Skip to main content

Gegenwärtiger Stand der Organtoxizität von Inhalationsanästhetika

  • Conference paper
Book cover Inhalationsanaesthetika

Zusammenfassung

Mit der Einführung von Halothan in die klinische Praxis im Jahre 1958 begann eine neue Ära der Anästhesie. Dieses potente, nicht brennbare Pharmakon machte eine rasche und leicht steuerbare Anästhesietiefe möglich und erlaubte dem Chirurgen die gefahrlose Anwendung von Elektrokoagulation. Der wahrscheinlich größte Vorteil dabei war der Sprung in ein Zeitalter differenzierter elektronischer Überwachungsmethoden, die durch dieses nicht entzündbare Anästhetikum möglich wurden. Dank Überwachungstechniken, die die Entwicklung der Raumfahrt mit sich gebracht hat, verbunden mit einem ständig zunehmenden Wissen auf den Gebieten der Physiologie und Pathophysiologie, werden nun chirurgische Verfahren, die bisher als zu gefährlich und komplex galten, routinemäßig durchgeführt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bottinger LE, Dalen E, Hallen B (1976) Halothane — Induced liver damage: An analysis of the material reported to the Swedish Adverse Drug Reaction Commitee. 1966–1973. Acta Anesthesiol Scand 20:40

    Article  Google Scholar 

  2. Brown BR Jr, Sipes IG, Sagalyn AM (1974) Mechanisms of acute hepatic toxicity: chloroform halothane, and glutathione. Anesthesiology 41:554

    Article  PubMed  CAS  Google Scholar 

  3. Bunker JP, Forrest WH, Mostellar T, Vandam LD (1969) A study of the possible association between halothane anesthesia and postoperative hepatic necrosis (National Halothane Study). US Government Printing Office, Washington

    Google Scholar 

  4. Dykes MH (1984) Is enflurane hapatotoxic (editorial). Anesthesiology 61:235

    Article  PubMed  CAS  Google Scholar 

  5. Inman WHW, Mushin WW (1974) Jaundice after repeated exposure to halothane: An analysis of reports to the Committee on Safety of Medicine. Br Med J 1:5

    Article  PubMed  CAS  Google Scholar 

  6. Kline MM (1980) Enflurane hepatitis. Gastroenterology 79:126

    PubMed  CAS  Google Scholar 

  7. Lindenbaum J, Liefer E (1963) Hepatic necrosis associated with halothane anesthesia. N Engl J Med 268:525

    Article  PubMed  CAS  Google Scholar 

  8. Lunam CA (1980) Halothane hepatotoxicity in a Guinea pig model. PhD dissertation, Flinders University of South Australia

    Google Scholar 

  9. Mazze RI, Shue GL, Jackson SH (1971) Renal dysfunction associated with methodyflurane anesthesia: A randomized, prospective clinical evaluation. JAMA 216:278

    Article  PubMed  CAS  Google Scholar 

  10. Mazze RI, Woodruff RT, Heerdt ME et al (1982) Isoniazid — Induced enflurane deflouridation in humans. Anesthesiology 57:5

    Article  PubMed  CAS  Google Scholar 

  11. McLain GE, Sipes IG, Brown BR Jr (1979) An animal model of halothane hepatotoxicity: Role of enzyme induction and hypoxia. Anesthesiology 51:321

    Article  PubMed  CAS  Google Scholar 

  12. Moult PJA, Sherlock S (1975) Halothane related hepatitis. A clinical study of 26 cases. Q J Med 44:99

    PubMed  CAS  Google Scholar 

  13. Musher WW, Rosen M, Bowen DJ, Campbell H (1969) Halothane and liver dysfunction: A retrospective study. US Government Printing Office, Washington

    Google Scholar 

  14. Recknagel RO, Ghosal AK (1966) Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity. Lab Invest 15:133

    Google Scholar 

  15. Shingu K, Eger EI Jr, Johnson BH (1984) Hypoxia may be more important than reductive metabolism in halo thane-induced hepatic injury. Anesth Analg 61:824

    Google Scholar 

  16. Stier A, Alter H, Hessler V et al (1964) Urinary excretion of bromide in halothane anesthesia. Anesth Analg 43:723

    Article  PubMed  CAS  Google Scholar 

  17. Uehleke H, Hellmer KH, Tabarelli-Poplawski S (1973) Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro. Nauyn Schmiedebrigs Arch Pharmacol 279: 39

    Article  CAS  Google Scholar 

  18. Van Dyke RA, Chenoweth MB, van Posnak A (1964) Metabolism of volatile anesthetics. Biochem Pharmacol 13:1239

    Article  Google Scholar 

  19. Vergami D, Tsantoulas D, Eddieston ALWF et al (1978) Sensitization to halothane-altered liver components in severe hepatic necrosis after halothane anesthesia. Lancet 11:801

    Article  Google Scholar 

  20. Vergami D, Mieli-Gergami G, Alberti A et al (1980) Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halo thane-associated hepatitis. N Engl J Med 303:66

    Article  Google Scholar 

  21. Virtue RW, Payne KW (1958) Postoperative death after fluothane. Anesthesiology 19:562

    Article  Google Scholar 

  22. Vourc’h G, Schnoebelen E, Buck F, Fruhling L (1960) Hepatonephrite aigue mortelle apres anesthesie comportant de L.halothane (fluothane). Anesth Analg (Paris) 17:466

    Google Scholar 

  23. Widger LA, Gandolfi AJ, van Dyke RA (1976) Hypoxia and halothane metabolism in vivo: Release of inorganic fluoride and halothane metabolite binding to cellular caustituents. Anesthesiology 44: 197

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Brown, B.R. (1986). Gegenwärtiger Stand der Organtoxizität von Inhalationsanästhetika. In: Peter, K., Brown, B.R., Martin, E., Norlander, O. (eds) Inhalationsanaesthetika. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07905-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07905-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15968-1

  • Online ISBN: 978-3-662-07905-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics