Treatment of Supratentorial Glioma Recurrencies with Re-Operation and Chemotherapy

  • D. Áfra

Abstract

For treatment of supratentorial glioma recurrencies there are two main alternatives: either reoperation or conservative treatment, i.e. irradiation and/or chemotherapy. The possibility of repeated surgical intervention seems to be rather limited. According to our earlier experiences a reasonably longer survival-time could be achieved by removal of rather circumscribed located recurrences mostly sited in the poles, with subsequent irradiation (1). Apart from this, surgical evacuation (14) or shunting of cystic recurrences might be mandatory in some cases (2).

Keywords

Sugar Toxicity Corticosteroid Dexamethasone Hydrochloride 

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References

  1. 1.
    Afra, D., Müller, W., Benoist, G., Schröder, R.: Supratentorial recurrences of gliomas. Results of reoperations on astrocytomas and oligodendrogliomas. Acta Neurochir. 43, 217–227 (1978)PubMedCrossRefGoogle Scholar
  2. 2.
    Afra, D., Norman, D., Levin, V.A.: Cyst in malignant gliomas. Identification by computerized tomography. J. Neurosurg. 53, 821–825 (1980)PubMedCrossRefGoogle Scholar
  3. 3.
    Bloom, H.J.G.: personal communicationGoogle Scholar
  4. 4.
    Chiuten, D.F., Rozencweig, M., Von Hoff, D.D., Muggia, F.M.: Clinical trials with the hexitol derivatives in the U.S. Cancer 47, 442–451 (1981)PubMedCrossRefGoogle Scholar
  5. 5.
    Eckhardt, S. (ed.): Dibromducitol. Budapest: Medicina 1982Google Scholar
  6. 6.
    Fewer, D., Wilson, C.B., Boldrey, E.B., Enot, J.K.: Phase II study of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) NSC-79039 in the treatment of brain tumors. Cancer Chemother. Reports 56, 421–427 (1972)Google Scholar
  7. 7.
    Fewer, D., Wilson, C.B., Levin, V.A.: Brain tumor chemotherapy. Springfield: Charles C. Thomas 1976Google Scholar
  8. 8.
    Gutin, Ph.H., Wilson, C.B., Kumar, A.R.V., Boldrey, E.B., Levin, V.A., Powell, M., Enot, K.J.: Phase II study of Procarbazine, CCNU and Vincristine combination chemotherapy in the treatment of malignant brain tumors Cancer 35, 1398–1404 (1975)Google Scholar
  9. 9.
    Jellinger, K., Kothbauer, P., Volc, D., Vollmer, R., Weiss, R.: Combination Chemotherapy (COMP Protocol) and radiotherapy of anaplastic supratentorial gliomas. Acta Neurochir. 51, 1–13 (1979)Google Scholar
  10. 10.
    Kumar, A.R.V., Renaudin, J., Wilson, C.B., Boldrey, E.B., Enot, K.J., Levin, V.A.: Procarbazinehydrochloride in the treatment of brain tumors. Phase II study. J. Neurosurg. 40, 365–371 (1974)CrossRefGoogle Scholar
  11. 11.
    Levin, V.A., Crafts, D.C., Wilson, C.B., Schultz, M.J., Boldrey, E.B., Enot, K.J., Pischer, T.L., Seager, M., Elashoff, R.M.: BCNU (NSC-409962) and Procarbazine (NSC-77213) treatment for malignant brain tumors. Cancer Treatm. Reports 60, 243–249 (1976)Google Scholar
  12. 12.
    Levin, V.A., Hoffman, W.F., Pischer, T.L., Seager, M.L., Boldrey, E.B., Wilson, C.B.: BCNU — 5-Fluorouracil combination therapy for recurrent malignant brain tumors. Cancer Treatment Reports 62, 2071–2076 (1978)PubMedGoogle Scholar
  13. 13.
    Levin, V.A., Wilson, C.B., Davis, R., W.ra, W.M., Pischer, T.L., Irwin, L.: A Phase III comparison of BCNU, hydroxyurea, and radiation therapy to BCNU and radiation therapy for treatment of primary malignant gliomas. J. Neurosurg. 51, 526–532 (1979)PubMedCrossRefGoogle Scholar
  14. 14.
    Poisson, M., Philippon, J., van Effentere, R.: Cerebral pseudocysts following chemotherapy of glioblastomas. Acta Neurochir. 39, 143–149 (1977)PubMedCrossRefGoogle Scholar
  15. 15.
    Reagen, T.J., Bisel, H.F., Childs, D.S., Jr., Layton, D.D., Rhoton, A.L., Jr., Taylor, W.M.: Controlled study of CCNU and radiation therapy in malignant astrocytomas. J. Neurosurg. 44, 186–190 (1976)CrossRefGoogle Scholar
  16. 16.
    Rosenblum, M.L., Reynolds, A.F., Smith, K.A., Rumack, B.H., Walker, M.D.: Chloroethyl-cyclohexyl-nitrosourea (CCNU) in the treatment of malignant brain tumors. J. Neurosurg. 39, 306–314 (1973)Google Scholar
  17. 17.
    Seiler, R.W., Greiner, R.H., Zimmermann, A., Markwalder, H.: Radiotherapy combined with Procarbazine, Bleomycin and CCNU in the treatment of high-grade supratentorial astrocytomas. J. Neurosurg. 48, 861–865 (1978)PubMedCrossRefGoogle Scholar
  18. 18.
    Walker, M.D., Alexander, E., jr., Hunt, W.E., McCarthy, C.S., Mahaley, M.S., Jr., Mealey, J., Jr., Norrhell, H.A., Owens, G., Ransohoff, J., Wilson, C.B., Gehan, E.A., Strike, T.A.: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative triaL J. Neurosurg. 49, 333–343 (1978)PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1982

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  • D. Áfra

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