Skip to main content
SpringerLink
Log in

New Promising Chemopreventive Agents and Mechanisms

  • Chapter
Mechanisms in Carcinogenesis and Cancer Prevention

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 156))

Abstract

The development of cancer is a multistage process which is generally divided into initiation, promotion and progression phases. In the initiation phase, a carcinogen, either directly or after metabolic activation to a reactive molecule, interacts with intracellular macromolecules (DNA, proteins). This may cause DNA damage, which, if not repaired, can result in mutations and genetic damage. These mutations eventually lead to an altered expression of oncogenes and tumor suppressor genes or, e.g., continuous activation of protein kinases during the promotion phase, and finally result in modified cell structure, uncontrolled cell proliferation, tumor growth, and metastases in the progression phase. This cascade of events offers a variety of targets for chemopreventive intervention to prevent or inhibit the slow process of cellular changes from early genetic lesions to tumor development.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 309.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 399.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahn D, Putt D, Kresty L, Stoner GD, Fromm D, Hollenberg PF (1996) The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. Carcinogenesis 17:821–828

    Article  PubMed  CAS  Google Scholar 

  • Barcelo S, Gardiner JM, Gescher A, Chipman JK (1996) CYP2E1-mediated mechanism of antigenotoxicity of the broccoli constituent sulforaphane. Carcinogenesis 17:277–282

    Article  PubMed  CAS  Google Scholar 

  • Barcelo S, Mace K, Pfeifer AM, Chipman JK (1998) Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 402:111–120

    Article  PubMed  CAS  Google Scholar 

  • Barch DH, Rundhaugen LM, Stoner GD, Pillay NS, Rosche WA (1996) Structure-function relationships of the dietary anticarcinogen ellagic acid. Carcinogenesis 17:265–269

    Article  PubMed  CAS  Google Scholar 

  • Ben Aziz A, Grossman S, Ascarelli I, Budowski P (1970) Linoleate oxidation induced by lipoxygenase and heme proteins: a direct spectrophotometric assay. Anal Biochem 34:88–100

    Article  Google Scholar 

  • Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM (2001) Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61:7456–7463

    PubMed  CAS  Google Scholar 

  • Bonnesen C, Eggleston IM, Hayes JD (2001) Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res 61: 6120–6130

    PubMed  CAS  Google Scholar 

  • Campagne MV, Thibodeaux H, van Bruggen N, Cairns B, Lowe DG (2000) Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. J Neurosci 20:5200–5207

    PubMed  CAS  Google Scholar 

  • Castonguay A, Gali H, Perchellet EM, Gao XM, Boukharta M, Jalbert G, Okuda T, Yoshida T, Hatano T, Perchellet J-P (1997) Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyani-din. Int J Oncol 10:367–373

    PubMed  CAS  Google Scholar 

  • Chiba K, Takakuwa T, Tada M, Yoshii T (1992) Inhibitory effect of acylphloroglucinol derivatives on the replication of vesicular stomatitis virus. Biosci Biotechnol Biochem 56:1769–1772

    Article  PubMed  CAS  Google Scholar 

  • Chung FL, Conaway CC, Rao CV, Reddy BS (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21:2287–2291

    Article  PubMed  CAS  Google Scholar 

  • Conaway CC, Getahun SM, Liebes LL, Pusateri DJ, Topham DK, Botero-Omary M, Chung FL (2000) Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer 38:168–178

    Article  PubMed  CAS  Google Scholar 

  • Constantinou A, Stoner GD, Mehta R, Rao K, Runyan C, Moon R (1995) The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro. Nutr Cancer 23:121–130

    Article  PubMed  CAS  Google Scholar 

  • Cozzi R, Ricordy R, Bartolini F, Ramadori L, Perticone P, De Salvia R (1995) Taurine and ellagic acid: two differently-acting natural antioxidants. Environ Mol Mutagen 26:248–254

