Advertisement

The Ultrastructure of Normal and Reactive Microglia

  • W. F. Blakemore
Part of the Acta Neuropathologica book series (NEUROPATHOLOGIC, volume 6)

Summary

Normal microglia have a distinct morphology. In rapidly, but not in slowly evolving pathological states the features used to identify the resting cell are often lost. When there is invasion by haematogenous monocytes, phagocytes develop whose origin - cerebral or haematogenous - cannot be ascertained on morphological features alone. These observations stress that microglia are part of the reticulo-endothelial system.

Key words

Glia microglia ultrastructure reticulo-endothelial system 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Roessmann, U., Friede, R.L.: Entry of labelled monocytic cells into the central nervous system. Acta neuropath. (Berl.) 10, 359–362 (1968).CrossRefGoogle Scholar
  2. 2.
    Adrian, E.K., Smotherman, R.D.: Leucocytic infiltration into the hypoglossal nucleus following injury to the hypoglossal nerve. Anat. Rec. 166, 99–115 (1970).PubMedCrossRefGoogle Scholar
  3. 3.
    Oehmichen, M., Grüninger, H., Saebisch, R., Narita, Y.: Mikroglia und Pericyten als Transformationsformen des Blut-Monocyten mit erhaltener Proliferationsfähigkeit. Acta neuropath. (Berl.) 23, 200–218 (1973).CrossRefGoogle Scholar
  4. 4.
    Kruger, L., Maxwell, D.S.: Electron microscopy of oligodendrocytes in normal rat cerebrum. Amer. J. Anat. 118, 411–436 (1966).PubMedCrossRefGoogle Scholar
  5. 5.
    Mugnaini, K., Walberg, F.: Ultrastructure of neuroglia. Ergebn. Anat. Entwickl.-Gesch. 37, 194–236 (1964).Google Scholar
  6. 6.
    Vaughn, J.E., Hinds, P.L., Skoff, R.P.: Electron microscopic studies of Wallerian degeneration in rat optic nerves. I. The multipotential glial. J. comp. Neurol. 140, 175–205 (1970).PubMedCrossRefGoogle Scholar
  7. 7.
    Mathews, M.A., Kruger, L.: Electron microscopy of non-neuronal cellular changes accompanying neural degeneration in thalamic nuclei of the rabbit. II. Reactive elements within the neuropil. J. comp. Neurol. 148, 313–346 (1973).CrossRefGoogle Scholar
  8. 8.
    Maxwell, D.S., Kruger, L.: The reactive oligodendrocyte. An electron microscopic study of cerebral cortex following alpha particle irradiation. Amer. J. Anat. 118, 437–460 (1966).PubMedCrossRefGoogle Scholar
  9. 9.
    Torvik, A., Skjörten, F.: Electron microscopic observations on nerve cell regeneration and degeneration after axon lesions. II. Changes in glial cells. Acta neuropath. (Berl.) 17, 265–282 (1971).CrossRefGoogle Scholar
  10. 10.
    Mori, S., Leblond, C. P.: Identification of microglia in light and electron microscopy. J. Comp. Neurol. 135, 57–80 (1969).PubMedCrossRefGoogle Scholar
  11. 11.
    Blakemore, W.F.: The ultrastructure of the subependymal plate in the rat. J. Anat. (Lond.) 104, 423–433 (1969).Google Scholar
  12. 12.
    Rio-Hortega, P. del: Microglia. In: Penfield, W. (ed.): Cytology and Cellular Pathology of the Nervous System, vol. 2, p. 481–534. New York: Paul B. Hoeber, Inc. 1932.Google Scholar
  13. 13.
    Blakemore, W.F.: Microglia reactions following thermal necrosis of the rat cortex: An electron microscopic study. Acta neuropath. (Berl). 21, 11–22 (1972).CrossRefGoogle Scholar
  14. 14.
    Blakemore, W.F.: Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone. J. neurol. Sci. 20, 63–72 (1973).PubMedCrossRefGoogle Scholar
  15. 15.
    Stenwig, A.E.: The origin of brain macrophages in traumatic lesions, Wallerian degeneration, and retrograde degeneration. J. Neuropath. exp. Neurol. 31, 696–704 (1972).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • W. F. Blakemore
    • 1
  1. 1.Wellcome Laboratory for Comparative Neurology, Department of Veterinary Clinical StudiesUniversity of CambridgeCambridgeEngland

Personalised recommendations