Summary
In previous experiments we have demonstrated that L-carnitine administration is capable of reducing olive oil-induced lipidaemia in the rat. In the present study we determined the effect of L-carnitine on the levels of (acyl)carnitines in heart and serum in addition to its effect on serum levels of lipids and ketone bodies after olive oil gavage feeding. L-carnitine was found to reduce the level of myocardial long-chain acylcarnitine which was increased by the olive oil treatment. It also increased the levels of carnitine and acid soluble acylarnitines in both heart and serum. L-carnitine administration caused a clearcut decrease of olive oil-induced lipidaemia and ketonaemia. These effects of added L-carnitine strongly suggest that the stimulation of the β-oxidation in the mitochondria (at the expense of extra mitochondrial triglycerceride synthesis) is suboptimal after fat loading.
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© 1987 Springer-Verlag Berlin Heidelberg
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Maccari, F., Arseni, A., Chiodi, P., Ramacci, M.T., Angelucci, L. (1987). The effect of exogenous L-carnitine on biochemical parameters in serum and in heart of the hyperlipidaemic rat. In: Stam, H., van der Vusse, G.J. (eds) Lipid metabolism in the normoxic and ischaemic heart. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-08390-1_9
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DOI: https://doi.org/10.1007/978-3-662-08390-1_9
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-08392-5
Online ISBN: 978-3-662-08390-1
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