Liver, Gallbladder, and Exocrine Pancreas

  • U. Deschl
  • R. C. Cattley
  • T. Harada
  • K. Küttler
  • J. R. Hailey
  • F. Hartig
  • B. Leblanc
  • D. S. Marsman
  • T. Shirai


Hyperplastic focus enzyme altered focus Hyperplasia, hepatocellular hyperplasia regenerative Hepatoma benign; liver cell tumor benign; hepatic adenoma benign; tumor liver cell benign; nodule type A Hepatoma malignant; carcinoma trabecular; nodule type B Tumor mixed poorly differentiated Adenoma papillary 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bannasch P, Mayer D, Venske G (1979) Pränatale Induktion von hepatocellulären Glykogenspeicherarealen and Tumoren bei Mäusen durch Äthylnitrosoharnstoff. Virchows Arch B 30: 143–160PubMedGoogle Scholar
  2. 2.
    Boorman GA, Sills RC (1999) Exocrine and endocrine pancreas. In: Maronpot RR, Boorman GA, Gaul BW (eds) Pathology of the mouse. Reference and atlas. Cache River Press, Vienna, pp 185–205Google Scholar
  3. 3.
    Diwan BA, Ward JM, Rice JM (1989) Promotion of malignant `embryonal’ liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine. Carcinogenesis 10: 1345–1348PubMedCrossRefGoogle Scholar
  4. 4.
    Dixon D, Maronpot RR (1994) Tumours of the pancreas. Pathology of tumours in laboratory animals, vol 2. Tumours of the mouse, 2nd edn. IARC Scientific Publications No. 111, Lyon, pp 281–303Google Scholar
  5. 5.
    Dixon D, Yoshitomi K, Boorman GA, Maronpot RR (1994) “Lipomatous” lesions of unknown cellular origin in the liver of B6C3F1 mice. Vet Pathol 31: 173–182Google Scholar
  6. 6.
    Enanz H (1985) Proliferation of Ito cells (fat-storing cells) in acute carbon tetrachloride liver injury. A light and electron microscopic autoradiographic study. Acta Pathol Jpn 35: 1301–1308Google Scholar
  7. 7.
    Evans JG, Collins MA, Lake BG, Butler WH (1992) The histology and development of hepatic nodules and carcinoma in C3H/He and C57BL/6 mice following chronic phenobarbitone administration. Toxicol Pathol 20: 585–594PubMedCrossRefGoogle Scholar
  8. 8.
    Factor VM, Radaeva SA (1993) Oval cells–hepatocytes relationships in Dipin-induced hepatocarcinogenesis in mice. Exp Toxicol Pathol 45: 239–244PubMedCrossRefGoogle Scholar
  9. 9.
    Factor VM, Radaeva SA, Thorgeirsson SS (1994) Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol 145: 409–422PubMedGoogle Scholar
  10. 10.
    Frith CH, Dooley K (1976) Hepatic cytologic and neoplastic changes in mice given benzidine dihydrochloride. J Natl Cancer Inst 56: 679–682PubMedGoogle Scholar
  11. 11.
    Frith CH, Ward JM (1979) A morphologic classification of proliferative and neoplastic hepatic lesions in mice. J Environ Pathol Toxicol 3: 329–351PubMedGoogle Scholar
  12. 12.
    Frith CH, Wiley L (1982) Spontaneous hepatocellular neoplasms and hepatic hemangiosarcomas in several strains of mice. Lab Anim Sci 32: 157–162PubMedGoogle Scholar
  13. 13.
    Frith CH, Baetcke KP, Nelson CJ, Schieferstein G (1980) Sequential morphogenesis of liver tumors in mice given benzidine dihydrochloride. Eur J Cancer 16: 1205–1216PubMedCrossRefGoogle Scholar
  14. 14.
    Frith CH, Ward JM, Turusov VS (1994) Tumours of the liver. Pathology of tumours in laboratory animals, vol 2. Tumours of the mouse, 2nd edn. IARC Scientific Publications No. 111, Lyon, pp 223–248Google Scholar
  15. 15.
    Hanigan MH, Winkler ML, Drinkwater NR (1993) Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis 14: 1035–1040PubMedCrossRefGoogle Scholar
  16. 16.
