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Cholesterol and myocardial membrane function

  • A. van der Laarse
Conference paper

Summary

The incorporation of cholesterol into phospholipid membranes changes the physical properties of the membranes, such as their phase transition, fluidity and homogeneity. In cholesterol-containing phospholipid membranes, integral proteins are surrounded by “annular” phospholipids which exclude cholesterol. Cellular cholesterol is supplied by circulating low-density lipoproteins, and by intracellular de novo synthesis. Cholesterol removal is predominantly handled by circulating high-density lipoproteins. In cardiomyopathic hamsters, myocardial membranes (sarcolemma, mitochondria, sarcoplasmic reticulum) have an increased cholesterol content. In ischaemic myocardium, cholesterol content of sarcolemma fell and that of mitochondria rose. Apparently, cholesterol is redistributed within the ischaemic heart cell. Phospholipids are degraded in sarcolemma, mitochondria and sarcoplasmic reticulum of ischaemic heart cells, probably by activation of phospholipases present in these membrane systems.

Key words

cholesterol phospholipids membranes membranes fluidity sarcolemma ischaemia mitochondria sarcoplasmic reticulum. 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. van der Laarse
    • 1
  1. 1.Department of CardiologyUniversity Hospital LeidenLeidenThe Netherlands

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