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Zytomegalie, Varizellen und Herpes

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Infektionserkrankungen der Schwangeren und des Neugeborenen

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Zusammenfassung

Die Herpesviren werden aufgrund ihres Zelltropismus und ihrer Vermehrungseigenschaften 3 Herpes-Unterfamilien zugeordnet. Von den human-pa-thogenen Herpesviren gehören die Herpes-simplex-Viren Typ I und II und das Varizellen-Zoster-Virus zur α-Unterfamilie, das Zytomegalievirus und die Herpesviren Typ 6 und 7 zur β-Unterfamilie und das Epstein-Barr-Virus und das humane Herpesvirus Typ 8 zur γ-Herpesvirusgruppe. Alle Vertreter dieser Virusfamilie gleichen sich in der Partikelmorphologie, der Vermehrung des DNA-Genoms im Zellkern, der Kodierung für mehrere Enzyme, die für die Regulation der Genomreplikation verantwortlich sind, sowie in ihrer Viruswirtsbeziehung. Ein weiteres charakteristisches Merkmal der Herpesviren ist, daß sie nach der Erstinfektion latent im Organismus verbleiben, daß aber durch meist unbekannte Einflüsse eine Reaktivierung des Virus ohne oder mit Krankheitssymptomatik erfolgen kann. Von besonderer Bedeutung für die Schwangerschaft und die Geburtshilfe ist das Zytomegalievirus, das Varizellen-Zoster-Virus und die Herpes-simplex-Viren Typ I und II.

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Literatur

  • Adler SP (1992) Cytomegalovirus and pregnancy. Curr Opin Obstet Gynecol 4:670–675

    Article  PubMed  CAS  Google Scholar 

  • Adler SP, Finney JW, Manganello AM et al. (1996) Prevention of child-to-mother transmission of cytomegalovirus by changing behaviors: a randomized controlled trial. Pediatr Infect Dis J 15(3):240–256

    Article  PubMed  CAS  Google Scholar 

  • Bale J, O’Neil M, Fowler S et al. (1993) Analysis of acquired human cytomegalovirus infections by polymerase chain reaction. J Clin Micobiol 31:2433–2438

    CAS  Google Scholar 

  • Demmler G (1996) Congenital cytomegalovirus infection and disease. Advances in Pediatr Infect Dis 11:135–162

    CAS  Google Scholar 

  • Dong ZW, Yan C, Yi W, Cui YQ (1994) Detection of congenital cytomegalovirus infection by using chorionic villi of the early pregnancy and polymerase chain reaction. Int J Gynaecol Obstet 44:229–231

    Article  PubMed  CAS  Google Scholar 

  • Donner C, Liesnard C, Brancart F, Rodesch F (1994) Accuracy of amniotic fluid testing before 21 weeks gestation in prenatal diagnosis of congenital cytomegalovirus infection. Prenat Diagn 14:1055–1059

    Article  PubMed  CAS  Google Scholar 

  • Enders G (1997) Infections of the fetus and neonate (other than rubella). In: Collier LH (ed) Topley & Wilson’s Microbiology and Microbial Infections, 9th edn, Chap. 4L Arnold, London (in press)

    Google Scholar 

  • Forestier F, Cox W, Daffos F et al. (1988) The assessment of fetal blood samples. Am J Obstet Gynecol 158:1184–1188

    PubMed  CAS  Google Scholar 

  • Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA (1992) The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 326 (10):663–667

    Article  PubMed  CAS  Google Scholar 

  • Fowler KB, Stagno S, Pass RF (1993) Maternal age and congenital cytomegalovirus infection: screening of two diverse newborn populations, 1980–1990. J Infect Dis 168: 552–556

    Article  PubMed  CAS  Google Scholar 

  • Grose C, Meehan T, Weiner C (1992) Prenatal diagnosis of congenital cytomegalovirus infection by virus isolation after amniocentesis. Pediatr Infect Dis J 11:605–607

    PubMed  CAS  Google Scholar 

  • Hagay ZJ, Biran G, Ornoy A, Reece EA (1996) Congenital cytomegalovirus infection: a longstanding problem still seeking a solution. Am J Obstet Gynecol 174:241–245

    Article  PubMed  CAS  Google Scholar 

  • Hogge WA, Buffone GJ, Hogge JS (1993) Prenatal diagnosis of cytomegaloviurs infection: A preliminary report. Prenat Diagn 13:131–136

