Extrakorporale Therapieverfahren bei Sepsis — Hämofiltration, Plasmapherese, Hämoperfusion

  • D. Barckow

Zusammenfassung

Unabhängig davon, ob bakterielle Toxine oder andere primär nichtbakterielle Aggressionen Auslöser für eine schließlich generalisierte Entzündungsreaktion des Organismus sind, immer werden die gleichen klassischen Kaskadensysteme angeregt:
  • das Komplementsystem,

  • das Gerinnungs-Fibrinolyse-System,

  • das Kallikrein-Kinin-System.

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Literatur

  1. 1.
    Asanuma Y, Takahashi T, Kato T, Kudo K, Koyama K (1989) Treatment of endotoxin shock due to gramnegative bacteremia using extracorporal circulation. Nippon-Shokakibyo- GakkaiZasshi 86: 246–252Google Scholar
  2. 2.
    Asanuma Y, Takahashi T, Koyama K et al. (1989) Exchange blood transfusion and on-line plasma exchange for sepsis in infants. ASAIO Trans 35: 343–345PubMedCrossRefGoogle Scholar
  3. 3.
    Bambauer R, Meyer S, Jung H, Goehl H, Nystrand R (1990) Sterile vs. non-sterile dialysis fluid in chronic hemodialysis treatment. ASAIO Trans 36: 317–320Google Scholar
  4. 4.
    Barckow D, Schirop T (1983) Isolierte Ultrafiltration beim akuten Lungenversagen. Intensivmedizin 20: 213–216Google Scholar
  5. 5.
    Barzilay E, Kessler D, Berlot G, Gullo A, Geber D, Ben Zeev I (1989) Use of extracorporeal supportive techniques as additional treatment for multiple organ failure patients. Crit Care Med 17: 634–637PubMedCrossRefGoogle Scholar
  6. 6.
    Baumann J,Kiene S, Kampfer I, Hofmann J (1991) Animal experiment studies of the distribution and elimination of marked endotoxin. Zentralbl Chir 116: 969–981PubMedGoogle Scholar
  7. 7.
    Baurmeister U, Travers M, Vienken J et al. (1989) Dialysate contamination and back filtration may limit the use of high-flux dialysis membranes. ASAIO Trans 35: 519–522PubMedCrossRefGoogle Scholar
  8. 8.
    Bellomo R, Tipping P, Boyce N (1993) Continuous veno-venous hemofiltration with dialysis removes cytokines from the circulation of septic patients [see comments]. Crit Care Med 21: 522–526PubMedCrossRefGoogle Scholar
  9. 9.
    Bende S, Bertok L (1986) Elimination of endotoxin from the blood by extracorporeal activated charcoal hemoperfusion in experimental canine endotoxin shock. Circ Shock 19: 239–244PubMedGoogle Scholar
  10. 10.
    Beutler B, Cerami A (1987) The biology of cachectin/TNF–a primary mediator of the host response. Ann Rev Immunol 7: 625–655CrossRefGoogle Scholar
  11. 11.
    Bjorvatn B, Bjertnaes L, Fadnes HO et al. (1984) Meningococcal septicaemia treated with combined plasmapheresis and leucapheresis or with blood exchange. Br Med J 288: 439–441CrossRefGoogle Scholar
  12. 12.
    Bone RC, Balk RA, Cerra FB et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101: 1644–1655PubMedCrossRefGoogle Scholar
  13. 13.
    Bottoms G, Fessler J, Murphey E et al. (1998) Efficacy of convective removal of plasma mediators of endotoxic shock by continuous veno-venous hemofiltration. Shock 5: 149–54 (issn 1073–2322)Google Scholar
  14. 14.
    Bozkurt F, Hörl WH (1987) Bedeutung der kontinuierlichen arteriovenösen Hämofiltration (CAVA) and arteriovenösen Hämodiafiltration ( AV-HDF) in der Intensivtherapie. Intensivmedizin 24: 248–254Google Scholar
  15. 15.
    Brigham KL, Meyrick B (1986) Endotoxin and lung injury. Am Rev Respir Dis 133: 913–927PubMedGoogle Scholar
  16. 16.
    Brunet P, Jaber K, Berland V, Baz M (1992) Anaphylactoid reactions during hemodialysis and hemofiltration: role of AN69 membrane and angiotensin I-converting enzyme inhibitors. Am J Kidney Dis 19: 444 447Google Scholar
  17. 17.
    Bysani GK, Shenep JL,Hildner WK, Stidham GL, Roberson PK (1990) Detoxification of plasma containing lipopolysaccharide by adsorption. Crit Care Med 18: 67–71Google Scholar
  18. 18.
    Carozzi S, Nasini MG, Caviglia PM, Schelotto C, Santoni O, Atti M(1992) Acetate free biofiltration. Effects on peripheral blood monocyte activation and cytokine release. ASAIO Trans 38: 52–54Google Scholar
  19. 19.
    Cheadle WG, Hanasawa K, Gallinaro RN et al. (1991) Endotoxin filtration and immune stimulation improve survival from sepsis. Surgery 110: 785–791PubMedGoogle Scholar
  20. 20.
    Colton CK (1978) Analysis of membrane processes for blood purification. Blood Purif 5: 202–251CrossRefGoogle Scholar
  21. 21.
    Coraim F, Pongratz-Coraim H, Mauritz W, Ebermann R (1986) Hämofiltration als Therapie des akuten Lungenversagens im kardiogenen Schock. Anästhesist 35: 187–192Google Scholar
  22. 22.
    Dietz T (1983) Untersuchungen zur Elimination von Endotoxin in vitro. Inauguraldissertation, BerlinGoogle Scholar
  23. 23.
    Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87: 2095–2147PubMedGoogle Scholar
  24. 24.
    Dobos GJ, Meske S, Keller E et al. (1990) Successful therapy of meningococcal sepsis in acute disseminated lupus with plasmapheresis, immunosuppression and antibiotics. Klin Wochenschr 68: 76–980CrossRefGoogle Scholar
  25. 25.
    Druml W (1995) Nonrenal indications for continuous hemofiltration therapy in patients with normal renal function. In: Sieberth HG, Stummvoll HK, Kierdorf H (eds) Continuous extra-corporal treatment in multiple organ dysfunction syndrome. Karger, Basel (Contrib Nephrol, vol 116 ), pp 121–129 )Google Scholar
  26. 26.
    Fisher CJ, Panacek EA (1989) Toxic shock syndrome. In: Shoemaker WC, Ayres S, Grenvik A, Holbrook RR, Thompson WL (eds) Textbook of critical care. Saunders, PhiladelphiaGoogle Scholar
  27. 27.
    Golper TA, Jenkins R, Wright M, Klein JB (1990) Tumor necrosis factor ( TNF) and hemofiltration membranes. Intensivbehandlung 15: 119Google Scholar
  28. 28.
    Gomez A, Wang R, Unruh H et al. (1990) Hemofiltration reverses left ventricular dysfunction during sepsis in dogs. Anesthesiology 73: 671–685PubMedCrossRefGoogle Scholar
  29. 29.
    Gotloib L, Barzilay E, Shustak A, Wais Z, Jaichenko J, Lev A (1986) Hemofiltration in septic ARDS. The artificial kidney as an artificial endocrine lung. Resuscitation 13: 123–132Google Scholar
  30. 30.
    Graben N (1980) Entgiftung mit Hämoperfusion. Bindernagel, FriedbergGoogle Scholar
  31. 31.
    Groeneveld ADJ (1990) Septic shock and multiple organ failure: treatment with hemofiltration? Intensive Care Med 16: 489–490PubMedCrossRefGoogle Scholar
  32. 32.
    Hanasawa K, Aoki H, Yoshioka T, Matsuda K, Tani T, Kodama M (1989) Novel mechanical assistance in the treatment of endotoxic and septicemic shock. ASAIO Trans 35: 341–343PubMedCrossRefGoogle Scholar
  33. 33.
    Hanasawa K, Tani T, Kodama M (1989) New approach to endotoxic and septic shock by means of polymyxin B immobilized fiber. Surg Gynecol Obstet 168: 323–331PubMedGoogle Scholar
  34. 34.
    Heering P, Morgera S,.Schmitz FJ, Willers R, Schultheiss HP, Strauer BE, Grabensee B (1997) Cytokine removal and cardivascular hemodynamics in septic patients with continuous venovenous hemofiltration. Intensive Care Med 23: 288–296Google Scholar
  35. 35.
    Hoffmann JN, Hartl WH, Deppisch R, Faist E, Jochum M, Inthorn D (1995) Hemofiltration in human sepsis: evidence for elimination of immunomodulatory substances. Kidney Int 48: 1563–1570PubMedCrossRefGoogle Scholar
  36. 36.
    Hoffmann JN, Hartl WH, Deppisch R, Faist E, Jochum M, Inthorn D (1996) Effect of hemofiltration on hemodynamics and systemic concentrations of anaphylatoxins and cytokines in human sepsis. Intensive Care Med 22: 1360–1367PubMedCrossRefGoogle Scholar
  37. 37.
    Hogquist KA, Unanue ER, Chaplin DD (1991) Release of IL-1 from mononuclear phagocytes. J Immunol 147: 2181–2186PubMedGoogle Scholar
  38. 38.
    Journois D, Pouard P, Greeley WJ, Mauriat P, Vouhé P, Safran D (1994) Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery. Anesthesiology 81: 1181–1189PubMedCrossRefGoogle Scholar
  39. 39.
    Klinkmann H, Falkenhagen D, Smollich BP (1985) Investigation of the permeability of highly permeable polysulfone membranes for pyrogens. Karger, Basel (Contr Nephrol, vol 46 ), pp 147–183Google Scholar
  40. 40.
    Koller WF, Benzer HM, Pauser GF (1985) CAVH in acute respiratory failure. In: Sieberth HG, Mann H (eds) Continuous arteriovenous hemofiltration (CAVH). Karger, BaselGoogle Scholar
  41. 41.
    Kramer P, Wigger W, Rieger J, Matthai D, Scheler F (1977) Arteriovenous haemofiltration: A new and simple method for treatment of over-hydrated patients resistant to diuretics. Klin Wochenschr 55: 1121–1122Google Scholar
  42. 42.
    Laude-Sharp M, Caroff M, Simard L et al. (1990) Induction of IL-1 during hemodialysis: transmembrane passage of intact endotoxins ( LPS ). Kidney Int 38: 1089–1094Google Scholar
  43. 43.
    Luderitz O, Galanos C, Lehmann V et al. (1973) Lipid A: Chemical structure and biological activity. J Infect Dis 128 Suppl: 17–29Google Scholar
  44. 44.
    Mauritz W, Sporn P, Schindler I, Zadrobilek E, Roth E, Appel W (1986) Akutes Nierenversagen bei abdomineller Sepsis. Anästh Intensivther Notfallmed 21: 212–217PubMedCrossRefGoogle Scholar
  45. 45.
    May LT, Santhanam U, Sehgal PB (1991) On the multimeric nature of natural human interleukin-6. J Biol Chem 266: 9950–9955PubMedGoogle Scholar
  46. 46.
    McCelland P, Williams PS, Yaqoob M, Mostafa SM, Bone JM (1990) Multiple organ failure:a role for plasma exchange? Intensive Care Med 16: 100–103CrossRefGoogle Scholar
  47. 47.
    Nakamura Y, Wakabayashi A, Wolley T, Mullin P, Ito Y, Connolly JE (1976) Total body washout for the treatment of endotoxin shock. Arch Surg 111: 783–786PubMedCrossRefGoogle Scholar
  48. 48.
    Nemes C, Niemer M (1992) Blutreinigungsverfahren. In: Niemer M, Nemes C, Lundsgaardhansen P, Blauhuth B (Hrsg) Datenbuch Intensivmedizin.G. Fischer, Stuttgart JenaGoogle Scholar
  49. 49.
    Nieter B, Sisova S, Klug C et al. (1991) Plasmaaustausch bei septisch-toxischen Krankheitsbildern. Nieren Hochdruckkrankh 20: 155–159Google Scholar
  50. 50.
    Nisbeth U, Hallgren R, Eriksson O, Danielson BG (1987) Endotoxemia in chronic renal failure. Nephron 45: 93–97PubMedCrossRefGoogle Scholar
  51. 51.
    Olbricht CJ (1992) Pharmakotherapie bei kontinuierlicher Hämofiltration. Intensivmedizin 29: 4–8Google Scholar
  52. 52.
    Ossenkoppele GJ, Meulen J van der, Bronsveld W, Thijs LG (1985) Continuous arteriovenous hemofiltration as an adjunctive therapy for septic shock. Crit Care Med 13: 102–104PubMedCrossRefGoogle Scholar
  53. 53.
    Osterud B (1985) Meningococcal septicemia: the use of plasmapheresis or blood exchange and how to detect severe endotoxin induced white cell activation. Scand J Clin Lab Invest Suppl 178: 47–51PubMedGoogle Scholar
  54. 54.
    Pegues AS, Sofer SS, McCallum RE, Hinshaw LB (1979) The removal of C14 labeled endotoxin by activated charcoal. Int J Artif Org 2: 153–158Google Scholar
  55. 55.
    Pusey CD, Aslam M, Cohen J, Courtney JM, Ryan CJ (1991) Experimental models of plasma perfusion. J Clin Apher 6: 99–102PubMedCrossRefGoogle Scholar
  56. 56.
    Rietschel ET, Brade H (1987) Lipopolysaccharide, die Endotoxine and 0-Antigene gramnegativer Bakterien: Chemische Struktur, biologische Wirkung and serologische Eigenschaften. Infection 15: 576–584Google Scholar
  57. 57.
    Röckel A,Abdelhamid S, Fliegel P, Walb D (1985) Elimination of low molecular weight proteins with high flux membranes. Karger, Basel (Contr Nephrol, vol 46 ), pp 69–74Google Scholar
  58. 58.
    Roth RI, Levin FC, Levin J (1993) Distribution of bacterial endotoxin in human and rabbit blood and effects of stroma-free hemoglobin. Infect Immun 61: 3209–3215PubMedGoogle Scholar
  59. 59.
    Roth RI, Kaca W, Levin J (1994) Hemoglobin: a new recognized binding protein for bacterial endotoxins ( LPS ). Prog Clin Biol Res 388: 161–172Google Scholar
  60. 60.
    Sander A, Armbruster W, Sander B, Daul AE, Lange R, Peters J (1997) Hemofiltration increases IL-6 clearance in early inflammatory response syndrome but does not alter IL-6 and TNFplasma concentrations. Intensive Care Med 23: 878–884PubMedCrossRefGoogle Scholar
  61. 61.
    Sawada K, Malchesky PS, Nose Y (1990) Available removal sytems: State of the art. In: Nydegger VE (ed) Therapeutic hemopheresis in the 1990’s. Karger Basel (Curr Stud Hematol Blood Tranfus, vol 57 ), pp 51–113 )Google Scholar
  62. 62.
    Schetz M, Ferdinande P, Van den Berghe G, Verwaest C, Lauwers P (1995) Removal of pro-inflammatory cytokines with renal replacement therapy: sense or nonsense? Intensive Care Med 21: 169–175PubMedCrossRefGoogle Scholar
  63. 63.
    Schindler R, Lonnemann G, Shaldon S, Koch KM, Dinarello CA (1990) Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement. Kidney Int 37: 85–93PubMedCrossRefGoogle Scholar
  64. 64.
    Schindler R, Linnenweber S, Schulz M et al. (1993) Gene expression of interleukin-1 beta during hemodialysis. Kidney Int 43: 712–21PubMedCrossRefGoogle Scholar
  65. 65.
    Schindler R, Lufft V, Lonnemann G et al. (1996) Induction of interleukin-1 and interleukin-1 receptor antagonists during contaminated dialysis with whole blood. Nephrol Dial Transplant 11: 101–108PubMedCrossRefGoogle Scholar
  66. 66.
    Schwerdtfeger R (1993) Verhalten der Plasmaproteine bei verschiedenen Methoden der therapeutischen Plasmapherese: Untersuchungen zur Notwendigkeit von Sekundärsystemen. Habilitationsschrift, BerlinGoogle Scholar
  67. 67.
    Sieberth HG (1982) Apparative Detoxikation: Plasmaseparation.Intensivmedizin 19: 74–78Google Scholar
  68. 68.
    Smith RA., Baglioni C (1986) The active form of tumor necrosis factor is a trimer. J Biol Chem 262 2345–2354Google Scholar
  69. 69.
    Staubach KH, Rau HG, Kooistra A et al. (1989) Can hemofiltration increase survival time in acute endotoxemia-a porcine shock model. Prog Clin Biol Res 308: 821–826PubMedGoogle Scholar
  70. 70.
    Steel CM, Hutchins D (1989) Soluble factors and cell-surface molecules involved in human B lymphocyte activation, growth and differentiation. Biochim Biophys Acta 989: 133–151PubMedGoogle Scholar
  71. 71.
    Stein B, Pfenninger E, Grunert A, Schmitz JE, Deller A, Kocher F (1991) The consequences of continuous haemofiltration on lung mechanics and extravascular lung water in a porcine endotoxic shock model. Intensive Care Med 17: 293–298PubMedCrossRefGoogle Scholar
  72. 72.
    Stokes DC, Shenep JL, Fishman M (1989) Polymyxin B prevents lipopolysaccharide induced release of tumor necrosis factor-alpha from alveolar macrophages. J Infect Dis 160: 52–57PubMedCrossRefGoogle Scholar
  73. 73.
    Storck M, Hartl WH, Zimmerer E, Inthorn D (1991) Comparison of pump-driven and spontaneous continuous haemofiltration in postoperative acute renal failure. Lancet 337: 452–455PubMedCrossRefGoogle Scholar
  74. 74.
    Susini G, Zuccetti M, Bortone F et al. (1990) Isolated ultrafiltration in cardiogenic pulmonary edema. Crit Care Med 18: 14–17PubMedCrossRefGoogle Scholar
  75. 75.
    Tani T,Hanasawa K, Kodama M (1989) Usefulness of endotoxic removal from the septic blood with direct hemoperfusion using PMX-F. Nippon Geka Gakkai Zasshi 90: 1370–1373PubMedGoogle Scholar
  76. 76.
    Tetta C, Camussi G, Turello et al. (1990) Production of cytokines in hemodialysis. Blood Purif 8: 337–346PubMedCrossRefGoogle Scholar
  77. 77.
    Vanholder R,Van Haecke E, Veys N, Ringoir S (1992) Endotoxin transfer through dialysis membranes: small vs. large pore membranes. Nephrol Dial Transplant 7: 333–339PubMedGoogle Scholar
  78. 78.
    Wegmüller E (1981) Die therapeutische Bedeutung der Plasmapherese bei Immunkrankheiten. Schweiz Med Wochenschr 111: 443–449PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2000

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  • D. Barckow

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