Kainate Receptors

  • J. Lerma
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 141)


The kainate receptor is a component of the glutamate signaling system that has remained elusive to investigators over the years. The lack of specific pharmacological tools has hampered the detection of these receptors in neurons of the central nervous system (CNS) and the determination of their physiological role. Until the cloning of the subunits that make up the kainate receptors, the evidence of their existence as independent receptors in neurons was weak, and it is only recently that we have become able to define the processes in which these receptors are involved (Lerma 1997). Indeed, in spite of considerable evidence from binding and autoradiographic experiments indicating the existence of high-affinity binding sites for kainate in the brain, with a distribution different from that of a-amino-3-hydroxy-5-methylisoxazole-4propionic-acid (AMPA)-binding sites (Young and Fagg 1990), they were not convincingly detected in brain neurons until more recently (Lerma et al. 1993).


Dorsal Root Ganglion Glutamate Receptor AMPA Receptor Mossy Fiber Editing Site 
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