Advertisement

Mediatorenelimination: Hämofiltration, Plasmapherese, Hämoperfusion

  • D. Barckow

Zusammenfassung

Unabhängig davon, ob bakterielle Toxine oder andere primär nicht bakterielle Aggressionen Auslöser für eine schließlich generalisierte Entzündungsreaktion des Organismus sind, immer werden die gleichen lebenswichtigen Kaskadensysteme angeregt:
  • das Komplementsystem,

  • das Gerinnungs-Fibrinolyse-System,

  • das Kallikrein-Kinin-System.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Asanuma Y, Takahashi T, Kato T, Kudo K, Koyama K (1989) Treatment of endotoxin shock due to gram-negative bacteremia using extracorporal circulation. Nippon Shokakibyo Gakkai Zasshi 86: 246–252PubMedGoogle Scholar
  2. 2.
    Asanuma Y, Takahashi T, Koyama K, Kato T, Omokawa S, Sueoka A, Tanaka J (1989) Exchange blood transfusion and on-line plasma exchange for sepsis in infants. ASAIO Trans 35: 343–345PubMedCrossRefGoogle Scholar
  3. 3.
    Bambauer R, Meyer S, Jung H, Goehl H, Nystrand R (1990) Sterile versus non-sterile dialysis fluid in chronic hemodialysis treatment. ASAIO Trans 36: 317–320Google Scholar
  4. 4.
    Barckow D, Schirop T (1983) Isolierte Ultrafiltration beim akuten Lungenversagen. Intensivmed 20: 213–216Google Scholar
  5. 5.
    Barzilay E, Kessler D, Berlot G, Gullo A, Geber D, Ben Zeev I (1989) Use of extracorporeal supportive techniques as additional treatment for multiple organ failure patients. Crit Care Med 17: 634–637PubMedCrossRefGoogle Scholar
  6. 6.
    Baumann J, Kiene S, Kampfer I, Hofmann J (1991) Animal experiment studies of the distribution and elimination of marked endotoxin. Zentralbl Chir 116: 969–981PubMedGoogle Scholar
  7. 7.
    Baurmeister U, Travers M, Vienken J, Harding G, Million C, Klein E, Pass T (1989) Dialysate contamination and back filtration may limit the use of high-flux dialysis membranes. ASAIO Trans 35: 519–522PubMedCrossRefGoogle Scholar
  8. 8.
    Bende S, Bertok L (1986) Eliminatiion of endotoxin from the blood by extracorporeal activated charcoal hemoperfusion in experimental canine endotoxin shock. Circulatory Shock 19: 239–244PubMedGoogle Scholar
  9. 9.
    Beutler B, Cerami A (1987) The biology of cachectin/TNF — a primary mediator of the host response. Ann Rev Immunol 7: 625–655CrossRefGoogle Scholar
  10. 10.
    Bjorvatn B, Bjertnaes L, Fadnes HO et al. (1984) Meningokoccal septicaemia treated with combined plasmapheresis and leucapheresis or with blood exchange. Br Med J 288:439–441CrossRefGoogle Scholar
  11. 11.
    Bone RC, Balk RA, Cerra FB et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101: 1644–1655PubMedCrossRefGoogle Scholar
  12. 12.
    Bozkurt F, Horl WH (1987) Bedeutung der kontinuierlichen arteriovenösen Hämofil-tration (CAVA) und arteriovenösen Hämodiafiltration (AV-HDF) in der Intensivtherapie. Intensivmedizin 24: 248–254Google Scholar
  13. 13.
    Brigham KL, Meyrick B (1986) Endotoxin and lung injury. Am Rev Respir Dis 133: 913–927PubMedGoogle Scholar
  14. 14.
    Brunet P, Jaber K, Berland V, Baz M (1992) Anaphylactoid reactions during hemodialysis and hemofiltration: role of AN69 membrane and angiotensin I-converting enzyme inhibitors. Am J Kidney Dis 19: 444–447PubMedGoogle Scholar
  15. 15.
    Bysani GK, Shenep JL, Hildner WK, Stidham GL, Roberson PK (1990) Detoxification of plasma containing lipopolysaccharide by adsorption. Crit Care Med 18: 67–71PubMedCrossRefGoogle Scholar
  16. 16.
    Carozzi S, Nasini MG, Caviglia PM, Schelotto C, Santoni O, Atti M (1992) Acetetate free biofiltration. Effects on peripheral blood monocyte activation and cytokine release. ASAIO Trans 38: 52–54CrossRefGoogle Scholar
  17. 17.
    Cheadle WG, Hanasawa K, Gallinaro RN, Nimmanwudipong T, Kodama M, Polk HC Jr (1991) Endotoxin filtration and imune stimulation improve survival from sepsis. Surgery 110: 785–791PubMedGoogle Scholar
  18. 18.
    Colton CK (1987) Analysis of membrane processes for blood purification. Blood Purif 5:202–251PubMedCrossRefGoogle Scholar
  19. 19.
    Coraim F, Pongratz-Coraim H, Mauritz W, Ebermann R (1986) Hämofiltration als Therapie des akuten Lungenversagens im Kardiogenen Schock. 35: 187–192Google Scholar
  20. 20.
    Diez T (1983) Untersuchungen zur Elimination von Endotoxin in vitro. Inauguraldissertation, BerlinGoogle Scholar
  21. 21.
    Dobos GJ, Meske S, Keller E, Riegel W, Vaith P, Peter HH, Schollmeyer P (1990) Successful therapy of meningococcal sepsis in acute disseminated lupus with plasmapheresis, immunosuppression and antibiotics. Klin Wochenschr 68: 976–980PubMedCrossRefGoogle Scholar
  22. 22.
    Fisher CJ, Panacek EA (1989) Toxic shock syndrome. In: Shoemaker WC, Ayres S, Grenvik A, Holbrook RR, Thompson WL (eds) Textbook of critical care. Saunders, Philadelphia London TokyoGoogle Scholar
  23. 23.
    Golper TA, Jenkins R, Wright M, Klein JB (1990) Tumor necrosis factor (TNF) and hemofiltration membranes. Intensivbehandlung 15: 119Google Scholar
  24. 24.
    Gomez A, Wang R, Unruh H et al. (1990) Hemofiltration reverses left ventricular dysfunction during sepsis in dogs. Anesthesiology 73: 671–685PubMedCrossRefGoogle Scholar
  25. 25.
    Gotloib L, Barzilay E, Shustak A, Wais Z, Jaichenko J, Lev A (1986) Hemofiltration in septic ARDS. The artificial kidney as an artificial endocrine lung. Resuscitation 13: 123–132PubMedCrossRefGoogle Scholar
  26. 26.
    Graben N (1980) Entgiftung mit Hämoperfusion. Bindernagel, FriedbergGoogle Scholar
  27. 27.
    Groeneveld ADJ (1990) Septic shock and multiple organ failure: treatment with hemofiltration? Intensive Care Med 16: 489–490PubMedCrossRefGoogle Scholar
  28. 28.
    Hanasawa K, Aoki H, Yoshioka T, Matsuda K, Tani T, Kodama M (1989) Novel mechanical assistance in the treatment of endotoxic and septicemic shock. ASAIO Trans 35: 341–343PubMedCrossRefGoogle Scholar
  29. 29.
    Hanasawa K, Tani T, Kodama M (1989) New approach to endotoxic and septic shock by means of polymyxin B immobilized fiber. Surg Gynecol Obstet 168: 323–331PubMedGoogle Scholar
  30. 30.
    Hogquist KA, Unanue ER, Chaplin DD (1991) Release of IL-1 from mononuklear phagocytes. J Immunol 147: 2181–2186PubMedGoogle Scholar
  31. 31.
    Koller WF, Benzer HM, Pauser GF (1985) CAVH in acute respiratory failure. In: Sieberth HG, Mann H (eds) Continuous arteriovenous remofiltration (CAVH) Karger, BaselGoogle Scholar
  32. 32.
    Klinkmann H, Falkenhagen D, Smollich BP (1985) Investigation of the permeability of highly permeable polysulfone membranes for pyrogens. Karger, Basel (Contr Nephrol, vol 46, pp 147–183)Google Scholar
  33. 33.
    Kramer P, Wigger W, Rieger J, Matthhai D, Scheler F (1977) Arteriovenous haemofil-tration: a new and simple method for treatment of over-hydrated patients resistant to diuretics. Klin Wochenschr 55: 1121–1122PubMedCrossRefGoogle Scholar
  34. 34.
    Lüderitz O, Galanos C, Lehmann V et al. (1973) Lipid A: Chemical structure and biological activity J Infect Dis 128 [Suppl]: S 17–S 29PubMedCrossRefGoogle Scholar
  35. 35.
    Mauritz W, Sporn P, Schindler I, Zadrobilek E, Roth E, Appel W (1986) Akutes Nierenversagen bei abdomineller Sepsis. Anästh Intensivther Notfallmed 21: 212–217PubMedCrossRefGoogle Scholar
  36. 36.
    May LT, Santhanam U, Sehgal PB (1991) On the multimeric nature of natural human Interleukin-6. J Biol Chem 266: 9950–9955PubMedGoogle Scholar
  37. 37.
    McCelland P, Williams PS, Yaqoob M, Mostafa SM, Bone JM (1990) Multiple organ failure: a role for plasma exchange? Intensive Care Med 16: 100–103CrossRefGoogle Scholar
  38. 38.
    Nakamura Y, Wakabayashi A, Wolley T, Mullin P, Ito Y, Connolly JE (1976) Total body washout for the treatment of endotoxin shock. Arch Surg 111: 783–786PubMedCrossRefGoogle Scholar
  39. 39.
    Nemes C, Niemer M (1992) Blutreinigungsverfahren. In: Niemer M, Nemes C, Lundsgaardhansen P, Blauhuth B (Hrsg) Datenbuch Intensivmedizin. Fischer, Stuttgart Jena New YorkGoogle Scholar
  40. 40.
    Nieter B, Sisova S, Klug C et al. (1991) Plasmaaustausch bei septisch-toxischen Krankheitsbildern Nieren-/Hochdruckkrankh 20: 155–159Google Scholar
  41. 41.
    Nisbeth U, Hallgren R, Eriksson O, Danielson BG (1987) Endotoxemia in chronic renal failure, Nephron 45: 93–97PubMedCrossRefGoogle Scholar
  42. 42.
    Olbricht CJ (1992) Pharmakotherapie bei kontinuierlicher Hämofiltration. Intensivmedizin 29: 4–8Google Scholar
  43. 43.
    Ossenkoppele GJ, Meulen J van der, Bronsveld W, Thijs LG (1985) Continuous arteriovenous hemofiltration as an adjunctive therapy for septic shock. Crit Care Med 13: 102–104PubMedCrossRefGoogle Scholar
  44. 44.
    Osterud B (1985) Meningococcal septicemia: the use of plasmapheresis or blood exchange and how to detect severe endotoxin induced white cell activation. Scand J Clin Lab Invest 178 [Suppl]: 47–51Google Scholar
  45. 45.
    Pegues AS, Sofer SS, McCallum RE, Hinshaw LB (1979) The removal of C14 labeled endotoxin by activated charcoal. Int J Artef Org 2: 153–158Google Scholar
  46. 46.
    Pusey CD, Aslam M, Cohen J, Courtney JM, Ryan CJ (1991) Experimental models of plasma perfusion. J Clin Apher 6: 99–102PubMedCrossRefGoogle Scholar
  47. 47.
    Rietschel ET, Brade H (1987) Lipopolysaccharide, die Endotoxine und O-Antigene gramnegativer Bakterien: Chemische Struktur, biologische Wirkung und serologische Eigenschaften. Infection 15: 576–584CrossRefGoogle Scholar
  48. 48.
    Röckel A, Abdelhamid S, Fliegel P, Walb D (1985) Elimination of low molecular weight proteins with high flux membranes. Contr Nephrol 46: 69–74Google Scholar
  49. 49.
    Sawada K, Malchesky PS, Nose Y (1990) Available removal systems: State of the art. In: Nydegger VE (ed) Therapeutic Hemapheresis in the 1990’s. Karger, Basel (Curr Stud Hematol Blood Transfus 57: 51–133)Google Scholar
  50. 50.
    Schwerdtfeger R (1993) Verhalten der Plasmoproteine bei verschiedenen Methoden der therapeutischen Plasmapherese: Untersuchungen zur Notwendigkeit von Sekundärsystemen. Habilitationsschrift, Berlin.Google Scholar
  51. 51.
    Sieberth HG (1982) Apparative Detoxikation: Plasmaseparation. Intensivmed 19: 74–78Google Scholar
  52. 52.
    Staubach KH, Rau HG, Kooistra A, Schardey HM, Hohlbach G, Schilberg FW (1989) Can hemofiltration increase survival time in acute endotoxemia — a procine shock model. Prog Clin Biol Res 308: 821–826PubMedGoogle Scholar
  53. 53.
    Steel CM, Hutchins D (1989) Soluble factors and cell-surface molecules involved in human B lymphocyte activation, growth and differentiation. Biochem Biophys Acta 989:133–151PubMedGoogle Scholar
  54. 54.
    Stein B, Pfenninger E., Grunert A, Schmitz JE, Deller A, Kocher F (1991) The consequences of continuous haemofîltration on lung mechanics and extravascular lung water in a procine endotoxic shock model. Intensive Care Med 17: 293–298PubMedCrossRefGoogle Scholar
  55. 55.
    Stokes DC, Shenep JL, Fishman M (1989) Polymyxin B prevents lipopolysaccharid induced release of tumor necrosis faktor-alpha from alveolare macrophages. J Infect Dis 160: 52–57PubMedCrossRefGoogle Scholar
  56. 56.
    Storck M, Hartl WH, Zimmerer E, Inthorn D (1991) Comparison of pump-driven and spontaneous continuous haemofîltration in postoperative acute renal failure. Lancet 337: 452–455PubMedCrossRefGoogle Scholar
  57. 57.
    Susini G, Zuccetti M, Bortone F, Salvi L, Cipolla CM, Rimondin A, Sisillo E (1990) Isolated ultrafiltration in cardiogenic pulmonary edema. Crit Care Med 18: 14–17PubMedCrossRefGoogle Scholar
  58. 58.
    Tani T, Hanasawa K, Kodama M (1989) Usefulnes of endotoxic removal from the septic blood with direct hemoperfusion using PMX-F. Nippon Geka Gakkai Zasshi 90: 1370–1373PubMedGoogle Scholar
  59. 59.
    Tetta C, Camussi G, Turello E, Salomone M, Aimo G, Priolo G, Segoloni G (1990) Production of cytokines in hemodialysis. Blood Purif 8: 337–346PubMedCrossRefGoogle Scholar
  60. 60.
    Vanholder R, Van Haecke E, Veys N, Ringoir S (1992) Endotoxin transfer through dialysis membranes: small versus large pore membranes. Nephrol Dial Transplant 7: 333–339PubMedGoogle Scholar
  61. 61.
    Wegmüller E (1981) Die therapeutische Bedeutung der Plasmapherese bei Immunkrankheiten. Schweiz Med Wochenschr 111: 443–449PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • D. Barckow

There are no affiliations available

Personalised recommendations