Skip to main content

In Vitro Culture and the Production of Secondary Metabolites in Stephania

  • Chapter
Medicinal and Aromatic Plants XII

Part of the book series: Biotechnology in Agriculture and Forestry ((AGRICULTURE,volume 51))

Abstract

The genus Stephania (Menispermaceae) comprises approximately 50 species distributed from Africa through Asia to Australia. The importance of the genus in traditional medicine in Asia and Africa is well documented (Min et al. 1986; Cao and Zhu 1997). The underground tubers of the vines are generally characterized by powerful pharmacological effects (Blanchfield et al. 1993).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akasu M, Itokawa H, Fujita M (1974) Four new fluorescent components isolated from the callus tissue of Stephania cepharantha. Tetrahedron Lett 41:3609–3612

    Article  Google Scholar 

  • Akasu M, Itokawa H, Fujita M (1975) Oxoaporphine alkaloids from the callus tissue of Stephania cepharantha. Phytochemistry 14:1673–1674

    Article  CAS  Google Scholar 

  • Akasu M, Itokawa H, Fujita M (1976) Biscoclaurine alkaloids in callus tissue of Stephania cepharantha. Phytochemistry 15:471–473

    Article  CAS  Google Scholar 

  • Amann M, Zenk MH (1987) Preparation of dehydrobenzylisoquinolines by immobilized (S)tetrahydroprotoberberine oxidase from plant cell cultures. Phytochemistry 26:3235–3240

    Article  CAS  Google Scholar 

  • Bhakuni DS, Singh AN, Jain S (1980) Biosynthesis of isotetrandrine. Tetrahedron 36:2149–2151

    Article  CAS  Google Scholar 

  • Bhakuni DS, Jain S, Chaturvedi R (1987) The biosynthesis of the alkaloids of Cissampelos pareira Linn. Tetrahedron 43:3975–3982

    Article  CAS  Google Scholar 

  • Blanchfield JT, Kitching W, Sands DPA, Thong YH, Kennard CHL, Byriel KA (1993) Alkaloids from some Australian Stephania (Menispermaceae) species. Nat Prod Lett 3:305–312

    Article  CAS  Google Scholar 

  • Cao Z-F, Zhu X-Q (1997) Antioxidant action of tetrandrine: an alkaloid from the roots of Radix stephania tetrandra, S Moore. J Sci Food Agric 73:106–110

    Article  CAS  Google Scholar 

  • Cassels BK, Breitmaier E, Zenk MH (1987) Bisbenzylisoquinoline alkaloids in Berberis cell cultures. Phytochemistry 26:1005–1008

    Article  CAS  Google Scholar 

  • Charles B, Bruneton J, Pharadai K, Tantisewie B, Guinaudeau H, Shamma M (1987) Some unusual proaporphine and aporphine alkaloids from Stephania venosa. J Nat Prod 50:1113–1117

    Article  CAS  Google Scholar 

  • Dagne E, Gunatilaka AAL, Kingston DGI (1993) 4’-O-Methylstephavanine from Stephania abyssinica. J Nat Prod 56:2022–2025

    Article  PubMed  CAS  Google Scholar 

  • Davydenkov VN, Tareeva NV, Kir’yanov AA, Bondarenko LT (1988) Qualitative determination of stepharine in the plant cell cultures of Stephania glabra. Khim-Farm Zh 22:326–328

    CAS  Google Scholar 

  • Deng J, Zhao S, Lou F (1990) A new monoquaternary bisbenzylisoquinoline alkaloid from Stephania tetrandra. J Nat Prod 53:993–994

    Article  CAS  Google Scholar 

  • Dwuma-Badu D, Ayim JSK, Withers SF, Agyemang NO, Ateya AM, El-Azizi MM, Knapp JE, Slatkin DJ, Schiff PL Jr (1980) Constituents of west African medicinal plants. XXVII. Alkaloids of Rhigiocarya racemifera and Stephania dinklagei. J Nat Prod 43:123–129

    Article  CAS  Google Scholar 

  • Guha KP, Mukherjee B (1979) Bisbenzylisoquinoline alkaloids — a review. J Nat Prod 42:1–84

    Article  CAS  Google Scholar 

  • Itokawa H, Akasu M, Fujita M (1973) Several oxidized sterols isolated from callus tissue of Stephania cepharantha. Chem Pharm Bull (Tokyo) 21:1386–1387

    Google Scholar 

  • Kang H-S, Kim Y-H, Lee C-S, Lee J-J, Choi I, Pyun K-H (1996) Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models. Mediators Inflammation 5:280–291

    Article  CAS  Google Scholar 

  • Koike L, Marsaioli A, Reis F de AM (1982) Carbon-13 nuclear magnetic resonance spectroscopy and conformational analysis of the daphnoline-repandine class of bis(benzylisoquinoline) alkaloids. J Org Chem 47:4351–4353

    Article  CAS  Google Scholar 

  • Kozuka M, Miyaji K, Sawada T, Tomita M (1985) A major alkaloid of the leaves and stems of Stephania rotunda. J Nat Prod 48:341–342

    Article  CAS  Google Scholar 

  • Kupchan SM, Suffness MI, White DNJ, McPhail AT, Sim GA (1968) The isolation and structural elucidation of 4-demethylhasubanonine, a new alkaloid from Stephania hernandifolia. J Org Chem 33:4529–4532

    Article  PubMed  CAS  Google Scholar 

  • Likhitwitayawuid K, Angerhofer CK, Cordell GA, Pezzuto JM (1993) Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta. J Nat Prod 56:30–38

    Article  PubMed  CAS  Google Scholar 

  • Min Z-D, Yang H-M, Mizuno M, Tanaka T (1986) Studies on chemical constituents and chemotaxonomy of genus Stephania in China. Gifu Yakka Daigaku Kiyo 35:28–35

    Google Scholar 

  • Nakaoji K, Nayeshiro H, Tanahashi T, Su Y, Nagakura N (1997) Bisbenzylisoquinoline alkaloids from Stephania cepharantha and their effects on proliferation of cultured cells from the murine hair apparatus. Planta Med 63:425–428

    Article  PubMed  CAS  Google Scholar 

  • Patra A, Montgomery CT, Freyer AJ, Guinaudeau H, Shamma M, Tantisewie B, Pharadai K (1987) The protoberberine alkaloids of Stephania suberosa. Phytochemistry 26:547–549

    Article  CAS  Google Scholar 

  • Popov YG (1985) Somatic embryogenesis and plant development in Stephania glabra tissue culture. Biol Nauki (Moscow) 6:86–89

    Google Scholar 

  • Rueffer M, El-Shagi H, Nagakura N, Zenk MH (1981) (S)-Norlaudanosoline synthase: the first enzyme in the benzylisoquinoline biosynthetic pathway. FEBS Lett 129:5–9

    Article  CAS  Google Scholar 

  • Schiff PL Jr (1983) Bisbenzylisoquinoline alkaloids. J Nat Prod 46:1–43

    Article  CAS  Google Scholar 

  • Shamina ZB, Savina TA, Osipova EA, Popov YG (1994) Improvement of Stephania glabra (Roxb) Miers. cell culture productivity. Russian J Plant Physiol 41:778–783

    Google Scholar 

  • Soni PL, Sharma HW, Bisen SS, Srivastava HC, Gharia MM (1986) Physicochemical studies of starch isolated from forest tubers Stephania glabra and Pueraria thomsonii. Starch 38:355–358

    Article  CAS  Google Scholar 

  • Stadler R, Zenk MH (1993) The purification and characterization of a unique cytochrome P-450 enzyme from Berberis stolonifera plant cell cultures. J Biol Chem 268:823–831

    PubMed  CAS  Google Scholar 

  • Stadler R, Kutchan TM, Loeffler S, Nagakura N, Cassels B, Zenk MH (1987) Revision of the early steps of reticuline biosynthesis. Tetrahedron Lett 28:1251–1254

