Orbital Tumors

  • Joseph A. MaurielloJr.
  • Joseph C. Flanagan
  • Steven E. Harms


As outlined in Chapter 1, the physician should determine whether the disease process is an inflammation or a tumor. Next, the disease process should be localized to the orbit, lacrimal gland, lacrimal sac, or eyelids. Tumors in the orbit may be further localized to the intraconal, peripheral (between the muscle cone but within the periorbita), and subperiosteal surgical spaces. Orbital tumors may arise secondarily from the adjacent brain and meninges, the sinus, surrounding orbital bones, lacrimal gland, lacrimal sac, surface of the globe, lid, or an intraocular tumor. Recognition of such possible origins will enhance the physician’s determination of the appropriate clinical differential diagnosis.


Optic Nerve Adenoid Cystic Carcinoma Fibrous Dysplasia Frontal Sinus Aneurysmal Bone Cyst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Rush JA, Younge BR, Campbell RJ, MacCarthy CS: Optic glioma. Ophthalmology 89:1213–1219, 1982.PubMedGoogle Scholar
  2. 2.
    Deen HG, Scheithauer BW, Ebersold M: Clinical and pathologic study of meningiomas of the first two decades. J Neurosurg 56:317–322, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Susac JO, Martins AN, Whaley RA: Intracanalicular meningioma with normal tomography. J Neurosurg 46:659–662, 1977.PubMedCrossRefGoogle Scholar
  4. 4.
    Wilson MB, Gordon M, Lehman RA: Meningiomas confined to the optic canal and foramina. Surg Neurol 12:21–28, 1979.PubMedGoogle Scholar
  5. 5.
    Karp LA, Zimmerman LE, Borit A, Spencer WH: Primary intraorbital meningioma. Arch Ophthalmol 91:551–567, 1974.CrossRefGoogle Scholar
  6. 6.
    Wright JE, Call MB, Liaricos S: Primary intraorbital meningioma. Br J Ophthalmol 64:553–558, 1980.PubMedCrossRefGoogle Scholar
  7. 7.
    Miller NR, Iliff WJ, Green WR: Evaluation and management of gliomas of the anterior visual pathways. Brain 97:743–754, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Hoyt WF, Meshel LG, Lesseil S, Schatz NJ: Malignant glioma of adulthood. Brain 96:121–132, 1973.PubMedCrossRefGoogle Scholar
  9. 9.
    Spoor TC, Kennerdell JA, Martinez AJ, Zarub D: Malignant gliomas of the optic nerve pathways. Am J Ophthalmol 89:284–292, 1980.PubMedGoogle Scholar
  10. 10.
    Borit A, Richardson EP: The biologic and clinical behavior of pilocytic astrocytomas of the optic pathways. Brain 105:161–187, 1982.PubMedCrossRefGoogle Scholar
  11. 11.
    Harper CG, Stewart-Wynne EG: Malignant optic gliomas in adults. Arch Neurol 35:731–735, 1978.PubMedCrossRefGoogle Scholar
  12. 12.
    Manor RS, Israeli J, Sandbank U: Malignant optic glioma in a 70—year—old patient. Arch Ophthalmol 94:1142–1144, 1976.PubMedCrossRefGoogle Scholar
  13. 13.
    Wilson B: Meningiomas of the anterior visual system. Surv Ophthalmol 26:109–125, 1981.PubMedCrossRefGoogle Scholar
  14. 14.
    Wolter JR, Benz SC: Ectopic meningioma of the superior orbital rim. Arch Ophthalmol 94:1920–1922, 1976.PubMedCrossRefGoogle Scholar
  15. 15.
    Pompili A, Caroli R, Cattani R, Iachetti M: Intradiploic meningioma of the orbital roof. Neurosurgery 12:565–568, 1983.PubMedCrossRefGoogle Scholar
  16. 16.
    Stern J, DiGiacinto GV, Hosepian EM: Neurofibromatosis and optic glioma: Clinical and morphological correlations. Neurosurgery 4:524–528, 1979.PubMedCrossRefGoogle Scholar
  17. 17.
    Stern J, Jakobiec FA, Housepian EM: The architecture of optic nerve gliomas with and without neurofibromatosis. Arch Ophthalmol 98:505–511, 1980.PubMedCrossRefGoogle Scholar
  18. 18.
    Lewis RA, Gerson LP, Axelson KA, et al: von Recklinghausen neurofibro—matosis. II. Incidence of optic gliomata. Ophthalmology 91:929–935, 1984.PubMedGoogle Scholar
  19. 19.
    Jakobiec FA, Depot MJ, Kennerdell JS, et al: Combined clinical and computed tomographic diagnosis of orbital glioma and meningioma. Ophthalmology 91:137–155, 1984.PubMedGoogle Scholar
  20. 20.
    Sibony PA, Krauss MR, Kennerdell JS, et al: Optic nerve sheath meningioma. Ophthalmology 91:1313–1326, 1984.PubMedGoogle Scholar
  21. 21.
    Charles NC, Nelson L, Brookner AR, et al: Pilocytic astrocytoma of the optic nerve with hemorrhagic and extreme cystic degeneration. Am J Ophthalmol 92:691–695, 1981.PubMedGoogle Scholar
  22. 22.
    Grimson BS, Perry DD: Enlargement of the optic disc in childhood optic nerve tumors. Am J Ophthalmol 97:627–631, 1984.PubMedGoogle Scholar
  23. 23.
    Foxman S, Cameron JD: Clinical implications of bilateral microphthalmos with cyst. Am J Ophthalmol 97:632–638, 1984.PubMedGoogle Scholar
  24. 24.
    Imes RK, Schatz H, Hoyt WF, et al: Evolution of optociliary veins in optic nerve sheath meningioma. Arch Ophthalmol 103:59–60, 1985.PubMedCrossRefGoogle Scholar
  25. 25.
    Lloyd GAS: Primary orbital meningioma: A review of 41 patients investigated radiologically. Clin Radiol 33:181–187, 1980.CrossRefGoogle Scholar
  26. 26.
    Mark LE, Kennerdell JS, Maroon JC, et al: Microsurgical removal of a primary intraorbital meningioma. Am J Ophthalmol 86:704–709, 1978.PubMedGoogle Scholar
  27. 27.
    Tenny RT, Laws ER, Younge BR, Rush JA: The neurosurgical management of optic glioma results in 104 patients. J Neurosurgery 57:452–458, 1982.CrossRefGoogle Scholar
  28. 28.
    Cooling RJ, Wright JE: Arachnoid hyperplasia in optic nerve glioma: Confusion with orbital meningioma. Br J Ophthalmol 63:596–599, 1979.PubMedCrossRefGoogle Scholar
  29. 29.
    Anderson DR, Spencer WH: Ultrastructural and histochemical observations of optic nerve gliomas. Arch Ophthalmol 83:325, 1970.Google Scholar
  30. 30.
    Mullaney J, Walsh J, Lee WR, Adams JH: Recurrence of astrocytoma of optic nerve after 48 years. Br J Ophthalmol 60:539–543, 1976.PubMedCrossRefGoogle Scholar
  31. 31.
    Montgomery AB, Griffin T, Parker RG, Gerdes AJ: Optic nerve glioma: The role of radiation therapy. Cancer 40:2079–2080, 1977.PubMedCrossRefGoogle Scholar
  32. 32.
    Dosoretz DE, Blitzer P, Wang C, Linggood R: Management of glioma of the optic nerve and/or chiasm: An analysis of 20 cases. Cancer 45:1467—1471, 1980.PubMedCrossRefGoogle Scholar
  33. 33.
    Rosenberg LF, Miller NR: Visual results after microsurgical removal of meningiomas involving the anterior visual system. Arch Ophthalmol 102:1019–1023, 1984.PubMedCrossRefGoogle Scholar
  34. 34.
    Wright JE, McDonald WI, Call NB: Management of optic nerve glioma. Br J Ophthalmol 64:545–552, 1980.PubMedCrossRefGoogle Scholar
  35. 35.
    Marquardt MD, Zimmerman LE: Histopathology of meningiomas and gliomas of the optic nerve. Human Pathol 13:226–235, 1982.CrossRefGoogle Scholar
  36. 36.
    Font RL, Cruxatto JO: Intracellular inclusions in meningothelial meningioma. J Neuropathol Exp Neurol 39:575, 1980.PubMedCrossRefGoogle Scholar
  37. 37.
    Font RL, Wheeler T, Boniuk M: Intravascular papillary endothelial hyperplasia of the orbit and ocular adnexae. Arch Ophthalmol 101:1731–1736, 1983.PubMedCrossRefGoogle Scholar
  38. 38.
    Ruchman MC, Flanagan JC: Cavernous hemangiomas of the orbit. Ophthalmology 90:1328–1336, 1983.PubMedGoogle Scholar
  39. 39.
    Cruxatto JO, Font RL: Hemangiopericytoma of the orbit: A clinicopathologic study of 30 cases. Human Pathol 13:210–218, 1982.CrossRefGoogle Scholar
  40. 40.
    Jakobiec FA, Howard GM, Jones IS, Wolff M: Hemangiopericytoma of the orbit. Am J Ophthalmol 78:816–834, 1974.PubMedGoogle Scholar
  41. 41.
    Henderson JW, Farrow GM: Primary orbital hemangiopericytoma: An aggressive and potentially malignant neoplasm. Arch Ophthalmol 96:666—673, 1978.PubMedCrossRefGoogle Scholar
  42. 42.
    Grant EG, Gronvail S, Sarosi TE, et al: Sonographic findings in four cases of hemangiopericytoma: Correlation with computed tomographic, angiographic and pathologic findings. Ultrasound 142:447–451, 1982.Google Scholar
  43. 43.
    Chilsholm IA, Polyzoidis K: Recurrence of benign orbital neurilemmoma (schwannoma) after 22 yeras. Can J Ophthalmol 17:271–273, 1982.Google Scholar
  44. 44.
    Konrad EA, Thiel HJ: Schwannoma of the orbit. Ophthalmologica 188:118–127, 1984.PubMedCrossRefGoogle Scholar
  45. 45.
    Pereira LA, Choo YB: Schwannoma of the infraorbital nerve. Ear Nose Throat J 58:236–239, 1979.PubMedGoogle Scholar
  46. 46.
    Jones HS, Clwyd H: Benign schwannoma involving the infratemporal fossa and orbit. Laryngoscope 93:200–201, 1983.PubMedCrossRefGoogle Scholar
  47. 47.
    Boniuk M, Messmer EP, Font RL: Hemangiopericytoma of the meninges of the optic nerve. A clinicopathologic report including electron microscopic observations. Ophthalmology 92:1780–1787, 1985.PubMedGoogle Scholar
  48. 48.
    Cappaert WE, Kiprov RV, Frank KE: Sector b—scan ultrasonographic ‘hemangiomalike’ pattern. Arch Ophthalmol 101:74–76, 1983.PubMedCrossRefGoogle Scholar
  49. 49.
    Jakobiec FA, Jones IS: Neurogenic tumors, in Jones IS, Jakobiec FA (eds): Diseases of the Orbit. Hagerstown, MD: Harper and Row, 1979, pp 1–45.Google Scholar
  50. 50.
    Eggers H, Jakobiec FA, Jones IA: Optic nerve gliomas, in Jones IS, Jakobiec FA (eds): Diseases of the Orbit. Hagerstown, MD: Harper and Row, 1982, pp 1–17.Google Scholar
  51. 51.
    Krohel GB, Rosenberg PN, Wright JE, Smith RS: Localized orbital neurofibromas. Am J Ophthalmol 100:458–464, 1985.PubMedGoogle Scholar
  52. 52.
    Goldstein BG, Font RL, Alper MG: Granular cell tumor of the orbit: A case report including electron microscopic observations. Ann Ophthalmol 14:231–237, 1982.PubMedGoogle Scholar
  53. 53.
    Jakobiec FA, Font RL: Orbit, in Spencer WH (ed): Ophthalmic Pathology Vol 3. Philadelphia, PA: WB Saunders, 1986, pp 2476–2766.Google Scholar
  54. 54.
    Jakobiec FA, Jones IS: Mesenchymal and fibro—osseous tumors, in Jones IS, Jakobiec FA (eds): Diseases of the Orbit. Hagerstown, MD: Harper and Row, 1982, pp 1–42.Google Scholar
  55. 55.
    Enzinger FM, Harvey DA: Spindle cell lipoma. Cancer 36:1852, 1975.PubMedCrossRefGoogle Scholar
  56. 56.
    Bartley GB, Yeatts RP, Garrity JA, et al: Spindle cell lipoma of the orbit. Am J Ophthalmol 100:605–609, 1985.PubMedGoogle Scholar
  57. 57.
    Font RL, Hidayat AA: Fibrous histiocytoma of the orbit. Human Pathol 13:199–209, 1982.CrossRefGoogle Scholar
  58. 58.
    Font RL, Zimmerman LE: Nodular fasciitis of the eye and adnexae. A report of ten cases. Arch Ophthalmol 75:475–481, 1966.PubMedCrossRefGoogle Scholar
  59. 59.
    Abramson DH, Ellsworth RM, Kitchin FD, Tung G: Second nonocular tumors in retinoblastoma survivors. Are they radiation—induced? Ophthalmology 91:1351–1355, 1984.PubMedGoogle Scholar
  60. 60.
    Font RL, Jurco S, Brechner RJ: Postradiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma. Arch Ophthalmol 101:1557–1561, 1983.PubMedCrossRefGoogle Scholar
  61. 61.
    Folberg R, Cleasby G, Flanagan JC, et al: Orbital leiomyosarcoma after radiation therapy for bilateral retinoblastoma. Arch Ophthalmol 101:1562–1565, 1983.PubMedCrossRefGoogle Scholar
  62. 62.
    Leff SR, Henkind P: Rhabdomyosarcoma and late malignant melanoma of the orbit. Ophthalmology 90:1258–1260, 1983.PubMedGoogle Scholar
  63. 63.
    Hufnagel T, Ma L, Kuo T: Orbital angiosarcoma with subconjunctival presentation. Report of a case and literature review. Ophthalmology 94:72–77, 1987.PubMedGoogle Scholar
  64. 64.
    Guccion J, Font RI, Enzinger FM, et al: Extraskeletal mesenchymal chondrosarcoma. Arch Pathol 95:336–340, 1973.PubMedGoogle Scholar
  65. 65.
    Knowles DM, Jakobiec FA, Rosen M, Howard G: Amyloidosis of the orbit and adnexae. Surv Ophthalmol 19:367–384, 1975.PubMedGoogle Scholar
  66. 66.
    Marsh WM, Streeten BW, Hoepner JA, et al: Localized conjunctival amyloidosis associated with extranodal lymphoma. Ophthalmology 94:61–64, 1987.PubMedGoogle Scholar
  67. 67.
    Alper MG, Zimmerman LE, LaPiana FG: Orbital manifestations of Erdheim—Chester disease. Trans Am Ophthalmol Soc 81:64–85, 1983.PubMedGoogle Scholar
  68. 68.
    Ranchod M, Kempson RL: Smooth muscle tumors of the gastrointestinal tract and retroperitoneum. A pathologic analysis of 100 cases. Cancer 39:255–262, 1977.PubMedCrossRefGoogle Scholar
  69. 69.
    Nasr AM, Biodi FC, Lindahl S, Hinkins J: Congenital generalized multicentric myofibromatosis with orbital involvement. Am J Ophthalmol 102:779—787, 1986.PubMedGoogle Scholar
  70. 70.
    Krohel GB, Wright JE: Orbital hemorrhage. Am J Ophthalmol 88:254–258, 1979.PubMedGoogle Scholar
  71. 71.
    Flanagan JC: Vascular problems of the orbit. Ophthalmology 86:896–913, 1979.PubMedGoogle Scholar
  72. 72.
    Winter J, Centeno RS, Bentson JR: Maneuver to aid diagnosis of orbital varix by computed tomography. Am J Neuroradiol 3:39, 1982.PubMedGoogle Scholar
  73. 73.
    Bullock JD, Bartley GB: Dynamic proptosis. Am J Ophthalmol 112:104–110, 1986.Google Scholar
  74. 74.
    Katz B, Carmody R: Subperiosteal orbital hematoma induced by the Valsalva maneuver. Am J Ophthalmol 100:617–618, 1985.PubMedGoogle Scholar
  75. 75.
    Rathbun JE, Hoyt WF, Beard C: Surgical management of orbitofrontal varix in Klippel—Trenaunay—Weber syndrome. Am J Ophthalmol 70:109, 1970.PubMedGoogle Scholar
  76. 76.
    Lamar L, Farber G, O’Quinn S: Klippel—Trenaunay—Weber syndrome. Arch Dermatol 91:58, 1965.PubMedCrossRefGoogle Scholar
  77. 77.
    Mankad V, Gray G, Miller D: Bilateral nephroblastomatosis and Klippel—Trenaunay syndrome. Cancer 33:1462, 1974.PubMedCrossRefGoogle Scholar
  78. 78.
    Sevel D, Rosales A: Orbital blood cyst. Br J Ophthalmol 62:571–574, 1978.PubMedCrossRefGoogle Scholar
  79. 79.
    Skalka HW, Callahan MA: “Congenital” hematic cyst of the orbit. Ann Ophthalmol 11:1103–1107, 1979.PubMedGoogle Scholar
  80. 80.
    Cameron D: Hematic cyst of the orbit. Paper presented at the biannual AFIP Alumni Meeting, June, 1985.Google Scholar
  81. 81.
    Beyer R, Levine MR, Sternbery I: Orbital varices: A surgical approach. Ophthalmic Plast Reconstr Surg 1:205–210, 1985.CrossRefGoogle Scholar
  82. 82.
    Biodi FC: Pathology of orbital bones. The XXXII Edward Jackson Memorial Lecture. Am J Ophthalmol 81:1–26, 1976.Google Scholar
  83. 83.
    Margo CE, Ragsdale BD, Perman KI, et al: Psammomatoid (juvenile) ossifying fibroma of the orbit. Ophthalmology 92:150–159, 1985.PubMedGoogle Scholar
  84. 84.
    Jakobiec FA, Potter GD, Mitchell J, Jones IS: Ossifying fibromas of the orbital roof. Proc Third Int Symp on Orbital Disorders, (Amsterdam) 325–333, 1977.Google Scholar
  85. 85.
    Shields JA, Nelson LB, Brown JF, Dolinskas C: Clinical, computed tomographic, and histopathologic characteristics of juvenile ossifying fibroma with orbital involvement. Am J Ophthalmol 96:650–653, 1983.PubMedGoogle Scholar
  86. 86.
    Jakobiec FA, Jones IS: Mesenchymal and fibro—osseous tumors of the orbit, in Duane T (ed): Clinical Ophthalmology. Hagerstown, MD: Harper and Row, 1976, pp 1–42.Google Scholar
  87. 87.
    Margo CE, Weiss A, Mutaz BH: Psammomatoid ossifying fibroma. Arch Ophthalmol 104:1347–1351, 1986.PubMedCrossRefGoogle Scholar
  88. 88.
    Moore AT, Buncic JR, Munro IR: Fibrous dysplasia of the orbit in childhood. Ophthalmology 92:12–20, 1985.PubMedGoogle Scholar
  89. 89.
    Donoso LA, Magargal LE, Eiferman RA: Fibrous dysplasia of the orbit with optic nerve decompression. Ann Ophthalmol 14:80–83, 1982.PubMedGoogle Scholar
  90. 90.
    Jaffe HL: Tumors and Tumorous Conditions of the Bones and Joints. Philadelphia: Lea and Febiger, 1958.Google Scholar
  91. 91.
    Spjut HF, Dorfman HD, Fechner RF, Ackerman LV: Tumors of bone and cartilage. Atlas of Tumor Pathology, Fascicle 5. Washington, DC: Armed Forces Institute of Pathology, 1970, p 132.Google Scholar
  92. 92.
    Ronner HJ, Jones IS: Aneurysmal bone cyst of the orbit: A review. Ann Ophthalmol 15:626–629, 1983PubMedGoogle Scholar
  93. 93.
    Jaffe HL, Lichtenstein L: Solitary unicameral bone cyst with emphasis on the roentgen picture. The pathologic appearance and the pathogenesis. Arch Surg 44:1004–1025, 1942.CrossRefGoogle Scholar
  94. 94.
    Biesecker JL, Marcove RC, Huvos AG, Mike V: Aneurysmal bone cysts: A clinicopathologic study of 66 cases. Cancer 26:615–625, 1970.PubMedCrossRefGoogle Scholar
  95. 95.
    Tillman BP, Dahlin DK, Lipscomb PR, Stewart JR: Aneurysmal bone cyst: An analysis of 95 cases. Mayo Clin Proc 43:478–495, 1968.PubMedGoogle Scholar
  96. 96.
    Powell JO, Glaser JS: Aneurysmal bone cyst of the orbit. Arch Ophthalmol 93:340–342, 1975.PubMedCrossRefGoogle Scholar
  97. 97.
    Fu YS, Persin KH: Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study: III. Cartilaginous tumors (chondroma, chondrosarcoma). Cancer 34:453, 1974.PubMedCrossRefGoogle Scholar
  98. 98.
    Shepherd WF, Maguire CJ, Bailey IC: Benign osteoblastoma of the orbit. Irish J Med Sci 146(abs):150, 1977.Google Scholar
  99. 99.
    Lowder CY, Berlin AJ, Cox WA, Hahn JF: Benign osteoblastoma of the orbit. Ophthalmology 93:1351–1354, 1986.PubMedGoogle Scholar
  100. 100.
    Babel J: Osteoclastome et granuloma a cellules geantes du rebord orbitaire. Ann Ocul 206:725, 1973.Google Scholar
  101. 101.
    Guccion J, Enzinger F: Malignant giant cell tumors of soft parts. Cancer 29:1518, 1972.PubMedCrossRefGoogle Scholar
  102. 102.
    Mandel MR, Stewart WB: Periorbital osteosarcoma: An unusual case report and review of the clinical and histopathologic features. Ophthalmic Plast ReconstrSurg 1:129–136, 1985.CrossRefGoogle Scholar
  103. 103.
    Henderson JW: Osseous and cartilagenous tumors, in Henderson JW (ed): Orbital Tumors. Philadelphia: WB Saunders, 1980, pp 198–245.Google Scholar
  104. 104.
    Illif C, Ossofsky H: Infantile cortical hyperostosis: An unusual cause of proptosis. Am J Ophthalmol 53:976, 1962.Google Scholar
  105. 105.
    Naiman J, Green WR, d’Heurle D, et al: Brown tumor of the orbit associated with primary hyperparathyroidism. Am J Ophthalmol 90:565–571, 1980.PubMedGoogle Scholar
  106. 106.
    Hamlin WB, Lund PK: Giant—cell tumors of the mandible and facial bones. Arch Otolaryngol 86:658, 1967.PubMedCrossRefGoogle Scholar
  107. 107.
    Ferry AP: Brown tumors (fibro—osseous bone replacement and overgrowth) of the orbit in hyperparathyroidism. Metabolic Pediatric Ophthalmol 3:67, 1979.Google Scholar
  108. 108.
    Kobayashi S, Kyoshima K, Nakagawa F, et al: Diploic meningioma of the orbital roof. Surg Neurol 13:277–281, 1980.PubMedGoogle Scholar
  109. 109.
    Wolter JR, Benz SC: Ectopic meningioma of the superior orbital rim. Arch Ophthalmol 94:1920–1922, 1976PubMedCrossRefGoogle Scholar
  110. 110.
    Craig WM, Gogela LG: Intraorbital meningiomas, clinicopathological study. Am J Ophthalmol 32:1663–1680, 1949.PubMedGoogle Scholar
  111. 111.
    Gardner EJ: Follow—up study of a family group exhibiting dominant inheritance for a syndrome including intestinal polyps, osteomas, fibromas and epidermal cysts. Am J Hum Genet 14:376–390, 1962.PubMedGoogle Scholar
  112. 112.
    Blair NT, Trempe MD: Hyperplasia of the retinal pigment epithelium associated with Gardner’s syndrome. Am J Ophthalmol 90:661–667, 1980.PubMedGoogle Scholar
  113. 113.
    Sherman RS, Wilner D: The roentgen diagnosis of hemangioma of bone. Am J Roentgenol Radium Ther Nucl Med 86:1146, 1961.PubMedGoogle Scholar
  114. 114.
    Brackup AH, Haller ML, Danber MM: Hemangioma of the bony orbit. Am J Ophthalmol 90:258–261, 1980.PubMedGoogle Scholar
  115. 115.
    Eretto P, Krohel GB, Shihab ZM, et al: Optic neuropathy in Paget’s disease. Am J Ophthalmol 97:505–510, 1984.PubMedGoogle Scholar
  116. 116.
    Chen JR, Rhee RS, Wallach A, et al: Neurologic disturbances in Paget’s disease of bone. Response to calcitonin. Neurology 29:448, 1979.PubMedCrossRefGoogle Scholar
  117. 117.
    Ryan WG: Treatment of Paget’s disease of bone with mithramycin. Clin Orthop 127:106, 1977.PubMedGoogle Scholar
  118. 118.
    Small ML, Green WR, Johnson LC: Lipoma of the frontal bone. Arch Ophthalmol 97:129–132, 1979.PubMedCrossRefGoogle Scholar
  119. 119.
    Johnson LN, Krohel GB, Yeon EB, Parnes SM: Sinus tumors invading the orbit. Ophthalmology 91:209–217, 1984.PubMedGoogle Scholar
  120. 120.
    Jakobiec FA, Trokel S, Iwamoto T: Sino—orbital polyposis. Arch Ophthalmol 97:2353–2357, 1979.PubMedCrossRefGoogle Scholar
  121. 121.
    Jakobiec FA, Rootman J, Jones IS: Secondary and metastatic tumors of the orbit in Jones IS, Jakobiec FA (eds): Diseases of the Orbit. Hagerstown, MD: Harper and Row, 1979, pp 503–569.Google Scholar
  122. 122.
    Spiro R, Huvos AG, Strong EW: Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases. Am J Surg 128:512–520, 1974.PubMedCrossRefGoogle Scholar
  123. 123.
    Jakobiec FA, Mitchell J, Chauhan PM, Iwamoto T: Mesectodermal leiomyosarcoma of the antrum and orbit. Am J Ophthalmol 85:51–57, 1978.PubMedGoogle Scholar
  124. 124.
    Trautason OI, Felson SE: Cause of enophthalmos secondary to maxillary sinus mucocele. Am J Ophthalmol 95:838–840, 1983.CrossRefGoogle Scholar
  125. 125.
    Frederick J, Braude AI: Anaerobic infection of the paranasal sinuses. N Engl J Med 290:135–137, 1974.PubMedCrossRefGoogle Scholar
  126. 126.
    Kaufman SJ: Orbital mucopyoceles. Two cases and a review. Surv Ophthalmol 25:253–262, 1981.PubMedCrossRefGoogle Scholar
  127. 127.
    Iliff CE: Mucoceles in the orbit. Arch Ophthalmol 89:392–395, 1973.PubMedCrossRefGoogle Scholar
  128. 128.
    Tenzel RR, Groff J: Anterior ethmoidal mucocele. Am J Ophthalmol 62:160–161, 1966.PubMedGoogle Scholar
  129. 129.
    Fascenelli FW: Maxillary sinus abnormalities. Arch Otolaryngol 90:190—193, 1969.PubMedCrossRefGoogle Scholar
  130. 130.
    Ritter FN: The surgical anatomy of the nasal sinuses. Otolaryngol Clin N Am 4:2–11, 1971.Google Scholar
  131. 131.
    Johnson LN, Hepler RS, Yee RD, et al: Sphenoid sinus mucocele (anterior clinoid variant) mimicking diabetic ophthalmoplegic and retrobulbar neuritis. Am J Ophthalmol 102:111–115, 1986.PubMedCrossRefGoogle Scholar
  132. 132.
    Abrahamson IR, Baluyot ST, Tew JM, Scioville G: Frontal sinus mucocele. Ann Ophthalmol 11:173–178, 1979.PubMedGoogle Scholar
  133. 133.
    Ginsberg J, Polanco GB, Margolin HN, Pescovitz H: Malignant inverted papilloma characterized by proptosis. Am J Ophthalmol 82:129–135, 1976.PubMedGoogle Scholar
  134. 134.
    Hyams VJ: Papillomas of the nasal cavity and paranasal sinuses. Ann Otolaryngol Rhinol Laryngol 80(suppl 1–3): 192, 1971.Google Scholar
  135. 135.
    Karcioglu ZA, Wesley RE, Greenidge KC, McCord CD: Proptosis and pseudocyst formation from inverted papilloma. Ann Ophthalmol 14:443—448, 1982.PubMedGoogle Scholar
  136. 136.
    Lee KF, Hodes PJ, Greenberg L, Simotti A: Three rare causes of unilateral exophthalmos. Radiology 90:1009–1015, 1968.PubMedGoogle Scholar
  137. 137.
    Batsakis JG: Tumors of the Head and Neck. Baltimore: Williams and Wilkins, 1975, pp 76–85.Google Scholar
  138. 138.
    Snyder RN, Perkin KH: Papillomatosis of nasal cavity and paranasal sinuses (inverted papilloma, squamous papilloma). Cancer 30:668, 1972.PubMedCrossRefGoogle Scholar
  139. 139.
    McGavran M, Sessions D, Dorfman R, et al: Nasopharyngeal angiofibroma. Arch Otolaryngol 90:68, 1969.PubMedCrossRefGoogle Scholar
  140. 140.
    Christiansen T, Duvall A, Rosenberg Z, Carley R: Juvenile nasopharyngeal angiofibroma. Trans Am Acad Ophthalmol Otolaryngol 78:140, 1974.Google Scholar
  141. 141.
    Stern RM, Beauchamp GR, Berlin AJ: Ocular findings in juvenile nasopharyngeal angiofibroma. Ophthalmic Surg 17:560–564, 1986.PubMedGoogle Scholar
  142. 142.
    Skolnik EM, Massari FS, Tenta LT: Olfactory neuroepithelioma. Review of the world literature and presentation of two cases. Arch Otolaryngol 84:644–653, 1966.PubMedCrossRefGoogle Scholar
  143. 143.
    Rakes SM, Yeatts P, Campbell RJ: Ophthalmic manifestations of esthesio—neuroblastoma. Ophthalmology 92:1749–1753, 1985.PubMedGoogle Scholar
  144. 144.
    Parke DW, Font RL, Boniuk M, McCrary JA: ‘Cholesteatoma’ of the orbit. Arch Ophthalmol 100:612–616, 1982.PubMedCrossRefGoogle Scholar
  145. 145.
    Hellquist H, Lundgren J, Olofsson J: Cholesterol granuloma of the maxillary and frontal sinuses. J Otorhinolaryngol Relat Spec 46:153–158, 1984.CrossRefGoogle Scholar
  146. 146.
    Ramsey GS, Laws HW, Prichard JE, et al: Post—traumatic granuloma of the bony orbit simulating tumor. Can Med Assoc J 59:206–211, 1948.PubMedGoogle Scholar
  147. 147.
    Osborne DA, Wallace M: Carcinoma of the frontal sinus associated with epidermoid cholesteatoma. J Laryngol Otolaryngol 81:1921–1932, 1967.Google Scholar
  148. 148.
    Coates GM: Cholesteatoma of the frontal sinus. Arch Otolaryngol 26:29–37, 1937.CrossRefGoogle Scholar
  149. 149.
    Martin JA, Robertson DM: Extrascleral extension of choroidal melanoma diagnosed by ultrasound. Ophthalmology 90:1554–1559, 1983.PubMedGoogle Scholar
  150. 150.
    Font RI, Spaulding AG, Zimmerman LE: Diffuse malignant melanoma of the uveal tract: A clinicopathologic report of 54 cases. Trans Am Acad Ophthalmol Otolaryngol 72:877–894, 1968.PubMedGoogle Scholar
  151. 151.
    Sassani JW, Weinstein JM, Graham WP: Massively invasive diffuse choroidal melanoma. Arch Ophthalmol 103:945–948, 1985.PubMedCrossRefGoogle Scholar
  152. 152.
    Duffin RM, Straatsma BR, Foos RY, Kerman BM: Small malignant melanoma of the choroid with extraocular extension. Arch Ophthalmol 99:1827–1830, 1981.PubMedCrossRefGoogle Scholar
  153. 153.
    Seiff SR, Shorr N, Kopelman J: Orbital extension of uveal melanoma. Ann Ophthalmol 18:171–173, 1986.PubMedGoogle Scholar
  154. 154.
    Shammas HF, Biodi FC: Orbital extension of choroidal and ciliary body melanomas. Arch Ophthalmol 95:2002–2005, 1977.PubMedCrossRefGoogle Scholar
  155. 155.
    Shields JA, Augsburger JJ, Donoso LA, et al: Hepatic metastasis and orbital recurrence of uveal melanoma after 42 years. Am J Ophthalmol 100:666–668, 1985.PubMedGoogle Scholar
  156. 156.
    Saunders DH, Rodrigues MM, Shannon GM: Orbital recurrence of malignant melanoma of the choroid 24 years after enucleation. Ophthalmic Surg 8:31, 1977.PubMedGoogle Scholar
  157. 157.
    Donoso LA, Augsburger JJ, Sheilds JA, et al: Metastatic uveal melanoma: Correlation between survival times and cytomorphometry of primary tumors. Arch Ophthalmol 104:76–78, 1986.PubMedCrossRefGoogle Scholar
  158. 158.
    Shields JA, Augsburger JJ, Dougherty MJ: Orbital recurrence of choroidal melanoma 20 years after enucleation. Am J Ophthalmol 97:767–770, 1984.PubMedGoogle Scholar
  159. 159.
    Shields JA: Current approaches to the diagnosis and management of choroidal melanomas. Surv Ophthalmol 21:443–463, 1977.PubMedCrossRefGoogle Scholar
  160. 160.
    Starr HJ, Zimmerman LE: Extrascleral extension and orbital recurrence of malignant melanomas of the choroid and ciliary body. Int Ophthalmol Clin 2:369–384, 1962.CrossRefGoogle Scholar
  161. 161.
    Zimmerman LE, McLean IW: An evaluation of enucleation in the management of uveal melanoma. Am J Ophthalmol 87:741–760, 1979.PubMedGoogle Scholar
  162. 162.
    Char DH, Phillips TL: The potential for adjuvant radiotherapy in choroidal melanoma. Arch Ophthalmol 100:247–248, 1982.PubMedCrossRefGoogle Scholar
  163. 163.
    Shields JA, Augsburger J: Current approaches to the diagnosis and managment of retinoblastoma. Surv Ophthalmol 25:347–372, 1981.PubMedCrossRefGoogle Scholar
  164. 164.
    Jakobiec FA, Rootman J, Jones IS: Secondary and metastatic tumors of the orbit, in Duane TD, Jaeger EA (eds): Clinical Ophthalmology. Philadelphia, PA: Harper and Row, 1982, pp 1–67.Google Scholar
  165. 165.
    Char DH, Hedges TR, Norman D: Retinoblastoma CT diagnosis. Ophthalmology 91:1347–1350, 1984.PubMedGoogle Scholar
  166. 166.
    Haik BG, Louis LS, Smith ME, et al: Computed tomography of the nonrhegmatogenous retinal detachment in the pediatric patient. Ophthalmology 92:1133–1142, 1985.PubMedGoogle Scholar
  167. 167.
    Haik BG, Louis LS, Smith ME, et al: Magnetic resonance imaging in the evaluation of leukocoria. Ophthalmology 92:1143–1152, 1985.PubMedGoogle Scholar
  168. 168.
    Broughton WL, Zimmerman LE: A clinicopathological study of 56 cases of intraocular medulloepitheliomas. Am J Ophthalmol 85:407–418, 1978.PubMedGoogle Scholar
  169. 169.
    Orellana J, Roberto AM, Font RL, et al: Medulloepithelioma diagnosed by ultrasound and vitreous aspirate. Ophthalmology 90:1531–1539, 1983.PubMedGoogle Scholar
  170. 170.
    Green WR, Iliff WJ, Trotter R: Malignant teratoid medulloepithelioma of the optic nerve. Arch Ophthalmol 91:451, 1974.PubMedCrossRefGoogle Scholar
  171. 171.
    Zimmerman LE, Font R, Andersen SR: Rhabdomyosarcomatous differentiation in malignant intraocular medulloepitheliomas. Cancer 30:817, 1962.CrossRefGoogle Scholar
  172. 172.
    Luxenberg MN, Guthrie TH: Chemotherapy of basal cell and squamous cell carcinoma of the eyelids and periorbital tissues. Ophthalmology 93:504—510, 1986.PubMedGoogle Scholar
  173. 173.
    Mohs FE: Micrographic surgery for the microscopically controlled excision of eyelid cancers. Arch Ophthalmol 104:901–908, 1986.PubMedCrossRefGoogle Scholar
  174. 174.
    Putterman AM: Conjunctival map biopsy to determine pagetoid spread. Am J Ophthalmol 1022:87–90, 1986.Google Scholar
  175. 175.
    Aurora A, Luxenberg M: Case report of adenocarcinoma of glands of Moll. Am J Ophthalmol 70:984, 1970.PubMedGoogle Scholar
  176. 176.
    Miller WL: Sweat gland carcinoma. Am J Clin Pathol 47:767, 1967.PubMedGoogle Scholar
  177. 177.
    Zimmerman LE: The cancerous, precancerous, and pseudocancerous lesions of the cornea and conjunctiva, in Rycroft PV (ed): The Poklington Memorial Lecture in Corneoplastic Surgery. New York: Pergamon Press, 1969, pp 547–555.Google Scholar
  178. 178.
    Margo CE, Weitzenkorn DE: Mucoepidermoid carcioma of the conjunctiva: Report of a case in a 36—year—old with paranasal sinus invasion. Ophthalmic Surg 17:151–154, 1986.PubMedGoogle Scholar
  179. 179.
    Rao NA, Font RL: Mucoepidermoid carcinoma of the conjunctiva: A clinicopathologic study of five cases. Cancer 38:1696–1709, 1976.CrossRefGoogle Scholar
  180. 180.
    Ferry AP, Font RL: Carcinoma metastatic to the eye and orbit. II. A clinicopathological study of 26 patients with carcinoma metastatic to the anterior segment of the eye. Arch Ophthalmol 93:472–484, 1975.PubMedCrossRefGoogle Scholar
  181. 181.
    Ferry AP, Font RL: Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol 92:276–286, 1974.PubMedCrossRefGoogle Scholar
  182. 182.
    Font RL, Ferry AP: Carcinoma metastatic to the eye and orbit. III. A clinicopathologic study of 28 cases metastatic to the orbit. Cancer 38:1326–1335, 1976.PubMedCrossRefGoogle Scholar
  183. 183.
    Bloch RS, Gartner S: The incidence of ocular metastatic carcinoma. Arch Ophthalmol 85:673, 1971.PubMedCrossRefGoogle Scholar
  184. 184.
    Albert DM, Rubenstein RA, Scheie HG: Tumor metastasis to the eye. Part II. Clinical study in infants and children. Am J Ophthalmol 63:727–732, 1967.PubMedGoogle Scholar
  185. 185.
    Rush JA, Waller RR, Campbell RJ: Orbital carcinoid tumor metastatic from the colon. Am J Ophthalmol 89:636–640, 1980.PubMedGoogle Scholar
  186. 186.
    Riddle PJ, Font RL, Zimmerman LE: Carcinoid tumors of the eye and orbit: A clinicopathologic study of 15 cases, with histochemical and electron microscopic observations. Human Pathol 13:459–469, 1982.CrossRefGoogle Scholar
  187. 187.
    Reifler DM, Davison P: Histochemical analysis of breast carcinoma metastatic to the orbit. Ophthalmology 93:254–259, 1986.PubMedGoogle Scholar
  188. 188.
    Howard GM, Jakobiec FA, Trokel SL, et al: Pulsating metastatic tumor of the orbit. Am J Ophthalmol 85:767–771, 1978.PubMedGoogle Scholar
  189. 189.
    Rush JA, Older JJ, Richman AV: Testicular seminoma metastatic to the orbit. Am J Ophthalmol 91:258–260, 1981.PubMedGoogle Scholar
  190. 190.
    Kennerdell JS, Slamovits TL, Dekker A, Johnson BL: Orbital fine—needle aspiration biopsy. Am J Ophthalmol 99:547–551, 1985.PubMedGoogle Scholar
  191. 191.
    Spoor TC, Kennerdell JS, Dekker A, et al: Orbital fine needle aspiration biopsy with B—scan guidance. Am J Ophthalmol 89:274–277, 1980.PubMedGoogle Scholar
  192. 192.
    Krohel GB, Tobin DR, Chavis RM: Inaccuracy of fine needle aspiration biopsy. Ophthalmology 92:666–670, 1985.PubMedGoogle Scholar
  193. 193.
    Norris JL: Orbital endoscopy. Oto—ophthalmol Soc 59:145, 1978.Google Scholar
  194. 194.
    Hyman RA, Edwards JH: MR imaging versus CT in the evaluation of orbital lesions. Geriatr Ophthalmol 1:15–20, 1985.Google Scholar
  195. 195.
    Sullivan JA, Harms SE: Surface—coil MR imaging of orbital neoplasms. Am J Neurorad 7:29–34, 1986.Google Scholar
  196. 196.
    Holman RE, Grinson BS, Drayer BP, et al: Magnetic resonance imaging of optic glioma. Am J Ophthalmol 100:596–601, 1985.PubMedGoogle Scholar
  197. 197.
    Sobel DF, Kelly W, Kjos BO, et al: MR imaging of orbital and ocular disease. AJNR 6:259–264, 1985.PubMedGoogle Scholar
  198. 198.
    Char DH, Sobel D, Kelly WM, et al: Magnetic resonance scanning in orbital tumor diagnosis. Ophthalmology 92:1305–1310, 1985.PubMedGoogle Scholar
  199. 199.
    Haik BG, Louis LS, Smith ME: Nuclear magnetic resonance imaging in orbital disease. Ophth Forum 3:31–34, 1985.Google Scholar
  200. 200.
    Edwards JH, Hyman RA, Vacirca SJ: Magnetic resonance imaging of the orbit. AJNR 6:253–258, 1985.Google Scholar
  201. 201.
    Schenck JF, Hait HR, Foster IH, et al: Improved MR imaging of the orbit at 1.5 T with surface coils. AJNR 6:193–196, 1985.Google Scholar
  202. 202.
    Sobel DF, Moseley IF: Brant—Zawadzki M: Magnetic resonance imaging (MRI) of the eye and orbit, in Gonzalez CF, Becker MH, Flanagan JC (eds): Diagnostic Imaging in Ophthalmology. New York: Springer—Verlag, 1986, pp 99–114.CrossRefGoogle Scholar
  203. 203.
    Sullivan JA, Harms SE: Characterization of orbital lesions by surface coil. MR Imaging Radiographics 7:9–28, 1987.Google Scholar
  204. 204.
    Mafee J, Peyman G, Peace J, et al: Magnetic resonance imaging in the evaluation and differentiation of uveal melanomas. Ophthalmology 94:341–348, 1987.PubMedGoogle Scholar
  205. 205.
    Byrne SF, Glaser JS: Orbital tissue differentiation with standardized echography. Ophthalmology 90:1071–1090, 1983.PubMedGoogle Scholar
  206. 206.
    Coleman DJ, Dallow RL: Orbital ultrasonography, in Duane TD, Jaeger EA (eds): Clinical Ophthalmology, Vol. 2. Philadelphia: Harper and Row, 1982, pp 1–16.Google Scholar
  207. 207.
    McNutt LC, Kaefring SL, Ossoinig KC: Echographic measurement of extraocular muscles, in White D, Brown RE (eds): Ultrasound in Medicine, Vol 3A. Clinical Aspects. New York: Plenum Press, 1977, pp 927–932.Google Scholar
  208. 208.
    Coleman DJ, Lizzi FL, Jack RL: Ultrasonography of the eye and orbit. Philadelphia: Lea and Febiger, 1977, p 331.Google Scholar
  209. 209.
    Ossoinig KC.: Orbital disorders, in de Vlieger M (ed): Handbook of Clinical Ultrasound. New York: John Wiley & Sons, 1978, pp 884–904.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Joseph A. MaurielloJr.
  • Joseph C. Flanagan
  • Steven E. Harms

There are no affiliations available

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