Skip to main content
SpringerLink
Log in

Einleitung

  • Chapter
Monoklonale Antikörper

  • 192 Accesses

Zusammenfassung

Ein einzelner aktivierter B-Lymphozyt synthetisiert Antikörper einer einzigen Spezifität. Auch Tumoren von B-Lymphozyten (Myelom, Plasmocytom) produzieren Antikörper, deren Spezifität sich jedoch nicht vorherbestimmen läßt. Da ein solcher Tumor aus einer einzigen entarteten Zelle entsteht, sind die von allen Nachkommen dieser Zelle produzierten Antikörper völlig einheitlich, d. h. monoklonal.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Jonak ZL, Owen JA, Machy P, Leserman LD, Greig RG (1988) Gene transfection and lymphocyte immortalization: a new approach to human monoclonal antibody production. Adv Drug Deliv Rev 2: 207–228

    Article  CAS  Google Scholar 

  • Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497

    Article  PubMed  Google Scholar 

  • Lo MMS, Tsong TY, Conrad MK, Strittmatter SM, Hester LD, Snyder SH (1984) Monoclonal antibody production by receptor-mediated electrically induced cell fusion. Nature 310: 792–794

    Article  PubMed  CAS  Google Scholar 

  • Peters JH (1981) Hybridomas of mouse dendritic cells (DC) expressing phenotypic markers of CD including growth-stimulatory action on T-lymphocytes. In: Resch K, Kirchner H (eds) Mechanisms of lymphocyte activation. Elsevier/North Holland, Amsterdam New York Oxford, pp 537–540

    Google Scholar 

  • Ringertz NR, Savage RE (1976) Cell hybrids. Academic Press New York San Francisco London

    Google Scholar 

  • Treves AJ, Fuks Z, Voss R, Tal T, Barak V, Konijn AM, Kaplan R, Laskov R (1984) Establishment of cell lines from somatic cell hybrids between human monocytes and mouse myeloma cells. J Immunol 132: 690–694

    PubMed  CAS  Google Scholar 

  • Zimmermann U (1982) Electric field-mediated fusion and related electrical phenomena. Biochim Biophys Acta 694: 227–277

    Article  PubMed  CAS  Google Scholar 

  • Baldwin RW, Byers V, Eds (1985) Monoclonal antibodies for cancer detection and therapy. Academic Press, London.

    Google Scholar 

  • Bast RC, Klug TL, St. John E, Jenison E, Niloff JM, Lazarus H, Berkowitz RS, Leavitt T, Griffith CT, Parker L, Zarawski VR, Knapp RC (1983) A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. New Engl J. Med. 309: 883–887

    Google Scholar 

  • Bitter-Suermann D, Roth J (1987) Monoclonal antibodies to polysialic acid reveal epitope sharing between invasive pathogenic bacteria, differentiating cells and tumor cells. Immunol Res 6: 225–237

    Article  PubMed  CAS  Google Scholar 

  • Boss BD, Langman R, Trowbridge I, Dulbecco R, Eds (1983) Monoclonal antibodies and cancer. Academic Press, Orlando.

    Google Scholar 

  • Bosslet K (1985) Nachweis Gewebs-spezifischer Tumor-assoziierter Antigene mittels monoklonaler Antikörper. Diagn. Labor 35: 36–40

    Google Scholar 

  • Chanh TC, Dreesman GR, Kennedy RC (1987) Monoclonal anti-idiotypic antibody mimics the CD4 receptor and binds human immunodeficiency virus. Proc Natl Acad Sci USA 84: 3891–3895

    Article  PubMed  CAS  Google Scholar 

  • Ehrlich PA, Moyle WR, Moustafa ZA (1983) Further characterization of cooperative interactions of monoclonal antibodies. J Immunol 131: 1906–1912

    PubMed  CAS  Google Scholar 

  • Eisenbarth GS (1981) Application of monoclonal antibody techniques to biochemical research. Anal Biochem 111: 1–16

    Article  PubMed  CAS  Google Scholar 

  • Feller AC (1985) Monoklonale Antikörper in der Diagnostik maligner Lymphome. Diagn. Labor 35: 23–35

    Google Scholar 

  • Goldenberg DM (1987) Current status of cancer imaging with radiolabeled antibodies. J Cancer Res Clin Oncol 113: 203–208

    Article  PubMed  CAS  Google Scholar 

  • Gosh S, Campbell AM (1986) Multispecific monoclonal antibodies. Immunol today 7: 217–222

    Article  Google Scholar 

  • Haynes BF, Eisenbarth JS (1983) Monoclonal antibodies: A probe for the study of autoimmunity and immunodeficiency. Academic Press London New York

    Google Scholar 

  • Houba V, Chan SH (eds) (1980) Properties of the monoclonal antibodies produced by hybridoma technology and their application to the study of diseases. UNDP/World Bank/ WHO, Geneva

    Google Scholar 

  • Iversen OH (1982) Volvolon. A recently discovered peptide hormone from the pineal body. Can Med Ass J 126: 787–790

    PubMed  CAS  Google Scholar 

  • Knapp W (1985) Monoklonale Antikörper in der Leukämiediagnostik. Diagn. Labor 35: 12–22

    Google Scholar 

  • Knowles DM II, Dodson LD, Raab R (1983) The application of monoclonal antibodies to the characterization and diagnosis of lymphoid neoplasmas: a review of recent studies. Diag Immunol 1: 142–149

    Google Scholar 

  • Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497

    Article  PubMed  Google Scholar 

  • Kurrle R, Enssle KH, Seiler FR (1988) Monoclonal antibodies to leukocyte differentiation antigens for therapeutic use. Behring Inst. Mitt. 82: 154–173

    Google Scholar 

  • Macario AJL, Macario, EC de, Eds (1985) Monoclonal antibodies against bacteria. Academic Press, Orlando.

    Google Scholar 

  • McMichael AJ, Fabre JW, Eds (1982) Monoclonal antibodies in clinical medicine. Academic Press, London.

    Google Scholar 

  • McNamara MK, Ward RE, Köhler H (1984) Monoclonal idiotype vaccine against S. pneumoniae infection. Science 226: 1325–1326

    Article  PubMed  CAS  Google Scholar 

  • Milstein C (1981) Monoclonal antibodies from hybrid myelomas. Proc Roy Soc Lond 211: 393–412

    Article  CAS  Google Scholar 

  • Milstein C (1982) Monoklonale Antikörper. Spektrum der Wissenschaften. Heidelberg 97–108 Mitchell MS, Oettgen HF, Eds (1982) Hybridomas in cancer Diagnosis and treatment. In: Progress in Cancer Research and therapy, Vol. 21. Raven Press New York.

    Google Scholar 

  • Möller G (ed.) (1979) Hybrid myeloma antibodies against MHC products. Immunological Reviews 47 Muksgaard Copenhagen Einsatz von monoklonalen Antikörpern am Menschen 11

    Google Scholar 

  • Moldofsky PJ, Sears HF, Mulhern CB, Hammond ND, Powe J, Gatenby RA, Steplewski Z, Koproswski H (1984) Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal antibody imaging. New England J. Med. 311: 106–107

    Google Scholar 

  • Moyle WR, Anderson DM, Ehrlich PA (1983) A circular antibody-antigen complex is responsible for increased affinity shown by mixtures of monoclonal antibodies to human chorionic gonadotropin. J Immunol 131: 1900–1905

    PubMed  CAS  Google Scholar 

  • Olsson L (1983) Monoclonal antibodies in clinical immunology. Allergy 38: 145–154

    Article  PubMed  CAS  Google Scholar 

  • Raza A, Preisler HD, Mayers GL, Bankert R (1984) Rapid enumeration of S-phase cells by means of monoclonal antibodies. New Engl J Med 310: 991

    PubMed  CAS  Google Scholar 

  • Reagan KJ, Wunner WH, Wiktor TJ, Koprowski H (1983) Antiidiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein. J Virol 48: 660–668

    PubMed  CAS  Google Scholar 

  • Rollins DE, Brizgys M (1986) Immunological approach to poisoning. Ann Emerg Med, 15 (9): 1046–1051

    Article  PubMed  CAS  Google Scholar 

  • Rosen ST, Winter JN, Epstein AL (1983) Application of monoclonal antibodies to tumor diagnosis and therapy. Ann Clin Lab Sci 13: 173–184

    PubMed  CAS  Google Scholar 

  • Stein KE, Söderström T (1984) Neonatal administration of idiotype or anti-idiotype primes for protection against E. coli K13 infection in mice. J Exp Med 160: 1001–1011

    CAS  Google Scholar 

  • Tramontano A, Janda KD, Lerner RA (1986) Catalytic antibodies. Science 234: 1566–1570

    Google Scholar 

  • Uytdehaag FGCM, Osterhus ADME (1985) Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody. J Immunol 134: 1225–1334

    Google Scholar 

  • Walter G, Friesen H-J, Harthus H-P (1988) Anti-idiotypic antibodies: powerful tools in diagnosis and therapy. Behring Inst Mitt 82: 182–192

    PubMed  CAS  Google Scholar 

  • Baudrihuye N (Ed) (1986) Requirements for the production and quality control of monoclonal antibodies of murine origin intended for the use in man. Document III/859/86, Draft 4, June 1986. Europ. Federation of Pharmaceutical Industries’ Associations

    Google Scholar 

  • Begent RHJ et al. (1986) Operation manual for controlling production, preclinical toxicology and phase I trials of anti-tumor antibodies and drug antibody conjugates. Br J Cancer 54: 557–568

