Skip to main content

Metabolismus und akute Toxizität volatiler Anästhetika

  • Conference paper
Inhalationsanaesthetika

Zusammenfassung

Es ist wohldokumentiert, daß die halogenierten Methanderivate CCl4 und — in geringerem Maß — CHCl3, also auch das bis weit in die 50er Jahre hinein eingesetzte Narkosemittel Chloroform, Lebergifte sind [10]. Der Verdacht, daß auch das Halothan gelegentlich Leberreaktionen bis hin zu tödlichen Lebernekrosen auslösen kann, ist ebenfalls nicht unbegründet [5].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Berman ML, Kuhnert L, Phythyon JM, Holaday DA (1983) Isoflurane and enflurane-induced hepatic necrosis in trijodthyronine-pretreated rats. Anesthesiology 58:1

    Article  PubMed  CAS  Google Scholar 

  2. Bloxam DL (1967) Effects of various anaesthetics on the metabolism and general condition of the isolated perfused rat liver. Biochem Pharmacol 16:283

    Article  PubMed  CAS  Google Scholar 

  3. Halsey MJ, Sawyer DC, Eger EI II et al (1971) Hepatic metabolism of halothane, methoxyilurane, cyclopropane, ethrane and forane in miniatur swine. Anesthesiology 35:262

    Article  Google Scholar 

  4. Klatskin G (1969) In: Schmitt L (ed) Diseases of the liver. Lippincott, Philadelphia

    Google Scholar 

  5. Klion FM, Schaffner P, Popper H (1969) Hepatitis after exposure to halothane. Ann Intern Med 71: 467

    Article  PubMed  CAS  Google Scholar 

  6. Lewis JH, Zimmermann HJ, Ishak KG, Mullick FG (1983) Enflurane hepatotoxicity. A clinicopathologic study. Ann Intern Med 98:984

    Article  PubMed  CAS  Google Scholar 

  7. Mazze RI, Calverley MD, Smith NT (1977) Inorganic fluoride nephrotoxicity: Prolonged enflurane and halothane anesthesia in volunteers. Anesthesiology 46:265

    Article  PubMed  CAS  Google Scholar 

  8. McLain GE, Sipes JG, Brown BR Jr (1979) An animal model of halothane hepatotoxicity: Roles of enzyme induction and hypoxia. Anesthesiology 51:321

    Article  PubMed  CAS  Google Scholar 

  9. National Halothane Study (1969) Government Printing Office, Washington

    Google Scholar 

  10. Recknagel RO (1967) Carbon tetrachloride hepatotoxicity. Pharmacol Rev 19/2:145

    PubMed  CAS  Google Scholar 

  11. Ross WT, Daggy BP, Cardell RR (1979) Hepatic necrosis caused by halothane and hypoxia. Anesthesiology 51:327

    Article  PubMed  CAS  Google Scholar 

  12. Sawyer DC, Eger EI II, Bahiman SH et al (1971) Concentration dependence of hepatic halothane metabolism. Anesthesiology 34:230

    Article  PubMed  CAS  Google Scholar 

  13. Sharp JH, Trudell JR, Cohen EN (1979) Volatile metabolites and decomposition products of halothane in man. Anesthesiology 50:2

    Article  PubMed  CAS  Google Scholar 

  14. Uehleke H, Hellmer KH, Tabarelli-Poplawski S (1973) Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro. Arch Exp Pathol Pharmacol 279:39

    Article  CAS  Google Scholar 

  15. Widger LA, Gandolfi AH, van Dyke RA (1976) Hypoxia and halothane metabolism in vivo. Anesthesiology 44:197

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hempel, V., Heipertz, W., Gärtner, H.V., Schmelzte, M. (1986). Metabolismus und akute Toxizität volatiler Anästhetika. In: Peter, K., Brown, B.R., Martin, E., Norlander, O. (eds) Inhalationsanaesthetika. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07905-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07905-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15968-1

  • Online ISBN: 978-3-662-07905-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics