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Lipid metabolism in the normoxic and ischaemic heart pp 121–125Cite as

Membrane phospholipid metabolism during myocardial ischaemia: past, present and future

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Summary

Alterations in myocardial membrane phospholipids may play an important role in the pathogenesis of ischaemic myocardial cell injury. Studies in canine myocardium, perfused rat heart, and cultured myocardial cells have demonstrated that the accumulation of free arachidonic acid correlates with the development of irreversible cell injury. Accumulation of other phospholipid hydrolysis products, including amphiphilic compounds such as lysophosphatidylcholine, has also been reported. The biochemical mechanisms which are responsible for phospholipid hydrolysis and arachidonic acid accumulation during ischaemia are unknown. This manuscript provides a synopsis of previous work in this field and suggests new directions for the field of myocardial phospholipid metabolism.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Texas Health Science Center, Dallas, Texas, USA

    Dr. Anjan Sen, J. T. Willerson & K. R. Chien

  2. Department of Medicine, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, TX, 75235-9034, USA

    Dr. Anjan Sen

  3. Department of Pathology, University of Texas Health Science Center, Dallas, Texas, USA

    L. M. Buja

Authors
  1. Dr. Anjan Sen
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  2. L. M. Buja
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  3. J. T. Willerson
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  4. K. R. Chien
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Editor information

H. Stam G. J. van der Vusse

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© 1987 Springer-Verlag Berlin Heidelberg

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Sen, A., Buja, L.M., Willerson, J.T., Chien, K.R. (1987). Membrane phospholipid metabolism during myocardial ischaemia: past, present and future. In: Stam, H., van der Vusse, G.J. (eds) Lipid metabolism in the normoxic and ischaemic heart. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-08390-1_15

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  • DOI: https://doi.org/10.1007/978-3-662-08390-1_15

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-08392-5

  • Online ISBN: 978-3-662-08390-1

  • eBook Packages: Springer Book Archive

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