Abstract
Cavity ring-down spectroscopy (CRDS) is revolutionizing the sensitivity, speed, ease of use, robustness, and portability of trace chemical species detection. Today, CRDS is being commercialized across a broad range of application areas, including medical diagnostics, industrial process control, environmental monitoring, and civilian and military security. In this monograph we will address the application of CRDS to medical breath testing, a new field in medical diagnostics that promises to usher in a new era of testing methodology with improved specificity, sensitivity, and painless administration compared to the current generation of medical tests.
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References
Anderson DZ, Frisch JC, Masser CS. (1984) Mirror Reflectometer Based on Optical Cavity Decay Time, Appl. Opt. 23: 1238–1245
Busch KW, Busch MA. (1997) Cavity Ringdown Spectroscopy: An Ultratrace Absorption Measurement Technique, ACS Symposium Series 720, Oxford
Crosson ER, Ricci KN, Richman BA, Chilese FC, Owano TG, Provencal RA, Todd MW, Glasser J, Kachanov AA, Paldus BA, Spence TG, Zare RN. (2002) Stable Isotope Ratios Using Cavity Ringdown Spectroscopy: Determination of 13C/12C for Carbon Dioxide in Human Breath, Anal. Chem. 74(9): 2003–7
Dahnke H, Hering P, Kleine D, Murtz M. (2001) Real-time monitoring of ethane in human breath using mid-infrared cavity leak-out spectroscopy Appl. Phys. B 72:971–975
Hodges JT, Looney JP, Zee RDv (1996) Response of a Ringdown Cavity to an Arbitrary Excitation, J. Chem. Phys. 105(23):10278–10288
Jongma RT, Boogart MGH, Holleman I, Meijer G. (1995) Trace Gas Detection with Cavity Ringdown Spectroscopy, Rev Sci Instrum 66 (4): 2821–2828
O’Keefe A, Deacon DAG (1988) Cavity ring-down optical spectrometer for absorption measurements using pulsed laser sources, Rev. Sci. Inst. 59: 2544–2551
O’Keefe A, Scherer JJ, Cooksy AL, Sheeks R, Heath J, Saykally RJ. (1990) Cavity ringdown dye laser spectroscopy of jet-cooled metal clusters: Cu2 and Cu3, Chem. Phys. Lett. 172: 214
Paldus BA, Harris JS, Martin J, Xie J, Zare RN. (1997) Laser diode cavity ringdown spectroscopy using acousto-optic modulator stabilization, J Appl. Phys. 82(7):3199–3204
Paldus BA, Harb CC, Spence TG, Wilke B, Xie J, Harris JS, Zare RN (1998) Cavity-locked ring-down spectroscopy, J Appl. Phys. 83(8) 3991–3997
Paldus BA, Harb CC, Spence TG, Zare RN, Gmachl C, Capasso F, Sivco DL, Bailargeon JN, Hutchinson AL, Cho AY (2000) Cavity ringdown spectroscopy using mid-infrared quantum-cascade lasers, Opt. Lett. 25 (9): 666–668
Romanini D, Lehmann KK (1993) Ringdown Cavity Absorption Spectroscopy of the Very Weak HCN Overtone Bands with Six, Seven, and Eight Stretching Quanta, J. Chem. Phys. 99 (9): 6287–6301
Romanini D, Kachanov AA, Sadeghi N, Stoeckel F (1997) CW Cavity Ringdown Spectroscopy, Chem. Phys. Lett. 264: 316–322
Spence TG, Harb CC, Paldus BA, Zare RN, Willke B, Byer RL (2000) A laser-locked cavity ringdown spectrometer employing an analog detection scheme. Rev. Sci. Instrum. 71: 347–353
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Paldus, B.A., Crosson, E.R., Dahnke, H. (2004). Practical Applications of CRDS in Medical Diagnostics. In: Hering, P., Lay, J.P., Stry, S. (eds) Laser in Environmental and Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08255-3_15
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DOI: https://doi.org/10.1007/978-3-662-08255-3_15
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