    Article  PubMed  CAS  Google Scholar 

  • Crespi CL, Miller VP, Penman, BW (1997) Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450. Anal Biochem 248:188–190

    Article  PubMed  CAS  Google Scholar 

  • Dekanski JB (1980) Antiprostatic activity of bifluranol, a fluorinated bibenzyl. Br J Pharmacol 71:11–16

    PubMed  CAS  Google Scholar 

  • Dow LR, Chou TT, Bechle MB, Goddard C, Larson RE (1994) Identification of tricyclic analogs related to ellagic acid as potent/selective tyrosine protein kinase inhibitors. J Med Chem 37:224–231

    Article  Google Scholar 

  • Festa F, Aglitti T, Duranti G, Ricordy R, Perticone P, Cozzi R (2001) Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay. Anticancer Res 21(6A):3903–3908

    PubMed  CAS  Google Scholar 

  • Fimognari C, Nusse M, Cesari R, Iori R, Cantelli-Forti G, Hrelia P (2002) Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the iso-thiocyanate sulforaphane. Carcinogenesis 23:581–586

    Article  PubMed  CAS  Google Scholar 

  • Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Terce F (2000) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 60:1426–1433

    PubMed  CAS  Google Scholar 

  • Gamal-Eldeen A, Gerhäuser C, Frank N, Bartsch H (2001) Ellagic acid induces antioxidant mechanisms in cultured human hepatocellular carcinoma cells HUH-7. J Cancer Res Clin Oncol 127:S34

    Article  Google Scholar 

  • Gerhauser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf H-R, Frank N, Bartsch H, Becker H (2001) Xanthohumol from hop (Humulus lupulus) as a novel potential cancer chemopreventive agent. Proc Am Assoc Cancer Res 42:18

    Google Scholar 

  • Gerhauser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf H-R, Frank N, Bartsch H, Becker H (2002) Cancer Chemopreventive Activity of Xanthohumol, a Natural Product derived from Hop. Molecular Cancer Therapeutics 1:959–969

    PubMed  CAS  Google Scholar 

  • Gerhäuser C, Heiss E, Klimo K, Neumann I, Becker H, Eicher Th, Bartsch H (2000) Bibenzyl derivatives as novel lead compounds in chemoprevention. Proc Am Assoc Cancer Res 41:412

    Google Scholar 

  • Gerhäuser C, Klimo K, Heiss E, Neumann I, Gamal Eldeen A, Knauft J, Liu G, Sitthimonchai S, Frank N (2002) Mechanism-based in vitro Screening of Potential Cancer Chemopreventive Agents. Mutation Research (Fundamental and Molecular Mechanisms of Mutagenesis) (in press)

    Google Scholar 

  • Gerhauser C, Mar W, Lee SK, Suh N, Luo Y, Kosmeder J, Luyengi L, Fong HH, Kinghorn AD, Moriarty RM, Mehta RG, Constantinou A, Moon RC, Pezzuto JM (1995) Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nat Med 1:260–266

    Article  PubMed  CAS  Google Scholar 

  • Gerhauser C, You M, Liu J, Moriarty RM, Hawthorne M, Mehta RG, Moon RC, Pezzuto JM (1997) Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Res 57:272–278

    PubMed  CAS  Google Scholar 

  • Ghisalberti EL (1996) Bioactive acylphloroglucinol derivatives from Eucalyptus species. Phytochem 41:7–22

    Article  CAS  Google Scholar 

  • Haapalainen L, Widen CJ (1970) Thin-layer chromatographic separation of phloroglu-cinol derivatives from Dryopteris ferns at different pH values. Farm Aikak 79: 161–173

    CAS  Google Scholar 

  • Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C (2001) Nuclear factor- kB is a molecular target for sulforaphane-mediated antiinflammatory mechanisms. J Biol Chem 276:32008–32015

