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Klinische Bedeutung der Biotransformation

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Inhalationsanaesthetika

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Zusammenfassung

Die volatilen Narkotika sind keine inerten Stoffe, sondern werden mit Hilfe des arzneimittelabbauenden Enzymsystems vornehmlich in der Leber metabolisiert. Die gelegentlich nach flüchtigen Narkotika beobachteten Läsionen von Leber und Niere lenken den Verdacht auf die während der Biotransformation entstehenden Zwischenprodukte und Metaboliten [24]. Das individuelle Risiko toxischer Nebeneffekte ist leichter abzuschätzen, wenn nicht nur Abbauwege und Stoffwechselendprodukte, sondern auch die Geschwindigkeit des Stoffwechsels bekannt sind.

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Literatur

  1. Bauereisen E (1980) Regulationsmechanismen der Leberdurchblutung. In: Weis KH, Cunitz G (Hrsg) 25 Jahre DGAI. Springer, Berlin Heidelberg New York (Anästhesiologie und Intensivmedizin, Bd 130, S 242)

    Google Scholar 

  2. Brown BR (1971) The diphasic action of halothane on the oxidative metabolism of drugs by the liver. Anesthesiology 35:241

    Article  PubMed  CAS  Google Scholar 

  3. Chase RE, Holaday DA, Fiserova-Bergerova V, Saidman LJ, Mack FE (1971) The biotransformation of ethrane in man. Anesthesiology 35:262

    Article  PubMed  CAS  Google Scholar 

  4. Cousins MJ, Mazze RI (1973) Methoxyflurane nephrotoxicity: A study of dose-response in man. JAMA 225:1611

    Article  PubMed  CAS  Google Scholar 

  5. Cousins MJ, Sharp JH, Gourlay GK, Adams JF, Haynes WD, Whitehead F (1979) Hepatoxicity and halothane metabolism in an animal model with application for human toxicity. Anaesth Intensive Care 7:9

    PubMed  CAS  Google Scholar 

  6. Danhof M, Breimer DD (1979) Studies on the different metabolic pathways of antipyrine in man. I. Oral administration of 250, 500 and 1000 mg to healthy volunteers. Br J Clin Pharmacol 8:529–537

    Article  PubMed  CAS  Google Scholar 

  7. Gebhardt I, Frickel S, Rietbrock I (in Vorbereitung) Quantitativer Nachweis von Ethan und Penthan in der Ausatemluft

    Google Scholar 

  8. Gourlay GK, Adams JF, Cousins MJ, Sharp JH (1980) Time-course of formation of volatile reductive metabolites of halothane in humans and animal model. Br J Anaesth 52:331

    PubMed  CAS  Google Scholar 

  9. Harper MH, Collins P, Johnson B (1982) Hepatic injury following halothane, enflurane and isoflurane anesthesia in rats. Anesthesiology 56:14

    Article  PubMed  CAS  Google Scholar 

  10. Holaday DA, Rudofsky S, Treuhaft PS (1970) The metabolic degradation of methoxyflurane in man. Anesthesiology 33:579

    Article  CAS  Google Scholar 

  11. Holaday DA, Fiserova-Bergerova V, Latto JP, Zumbiel MA (1975) Resistance of isoflurane to biotransformation in man. Anesthesiology 43:325

    Article  PubMed  CAS  Google Scholar 

  12. Irestedt L (1982) Sauerstoffversorgung der Leber und Fluoridfreisetzungwährend Halothananästhesie. In: Peter K, Jesch F (Hrsg) Inhalationsanästhesie heute und morgen. Springer, Berlin Heidelberg New York (Anästhesiologie und Intensivmedizin, Bd 149, S11)

    Google Scholar 

  13. Lazarus G, Rietbrock I (1980) Current knowledge on pharmacokinetics of halothane and enflurane. Acta Anaesthesiol Belg 31:185

    PubMed  CAS  Google Scholar 

  14. Maiorino RM, Sipes IG, Gandolfi A-J, Brown B-R, Lind RC (1981) Factors affecting the formation of chlorotrifluoroethane and chlorodifluorothylene from halothane. Anesthesiology 54:383

    Article  PubMed  CAS  Google Scholar 

  15. Mansuy D, Nastainczyk W, Ullrich V (1979) The mechanism of halothane binding to microsomal cytochrome P450. Naunyn Schmiedebergs Arch Pharmacol 285:315

    Article  Google Scholar 

  16. Mason HS (1957) Mechanisms of oxygen metabolism. Adv Enzymol 19:79

    CAS  Google Scholar 

  17. McLain GE, Sipes IG, Brown BR (1979) An animal model of halothane hepatoxicity: Roles of enzyme induction and hypoxic Anesthesiology 51:321

    Article  PubMed  CAS  Google Scholar 

  18. Nastainczyk W, Ullrich V, Sies H (1978) Effect of oxygen concentration on the reaction of halothane with cytochrome P450 in liver microsomes and isolated perfused rat liver. Biochem Pharmacol 27:387

    Article  PubMed  CAS  Google Scholar 

  19. Neuberger J, Davis M (1984) Advances in understanding of halothane hepatitis. Tips 4:19

    Google Scholar 

  20. Plummer JL, Beckwith ALJ, Basin FN, Adams JF, Cousins M J, Hall P (1982) Free radical formation in vivo and hepatoxicity due to anesthesia with halothane. Anesthesiology 57:160

    Article  PubMed  CAS  Google Scholar 

  21. Recknagel R, Glende E (1973) Carbon tetrachloride hepatoxicity, an example of lethal cleavage. Crit Rev Toxicol 2:263

    Article  Google Scholar 

  22. Rehder K, Forbes J, Alter H, Hessler O, Stier A (1967) Halothane biotranformation in man. A quantitative study. Anesthesiology 28:711

    Article  PubMed  CAS  Google Scholar 

  23. Reynolds ES, Moslen MT (1974) Liver injury following halothane anesthesia in phenobarbital pre-treated rats. Biochem Pharmacol 23:189

    Article  PubMed  CAS  Google Scholar 

  24. Rietbrock I (1975) Biotransformation von Inhalationsanästhetika und ihre Bedeutung für klinische Nebenwirkungen. Anaesthesist 24:381

    PubMed  CAS  Google Scholar 

  25. Rietbrock I, Eberhard R, Greeff M v d, Breimer BB (in Vorbereitung) Effects of portal hypertension and hypoxia on drug metabolism

    Google Scholar 

  26. Sawyer DC, Eger EI jr, Bahlman SH, Cullen BF, Impelman D (1971) Concentration dependence of hepatic halothane metabolism. Anesthesiology 34:230

    Article  PubMed  CAS  Google Scholar 

  27. Sharp JH, Trudell JR, Cohen EN (1979) Volatile metabolites and decomposition products of halothane in man. Anesthesiology 50:2

    Article  PubMed  CAS  Google Scholar 

  28. Stier A (1965) Der Stoffwechsel des Halothane und seine pharmakologisch-toxikologische Bedeutung. Habilitationsschrift, Universität Würzburg

    Google Scholar 

  29. Van Dyke RA, Chenoweth MB (1965) Metabolism of volatile anesthetics. Anesthesiology 26:348

    Article  Google Scholar 

  30. Van Dyke RA, Wood CL (1975) In vitro studies on irreversible binding of halothane metabolite to microsomes. Drug Metab Dispos 3:51

    PubMed  Google Scholar 

  31. Welton AF, O’Neal O, Chaney LC, Aust SD (1975) MultipUcity of cytochrome P450 hemoproteins in rat liver microsomes. J Biol Chem 250:563

    Google Scholar 

  32. Widger LA, Gandolfi AJ, van Dyke RA (1976) Hypoxia and halothane metabolism in vivo. Release of inorganic fluoride and halothane metabolite binding to cellular constituents. Anesthesiology 44:197

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. I. Rietbrock
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Editors and Affiliations

  1. Institut für Anästhesiologie, Klinikum Großhadern, Ludwig-Maximilians-Universität, Marchioninistraße 15, 8000, München, Deutschland

    Klaus Peter , Burnell R. Brown , Eike Martin  & Olof Norlander , ,  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Rietbrock, I. (1986). Klinische Bedeutung der Biotransformation. In: Peter, K., Brown, B.R., Martin, E., Norlander, O. (eds) Inhalationsanaesthetika. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07905-8_1

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  • DOI: https://doi.org/10.1007/978-3-662-07905-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15968-1

  • Online ISBN: 978-3-662-07905-8

  • eBook Packages: Springer Book Archive

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