    Harada T, Maronpot RR, Enomoto A, Tamano S, Ward JM (1996) Changes in the liver and gallbladder. In Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM (eds) Pathobiology of the aging mouse, vol. 2. ILSI Press, Washigton DC, pp 207–241Google Scholar
  17. 17.
    Harada T, Enomoto A, Boorman GA, Maronpot RR (1999) Liver and gallbladder. In: Maronpot RR, Boorman GA, Gaul BW (eds) Pathology of the mouse. Reference and atlas. Cache River Press, Vienna, pp 119–183Google Scholar
  18. 18.
    Hoover KL (1985) Oval cell hyperplasia, liver, mouse, rat. In Jones TC, Mohr U, Hunt RD (eds) Digestive system. ILSI Monograph, ILSI Press, Washington DC, pp 125–127Google Scholar
  19. 19.
    Kakizoe S, Goldfarb S, Pugh TD (1989) Focal impairment of growth in hepatocellular neoplasms of C57BL/6 mice: a possible explanation for the strain’s resistance to hepatocarcinogenesis. Cancer Res 49: 3985–3989PubMedGoogle Scholar
  20. 20.
    Kimbrough RD, Linder RE (1974) Induction of adenofibrosis and hepatomas of the liver in BALB-cJ mice by polychlorinated biphenyls (Aroclor 1254). J Natl Cancer Inst 53: 547–552PubMedGoogle Scholar
  21. 21.
    Koen H, Pugh TD, Goldfarb S (1983) Hepatocarcinogenesis in the mouse. Combined morphologic-stereologic studies. Am J Pathol 112: 89–100Google Scholar
  22. 22.
    Lewis DJ (1984) Spontaneous lesions of the mouse biliary tract. J Comp Pathol 94: 263–271PubMedCrossRefGoogle Scholar
  23. 23.
    Lipsky MM, Tanner DC, Hinton DE, Trump BF (1984) Reversibility, persistence, and progression of safrole-induced mouse liver lesions following cessation of exposure. In: Popp JA (ed) Mouse liver neoplasia. Current perspectives. Hemisphere Publishing, Washington DC, pp 161–177Google Scholar
  24. 24.
    Longnecker DS (1986) Experimental models of exocrine pancreatic tumours. In: Go VLW, Gardener JD, Brooks FP, Lebenthal E, Diamagno EP, Scheele GA (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven Press, New York, pp 443–458Google Scholar
  25. 25.
    Malarkey DE, Devereux TR, Dinse GE, Mann PC, Maronpot RR (1995) Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation. Carcinogenesis 16: 2617–2625PubMedCrossRefGoogle Scholar
  26. 26.
    Maronpot RR, Haseman JK, Boorman GA, Eustis SL, Rao GN, Huff JE (1987) Liver lesions in B6C3F1 mice: the National Toxicology Program, experience and position. Arch Toxicol Suppl 10: 10–26PubMedCrossRefGoogle Scholar
  27. 27.
    Nonoyama T, Fullerton F, Reznik G, Bucci TJ, Ward JM (1988) Mouse hepatoblastomas: a histologic, ultrastructural, and immunohistochemical study. Vet Pathol 25: 286–296PubMedCrossRefGoogle Scholar
  28. 28.
    Nonoyama T, Reznik G, Bucci TJ, Fullerton F (1986) Hepatoblastoma with squamous differentiation in a B6C3F1 mouse. Vet Pathol 23: 619–622PubMedGoogle Scholar
  29. 29.
    Standeven AM, Wolf DC, Goldsworthy TL (1994) Interactive effects of unleaded gasoline and estrogen on liver tumor promotion in female B6C3F1 mice. Cancer Res 54: 1198–1204PubMedGoogle Scholar
  30. 30.
    Stinson SF, Hoover KL, Ward JM (1981) Quantitation of differences between spontaneous and induced liver tumors in mice with an automated image analyzer. Cancer Lett 14: 143–150PubMedCrossRefGoogle Scholar
  31. 31.
    Thorpe E, Walker AIT (1973) The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, beta-BHC and gamma-HBC. Food Cosmet Toxicol 11: 433–442Google Scholar
  32. 32.
    Tillmann T, Kamino K, Dasenbrock C, Germann PG, Kohler M, Morawietz G, Campo E, Cardesa A, Tomatis L, Mohr U (1999) Ito cell tumor: immunohistochemical investigations of a rare lesion in the liver of mice. Toxicol Pathol 27: 364–369PubMedCrossRefGoogle Scholar
  33. 33.
    Tsuji S, Ogawa K, Takasaka H, Sonoda T, Mori M (1988) Clonal origin of gamma-glutamyl transpeptidase-positive hepatic lesions induced by initiation-promotion in ornithine carbamoyltransferase mosaic mice. Jpn J Cancer Res 79: 148–151PubMedCrossRefGoogle Scholar
  34. 34.
    Turusov VS, Day NE, Tomatis L, Gati E, Charles RT (1973a) Tumors in CF-1 mice exposed for six consecutive generations to DDT. J Natl Cancer Inst 51: 983–997PubMedGoogle Scholar
  35. 35.
    Turusov VS, Deringer MK, Dunn TB, Stewart HL (1973b) Malignant mouse-liver tumors resembling human hepatoblastomas. J Natl Cancer Inst 51: 1689–1695PubMedGoogle Scholar
  36. 36.
    Vesselinovitch SD, Mihailovich N, Rao KVN (1978) Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice. Cancer Res 38: 2003–2010PubMedGoogle Scholar
  37. 37.
    Ward JM (1980) Morphology of hepatocellular neoplasms in B6C3F1 mice. Cancer Lett 9: 319–325PubMedCrossRefGoogle Scholar
  38. 38.
    Ward JM (1984a) Morphology of potential preneoplastic hepatocyte lesions and liver tumors in mice and a comparison with other species. In: Popp JA (ed) Mouse liver neoplasia, current perspectives. Hemisphere, Washington, pp 1–26Google Scholar
  39. 39.
    Ward JM (1984b) Pathology of toxic, preneoplastic, and neoplastic lesions. In: Douglas JF (ed) Carcinogenesis and mutagenesis testing, Humana Press, Clifton NJ, pp 97–130CrossRefGoogle Scholar
  40. 40.
    Ward JM, Rice JM, Creasia D, Lynch P, Riggs C (1983) Dissimilar patterns of promotion by di(2ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice. Carcinogenesis 4: 1021–1029PubMedCrossRefGoogle Scholar
  41. 41.
    Ward TM, Diwan BA, Ohshima M, Hu H, Schuller HM, Rice JM (1986) Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro. Environ Health Perspect 65: 279–291PubMedGoogle Scholar
  42. 42.
    Ward JM, Lynch P, Riggs C (1988) Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital. Cancer Lett 39: 9–18PubMedCrossRefGoogle Scholar
  43. 43.
    Ward JM, Diwan BA, Lubet RA, Henneman JR, Devor DE (1990) Liver tumor promoters and other mouse liver carcinogens. In: Stevenson D, McClain M, Popp J, Slaga T, Ward J, Pitot H (eds) Mouse liver carcinogenensis: mechanisms and species comparisons Alan R. Liss, New York, pp 85–108Google Scholar
  44. 44.
    Ward JM, Anver MR, Haines DC, Benveniste RE (1994) Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am J Pathol 145: 959–968PubMedGoogle Scholar
  45. 45.
    Ward JM, Fox JG, Anver MR, Haines DC, George CV, Collins MJ Jr, Gorelick PL, Nagashima K, Gonda MA, Gilden RV, et al. (1994) Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. J Natl Cancer Inst 86: 1222–1227PubMedCrossRefGoogle Scholar
  46. 46.
    Yoshitomi K, Alison RH, Boorman GA (1986) Adenoma and adenocarcinoma of the gallbladder in aged laboratory mice. Vet Pathol 23: 523–527PubMedCrossRefGoogle Scholar
  47. 47.
    Yoshitomi K, Boorman GA (1994) Tumours of the gallbladder. Pathology of tumours in laboratory animals, vol 2. Tumours of the mouse, 2nd edn. IARC Scientific Publications No. 111, Lyon, 271–279Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • U. Deschl
  • R. C. Cattley
  • T. Harada
  • K. Küttler
  • J. R. Hailey
  • F. Hartig
  • B. Leblanc
  • D. S. Marsman
  • T. Shirai

There are no affiliations available

Personalised recommendations