    Article  PubMed  CAS  Google Scholar 

  • Henderson MC, Miranda CL, Stevens JF, Deinzer ML, Buhler DR (2000) In vitro inhibition of human P450 enzymes by prenylated flavonoids from hop Humulus lupulus. Xenobiotica 30:235–251

    Article  PubMed  CAS  Google Scholar 

  • Holmes-McNary M, Baldwin AS Jr (2000) Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 60:3477–3483

    PubMed  CAS  Google Scholar 

  • Hsieh TC, Burfeind P, Laud K, Backer JM, Traganos F, Darzynkiewicz Z, Wu JM (1999) Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials. Int J Oncol 15:245–252

    PubMed  CAS  Google Scholar 

  • Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220

    Article  PubMed  CAS  Google Scholar 

  • Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB (2002) Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 8:893–903

    PubMed  CAS  Google Scholar 

  • Kapadia GJ, Tokuda H, Konoshima T, Takasaki M, Takayasu J, Nishino H (1996) Antitumor promoting activity of Dryopteris phlorophenone derivatives. Cancer Lett 105:161–165

    Article  PubMed  CAS  Google Scholar 

  • Kuhl P, Shiloh R, Jha H, Murawski U, Zilliken F (1984) 6,7,4’-Trihydroxyisoflavan: a potent and selective inhibitor of 5-lipoxygenase in human and porcine peripheral blood leukocytes. Prostaglandins 28:783–804

    PubMed  CAS  Google Scholar 

  • Kuo SM, Leavitt PS (1999) Genistein increases metallothionein expression in human intestinal cells, Caco-2. Biochem Cell Biol 77:79–88

    Article  PubMed  CAS  Google Scholar 

  • Lee SK, Song L, Mata-Greenwood E, Kelloff GJ, Steele VE, Pezzuto JM (1999) Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer Res 19:35–44

    PubMed  CAS  Google Scholar 

  • Littlefield BA, Gurpide E, Markiewicz L, McKinley B, Hochberg, RB (1990) A simple and sensitive microtiter plate estrogen bioassay based on stimulation of alkaline phosphatase in Ishikawa cells: estrogenic action of delta 5 adrenal steroids. Endocrinology 127:2757–2762

    Article  PubMed  CAS  Google Scholar 

  • Maheo K, Morel F, Langouet S, Kramer H, Le Ferrec E, Ketterer B, Guillouzo A (1997) Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res 57:3649–3652

    PubMed  CAS  Google Scholar 

  • Markiewicz L, Hochberg RB, Gurpide E (1992) Intrinsic estrogenicity of some progestagenic drugs. J Steroid Biochem Mol Biol 41:53–58

    Article  PubMed  CAS  Google Scholar 

  • Mehta RG (2000) Experimental basis for the prevention of breast cancer. Eur J Cancer 36:1275–1282

    Article  PubMed  CAS  Google Scholar 

  • Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML, Barnes DW, Buhler DR (1999) Antiproliferative and cytotoxic effects of prenylated flavonoids from hop (Humulus lupulus) in human cancer cell lines. Food Chem Toxicol 37:271–285

    Article  PubMed  CAS  Google Scholar 

  • Miranda CL, Aponso GL, Stevens JF, Deinzer ML, Buhler DR (2000a) Prenylated chal-cones and flavanones as inducers of quinone reductase in mouse Hepa lclc7 cells. Cancer Lett 149:21–29

    Article  PubMed  CAS  Google Scholar 

  • Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR (2000b) Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro. J Agric Food Chem 48:3876–3884

    Article  PubMed  CAS  Google Scholar 

  • Miyazawa M, Shimamura H, Nakamura S, Sugiura W, Kosaka H, Kameoka H (1999) Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. J Agric Food Chem 47:2163–2167

    Article  PubMed  CAS  Google Scholar 

  • Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW (1999) p53/p21 (WAF1/CIP1) Expression and its possible role in Gl arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett 136:215–221

    Google Scholar 

  • Payen L, Courtois A, Loewert M, Guillouzo A, Fardel O (2001) Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochem Biophys Res Commun 282:257–263

    Article  PubMed  CAS  Google Scholar 

  • Pengsuparp T, Serit M, Hughes SH, Soejarto DD, Pezzuto JM (1996) Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of Calophyllum teysmannii. J Nat Prod 59:839–842

    Article  PubMed  CAS  Google Scholar 

  • Perchellet JP, Gali HU, Perchellet EM, Klish DS, Armbrust AD (1992) Antitumor promoting activities of tannin acid, ellagic acid, and several gallic acid derivatives in mouse skin. Basic Life Sci 59:783–801

    PubMed  CAS  Google Scholar 

  • Pettit GR, Singh SB, Boyd MR, Hamel E, Pettit RK, Schmidt JM, Hogan F (1995) Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(la). J Med Chem 38:1666–1672

    Article  PubMed  CAS  Google Scholar 

  • Pettit GR, Singh SB, Schmidt JM, Niven ML, Hamel E, Lin CM (1988) Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum. J Nat Prod 51:517–527

    Article  PubMed  CAS  Google Scholar 

  • Pick E, Mizel D (1981) Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J Immunol Methods 46:211–226

    Article  PubMed  CAS  Google Scholar 

  • Prior RL, Cao G (1999) In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med 27:1173–1181

    Article  PubMed  CAS  Google Scholar 

  • Prochaska HJ, Santamaria AB (1988) Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anti-carcinogenic enzyme inducers. Anal Biochem 169:328–336

    Article  PubMed  CAS  Google Scholar 

  • Radtke J, Linseisen J, Wolfram G (1998) Phenolic acid intake of adults in a Bavarian subgroup of the national food consumption survey. Zeitschrift für Ernährungswissenschaft 37:190–197

    Article  PubMed  CAS  Google Scholar 

  • Richon VM, Webb Y, Merger R, Sheppard T, Jursic B, Ngo L, Civoli F, Breslow R, Rifkind RA, Marks PA (1996) Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci USA 93:5705–5708

    Article  PubMed  CAS  Google Scholar 

  • Ridnour LA, Winters RA, Ercal N, Spitz DR (1999) Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl) maleimide derivatives. Methods Enzymol 299:258–267

    Article  PubMed  CAS  Google Scholar 

  • San RHC, Chan RIM (1987) Inhibitory effect of phenolic compounds on aflatoxin B1 metabolism and induced mutagenesis. Mutat Res 177:229–239

    Article  PubMed  CAS  Google Scholar 

  • Srinivasan P, Vadhanam MV, Arif JM, Gupta RC (2002) A rapid screening assay for antioxidant potential of natural and synthetic agents in vitro. Int J Oncol 20: 983–986

    PubMed  CAS  Google Scholar 

  • Steele VE, Kelloff GJ, Wilkinson BP, Arnold JT (1990) Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. Cancer Res 50:2068–2074

    PubMed  CAS  Google Scholar 

  • Steele VE, Sharma S, Mehta R, Elmore E, Redpath L, Rudd C, Bagheri D, Sigman CC, Kelloff GJ (1996) Use of in vitro assays to predict the efficacy of chemopreventive agents in whole animals. J Cell Biochem Suppl 26:29–53

    Article  PubMed  CAS  Google Scholar 

  • Stevens JF, Ivancic M, Hsu VL, Deinzer ML (1997) Prenylflavonoids from Humulus lupulus, Phytochemistry 44:1575–1585

    Article  CAS  Google Scholar 

  • Stoner GD, Morse AM (1997) Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer. Cancer Lett 114:113–119

    Article  PubMed  CAS  Google Scholar 

  • Stresser DM, Turner SD, McNamara J, Stocker P, Miller VP, Crespi CL, Patten CJ (2000) A high-throughput screen to identify inhibitors of aromatase (CYP19). Anal Biochem 284:427–430

    Article  PubMed  CAS  Google Scholar 

  • Suh N, Luyengi L, Fong HH, Kinghorn AD, Pezzuto JM (1995) Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res 15:233–239

    PubMed  CAS  Google Scholar 

  • Takasaki M, Konoshima T, Etoh H, Pal-Singh I, Tokuda H, Nishino H (2000) Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis. Cancer Lett 155:61–65

    Article  PubMed  CAS  Google Scholar 

  • Takasaki M, Konoshima T, Kozuka M, Tokuda H (1995) Antitumor-promoting activities of euglobals from Eucalyptus plants. Biol Pharm Bull 18:435–438

    Article  PubMed  CAS  Google Scholar 

  • Takasaki M, Konoshima T, Shingu T, Tokuda H, Nishino H, Iwashima A, Kozuka M (1990) Structures of euglobal-Gl, -G2, and -G3 from Eucalyptus grandis, three new inhibitors of Epstein-Barr virus activation. Chem Pharm Bull (Tokyo) 38: 1444–1446

    Article  CAS  Google Scholar 

  • Tanaka T, Kojima T, Kawamori T, Wang A, Suzui M, Okamoto K, Mori H (1993) Inhibition of 4-nitroquinoline-l-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis 14:1321–1325

    Article  PubMed  CAS  Google Scholar 

  • Ukeda H, Maeda S, Ishii T, Sawamura M (1997) Spectrophotometric assay for superoxide dismutase based on tetrazolium salt 3′,l-(phenylamino)-carbonyl-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzenesulfonic acid hydrate reduction by xanthine-xanthine oxidase. Anal Biochem 251:206–209

    Article  PubMed  CAS  Google Scholar 

  • van Amsterdam FT, Roveri A, Maiorino M, Ratti E, Ursini F (1992) Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med 12:183–187

    Article  PubMed  Google Scholar 

  • Waffo-Teguo P, Hawthorne ME, Cuendet M, Merillon JM, Kinghorn AD, Pezzuto JM, Mehta RG (2001) Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer 40: 173–179

    Article  PubMed  CAS  Google Scholar 

  • Widen CJ, Fraser-Jenkins CR, Reichstein T, Sarvela J (2001) A survey of phenolic compounds in Dryopteris and related fern genera. Part III. Ann Bot Fennici 38:99–138

    CAS  Google Scholar 

  • Wormke M, Castro-Rivera E, Chen I, Safe S (2000) Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. J Steroid Biochem Mol Biol 72:197–207

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P (1994) Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A 91:3147–3150

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, Talalay P, Cho CG, Posner GH (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A 89:2399–2403

    Article  PubMed  CAS  Google Scholar 

  • Zheng GQ, Ho DK, Elder PJ, Stephens RE, Cottrell CE, Cassady JM (1994) Ohioensins and pallidisetins: novel cytotoxic agents from the moss Polytrichum pallidisetum. J Nat Prod 57:32–41

    Article  PubMed  CAS  Google Scholar 

  • Zinsmeister HD, Becker H, Eicher Th (1991) Bryophytes, a source of biologically active naturally occurring material? Angew Chem Int Edn Engl 30:130–147

    Article  Google Scholar 

Download references

Authors
  1. C. Gerhäuser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Frank
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Unit of Chemoprevention, International Agency for Research on Cancer, 150, cours Albert-Thomas, 69372, Lyon, France

    Harri U. Vainio

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gerhäuser, C., Frank, N. (2003). New Promising Chemopreventive Agents and Mechanisms. In: Vainio, H.U., Hietanen, E.K. (eds) Mechanisms in Carcinogenesis and Cancer Prevention. Handbook of Experimental Pharmacology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08602-5_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-08602-5_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07859-0

  • Online ISBN: 978-3-662-08602-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation