Zusammenfassung
Wie in Kap. 4 ausgeführt, kommen 5% der Brustkrebserkrankungen entsprechend einem autosomal dominanten Erbgang und weitere 10% aufgrund prädisponierender Gene mit niedriger Penetranz familiär gehäuft vor.
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Literatur
Arnold N, Hägele L, Walz L, Schempp W, Pfisterer J, Bauknecht T, Kiechle M (1996) Overrepresentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer. Genes Chromosomes Cancer 16: 46–54
Caldes T, Perez-Segura P, Tosar A, De La Hoya M, Diaz-Rubio E (2000) Low frequency of microsatellite instability in sporadic breast cancer. Int J Oncol 16:1235–1242
Cheng C-W, Wu P-E, Yu J-C, Huang C-S, Yue C-T, Wu C-W, Shen C-Y (2001) Mechanisms of inactivation of Ecadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 20:3814–3823
Esteller M, Silva JM, Dominguez G et al. (2000) Promotor hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92:564–569
Feinberg AP (2001) Cancer epigenetics takes center stage. Proc Natl Acad Sci USA 98:392–394
Forozan F, Mahlamäki EH, Monni O et al. (2000) Comparative Genomic Hybridization analysis of 38 breast cancer cell lines: A basis for interpreting complementary DNA micro array data. Cancer Res 60: 4519–4525
Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG (2000) Methylation patterns of the E-cadherin 5’ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 275:2727–2732
Jain AN, Chin K, Borresen-Dale A-L, Erikstein BK, Lonning PE, Kaaresen R, Gray JW (2001) Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc Natl Acad Sci USA 98:7952–7957
Loeb LA (2001) A mutator phenotype in cancer. Cancer Res 61: 3230–3239
Loveday RL, Greenman J, Simcox DL, Speirs V, Drew PJ, Mon-son JRT, Kerin MJ (2000) Genetic changes in breast cancer detected by comparative genomic hybridisation. Int J Cancer 86:494–500
Miyoshi Y, Iwao K, Egawa C, Noguchi S (2001) Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. Int J Cancer 92: 370–373
Nowell PC (1989) The clonal nature of neoplasia. Cancer Cells 1: 29–30
Peltomaki P (2001) Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum Mol Genet 10: 735–740
Rice JC, Futscher BW (2000) Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoace-tylation and chromatin condensation of the BRCAi promoter. Nucleic Acids Res 28:3233–3239
Rummukainen J, Kytola S, Karhu R, Farnebo F, Larsson C, Isola JJ (2001) Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridisation, fluorescence in situ hybridization, and spectral karyotyping. Cancer Genet Cytogenet 126:1–7
Simon R, Nocito A, Hübscher T et al. (2001) Patterns of HER-2/neu amplification and overexpression in primary and metastatic breast cancer. J Natl Cancer Inst 93:1141–1146
Tanner M, Järvinen P, Isola J (2001) Amplification of HER-2/neu and Topoisomerase IIa in primary and metastatic breast cancer. Cancer Res 61: 5345–5348
Teixeira MR, Tsarouha H, Kraggerud SM et al. (2001) Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridisation analysis. Neoplasia 3: 204–214
Tomlinson IPM (2001) Mutations in normal breast tissue and breast tumors. Breast Cancer Res 3: 299–303
Weimer J, Kiechle M, Arnold N (2000) FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements. Cytogenet Cell Genet 88:114–118
Xu X, Brodie SG, Yang X et al. (2000) Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 19:1868–1874
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Arnold, N. (2002). Sporadisches Mammakarzinom — genetische Veränderungen. In: Kreienberg, R., Volm, T., Möbus, V., Alt, D. (eds) Management des MAMMAKARZINOMS. Onkologie Aktuell . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08460-1_6
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DOI: https://doi.org/10.1007/978-3-662-08460-1_6
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