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Management der In-situ-Karzinome

  • M. Mitze
Chapter
Part of the Onkologie Aktuell book series (ONKAKTUELL)

Zusammenfassung

Bei dieser Läsion finden sich Vergrößerungen der Drüsenläppchen mit Vermehrung und Auftreibung der Azini. Diese sind angefüllt mit einem monomorphen Epithel ohne nennenswerte Atypien. Dieses Epithel kann sich zudem über die Läppchen hinaus in die angrenzenden Milchgänge ausbreiten. Die Bezeichnung der Läsion als „Carcinoma in situ“ erfolgte durch Foote u. Stewart (1941), die derartige Veränderungen häufig in der Nachbarschaft invasiver lobulärer Karzinome fanden. Die Klassifikation dieser Veränderungen als Carcinoma in situ bezieht sich vorwiegend auf deren prognostische Bedeutung, die Morphologie der Läsionen zeigt lediglich ein monomorphes (möglicherweise monoklonales) Epithel ohne Atypien, allerdings mit einem Verlust der basalen Epithellage (Abb. 12.1).

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© Springer-Verlag Berlin Heidelberg 2002

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  • M. Mitze

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