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Lipid metabolism in the normoxic and ischaemic heart pp 127–135Cite as

The effects of ischaemia, lysophosphatidylcholine and palmitoylcarnitine on rat heart phospholipase A2 activity

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Summary

Phospholipase A2 activity was studied in the isolated rat heart following coronary artery ligation. In both the homogenate and mitochondrial fractions phospholipase A2 activity was significantly depressed at 20 min post ligation in the ischaemic region only. This is at a time of peak lysophospholipid concentration and severity of arrhythmias. No such depression of activity was seen in a crude sarcolemmal fraction, possibly due to washout of inhibitory factors during isolation. Lysophosphatidylcholine and palmitoylcarnitine, two amphiphiles known to accumulate during ischaemia, were both shown to be capable of inhibiting phospholiphase A2.

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Author information

Authors and Affiliations

  1. Pharmacology Group School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath and Sandwich, Kent, UK

    J. M. Bentham & B. Woodward

  2. Pharmacology Group School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath and Pfizer Central Research, Sandwich, Kent, UK

    A. J. Higgins

  3. Pharmacology Group, School of Pharmacy and Pharmacology, Claverton Down, Bath Avon, BA2 7AY, UK

    B. Woodward

Authors
  1. J. M. Bentham
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  2. A. J. Higgins
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  3. B. Woodward
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H. Stam G. J. van der Vusse

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© 1987 Springer-Verlag Berlin Heidelberg

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Bentham, J.M., Higgins, A.J., Woodward, B. (1987). The effects of ischaemia, lysophosphatidylcholine and palmitoylcarnitine on rat heart phospholipase A2 activity. In: Stam, H., van der Vusse, G.J. (eds) Lipid metabolism in the normoxic and ischaemic heart. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-08390-1_16

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  • DOI: https://doi.org/10.1007/978-3-662-08390-1_16

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-08392-5

  • Online ISBN: 978-3-662-08390-1

  • eBook Packages: Springer Book Archive

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