Hyperprolactinaemia: Results of Operation in Patients Selected on the Basis of Dynamic Endocrine Tests
In 1979 we suggested that dynamic endocrine tests would be useful in the detection of small prolactinomas, irrespective of radiological findings (1). Among our reasons for this approach were, first, the uncertainty about the significance of minor changes in the radiological appearances of the pituitary fossa, and second, the hope that optimum results would be obtained by an operation performed before a tumour had become large enough to produce a markedly abnormal fossa. Forty women thought to have an intrasellar prolactinoma, on the basis of abnormal prolactin dynamics, have now undergone trans-sphenoidal operation. We report the findings at operation and their relationship to the preoperative endocrine and radiological studies, and results of this method of management.
KeywordsFiltration Adenoma Cortisol Penicillin Prolactin
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- 2.Burrow, G.N., Wortzman, G., Rewcastle, N.B., Holgate, R., Kovacs, K.: Microadenoma of pituitary and abnormal sella tomograms in an unselected autopsy series. New EngL J. Med (in press)Google Scholar
- 3.Fahlbusch, R.: Surgical failures in prolactinomas. In: Pituitary Adenomas, Biology, Physiopathology and Treatment. Derome, P.J., Jedynak, L.P., Peillon, F. (eds), pp. 273–284. Paris: AesclepiosGoogle Scholar
- 4.Hardy, J., Mohr, G.: Le prolactinome aspects chirurgicaux. Neurochirurgie 27, SuppL 1, 41–60 (1981)Google Scholar
- 5.Lancet Editorial. Hyperprolactinaemia: pituitary tumour or not? Lancet 1, 517–519 (1980)Google Scholar
- 6.Schlechte, J., Sherman, B., Halmi, N., Van Hilden, J., Chapler, F., Dolan, K., Granner, D,, Duello, T., Harris, C.: Prolactin-secreting pituitary tumours in amenorrhoeic women: a comprehensive study. Endocrine Reviews 1, 295–308 (1981)Google Scholar