Abstract
Ambient air and the human breath both contain many different volatile organic and inorganic compounds. Most of them are present in very low concentrations. The analysis of these trace gases leads in case of ambient air to a better understanding of the atmospheric chemistry and in the case of breath tests to a deeper knowledge of the physiological processes in the human body. Amongst other sources these compounds are produced in the human organism and find their way via the blood through the lungs into the human breath. Most of the volume fractions of these trace gases are on the order of some ppb (parts per billion: 1:109) down to several ppt (parts per trillion: 1:1012). This shows the need for ultra sensitive analytical methods for the in-vivo monitoring of human breath, which helps to understand various physiological and pathophysiological processes in the human organism.
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References
Aghdassi E and Allard JP (2000) Breath alkanes as a marker of oxidative stress in different clinical conditions, Free Radic. Biol. Med. 28: 880–886
Bachem E, Dax A, Fink T, Weidenfeller A, Schneider M, and Urban W (1993) Recent progress with the CO-overtone Av=2 laser, Appl. Phys. B. 57: 185–191
Dahnke H, Basum Gv, Kleinermanns K, Hering P, and Mürtz M (2002) Rapid formaldehyde monitoring in ambient air by means of cavity leak-out spectroscopy, Appl. Phys. B 75: 311–316
Dahnke H, Kleine D, Hering P, and Mürtz M ( 2001 a) Real-time monitoring of ethane in human breath using mid-infrared cavity leak-out spectroscopy, Appl. Phys. B 72: 971–975
Dahnke H, Kleine D, Urban C, Hering P, and Mürtz M (2001b) Isotopic ratio measurement of methane in ambient air using mid-infrared cavity leak-out spectroscopy, Appl. Phys. B 72: 121–125
Engeln R, vonHelden G, Berden G, and Meijer G (1996) Phase shift cavity ring down absorption spectroscopy, Chem. Phys. Lett. 262: 105–109
Esterbauer H (1996) Estimation of peroxidative damage. A critical review, Pathol. Biol. (Paris) 44: 25–28
Ganser H, Frech B, Jentsch A, Mürtz M, Gmachl C, Capasso F, Sivco DL, Baillargeon JN, Hutchinson AL, Cho AY, and Urban W (2001) Investigation of the spectral width of quantum cascade laser emission near 5.2 µm by a heterodyne experiment, Opt. Commun. 197: 127–130
Gardner HW (1989) Oxygen radical chemistry of polyunsaturated fatty acids, Free Radic. Biol. Med. 7: 65–86
Habib MP, Clements NC, and Garewal HS (1995) Cigarette smoking and ethane exhalation in humans, Am. J. Respir. Crit Care Med. 151: 1368–1372
HITRAN (1996) Database available at http://www.hitran.com
IPCC (1995) Second assesment report: climate change 1995; available at http://www.ipcc.ch
Kennet JP, Cannariato KG, Hendy IL, and Behl RJ (2000) Carbon isotopic evidence for methane hydrate instability during quaternary interstadials, Science 288: 128–133
Kleine D, Dahnke H, Urban W, Hering P, and Mürtz M (2000) Real-time detection of (CH4)-C-13 in ambient air by use of mid-infrared cavity leak-out spectroscopy, Opt. Lett. 25: 1606–1608
Kleine D, Mürtz M, Lauterbach J, Dahnke H, Urban WG, Hering P, and Kleinermanns K (2001) Atmospheric trace gas analysis with cavity ring-down spectroscopy, Isr. J. Chem. 41: 111–116
Kneepkens CM, Lepage G, and Roy CC (1994) The potential of the hydrocarbon breath test as a measure of lipid peroxidation, Free Radic. Biol. Med. 17: 127–160
Knutson MD, Handelman GJ, and Viteri FE (2000) Methods for measuring ethane and pentane in expired air from rats and humans, Free Radic. Biol. Med. 28: 514–519
Mürtz M, Frech B, Palm P, Lotze R, and Urban W (1998) Tunable carbon monoxide overtone laser sideband system for precision spectroscopy from 2.6 to 4.1 µm, Opt. Left. 23: 58–60
Mürtz M, Frech B, and Urban W (1999a) High-resolution cavity leak-out absorption spectroscopy in the 10 üm region, Appl. Phys. B 68: 243–249
Mürtz M, Kayser T, Kleine D, Stry S, Hering P, and Urban W (1999b) Recent developments on cavity ring-down spectroscopy with tunable cw lasers in the mid-infrared, Proc SPIE 3758: 53–62
Paldus BA, Harb CC, Spence TG, Wilke B, Xie J, Harris JS, and Zare RN (1998) Cavity-locked ring-down spectroscopy, J. Appl. Phys. 83: 3991–3997
Paldus BA, Harb CC, Spence TG, Zare RN, Gmachl C, Capasso F, Sivco DL, Baillargeon JN, Hutchinson AL, and Cho AY (2000) Cavity ringdown spectroscopy using mid-infrared quantum-cascade lasers, Opt. Lett. 25: 666–668
Popp A, Dahnke H, Orphal J, Basum Gv, Burrows JP, and Kühnemann F (2000) HASIBO- a database for high-resolution absorption cross-sections of VOCs in the mid-IR
Popp A, Müller F, Kühnemann F, Schiller S, Basum Gv, Dahnke H, Hering P, and Mürtz M (2002) Ultra-sensitive mid-infrared cavity leak-out spectroscopy using a cw optical parametric oscillator, Appl. Phys. B (submitted)
Pryor WA and Godber SS (1991) Noninvasive measures of oxidative stress status in humans, Free Radic. Biol. Med. 10: 177–184
Richter D, Lancaster DG, and Tittel FK (2000) Development of an automated diode-laserbased multicomponent gas sensor, Appl. Opt. 39: 4444–4450
Risby TH, Sehnert SS, Jiang L, and Burdick JF (2001) Volatile biomarkers for analysis of hepatic disorders Patent:6248078
Romanini D, Kachanov AA, Sadeghi N, and Stoeckel F (1997) CW cavity ring down spectroscopy, Chem. Phys. Lett. 264: 316–322
Sies H (1985) Oxidative stress: oxidants and antioxidants
Stry S, Hering P, and Mürtz M (2002) Portable difference-frequency laser based cavity leak-out spectrometer for trace gas analysis, Appl. Phys. B 75: 297–303
Urban W (1995) Physics and spectroscopic applications of carbon-monoxide lasers, a re-view, Infrared Phys. Techn. 36: 465–473
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Dahnke, H., Stry, S., von Basum, G. (2004). Medical Trace Gas Detection by Means of Mid-Infrared Cavity Leak-Out Spectroscopy. In: Hering, P., Lay, J.P., Stry, S. (eds) Laser in Environmental and Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08255-3_14
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DOI: https://doi.org/10.1007/978-3-662-08255-3_14
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