Summary
Out of 960 human brain neoplasms seven primary lymphomas were cultured and grown up to twenty-eight days. The monolayers had common cytological characteristics; /i/ immediately after explantation a high density of uniform cells was observ. d. /ii/ many cells were lost during subsequent medium changes; /iii/ the monolayers contained lymphocyte-like cells in different numbers. According to their indiv. d. al characteristics the cultures could be classified into three categories: 1./ In the cultures of three tumours lymphocyte-like cells predominated. These tumours had low proliferative capacity in vitro. 2./ Cultures of three other tumours consisting mainly of tissue macrophages had a high proliferative capacity in vitro. 3./ Cultures of a single tumour showed the combined features of the former two categories: both lymphocyte-like cells, and tissue macrophages were present. These cultures showed the highest proliferative activity.
On the basis of these findings it is quite possible that besides other methods, tissue culture technique may be useful in the classification of brain lymphomas.
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References
Kersting, G.: Die Gewebszüchtung menschlicher Hirngeschwülste. Berlin-Göttingen-Heidelberg: Springer 1961.
Lumsden, C.E.: The study by tissue culture of tumours of the nervous system. In: Russel, D.S. and Rubinstein, L.J.: Pathology of tumours of the nervous system, p. 334–420. London: Arnold, E., Ltd. 1971.
Murray, M.R., Stout, A.P.: The classification and diagnosis of human tumors by tissue culture methods. Texas Rep. Biol. Med. 12, 898–915 (1954).
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© 1975 Springer-Verlag Berlin Heidelberg
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Gazso, L., Slowik, F. (1975). Primary Lymphomas of the Central Nervous System; in vitro Culture Observations. In: Jellinger, K., Seitelberger, F. (eds) Malignant Lymphomas of the Nervous System. Acta Neuropathologica, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08456-4_17
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DOI: https://doi.org/10.1007/978-3-662-08456-4_17
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