    Article  CAS  Google Scholar 

  • Stadler R, Loeffler S, Cassels BK, Zenk MH (1988) Bisbenzylisoquinoline biosynthesis in Berberis stolonifera cell cultures. Phytochemistry 27:2557–2565

    Article  CAS  Google Scholar 

  • Sugimoto Y, Yamada Y (1993) Involvement of tyramine in bisbenzylisoquinoline biosynthesis in cultured roots of Stephania cepharantha. J Nat Prod 56:1229–1233

    Article  CAS  Google Scholar 

  • Sugimoto Y, Sugimura Y, Yamada Y (1988) Production of bisbenzylisoquinoline alkaloids in cultured roots of Stephania cepharantha. Phytochemistry 27:1379–1381

    Article  CAS  Google Scholar 

  • Sugimoto Y, Sugimura Y, Yamada Y (1990) Biosynthesis of bisbenzylisoquinoline alkaloids in cultured roots of Stephania cepharantha. FEBS Lett 273:82–86

    Article  PubMed  CAS  Google Scholar 

  • Sugimoto Y, Kawaminami S, Yamada Y (1993) Biosynthetic relationship of aromoline and berbamine in cultured roots of Stephania cepharantha. Phytochem Anal 4:100–102

    Article  CAS  Google Scholar 

  • Sugimoto Y, Uchida S, Inanaga S, Isogai A (1997) Effect of P-450 inhibitors on benzylisoquinoline alkaloid biosynthesis in cultured roots of Stephania cepharantha and Menispermum dauricum. J Plant Physiol 150:376–380

    Article  CAS  Google Scholar 

  • Suzuki S, Fujino H, Tatsuo Y, Yamazaki N, Yoshizaki M (1992) Rapid propagation of Stephania cephalantha Hayata by tissue culture. Jpn J Breed 42:769–777

    Google Scholar 

  • Taga T, Akimoto N, Ibuka T (1984) Stephadiamine, a new skeletal alkaloid from Stephania japonica: the first example of a C-norhasubanan alkaloid. Chem Pharm Bull (Tokyo) 32:4223–4225

    Article  CAS  Google Scholar 

  • Tantisewie B, Amurrio S, Guinaudeau H, Shamma M (1989) New bisbenzylisoquinolines from Stephania pierrii. J Nat Prod 52:846–851

    Article  CAS  Google Scholar 

  • Thornber CW (1970) Alkaloids of the Menispermaceae. Phytochemistry 9:157–187

    Article  CAS  Google Scholar 

  • Wang X-K, Zhao T-F (1990) The distribution and biological activity of the alkaloids from Stephania plants. Chin Pharm J 25:3–6

    CAS  Google Scholar 

  • Wang X-K, Zhao Y-R, Zhao T-F, Che C-T (1995) Further constituents of Stephania sutchuenensis. Planta Med 61:99

    Article  PubMed  CAS  Google Scholar 

  • Yamada Y, Fujita Y (1983) Production of useful compounds in culture. In: Evans DA, Sharp WR, Ammirato PV, Yamada Y (ed) Handbook of plant cell culture, vol 1. Macmillan, New York, pp 717–728

    Google Scholar 

  • Yang H-M, Chen Y (1994) Chemosystematic notes of genus Stephania (Menispermaceae) in China. Acta Bot Sin 36:14–22

    Google Scholar 

  • Zhen P, Chen P, Wang H (1994) Analysis of tetrandrine and demethyltetrandrine in Chinese medicinal herbs Stephania tetrandra S. Moore by high performance liquid chromatography. Fenxi Kexue Xuebao 10:20–23

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sugimoto, Y. (2002). In Vitro Culture and the Production of Secondary Metabolites in Stephania . In: Nagata, T., Ebizuka, Y. (eds) Medicinal and Aromatic Plants XII. Biotechnology in Agriculture and Forestry, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08616-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-08616-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07503-2

  • Online ISBN: 978-3-662-08616-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics