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Therapie mit Proteinaseinhibitoren. Antithrombin III

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Intensivtherapie bei Sepsis und Multiorganversagen

Zusammenfassung

Das ausgedehnte Gewebetrauma, Schockereignisse und v. a. bakterielle Infektionen führen nach heutigem Kenntnisstand zur Aktivierung der humoralen Kaskadensysteme: Gerinnungs-/Fibrinolysesystem, Komplementsystem, Kallikrein-/Kininsystem. Faktoren aus diesen Systemen sind in der Lage, das Sepsissyndrom mit Organversagen direkt (durch unmittelbare Beeinträchtigung von Zell- und Organfunktionen) oder indirekt durch Aktivierung von Zellsystemen mit konsekutiver Liberierung von Entzündungsmediatoren zu beeinflussen. Dabei sind ganz offensichtlich nicht einzelne Komponenten, sondern vielmehr komplexe Interaktionen zahlreicher Faktoren maßgebend für die Auslösung und Manifestation des septischen Geschehens bis hin zum Organversagen (Abb. 6.1).

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Authors
  1. D. Inthorn
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Editors and Affiliations

  1. Medizinische Klinik I, Städtisches Krankenhaus Hildesheim Lehrkrankenhaus, Medizinischen Hochschule Hannover, Weinberg 1, W-3200, Hildesheim, Deutschland

    Hans-Peter Schuster

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© 1993 Springer-Verlag Berlin Heidelberg

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Inthorn, D. (1993). Therapie mit Proteinaseinhibitoren. Antithrombin III. In: Schuster, HP. (eds) Intensivtherapie bei Sepsis und Multiorganversagen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07960-7_6

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  • DOI: https://doi.org/10.1007/978-3-662-07960-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07961-4

  • Online ISBN: 978-3-662-07960-7

  • eBook Packages: Springer Book Archive

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