Störungen im Prolaktinhaushalt

  • Freimut A. Leidenberger

Zusammenfassung

Störungen im Prolaktinhaushalt, insbesondere die Hyperprolaktinämie, sind häufige Erscheinungen in der endokrinologischen Sprechstunde. Sie wirken sich potentiell auf viele andere Organfunktionen aus (z.B. Ovarien, Nebennierenrinde) oder sind Symptome und Begleiterscheinungen anderer Endokrinopathien, verschiedener Stoffwechselstörungen oder Erkrankungen (s. folgende übersicht). Die Bestimmung der Prolaktinspiegel im Blut stellt also eine der wichtigsten und häufigsten differentialdiagnostischen Maßnahmen bei Abklärung endokriner Störungen, insbesondere ovarieller Störungen, dar.

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Literatur

  1. Aitken JM et al. (1973) Oestrogen replacement therapy for prevention of osteoporosis after oophorectomy. Br Med J 3: 515PubMedCrossRefGoogle Scholar
  2. Archer DF, Josimovich JB (1975) Response of serum prolactin to exogenous stimulation. Fertil Steril 26: 627PubMedGoogle Scholar
  3. Asa SL, Penz G, Kovacs K, Ezrin C (1982) Prolactin cells in the human pituitary. Arch Pathol Lab Med 106:360PubMedGoogle Scholar
  4. Auhagen-Stephanos U (1982) Kasuistischer Beitrag zur Diskussion psychosomatischer Zusammenhänge bei Hyper-prolaktinämie. Gynäkologe 15:198PubMedGoogle Scholar
  5. Belisle S, Menard J (1980) Adrenal androgen production in hyperprolactinemic states. Fertil Steril 33:396PubMedGoogle Scholar
  6. Ben-David M, Schenker JG (1983) Transient hyperprolactine-mia: a correctable cause of idiopathic female infertility. J Clin Endocrinol Metab 57: 442PubMedCrossRefGoogle Scholar
  7. Bigazzi M, Ronga R, Lancranjan I et al. (1979) A pregnancy in an acromegalic women during bromocriptine treatment: effects on growth hormone and prolactin in the maternal, fetal, and amniotic compartments. J Clin Endocrinol Metab 48:9PubMedCrossRefGoogle Scholar
  8. Bispink L (1987) Die Bedeutung der präklinischen Hypothyreose als Ursache von Ovarialfunktionsstörungen. Inauguraldissertation, Universität HamburgGoogle Scholar
  9. Blake RE, Maroulis GB, Sherman BM, Khalil A (1986) Prolactinoma and adrenal androgens.J Reprod Med 31: 675PubMedGoogle Scholar
  10. Board JA, Storlazzi E, Schneider V (1981) Nocturnal prolactin levels in infertility. Fertil Steril 36: 720PubMedGoogle Scholar
  11. Bohnet HG (1981) Prolaktin und seine Bedeutung für die Frau. Grosse, BerlinGoogle Scholar
  12. Bohnet HG (1986) Hyperprolaktinämie. Grosse, BerlinGoogle Scholar
  13. Bohnet HG, Dahlen HG, Wuttke W, Schneider HPG (1976) Hyperprolactinemic anovulatory syndrome. J Clin Endocrinol Metab 42:132PubMedCrossRefGoogle Scholar
  14. Bohnet HG, Hanker JP, Horowski R, Wickings EJ, Schneider HPG (1979) Suppression of prolactin secretion by lisuride throughout the menstrual cycle and in hyperprolactinaemic menstrual disorders. Acta Endocrinol (Copenh) 92: 8Google Scholar
  15. Bohnet HG, Fiedler K, Leidenberger FA (1981) Subclinical hypothyreoidism and infertility. Lancet II: 1278CrossRefGoogle Scholar
  16. Bohnet HG, Kato K, Niemann D (1986) Thyroid function and prolactin secretion in women with menstruel disorders and/or infertility. In: Medeiros-Neto G, Gaitan E (eds) Frontiers in thyroidology, vol I. Plenum Press, New York, p 270Google Scholar
  17. Bonhoff A, Vuille JC, Gomez F, Gellersen B (1995) Identification of marcoprolactin in a patient with asymptomatic hyper-prolactinemia as a stable PRL-IgG complex. Exp Clin Endocrinol 103: 252CrossRefGoogle Scholar
  18. Boyar RM, Kapen S, Finkelstein JW et al. (1974) Hypothalamic-pituitary function in diverse hyperprolactinemic states. J Clin Invest 53:1588PubMedCrossRefGoogle Scholar
  19. Brue T, Pellegrini I, Priou A, Morange I, Jaquet P (1992) Prolactinomas and resistance to dopamine agonists. Horm Res 38: 84PubMedCrossRefGoogle Scholar
  20. Buckman MR, Peake GT, Srivastava L (1981) Patterns of spontaneous LH release in normo- and hyperprolactinaemic women. Acta Endocrinol 97:305PubMedGoogle Scholar
  21. Canales ES, Garcia IC, Ruiz JE, Zarate A (1981) Bromocriptine as prophylactic therapy in prolactinoma during pregnancy. Fertil Steril 36:524PubMedGoogle Scholar
  22. Carter JN, Tyson JE, Warne GL, McNeilly AS, Faiman C, Friesen HG (1977) Adrenocortical function in hyperprolactinemic women. J Clin Endocrinol Metab 45: 973PubMedCrossRefGoogle Scholar
  23. Chiodini PG, Liuzzi A, Verde G et al. (1980) Size reduction of a prolactin secreting adenoma during long-term treatment with the dopamine agonist lisuride. Clin Endocrinol 12: 47CrossRefGoogle Scholar
  24. Daly DC, Riddick DH (1984) The pituitary: physiology and disorders in infertile women. In: Aiman J (ed) Infertility. Springer, Berlin Heidelberg New York, p 50Google Scholar
  25. Daughaday W (1985) The anterior pituitary. In: Wilson JD, Foster DW (eds) Williams Textbook of endocrinology. Saunders, Philadelphia, p 607Google Scholar
  26. del Pozo E et al. (1977) In: Crossignani PG, Robyn C (eds) Endocrine correlations, prolactin and human reproduction. Academic Press, New York, p 61Google Scholar
  27. Denef C, Andries M (1983) Evidence for paracrine interaction between gonadotrophs and lactotrophs in pituitary cell aggregates. Endocrinol 112: 813CrossRefGoogle Scholar
  28. DiMattia GE, Gellersen B, Bohnet HG, Friesen HG (1988) A human B-lymphoblastoid cell line produces prolactin. Endocrinol 122: 2508CrossRefGoogle Scholar
  29. Divers WA, Yen SSC (1983) Prolactin-producing microadenomas in pregnancy. Obstet Gynecol 62: 425PubMedGoogle Scholar
  30. Espersen T, Ditzel J (1977) Pregnancy and delivery under bromocriptine therapy. Lancet 2: 985PubMedCrossRefGoogle Scholar
  31. Evans WS, Thorner MO (1984) Mechanisms for hypogonadism in hyperprolactinaemia. Semin Reprod Endocrinol 2: 9CrossRefGoogle Scholar
  32. Evans WS, Cronin MJ, Thorner MO (1982) Hypogonadism in hyperprolactinemia: proposed mechanisms. In: Ganon WF, Martini L (eds) Frontiers in neuroendocrinology. Raven, New York, p 77Google Scholar
  33. Fahlbusch R, Nistor R, Buchfelder M, Huk W (1988) Imaging magnetic resonance (MRI) in the preoperative diagnosis of pituitary adenomas: a comparison with CT. In: Landolt AM et al. (eds) Advances in pituitary adenoma research. Perga-mon, Oxford, p 117Google Scholar
  34. Falk RJ (1992) Isolated prolactin deficiency: a case report. Fertil Steril 58:1060PubMedGoogle Scholar
  35. Fink G (1985) Has the prolactin inhibiting peptide at last been found? Nature 316: 487PubMedCrossRefGoogle Scholar
  36. Fink U, Bauer WM, Hartmann N, Oeckler R, Bise K, von Werder K, Engelhardt D (1988) Efficiancy of MRI in patients with pituitary adenomas. In: Landolt AM et al. (eds) Advances in pituitary adenoma research. Pergamon, Oxford, p 131Google Scholar
  37. Forbes AP, Henneman PH, Griswold GC, Albright F (1954) Syndrome characterized by galactorrhea, amenorrhea and low urinary FSH: comparison with acromegaly and normal lactation. J Clin Endocrinol Metab 14: 265PubMedCrossRefGoogle Scholar
  38. Franks S, Murray AF, Jequier AM, Steele S J, Nabarro JDN, Jacobs HS (1975) Incidence and significance of hyperprolactinaemia in women with amenorrhoea. Clin Endocrinol 4: 597CrossRefGoogle Scholar
  39. Frantz AG, Kleinberg DL, Noel GL (1972) Studies on prolactin in man. Recent Prog Horm Res 28: 527PubMedGoogle Scholar
  40. Fredricsson B, Björk G, Catlström K (1977) Short luteal phase and prolactin. Lancet 1:1210PubMedCrossRefGoogle Scholar
  41. Gala RR (1991) Prolactin and growth hormone in the regulation of the immune system. Proc Soc Exp Biol Med 198:513PubMedGoogle Scholar
  42. Gandon Y, Brassier G, Edan G, Carsin-Nicol B, Campion L, Vai-vre J, Cassin M (1988) Correlation between CT-scan, MRI and intraoperative findings in pituitary adenomas. In: Landolt AM et al. (eds) Advances in pituitary adenoma research. Pergamon, Oxford, p 135Google Scholar
  43. Gellersen B, DiMattia GE, Friesen HG, Bohnet HG (1989) Prolactin (PRL) mRNA from human decidua differs from pituitary PRL mRNA but resembles the IM-9-P3 lymphoblast PRL transcript. Mol Cell Endocrinol 64:127PubMedCrossRefGoogle Scholar
  44. Gemzell C, Wang CF (1979) Outcome of pregnancy in women with pituitary adenoma. Fertil Steril 31:363PubMedGoogle Scholar
  45. Giusti G, Bassi F, Borsi L et al. (1977) Effects of prolactin on the human adrenal cortex: plasma dehydroepiandrosterone sulphate in women affected by amenorrhoea with hyperprolac-tinemia. In: Crosignani PG, Robyn C (eds) Prolactin and reproduction. Academic Press, New York, p 239Google Scholar
  46. Gomez F, Reyes FI, Faiman C (1977) Nonpuerperal galactorrhea and hyperprolactinemia. Am J Med 62: 648PubMedCrossRefGoogle Scholar
  47. Griffith RW, Turkalji I, Braun P (1978) Outcome of pregnancy in mothers given bromocriptine. Br J Clin Pharmacol 5: 227PubMedCrossRefGoogle Scholar
  48. Grossman A (1987) Opioid peptides and reproductive function. Semin Reprod Endocrinol 5:115CrossRefGoogle Scholar
  49. Huang KE, Bonfiglio TA, Muechler EK (1991) Transient hyper-prolctinemia in infertile women with luteal phase deficiency. Obstet Gynecol 78: 651PubMedGoogle Scholar
  50. Jackson RD, Wortsman J, Malarkey WB (1985) Characterization of a large molecular weight prolactin in women with idiopathic hyperprolactinemia and normal menses. J Clin Endocrinol Metab 61: 258PubMedCrossRefGoogle Scholar
  51. Jakobs HS, Franks S, Murray MAF, Hull MGR, Steele SJ, Nabarro JDN (1976) Clinical and endocrine features of hyperprolac-tinaemic amenorrhoea. Clin Endocrinol 5: 439CrossRefGoogle Scholar
  52. Jewelewicz R, Van de Wiele RL (1980) Clinical course and outcome of pregnancy in twenty-five patients with pituitary microadenomas. Am J Obstet Gynecol 136:339PubMedGoogle Scholar
  53. Jürgensen O, Bardée B (1982) Zur Psychodynamik der Hyper-prolaktinämie. Gynäkologe 15:190PubMedGoogle Scholar
  54. Kandeel FR, Rudd BT, Butt WR, Logan Edwards R, London DR (1978) Androgen and Cortisol responses to ACTH Stimulation in women with hyperprolactinaemia. Clin Endocrinol 9:123CrossRefGoogle Scholar
  55. Kleinberg DL (1984) Medical treatment of pituitary tumors. Semin Reprod Endocrinol 2: 63CrossRefGoogle Scholar
  56. Kleinberg DL, Noel GL, Frantz AG (1977) Galactorrhea: a study of 235 cases including 48 with pituitary tumors. N Engl J Med 296:589PubMedCrossRefGoogle Scholar
  57. Kletzky OA (1984) Diagnostic approaches to hyperprolactine-mic states. Semin Reprod Endocrinol 2: 23CrossRefGoogle Scholar
  58. Klibanski A (1984) Osteoporosis and hyperprolactinemia. Semin Reprod Endocrinol 2: 93CrossRefGoogle Scholar
  59. Klibanski A, Neer RM, Beitins IZ, Ridgway EC, Zervas NT, McArthur JW (1980) Decreased bone density in hyperpro-lactinemic women. N Engl J Med 303:1511PubMedCrossRefGoogle Scholar
  60. Konôpka P, Raymond JP, Merceron RE, Seneze J (1983) Continuous administration of bromocriptine in the prevention of neurological complications in pregnant women with prolactinomas. Am J Obstet Gynecol 146:935PubMedGoogle Scholar
  61. Koppelman MCS, Kurtz DW, Morrish KA, Bou E, Sussner JK, Shapiro JR, Loriaux DL (1984) Vertebral body bone mineral content in hyperprolactinemic women. J Clin Endocrinol Metab 59:1050PubMedCrossRefGoogle Scholar
  62. Lachelin GCL, Abu-Fadil S, Yen SSC (1977) Functional delineation of hyperprolactinemic amenorrhea. J Clin Endocrinol Metab 44:1163PubMedCrossRefGoogle Scholar
  63. Lachelin GCL, Barnett M, Hopper BR, Brink G, Yen SSC (1979) Adrenal function in normal women and women with the polycystic ovary syndrome. J Clin Endocrinol Metab 49:892PubMedCrossRefGoogle Scholar
  64. Lappöhn RE, van de Wiel HBM, Brownell J (1992) The effect of two dopaminergic drugs on menstrual function and psychological state in hyperprolactinemia. Fertil Steril 58:321PubMedGoogle Scholar
  65. Larrea F, Sandoval JL, Salinas E, Franco-Rodriguez VA, Méndez I, Ulloa-Aguirre A (1995) Evidence for an altered luteinizing hormone sensitivity to naloxone in pathological hyperprolactinaemia. Clin Endocrinol 43:591CrossRefGoogle Scholar
  66. Lavric MV (1969) Galactorrhea and amenorrhea with polycystic ovaries. Am J Obstet Gynecol 104: 814PubMedGoogle Scholar
  67. Lengyel AMJ, Mussio W, Imamura P, Vieira JGH, Lancranja I (1993) Long-acting injectable bromocriptin (Parlodel LAR) in the chronic treatment of prolactin-secreting macroa-denomas. Fertil Steril 59: 980PubMedGoogle Scholar
  68. Leyendecker G, Nocke W, Schmidt-Gollwitzer M, Entzian W, del Pozo E (1977) Klinik der hyperprolaktinämischen Amenorrhoe. Gynäkologe 10: 93Google Scholar
  69. Lobo RA, Kletzky OA, Kaptein EM, Goebelsmann U (1980) Prolactin modulation of dehydroepiandrosterone sulfate secretion. Am J Obstet Gynecol 138: 632PubMedGoogle Scholar
  70. Loucopoulos A, Jewelewicz R (1984) Prolactinomas and pregnancy. Semin Reprod Endocrinol 2: 83CrossRefGoogle Scholar
  71. Lüdecke DK (1988) Chirurgische Therapie der Hyperprolak-tinämie. In: Jürgensen O (Hrsg) Hyperprolaktinämie — Pro-laktinom. Springer, Berlin Heidelberg New York, p 171CrossRefGoogle Scholar
  72. Lüdecke DK, Herrmann HD, Hörmann C, Desaga U, Saeger W (1983) Microsurgery and combination with dopamine agonists in the treatment of prolactinomas. In: Tous G et al. (eds) Prolactin and prolactinomas. Raven, New York, p 453Google Scholar
  73. Maeda T, Ushiroyama T, Okuda K, Fujimoto A, Ueki M, Sugi-moto O (1983) Effective bromocriptine treatment of a pituitary macroadenoma during pregnancy. Obstet Gynecol 61:117PubMedGoogle Scholar
  74. Marchetti B, Labrie F (1982) Prolactin inhibits pituitary luteinizing hormone-releasing hormone receptors in the rat. Endocrinol 111:1209CrossRefGoogle Scholar
  75. Marcovitz S, Hardy J (1984) Combined medical and surgical treatment of prolactin-producing pituitary tumors. Semin Reprod Endocrinol 2: 73CrossRefGoogle Scholar
  76. McNatty JP, Sawers RS, McNeilly AS (1974) A possible role for prolactin in control of steroid secretion by the human Graafian follicle. Nature 250: 653PubMedCrossRefGoogle Scholar
  77. McNeilly AS, Howie PW, Houston MJ (1980) In: Zatuchni GI et al. (eds) Research frontiers in fertility regulation. Harper & Row, New York, p 102Google Scholar
  78. Meema S, Bunker ML, Meema HE (1975) Preventive effect of estrogen on postmenopausal bone loss: a follow-up study. Arch Intern Med 135:1436PubMedCrossRefGoogle Scholar
  79. Melmed S (1984) Control of prolactin synthesis and secretion. Semin Reprod Endocrinol 2:1CrossRefGoogle Scholar
  80. Missale C, Losa M, Sigala S, Balsari A, Giovanelli M, Spano PF (1996) Nerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism. Mol Endocrinol 10: 272PubMedCrossRefGoogle Scholar
  81. Modena G, Potioli I (1977) Delivery after bromocriptine therapy. Lancet 2:558PubMedCrossRefGoogle Scholar
  82. Molitch ME (1985) Pregnancy and the hyperprolactinemic women. N Engl J Med 312:1364PubMedCrossRefGoogle Scholar
  83. Moult PJA, Rees LH, Besser GM (1982) Pulsatile gonadotrophin secretion in hyperprolactinaemic amenorrhoea and the response to bromocriptine therapy. Clin Endocrinol 16:153CrossRefGoogle Scholar
  84. Nikolics K, Mason AJ, Szonyi E, Ramachandran J, Seeburg PH (1985) A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone. Nature 116:511CrossRefGoogle Scholar
  85. Parker LN, Chang S, Odeli WD (1978) Adrenal androgens in patients with chronic marked elevation of prolactin. Clin Endocrinol 8:1CrossRefGoogle Scholar
  86. Pasteeis IL, Gausset P, Danguy A, Ectors F, Nicole CS, Varavudhi P (1972) Morphology of the lactotropes and somatotropes of man and monkey. J Clin Endocrinol Metab 34: 959CrossRefGoogle Scholar
  87. Pearce JM, McGarrick G, Chamberlain GVP, Jeffcoate SL (1980) Lack of effect of interview and gynaecological examination on plasma levels of prolactin and Cortisol. Br J Obstet Gynaecol 87:366PubMedCrossRefGoogle Scholar
  88. Peters F, Schuth W, Breckwoldt M (1982) Ist die Palpation der Mamma ein Störfaktor für die Prolaktinbestimmung. Geburtshilfe Frauenheilkd 42: 223PubMedCrossRefGoogle Scholar
  89. Priou A, Bruder N, Bégou D, Morange I, Graziani N, Grisoli F, Brue T (1995) Glycosylated and non-glycosylated prolactin forms are increased after opioid administrations as part of surgical anaesthesia. Clin Endocrinol 43: 213CrossRefGoogle Scholar
  90. Quigley ME, Judd SJ, Gilliland GB, Yen SSC (1979) Effects of dopamine antagonist on the release of gonadotropin and prolactin in normal women and women with hyperprolac-tinemic anovulation. J Clin Endocrinol Metab 48: 718PubMedCrossRefGoogle Scholar
  91. Quigley ME, Sheehan KL, Casper RF, Yen SSC (1980) Evidence for an increased opioid inhibition of luteinizing hormone secretion in hyperprolactinemic patients with pituitary microadenoma. J Clin Endocrinol Metab 50: 427PubMedCrossRefGoogle Scholar
  92. Riedel M, Noldus J, Saeger W, Lüdecke DK (1986) Sella lesions associated with isolated hyperprolactinemea. Acta Endocrinol (Copenh) 113:196Google Scholar
  93. Rjosk HK, von Werder K, Fahlbusch R (1976) Hyperprolaktinä-mische Amenorrhoe. Geburtshilfe Frauenheilkd 36:575PubMedGoogle Scholar
  94. Rjosk HK, Fahlbusch R, von Werder K (1982) Influence of pregnancies on prolactinomas. Acta Endocrinol 100:337PubMedGoogle Scholar
  95. Rossmanith WG, Boscher S, Ulrich U, Benz R (1993) Chrono-biology of prolactin secretion in women: diurnal and sleep-related variations in the pituitary lactotroph sensitivity. Neuroendocrinol 58: 263CrossRefGoogle Scholar
  96. Ruiz-Velasco V (1984) Pregnancy in hyperprolactinemia. Fértil Steril 41: 793PubMedGoogle Scholar
  97. Schlechte J, Sherman B (1984) Hyperprolactinemia and osteoporosis. Semin Reprod Endocrinol 2: 89CrossRefGoogle Scholar
  98. Schlechte J, Sherman B, Halmi N et al. (1980) Prolactin-secre-ting pituitary tumors in amenorrheic women: a comprehensive study. Endocr Rev 1: 295PubMedCrossRefGoogle Scholar
  99. Schneider HPG, Bohnet HG (1977) Hyperprolaktinämische Amenorrhoe und Anovulation. Gynäkologe 10: 84Google Scholar
  100. Schneider HPG, Hanker JP (1988) Zyklusstörung und Diagnostik der funtionell gestörten Fertilität. In: Schneider HPG, Lauritzen C, Nieschlag E (Hrsg) Grundlagen und Klinik der menschlichen Fortpflanzung, de Gruyter, Berlin, p 449Google Scholar
  101. Schrage R, Mühlbauer B (1992a) Zur ätiologie der pathologischen Mammasekretion. Frauenarzt 33:713Google Scholar
  102. Schrage R, Mühlbauer B (1992b) Zur Diagnostik und Therapie der pathologischen Mammasekretion (Teil 2). Frauenarzt 33:857Google Scholar
  103. Schröder S (1989) Die klinische Bedeutung der Galaktorrhoe in der Perimenopause. Inauguraldissertation, HamburgGoogle Scholar
  104. Schulz KD, Geiger W, Kloppenburg W (1977) Der Einfluß von prolaktininhibierenden Substanzen auf den normalen Zyklus und auf prolaktinabhängige normoprolaktinämi-sche Erkrankungen. Gynäkologe 10:113Google Scholar
  105. Seppälä M, Hirvonen E (1975) Raised serum prolactin levels associated with hirsutism and amenorrhoea. Br Med J 4:144PubMedCrossRefGoogle Scholar
  106. Shewchok AB, Adamson GD, Lessard P, Ezrin C (1980) The effect of pregnancy on suspect pituitary adenomas after conservative management of ovulation defects associated with galactorrhea. Am J Obstet Gynecol 136: 659Google Scholar
  107. Sinha YN (1995) Structural variants of prolactin: occurrence and physiological significance. Endocr Rev 16: 354PubMedGoogle Scholar
  108. Sluijmer AV, Lappöhn RE (1992) Clinical history and outcome of 59 patients with idiopathic hyperprolactinemia. Fértil Steril 58:72PubMedGoogle Scholar
  109. Sobrinho LG (1991) Neuropsychiatry of prolactin: causes and effects. Baillière’s Clin Endocrinol Metab 5:119CrossRefGoogle Scholar
  110. Sobrinho LG, Nunes MCP, Calhaz-Jorge C, Afonso AM, Pereira MC, Santos MA (1984) Hyperprolactinemia in women with paternal deprivation during childhood. Obstet Gynecol 64: 465PubMedGoogle Scholar
  111. Soule SG, Jacobs HS (1995) Prolactinomas: present day management. Br J Obstet Gynaecol 102:178PubMedCrossRefGoogle Scholar
  112. Spark RF, Baker R, Bienfang DC, Bergland R (1982) Reduktion von Hypophysentumoren durch Bromocriptin. Requiem für chirurgische Eingriffe an der Hypophyse? JAMA (Dtsch Ausg) 1: 483Google Scholar
  113. Tindall GT, Kovacs K, Horvath E, Thorner MO (1982) Human prolactin-producing adenomas and bromocriptine: a histological, immunocytochemical, ultrastructural, and morpho-metric study. J Clin Endocrinol Metab 55:1178PubMedCrossRefGoogle Scholar
  114. Turkalji I, Braun P, Krupp P (1982) Surveillance of bromocriptine in pregnancy. JAMA 247:1589CrossRefGoogle Scholar
  115. Tyson JE, Zacur HA, Huth J, Chapanis N (1992) Hyperprolactinemia blunts awareness of distress and depression: evidence for a specific behavioral and environmental setting for galactorrhea-amenorrhea. Semin Reprod Endocrinol 10: 246CrossRefGoogle Scholar
  116. van Roon E, van der Vijver JCM, Gerretsen G, Hekster REM, Wattendorff RA (1981) Rapid regression of a suprasellar extending prolactinoma after bromocriptine treatment during pregnancy. Fértil Steril 36:173PubMedGoogle Scholar
  117. Vermeulen A, Suy E, Rubens R (1977) Effect of prolactin on plasma DHEA (S) levels. J Clin Endocrinol Metab 44:1222PubMedCrossRefGoogle Scholar
  118. von Werder K (1985) Derzeitger Stand der Diagnostik und Therapie von Prolaktinomen. In: Schneider HPG (Hrsg) Dopergin in Klinik und Praxis — Neue Erkenntnisse. Med wiss Buchreihe, Schering AG, BerlinGoogle Scholar
  119. von Werder K, Eversmann T, Rjosk HK, Fahlbusch R (1982) Treatment of hyperprolactinemia. In: Ganong WF, Martini L (eds) Frontiers in neuroendocrinology. Raven, New York, p 123Google Scholar
  120. von Werder K, Fahlbusch R, Rjosk HK (1983) Macroprolactino-mas: clinical and therapeutic aspects. In: Tolis G et al. (eds) Prolactin and prolactinomas. Raven, New York, p 415Google Scholar
  121. Walker AM (1994) Phosphorylated and nonphosphorylated prolactin isoforms. Trends Endocrinol Metab 5:195PubMedCrossRefGoogle Scholar
  122. Waters MJ, Lusins S, Friesen HG (1984) Immunological and physiochemical evidence for tissue specific prolactin receptors in the rabbit. Endocrinol 114:1CrossRefGoogle Scholar
  123. Wenzel KW (1981) Pharmacological interference with in vitro tests of thyroid function. Metabolism 30: 717PubMedCrossRefGoogle Scholar
  124. Whittaker PG, Wilcox T, Lind T (1981) Maintained fertility in a patient with hyperprolactinemia due to big, big prolactin. J Clin Endocrinol Metab 53: 863PubMedCrossRefGoogle Scholar
  125. Wyss HI, del Pozo E, Huber P, Eppenberger U, Werner I, Campana A (1977) Corpus-luteum-Insuffizienz bei Hyperprolak-tinämie. Gynäkologe 10:109Google Scholar
  126. Yen SSC (1986) Prolactin in human reproduction. In: Yen SSC, Jaffe RB (eds) Reproductive endocrinology. Saunders, Philadelphia, p 237Google Scholar
  127. Yuen BH (1978) Bromocriptine, pituitary tumours, and pregnancy. Lancet 2:1314PubMedCrossRefGoogle Scholar
  128. Yuen BH (1992) Etiology and treatment of hyperprolactinemia. Semin Reprod Endocrinol 10:228CrossRefGoogle Scholar
  129. Zacur HA, Foster GV (1992) Hyperprolactinemia and polycystic ovarian syndrome. Semin Reprod Endocrinol 10:236CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Freimut A. Leidenberger
    • 1
    • 2
  1. 1.IHF Institut für Hormon- und FortpflanzungsforschungUniversität HamburgHamburgDeutschland
  2. 2.Endokrinologische Praxisgemeinschaft Leidenberger, Weise, Schulte, BreustedtHamburgDeutschland

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