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Verbesserung der Gewebeoxygenierung. Intensivtherapie bei Sepsis

  • K. Reinhart

Zusammenfassung

Gewebehypoxie gilt als wichtiger Kofaktor in der Pathogenese des Multiorgan-versagens [22]. Sie ist eine Folge der kardiozirkulatorischen Veränderungen, zu denen es durch die überschießende Mediatorenaktivierung kommt. Gleichzeitig ist davon auszugehen, daß Gewebehypoxie eine weitere aktivierende Wirkung auf die verschiedenen Mediator- und Kaskadensysteme hat. Einer adäquaten Gewebeoxygenierung kommt deshalb in der symptomatischen Therapie der Sepsis und des septischen Schocks eine zentrale Rolle zu, hierzu geeignete Strategien stehen deshalb im Mittelpunkt der intensivmedizinischen Maßnahmen. Folgende in Tabelle 10.1 aufgeführten Faktoren können zu einer unzureichenden Gewebeoxygenierung beim septischen Schock führen.

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© Springer-Verlag Berlin Heidelberg 1996

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  • K. Reinhart

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