, Goldberg MC, Smith CC, Schulkin J (1999) Effects of acute prednisone administration on memory, attention and emotion in healthy human adults. Psychoneuroendocrinology 24: 461–483

    Article  PubMed  CAS  Google Scholar 

  • Smith EE, Jonides 1 (1999) Storage and executive processes in the frontal lobes. Science 283: 1657–1661

    CAS  Google Scholar 

  • Smolnik R, Mölle M, Fehm HL, Born J (1999) Brain potentials and attention after acute and subchronic intranasal administration of ACTH4_10 and desacetyl-a-MSH in humans. Neu roendocrinology 70: 63–72

    CAS  Google Scholar 

  • Squire LR (1992) Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psycho) Rev 99 195–231

    Article  CAS  Google Scholar 

  • Timpl P, Spanagel R, Sillaber I et al. (1998) Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor. Nat Genet 19: 162–166

    Article  PubMed  CAS  Google Scholar 

  • Wagner U, Born J (2000) Neurochemische Emotionssysteme. In: Otto JH, Euler HA, Mandl H (Hrsg) Emotionspsychologie: Ein Handbuch. Psychologie, Weinheim, S498–518

    Google Scholar 

  • Wagner U, Gais S, Born J (2001) Emotional memory formation is enhanced across sleep intervals with high amounts of rapid eye movement sleep. Learn Mem 8: 112–119

    Article  PubMed  CAS  Google Scholar 

  • Wolf OT, Kirschbaum C (1999) Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans. Brain Res Brain Res Rev 30: 264–288

    Article  PubMed  CAS  Google Scholar 

  • Wolkowitz OM, Reus VI, Canick J, Levin B, Lupien S (1997) Glucocorticoid medication, memory and steroid psychosis in medical illness. Ann N Y Acad Sci 823: 81–96

    Article  PubMed  CAS  Google Scholar 

  • Wolkowitz OM, Reus VI (1999) Treatment of depression with antiglucocorticoid drugs. Psychosom Med 61: 698–711

    PubMed  CAS  Google Scholar 

  • Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1999) The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers. Psycho-pharmacology (Berl) 145: 260–266

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wagner, U., Born, J. (2004). Psychoendokrine Aspekte neuropsychologischer Funktionen: Die Hypothalamus-Hypophysen-Nebennierenrinden-Achse. In: Lautenbacher, S., Gauggel, S. (eds) Neuropsychologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08959-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-08959-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-08960-6

  • Online ISBN: 978-3-662-08959-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics