Primary Cerebral Reticulosis and Plasma Cell Differentiation

Part of the Acta Neuropathologica book series (NEUROPATHOLOGIC, volume 6)

Summary

Cerebral proliferative and tumour forming reticulosis are primary pathologic processes of the brain originating in the perivascular adventitial cell.

In these conditions this cell can transform into a histiocyte or microglial cell with characters of a macrophage. A reactive cell with endoplasmic reticulum, basement membrane and fibril forming properties, is also present (fibril forming reticular cell). The malignant tumours of the perivascular spaces (cerebral reticulosarcoma) are characterized by the presence of the dedifferentiated cells originating from the intraadventitial cell.

Under both proliferative and tumour forming conditions this cell may transform into a cell rich in endoplasmic reticulum, sometimes charged with Russell bodies and corresponds morphologically to the protein-forming plasma cell.

The properties of the intracerebral periadventitial cells are identical with those of the reticulo-histiocytic system described by Aschoff. As its structure and the elements into which it differentiates sharply differ from those of the cells belonging to the lymphocyte series the term malignant lymphoma of the brain given to these processes does not correspond to the fundamental characters of these pathological process.

Key words

Reticulosis Reticulosarcoma Brain Tumour Electron Microscopy Plasmacyte Russell bodies 

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References

  1. 1.
    Dav. d. H.: Elektronenmikroskopische Organpathologie, p. 423. Berlin: VEB-Verlag, 1967.Google Scholar
  2. 2.
    Vuia, O., Hager, H.: Primary Cerebral Blastomatous Reticulosis. Clinical, Pathological and Ultrastructural Study. J. neurol. Sci. 19, 407–423 (1973).PubMedCrossRefGoogle Scholar
  3. 3.
    Marchand, F.: Referat über die Herkunft der Lymphozyten und ihre Schicksale bei der Entzündung. Verh. dtsch. path. Ges. 16, 5–81 (1953).Google Scholar
  4. 4.
    Draganescu, St., Vuia, O.: Neuroreticuloses. Acta Neuropath. (Berl.) 4, 669–682 (1965).CrossRefGoogle Scholar
  5. 5.
    Horvat, B., Pena, C., Fisher, E.R.: Primary Reticulum cell Sarcoma (Microglioma) of the brain. Arch. Path. 87, 609–616 (1969).PubMedGoogle Scholar
  6. 6.
    Constantinidis, J., Escourolle, R.: Réticulose pallido-pedonculaire bilatérale et nécrosante. Arch. Suisse Neurol. Neurochir. Psychiat. 106, 223 (1970).Google Scholar
  7. 7.
    Vuia, O., Mehraien, P.: Cerebral reticuloplasmacytosis with hyperglobu-linemia. Europ. Neurol. 7, 155–168 (1972).CrossRefGoogle Scholar
  8. 8.
    French, J.D.: Plasmacytoma of the Hypothalamus. J. Neuropath. Exp. Neurol. 6, 265–270 (1947).PubMedCrossRefGoogle Scholar
  9. 9.
    Moosy, J., Wilson, C.L.B.: Solitary Intracranial Plasmacytoma. Arch. Neurol. 16, 212–216 (1967).CrossRefGoogle Scholar
  10. 10.
    Hager, H.: Ultrastrukturelle Befunde zur Zytopathologie der Entzündung im Zentralnervensystem. Z. allg. Path. 115, 619 (1970).Google Scholar
  11. 11.
    Weiner, L.P., Anderson, P.N., Allen, J.C.: Cerebral plasmacytoma with myeloma protein in the cerebrospinal fluid. Neurology (Minneap.) 16, 615–618 (1966).CrossRefGoogle Scholar
  12. 12.
    Cutler, R.W., Tourtelotte, W.W.: Synthesis of gammaglobulin inside the blood-brain barrier in subacute sclerosing panencephalitis. Riv. pat. nerv, ment. 92, 163–170 (1971).Google Scholar
  13. 13.
    Aschoff, L.: Morphologie des retikulo-endothelialen Systems. In Schittenhelm: Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Bd. 2, p. 473, Berlin: Springer 1925.CrossRefGoogle Scholar
  14. 14.
    Russel, D.S., Marshall, A.H.E., Smith, F.B.: Microgliomatosis Brain 71, 1–16 (1948).CrossRefGoogle Scholar
  15. 15.
    Vuia, O., Mehraien, P.: Primary Reticulosis of the Central Nervous System. J. neurol. Sci. 14, 469–482 (1971).PubMedCrossRefGoogle Scholar
  16. 16.
    Kernohan, J.W., Uihlein, A.: Sarcomas of the Brain. Springfield, Ill.: Thomas 1962.Google Scholar
  17. 17.
    Papilian, V.V., Vuia, O., Serban, M., Nagy, I.: Primary Reticulohistio-microglioblastomas of the Central Nervous System. Stud. Cerc. Neurol. 7, 183–192 (1962).Google Scholar
  18. 18.
    Vuia, O.: Das solitäre und multifokale polymorphe Granulom im Nervensystem. Arch. Psychiat. Neurol. 208, 309–325 (1966).CrossRefGoogle Scholar
  19. 19.
    Poon, P.S., Hirano, A., Zimmerman, H.M.: Electron Microscopic Atlas of the brain Tumours, p. 94. New York, London: Grune & Stratton 1971.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • O. Vuia
    • 1
  1. 1.Institute of NeuropathologyJustus Liebig UniversityGießenDeutschland

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