    Article  PubMed  CAS  Google Scholar 

  • Istas AS, Demmler GJ, Dobbins JG, Stewart JA (1995) National Congenital Cytomegalovirus Disease Registry Collaborating Group Surveillance for congenital cytomegalovirus disease: a report form the National Congenital Cytomegalovirus Disease Registry. Clin Infect Dis 20 (3):665–670

    Article  PubMed  CAS  Google Scholar 

  • Laifer SA, Ehrlich GD, Huff DS, Balsan MJ, Scantlebury VP (1995) Congenital cytomegalovirus infection in offspring of liver transplant recipients. Clin Infect Dis 20(1): 52–55

    Article  PubMed  CAS  Google Scholar 

  • Nigro G, Clerico A, Mandaini C (1993) Symptomatic congenital cytomegalovirus infection in two consecutive sister. Arch Dis Child 69:527–528

    Article  PubMed  CAS  Google Scholar 

  • Nigro G, Scholz H, Bartmann U (1994) Ganciclovir therapy for symptomatic congenital cytomegalovirus infection: A two-regimen experience. J Pediatr 124(2):318–322

    Article  PubMed  CAS  Google Scholar 

  • Pass RF, Fowler KB, Boppana SB (1991) Progress in cytomegalovirus research. In: Proceedings of the third international cytomegalovirus workshop, Bologna, Italy, June 1991, edited by Landini, M.P. London: Excerpta Medica, p 3–10

    Google Scholar 

  • Porath A, McNutt RA, Smiley LM et al. (1990) Effectiveness and cost benefit of a proposed live cytomegalovirus vaccine in the prevention of congenital disease. Rev Infect Dis 12:31–40

    Article  PubMed  CAS  Google Scholar 

  • Revello MG, Baldanti F, Furione M, Sarasini A, Percivalle E, Zavattoni M, Gerna G (1995) Polymerase chain reaction for prenatal diagnosis of congenital human cytomegalovirus infection. J Med Virol 47:462–466

    Article  PubMed  CAS  Google Scholar 

  • Schwebke K, Henry K, Balfour HHJ, Olson D, Crane RT, Jordan MC (1995) Congenital cytomegalovirus infection as a result of nonprimary cytomegalovirus disease in a mother with acquired immunodeficiency syndrome. J Pediatr 126(2):293–295

    Article  PubMed  CAS  Google Scholar 

  • Shen CY, Chang SF, Yang SL et al. (1994) Cytomegaloviurs is present in semen from a population of men seeking fertility evaluation. J Infect Dis 169:222–223

    Article  PubMed  CAS  Google Scholar 

  • Sinzger C, Plachter B, Grefte A, Jahn G (1996) Tissue macrophages are infected by human cytomegalovirus in vivo. J Infect Dis 173(l):240–245

    Article  PubMed  CAS  Google Scholar 

  • Sokol D, Demmler G, Buffone G (1993) Rapid epidemiologic analysis of cytomegalovirus by using polymerase chain reaction amplification of the L-S junction region. J Clin Microbiol 30:839–844

    Google Scholar 

  • Stagno S (1995) Cytomegalovirus. In: Infectious diseases of the fetus & newborn infants, edited by Remington JS, Klein JO, Saunders Company, 312–353

    Google Scholar 

  • Stronati M, Revello MG, Cerbo RM, Furione M, Rondini G, Gerna G (1995) Ganciclovir therapy of congenital human cytomegalovirus hepatitis. Acta Paediatr 84:340–341

    Article  PubMed  CAS  Google Scholar 

  • Vochem M, Hamprecht K, Jahn G, Speer CP (1997) Zytomegalievirusinfektionen von Frühgeborenen über die Muttermilch. Monatschr Kinderheilkd 145:619–625

    Article  Google Scholar 

  • Whitley RJ, Cloud G, Gruber W et al. (1997) Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. J Infect Dis 175:1080–1086

    Article  PubMed  CAS  Google Scholar 

Varizellen-Zoster

  • Arwin AM, Koropschak CM (1980) Immunoglobulins M and G to varicella-zoster virus measured by solid-phase radio-immunoassay: Antibody responses to varicella and herpes zoster infections. J Clin Microbiol 12:367–374

    Google Scholar 

  • Broussard RC, Payne K, George RB (1991) Treatment with acyclovir of varicella pneumonia in pregnancy. Chest 99:1045–1047

    Article  PubMed  CAS  Google Scholar 

  • Enders G (1985) Management of varicella-zoster contact and infection in pregnancy using a standardized varicella-zoster ELISA test. Postgrad Med 61:23–30

    Article  Google Scholar 

  • Enders G, Miller E, Cradock-Watson J, Bolley I, Ridehalgh M (1994) Consequences of varicella and herpes zoster in pregnancy: Prospective study of 1739 cases. Lancet 343: 1547–1550

    Article  Google Scholar 

  • Enders G (1997) Infections of the fetus and neonate (other than rubella). In: Collier LH (ed) Topley & Wilson’s Microbiolgoy and Microbial Infections, 9th edn, Chapt. 41. Arnold, London (in press)

    Google Scholar 

  • Gotthard H, Rabensteiner A, Delucca A, Lobbiani A, Nocco A, Colucci G (1991) Nachweis des Varicellenvirus mit der DNA-Sonde im fetalen Blut und im Fruchtwasser. Geburtshilfe Frauenheilkd 51:63–64

    Article  Google Scholar 

  • Keutel J (1968) Angeborene Varizellen. Z Kinderheilk 102:266–272

    Article  PubMed  CAS  Google Scholar 

  • Meyers JD (1974) Congenital varicellain term infants: Risk reconsidered. J. Infect Dis 129:215–217

    Article  PubMed  CAS  Google Scholar 

  • Miller E, Cradock-Watson JE, Ridehalgh MKS (1989) Outcome in newborn babies given an-tivaricella-zoster immunoglobulin ater perinatal maternal infection with varicella-zoster virus. Lancet 2:371–373

    Article  PubMed  CAS  Google Scholar 

  • Miller E., Marhsall R, Vurdien J (1993) Epidemillogy, outcome and control of varicella-zoster infeciton. Rev Med Microbiol 4:222–230

    Article  Google Scholar 

  • Pastuszak AL, Levy M, Schick B (1994) Outcome after maternal varicella infection in the first 20 weeks of pregnancy. N Engl J Med 330:901–905

    Article  PubMed  CAS  Google Scholar 

  • Puchhammer-Stöckl E, Kunz C, Wanger G, Enders G (1994) Detection of varizella-zoster virus (VZV) DNA in fetal tissue by polymerase chain reaction. J Perinat Med 22:47–50

    Article  Google Scholar 

  • Weller TH (1983) Varicella and herpes zoster: Changing concepts of the natural history, control, and importance of a not-so-benign virus. N Engl J Med 309:1434–1439

    Article  PubMed  CAS  Google Scholar 

  • Wutzler P, Sauerbrei A, Scholz H, Müller D, Wiedersberg H (1991) Varicella-Zoster-Virusinfektionen in der Schwangerschaft. Pädiat Prax 41:213–224

    Google Scholar 

  • Zieger W, Friese K, Weigel M, Becker KP, Melchert F (1994) Varizellen-Infektion am Geburtstermin. Z Geburtsh Perinat 198:134–137

    CAS  Google Scholar 

Herpes genitalis

  • Ades AE, Peckham CS, Date GE et al. (1989) Prevalence of antibodies to herpes simplex virus types 1 and 2 in pregnant women, and estimated rates of infection. J Epidemiol Community Health 43:53–60

    Article  PubMed  CAS  Google Scholar 

  • Andrews EB, Yankaskas BC, Cordero JF et al. (1992) Acyclovir in pregnancy registry: six years’ experience. Obstet Gynecol 79:7–13

    PubMed  CAS  Google Scholar 

  • Barton IG, Kinghorn GR, Najem S et al. (1982) Incidence of herpes simplex virus types 1 and 2 isolated from patients with herpes genitalis in Sheffield. Br J Ven Dis 58:44–47

    CAS  Google Scholar 

  • Brown ZA, Benedetti J, Ashley R et al. (1991) Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 324:1247–1252

    Article  PubMed  CAS  Google Scholar 

  • Brown ZA, Annholm A, Ashley R et al. (1993) HSV serological discordancy among sexual partners and rates of sero-conversion during pregnancy. Infectious Disease Society for Obstrectics and Gynecology, Stowe

    Google Scholar 

  • Enders G und Mitarbeiter (1996) Jahrbuch-Laborstatistik. Med.-diagn. Gemeinschaftslabor Prof. Enders und Koll. und Institut für Virologie, Infektiologie und Epidemiologie e.V., Stuttgart

    Google Scholar 

  • Enders G, Bartelt U, Risse B, Zauke M (1997) Evaluation of an enzyme immuno-assay co-bas® core for the specific detection of IgG antibodies to Herpes simplex virus type 2. Clinical Laboratory 43: in press

    Google Scholar 

  • Forsgren M, Sterner G, Anzen B et al. (1990) Management of women at term with pregnancy complicated by herpes simplex. Scand J Infect Dis (Suppl) 71:58–66

    CAS  Google Scholar 

  • Forsgren M, Skoog E, Jeansson S et al. (1994) Prevalence of antibodies to herpes simplex virus in pregnant women in Stockholm in 1969, 1983 and 1989: implications for STD epidemiology. Int J STD AIDS 5:113–116

    PubMed  CAS  Google Scholar 

  • Kawana T, Kawagoe K, Takizawa K et al. (1982) Clinical and virologic studies on female genital herpes. Obstet Gynecol 60:456–461

    PubMed  CAS  Google Scholar 

  • Koutsky LA, Stevens CE, Holmes KK et al. (1992) Underdiagnosis of genital herpes by current clinical and viral-isolation procedures. N Engl J Med 326:1533–1539

    Article  PubMed  CAS  Google Scholar 

  • Kulhanjian JA, Soroush V, Au DS et al. (1992) Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy. N Engl J Med 326:916–920

    Article  PubMed  CAS  Google Scholar 

  • Martius J (1996) Genitale Infektionen mit Herpes-simplex-Viren und humanen Papillomviren. Gynäkologe 29:96–104

    Google Scholar 

  • Mejden WI van der, Dumas AM (1987) Consensus preventie van herpes neonatorum. Ned Tijdschr Geneeskd 131:2030–2034

    Google Scholar 

  • Morishima T, Kawana T, Hirayama M et al. (1989) Clinical survey of neonatal herpes simplex virus infection in Japan. J Jpn Pediatr Soc 93:1990–1995

    Google Scholar 

  • Nahmias AI, Lee FK, Beckmann-Nahmias S (1990) Sero-epidemiological and-sociological patterns of herpes simplex virus infection in the world. Scand J Infect Dis (Suppl) 69:19–36

    CAS  Google Scholar 

  • Parvey LS, Ch’ien LT (1980) Neonatal herpes simplex virus infection introduced by fetal-monitor scalp electrodes. Pediatrics 65:1150–1153

    PubMed  CAS  Google Scholar 

  • Prober CG, Corey L, Brown ZA et al. (1992) The management of pregnancies complicated by genital infections with herpes simplex virus. Clin Infect Dis 15:1031–1038

    Article  PubMed  CAS  Google Scholar 

  • Randolph AG, Washington AE, Prober CG (1993) Cesarean delivery for women presenting with genital herpes lesions. Efficacy, risks and costs. JAMA 270:77–82

    Article  PubMed  CAS  Google Scholar 

  • Stray-Pedersen B (1990) Acyclovir in late pregnancy to prevent neonatal herpes simplex (letter). Lancet 336:756

    Article  PubMed  CAS  Google Scholar 

  • Stray-Pedersen B (1993) New aspects of perinatal infections. Ann Med 25:295–300

    Article  PubMed  CAS  Google Scholar 

  • Whitley RJ, Corey L, Arvin A et al. (1988) Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 158:109–116

    Article  PubMed  CAS  Google Scholar 

  • Whitley RJ (1990) Herpes simplex viruses. In: Fields BN, Knipe DM (eds) Fields Virology, 2nd edn. New York, Raven Press, pp 1843–1887

    Google Scholar 

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Authors
  1. K. Friese
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  2. G. Enders
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Editors and Affiliations

  1. Medizinische Fakultät, Frauenklinik und Poliklinik, Universität Rostock, D-18055, Rostock, Deutschland

    Klaus Friese

  2. Kinderklinik, Städtisches Krankenhaus, D-74064, Heilbronn, Deutschland

    Walter Kachel

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© 1998 Springer-Verlag Berlin Heidelberg

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Friese, K., Enders, G. (1998). Zytomegalie, Varizellen und Herpes. In: Friese, K., Kachel, W. (eds) Infektionserkrankungen der Schwangeren und des Neugeborenen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07887-7_6

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  • DOI: https://doi.org/10.1007/978-3-662-07887-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07888-4

  • Online ISBN: 978-3-662-07887-7

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