Abstract
There are several possible reasons why malignant brain tumours do not respond to chemotherapy. First, because of impaired drug delivery, chemotherapeutic agents might not reach all tumour cells in cytoxic concentrations. Second, tumour growth kinetics might affect the response to drugs because tumour cells are in an insensitive phase of the cell cycle when the drug is administered (10). Finally, tumour cells may survive therapy because of “inherent” cellular resistance.
Supported in part by NCI Grant CA-13525, the Morris Stulsaft Foundation, and a grant from the Deutsche Forschungsgemeinschaft
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Rosenblum, M.L. et al. (1982). Resistance of Brain Tumours to Chemotherapy: Preliminary Studies of Rat and Human Tumours. In: Brock, M. (eds) Modern Neurosurgery 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08801-2_13
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DOI: https://doi.org/10.1007/978-3-662-08801-2_13
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