    Article  Google Scholar 

  • Betriebsverordnung für pharmazeutische Unternehmer vom 8. März 1985 (BGBI,I) S. 546 Bicker et al. (1987) Empfehlungen für die Herstellung und Prüfung in vivo applizierbarer monoklonaler Antikörper. Dtsch Med Wschr 112: 194–198

    Google Scholar 

  • Bussard AE (1983) How pure are monoclonal antibodies? Develop Biol Standard. 57: 13–15

    Google Scholar 

  • Council directive of 22. December 1986 on the approximation of national measures relating to the placing on the market of high-technology medical products, particularly those derived from biotechnology (87/22/EEC). Official Journal of the European Communities No L 15/38 vom 17. 1. 1987

    Google Scholar 

  • Doel TR (1985) Inactivation of viruses produced in animal cell cultures. In: Animal Cell Biotechnology, Vol. 2. Academic Press, London, p 129

    Google Scholar 

  • Duffy SA, Moellering BJ, Prior GM, Doyle KR, Prior CP (1989) Recovery of therapeutic-grade antibodies: Protein A and Ion-exchange chromatography. Biopharm 2: 34–47

    Google Scholar 

  • FDA draft (1983) Points to consider in the manufacture of monoclonal antibody products for human use. Office of Biologics. July 25 1983

    Google Scholar 

  • Haase M (1987) Behördliche Anforderungen an die Herstellung und Prüfung von monoklonalen Antikörpern. Pharma Technol 4: 32–35

    Google Scholar 

  • Hoffman T (1987) Regulatory issues surrounding therapeutic uses of monoclonal antibody. In: Hybridoma Formation. Ed. Bartal A, Hishault Y. Humana Press, Clifton, NJ, pp 447–456

    Chapter  Google Scholar 

  • Hoffman T, Kenimer J, Stein KE (1985) Regulatory issues surrounding therapeutic uses of monoclonal antibodies. Points to consider in the manufacturing of injectible products for human use. In: Monoclonal Antibodies and Cancer Therapy. UCLA Symposium on Molecular and Cellular Biology. Ed. Reisfeld RA, Sell S. Alan R. Liss, New York, pp 431–440

    Google Scholar 

  • Monographie (1986) Immunsera für Menschen. In: Deutsches Arzneibuch, 9. Ausgabe 1986, Stuttgart. Deutscher Apotheker-Verlag. S. 903–904

    Google Scholar 

  • NN (1988) Guidelines on the production and quality control of monoclonal antibodies of murine origin intended for use in man. Tibtech 6: G5 - G8

    Google Scholar 

  • Notes to applicants for marketing authorizations on the requirements for the production and quality control of monoclonal antibodies of murine origin intended for use in man (EG-III/ 859/87/EN)

    Google Scholar 

  • Paul-Ehrlich-Institut (1984) Überlegungen zur Standardisierung und Prüfung von gentechnologisch hergestellten biologischen Produkten und von permanent wachsenden Zellinien als Substrate für Vakzineviren und für monoklonale Antikörper; Fassung vom 11.7.84. Bundesamt für Sera und Impfstoffe, 6000 Frankfurt am Main 70.

    Google Scholar 

  • Richtlinien über Allgemeine Anforderungen an die Herstellung und Prüfung von Sera, Impfstoffen und Testantigenen. Bundesanzeiger vom 5.11. 1975. Jahrgang 27, Nr. 206

    Google Scholar 

  • Revidierte Grundregeln der Weltgesundheitsorganisation für die Herstellung von Arzneimitteln und die Sicherung ihrer Qualität. Bundes-Anzeiger vom 3. Januar 1978, Jahrgang 30, Nr. 1

    Google Scholar 

  • Roedler HD (1984) Regulatory aspects in the Federal Republic of Germany. In: Safety and efficacy of radiopharmaceuticals. Ed. Kristensen E, Nörbygaard E. Nijhoff Publishers, Boston, The Hague, Dordrecht, Lancaster.

    Google Scholar 

  • WHO (1987) WHO meeting on cells for the production of biologicals. Wkly Epidem Rec 4: 13–15

    Google Scholar 

Download references

Authors
  1. J. H. Peters
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Baron
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Immunologie, Zentrum für Hygiene und Humangenetik, Georg-August-Universität, Kreuzbergring 57, D-3400, Göttingen, Deutschland

    Johann Hinrich Peters

  2. Diagnostika Forschung, Boehringer Mannheim GmbH, Bahnhofstraße 9-15, D-8132, Tutzing, Deutschland

    Horst Baumgarten

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Peters, J.H., Baron, D. (1990). Einleitung. In: Peters, J.H., Baumgarten, H. (eds) Monoklonale Antikörper. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08842-5_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-08842-5_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50844-1

  • Online ISBN: 978-3-662-08842-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation