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Immunsystem und Infektiologie pp 299–314Cite as

Infektionskrankheiten: Tropenmedizinische Aspekte

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Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 4))

Zusammenfassung

Der Verlauf von Infektionen wird durch Reaktionen zwischen Erreger- und Wirtsstrukturen bestimmt. Zahlreiche Reaktionen dieser Art finden zwischen spezialisierten Abwehrmolekülen des Wirts wie z. B. Antikörpern und zufällig beteiligten Erregerstrukturen statt. Ihnen stehen andere gegenüber, die vom Erreger ausgehen. Moleküle des Erregers reagieren dabei selektiv mit Zielmolekülen des Wirts, meist um Invasion, Vermehrung oder Persistenz des Erregers zu vermitteln. Eine große Zahl solcher Erregermoleküle sind bereits als Pathogenitätsfaktoren identifiziert und charakterisiert; sie alle zu beschreiben würde den Rahmen dieses Kapitels sprengen. Gleichermaßen von Interesse sind bei dieser Art Reaktionen die Partner auf Seiten des Wirts. Dies sind in der Regel Moleküle, die für die Entwicklung der Infektionserreger von essentieller Bedeutung sind.

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Literatur

  • Abel L, Demenais F (1988) Detection of major genes for susceptibility to leprosy and its subtypes in a Carribean island: Desirade island. Am J Hum Genet 42:256–266

    PubMed  CAS  Google Scholar 

  • Abel L, Dessein AJ (1997) The impact of host genetics on susceptibility to human infectious diseases. Curr Opin Immunol 9:509–516

    Article  PubMed  CAS  Google Scholar 

  • Abel L, Demenais F, Prata A, Souza AE, Dessein A (1991) Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma man-soni. Am J Hum Genet 48:959–970

    PubMed  CAS  Google Scholar 

  • Abel L, Vu DL, Oberti J, Nguyen VT, Van VC, Guilloud-Bataille M, Schurr E, Lagrange PH (1995) Complex segregation analysis of leprosy in southern Vietnam. Genet Epidemiol 12:63–82

    Article  PubMed  CAS  Google Scholar 

  • Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH (1992) Tumour necrosis factor a restores granulomas and induces egg-laying in schistosome-infected SCID mice. Nature 356:604–607

    Article  PubMed  CAS  Google Scholar 

  • Anderson R, Wang S, Osiowy C, Issekutz AC (1997) Activation of endothelial cells via antibody-enhanced Dengue virus infection of peripheral blood monocytes. J Virol 71:4.226–4.232

    Google Scholar 

  • Berendt AR, Simmons DL, Tansey J, Newbold CI, Marsh K (1989) Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature 341:57–59

    Article  PubMed  CAS  Google Scholar 

  • Beutler E (1994) G6PD deficiency. Blood 84:3.613–3.636

    Google Scholar 

  • Bienzle U, Ayeni O, Lucas AO, Luzzatto L (1972) Glucose-6-phosphate dehydrogenase and malaria. Greater resistance of females heterozygous for enzyme deficiency and of males with non-deficient variant. Lancet 1:107–110

    Article  PubMed  CAS  Google Scholar 

  • Blackwell JM (1996) Genetic susceptibility to leishmanial infections: studies in mice and man. Parasitology 112:S67–S74

    Article  PubMed  Google Scholar 

  • Bradley DJ (1974) Genetic control of natural resistance to Leishmania donovani. Nature 250:353–354

    Article  PubMed  CAS  Google Scholar 

  • Cabrera M, Shaw M-A, Sharpies C, Williams H, Castes M, Convit J, Blackwell JM (1995) Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J Exp Med 182:1259–1264

    Article  PubMed  CAS  Google Scholar 

  • Cattani JA, Gibson FD, Alpers MP, Crane GG (1987) Hereditary ovalocytosis and reduced susceptibility to malaria in Papua New Guinea. Trans R Soc Trop Med Hyg 81:705–709

    Article  PubMed  CAS  Google Scholar 

  • Cerami C, Frevert U, Sinnis P, Takacs B, Clavijo P, Santos MJ, Nussenzweig V (1992) The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites. Cell 70:1021–1033

    Article  PubMed  CAS  Google Scholar 

  • Chan J, Fujiwara T, Brennan P, McNeil M, Turco SJ, Sibille J-C, Snapper M, Aisen P, Bloom BR (1989) Microbial glycolipids: possible virulence factors that scavenge oxygen radicals. Proc Natl Acad Sci USA 86:2.453–2.457

    Google Scholar 

  • Chang K-P, Chaudhuri G, Fong D (1990) Molecular determinants of Leishmania virulence. Annu Rev Microbiol 44:499–529

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Maguire T, Hileman RE, Fromm JR, Esko JD, Linhardt RJ, Marks RM (1997) Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nat Med 3:866–871

    Article  PubMed  CAS  Google Scholar 

  • Choudhuri A, Polyakova J, Zbrzezna V, Williams K, Gulati S, Pogo AO (1993) Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. Proc Natl Acad Sci USA 90:10.793–10.797

    Google Scholar 

  • De Vries RRP (1992) HLA and disease: from epidemiology to immunotherapy. Eur J Clin Invest 22:1–8

    Article  PubMed  Google Scholar 

  • Desjardins M, Descoteaux A (1997) Inhibition of phagolysosomal biogenesis by the leishmania lipophosphoglycan. J Exp Med 185:2.061–2.068

    Article  Google Scholar 

  • Dolan SA, Proctor JL, Alling DW, Okubo Y, Wellems TE, Miller LH (1994) Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes. Mol Biochem Parasitol 64:55–63

    Article  PubMed  CAS  Google Scholar 

  • Field M, Rao MC, Chang EB (1989) Intestinal electrolyte transport and diarrheal disease. N Engl J Med 321:800–806

    Article  PubMed  CAS  Google Scholar 

  • Field SP, Hempelmann E, Mendelow BV, Fleming AF (1994) Glycophorin variants and Plasmodium falciparum :protective effect of the Dantu phenotype in vitro. Hum Genet 93:148–150

    Article  PubMed  CAS  Google Scholar 

  • Fraser GR, Giblett ER, Motulsky AG (1966) Population genetic studies in the Congo. III. Blood groups (ABO, MNSs, Rh, Jsa). Am J Hum Genet 18:546–552

    PubMed  CAS  Google Scholar 

  • Frevert U, Sinnis P, Cerami C, Shreffler W, Takacs B, Nussenzweig V (1993) Malaria circumsporozoite protein binds to heparin sulfate proteoglycans associated with the surface membrane of hepatocytes. J Exp Med 177:1287–1298

    Article  PubMed  CAS  Google Scholar 

  • Gorham JD, Güler ML, Steen RG, Mackey AJ, Daly MJ, Frederick K, Dietrich WF, Murphy KM (1996) Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc Natl Acad Sci USA 93:12.467–12.472

    Google Scholar 

  • Hagan P, Blumenthal UJ, Dunn D, Simpson AJG, Wilkins HA (1991) Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 349:243–245

    Article  PubMed  CAS  Google Scholar 

  • Haidane JBS (1949) Disease and evolution. Hereditas 35:S267–S273

    Article  Google Scholar 

  • Hatzigeorgiou DE, Geng J, Zhu B, Zhang Y, Liu K, Rom WN, Fenton MJ, Turco SJ, Ho JL (1996) Lipophosphoglycan from Leishmania suppresses agonist-induced interleukin 1β gene expression in human monocytes via a unique promoter sequence. Proc Natl Acad Sci USA 93:14.708–14.713

    Article  Google Scholar 

  • Higgs DR, Vickers MA, Wilkie AOM, Pretorius IM, Jarman AP, Weatherall DJ (1989) A review of the molecular genetics of the human α-globin gene cluster. Blood 73:1081–1104

    PubMed  CAS  Google Scholar 

  • Hill AVS, Allsopp CEM, Kwiatkowski D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael AJ, Greenwood BM (1991) Common West African HLA antigens are associated with protection from severe malaria. Nature 352:595–600

    Article  PubMed  CAS  Google Scholar 

  • Hill AVS, Elvin J, Willis AC, Aidoo M, Allsopp CEM, Gotch FM, Gao XM, Takiguchi M, Greenwood BM, Townsend AM, McMichael AJ, Whittle EHC (1992) Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434–439

    Article  PubMed  CAS  Google Scholar 

  • Holmgren J, Clemens J, Sack DA, Svernnerholm A-M (1989) New cholera vaccines. Vaccine 7:94–96

    Article  PubMed  CAS  Google Scholar 

  • Horuk R, Chitnis CE, Darbonne WC, Colby TJ, Rybicki A, Hadley TJ, Miller LH (1993) A receptor for the malarial parasite Plasmodium vivax :The erythrocyte chemokine receptor. Science 261:1182–1184

    Article  PubMed  CAS  Google Scholar 

  • Huisman TH (1993) The structure and function of normal and abnormal haemoglobins. Baillieres Clin Haematol 6:1–30

    Article  PubMed  CAS  Google Scholar 

  • Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu S-C (1991) Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Proc Natl Acad Sci USA 88:11022–11026

    Article  PubMed  CAS  Google Scholar 

  • Kemp SJ, Iraqi F, Darvasi A, Soller M, Teale AJ (1997) Localization of genes controlling resistance to trypanosomiasis in mice. Nat Genet 16:194–196

    Article  PubMed  CAS  Google Scholar 

  • Lara ML, Layrisse Z, Scorza JV, Garcia E, Stoikow Z, Granados J, Bias W (1991) Immunogenetics of human American cutaneous leishmaniasis. Study of HLA haplotypes in 24 families from Venezuela. Hum Immunol 30:129–135

    Article  PubMed  CAS  Google Scholar 

  • Liu S-C, Zhai S, Palek J, Golan DE, Amato D, Hassan K, Nurse GT, Babona D, Coetzer T, Jarolim P, Zaik M, Borwein S (1990) Molecular defect of the band 3 protein in southeast Asian ovalocytosis. N Engl J Med 323:1530–1538

    Article  PubMed  CAS  Google Scholar 

  • Liu J, Fujiwara TM, Buu NT, Sanchez FO, Cellier M, Paradis AJ, Frappier D, Skamene E, Gros P, Morgan K, Schurr E (1995) Identification and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am J Hum Genet 56:845–853

    PubMed  CAS  Google Scholar 

  • Marsh DG, Neely JD, Breazeale DR, Gosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:1152–1156

    CAS  Google Scholar 

  • McGuire W, Hill AVS, Allsopp CEM, Greenwood BM, Kwiatkowski D (1994) Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria. Nature 371:508–511

    Article  PubMed  CAS  Google Scholar 

  • Mekalanos JJ (1985) Cholera toxin: Genetic analysis, regulation, and role in pathogenesis. Curr Top Microbiol Immunol 118:97–118

    Article  PubMed  CAS  Google Scholar 

  • Miller LH (1994) Impact of malaria on genetic polymorphism and genetic disease in Africans and African Americans. Proc Natl Acad Sci USA 91:2.415–2.419

    Google Scholar 

  • Miller LH, Good MF, Milon G (1994) Malaria pathogenesis. Science 264:1878–1883

    Article  PubMed  CAS  Google Scholar 

  • Ming M, Ewen ME, Pereira MEA (1995) Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway. Cell 82:287–296

    Article  PubMed  CAS  Google Scholar 

  • Mock BA, Krall MM, Byrd LG, Chin H, Barton CH, Charles I, Liew FY, Blackwell JM (1994) The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. Eur J Immunogenet 21:231–238

    Article  PubMed  CAS  Google Scholar 

  • Montgomery RI, Warner MS, Lum BJ, Spear PG (1996) Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87:427–436

    Article  PubMed  CAS  Google Scholar 

  • Mosmann TR, Coffman RL (1989) Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 46:111–147

    Article  PubMed  CAS  Google Scholar 

  • Mosser DM, Edelson PJ (1987) The third component of complement (C3) is responsible for intracellular survival of Leishmania major. Nature 327:329–331

    Article  PubMed  Google Scholar 

  • Müller-Myhsok B, Stelma FF, Guisse-Sow F, Muntau B, Thye T, Burchard GD, Gryseels B, Horstmann RD (1997) Further evidence suggesting the presence of a locus on human chromosome 5q31-q33 influencing the intensity of infection with Schistosoma mansoni. Am J Hum Genet 61:452–454

    Article  PubMed  Google Scholar 

  • Ortega-Barria E, Pereira MEA (1991) A novel T. cruzi heparin-binding protein promotes fibroblast adhesion and penetration of engineered bacteria and trypanosomes into mammalian cells. Cell 67:411–421

    Article  PubMed  CAS  Google Scholar 

  • Pancake SJ, Holt GD, Mellouk S, Hoffman SL (1992) Malaria sporozoites and circumsporozoite proteins bind specifically to sulfated glycoconjugates. J Cell Biol 117:1351–1357

    Article  PubMed  CAS  Google Scholar 

  • Pauling L, Itano H, Singer SJ, Wells, IC (1949) Sickle cell anaemia: A molecular disease. Science 110:543–546

    Article  PubMed  CAS  Google Scholar 

  • Pereira MEA (1983) A developmentally regulated neuraminidase activity in Trypanosoma cruzi. Science 219:1444–1446

    Article  PubMed  CAS  Google Scholar 

  • Plant J, Glynn AA (1974) Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice. Nature 248:345–347

    Article  PubMed  CAS  Google Scholar 

  • Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CIM, Meyers DA, Levitt RC (1995) Genetic susceptibility to asthma — bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 333:894–900

    Article  PubMed  CAS  Google Scholar 

  • Proudfoot L, Nikolaev AV, Feng G-J, Wei X-Q, Ferguson MAJ, Brimacombe JS, Liew FY (1996) Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc Natl Acad Sci USA 93:10.984–10.989

    Article  Google Scholar 

  • Ramabukkana A, Salzer JL, Yurchenco PD, Tuomanen EI (1997) Neural targeting of Mycobacterium leprae by the G domain of the laminin-α2 chain. Cell 88:811–821

    Article  Google Scholar 

  • Raulet DH (1994) MHC class I-deficient mice. Adv Immunol 55:381–421

    Article  PubMed  CAS  Google Scholar 

  • Reid ME, Lomas-Francis C, Daniels GL, Chen V, Shen J, Ho YC, Hare V, Batts R, Yacob M, Smart E (1995) Expression of the erythrocyte antigen Henshaw (He; MNS6): serological and immunochemical studies. Vox Sang 68:183–186

    Article  PubMed  CAS  Google Scholar 

  • Riley EM, Olerup O, Bennett S, Rowe P, Allen SJ, Blackman MJ, Troye-Blomberg M, Holder AA, Greenwood BM (1992) MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum. Int Immunol 4:1055–1063

    Article  PubMed  CAS  Google Scholar 

  • Roberts DJ, Biggs B-A, Brown G, Newbold CI (1993) Protection, pathogenesis and phenotypic plasticity in Plasmodium falciparum malaria. Parasitol Today 9:281–286

    Article  PubMed  CAS  Google Scholar 

  • Roberts LJ, Baldwin TM, Curtis JM, Handman E, Foote SJ (1997) Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med 185:1705–1710

    Article  PubMed  CAS  Google Scholar 

  • Robson KJH, Hall JRS, Jennings MW, Harris TJR, Marsh K, Newbold CI, Tate VE, Weatherall DJ (1988) A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature 335:79–82

    Article  PubMed  CAS  Google Scholar 

  • Rostand KS, Esko JD (1997) Microbial adherence to and invasion through proteoglycans. Infect Immun 65:1–8

    PubMed  CAS  Google Scholar 

  • Ruwende C, Khoo SC, Snow RW, Yates SNR, Kwiatkowski D, Gupta S, Warn P, Allsopp CEM, Gilbert SC, Peschu N, Newbold CI, Greenwood BM, Marsh K, Hill AVS (1995) Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 376:246–249

    Article  PubMed  CAS  Google Scholar 

  • Schenkman S, Jiang M-S, Hart GW, Nussenzweig V (1991) A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell 65:1117–1125

    Article  PubMed  CAS  Google Scholar 

  • Schlesinger LS (1993) Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J Immunol 150:2.920–2.930

    Google Scholar 

  • Schlesinger LS, Horwitz MA (1991) Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) and IFNγ activation inhibits complement receptor function and phagocytosis of this bacterium. J Immunol 147:1983–1994

    PubMed  CAS  Google Scholar 

  • Schorey JS, Li Q, McCourt DW, Bong-Mastek M, Clark-Curtiss JE, Ratliff TL, Brown EJ (1995) A Mycobacterium leprae gene encoding a fibronectin binding protein is used for efficient invasion of epithelial cells and Schwann cells. Infect Immun 63:2.652–2.657

    Google Scholar 

  • Schorey JS, Carroll MC, Brown EJ (1997) A macrophage invasion mechanism of pathogenic mycobacteria. Science 277:1091–1093

    Article  PubMed  CAS  Google Scholar 

  • Shakibaei M, Frevert U (1996) Dual interaction of the malaria circumsporozoite protein with low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans. J Exp Med 184:1699–1711

    Article  PubMed  CAS  Google Scholar 

  • Sim BKL, Chitnis CE, Wasniowska K, Hadley TJ, Miller LH (1994) Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum. Science 264:1941–1944

    Article  PubMed  CAS  Google Scholar 

  • Sixma TK, Pronk SE, Kalk KH, Wartna ES, Zanten BAM van, Witholt B, Hol WGJ (1991) Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature 351:371–377

    Article  PubMed  CAS  Google Scholar 

  • Smith JD, Chitnis CE, Craig AG, Roberts DJ, Hudson-Taylor DE, Peterson DS, Pinches R, Newbold CI, Miller LH (1995) Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 83:101–110

    Article  Google Scholar 

  • Spangler BD (1992) Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol Rev 56:622–647

    PubMed  CAS  Google Scholar 

  • Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314

    Article  PubMed  CAS  Google Scholar 

  • Su X-Z, Heatwole VM, Wertheimer SP, Guinet F, Herrfeldt JA, Peterson DS, Ravetch JA, Wellems TE (1995) The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell 82:89–100

    Article  PubMed  CAS  Google Scholar 

  • Tarleton RL, Koller BH, Latour A, Postan M (1992) Susceptibility of β 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356:338–340

    Article  PubMed  CAS  Google Scholar 

  • Turco SJ, Descoteaux A (1992) The lipophosphoglycan of Leishmania parasites. Annu Rev Microbiol 46:65–94

    Article  PubMed  CAS  Google Scholar 

  • Unger P, Procter JL, Moulds JJ, Moulds M, Blanchard D, Guizzo MC, McCall LA, Cartron JP, Dahr W (1987) The Dantu erythrocyte phenotype of the NE variety. II. Serology, immunochemistry, genetics, and frequency. Blut 55:33–43

    Article  PubMed  CAS  Google Scholar 

  • Vachula M, Holzer TJ, Anderson BR (1989) Suppression of monocyte oxidative response by phenolic glycolipid I of Mycobacterium leprae. J Immunol 142:1696–1701

    PubMed  CAS  Google Scholar 

  • Vidal SM, Malo D, Vogan K, Skamene E, Gros P (1993) Natural resistance to infection with intracellular parasites: isolation of a candidate for bcg. Cell 73:469–485

    Article  PubMed  CAS  Google Scholar 

  • Wei X, Charles IG, Smith A, Ure J, Feng G, Huang F, Xu D, Muller W, Moncada S, Liew FY (1995) Altered immune response in mice lacking inducible nitric oxide synthase. Nature 375:408–411

    Article  PubMed  CAS  Google Scholar 

  • WHO (1993) Public health impact of schistosomiasis. Bull WHO 71:657–662

    Google Scholar 

  • Williams TN, Maitland K, Bennett S, Ganczakowski M, Peto TEA, Newbold CI, Bowden DK, Weatherall DJ, Clegg JB (1996) High incidence of malaria in α-thalassaemic children. Nature 383:522–525

    Article  PubMed  CAS  Google Scholar 

  • Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW (1997) Effects of a polymorphism in the human tumor necrosis factor a promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3.195–3.199

    Google Scholar 

  • Zerva L, Cizman B, Mehra NK, Alahari SK, Murali R, Zmijewski CM, Kamoun M, Monos DS (1996) Arginine at positions 13 or 70–71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy. J Exp Med 183:829–836

    Article  PubMed  CAS  Google Scholar 

  • Zhang G, Liu Y, Ruoho AE, Hurley JH (1997) Structure of the adenylyl cyclase catalytic core. Nature 386:247–253

    Article  PubMed  CAS  Google Scholar 

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Horstmann, R.D. (1999). Infektionskrankheiten: Tropenmedizinische Aspekte. In: Ganten, D., Ruckpaul, K. (eds) Immunsystem und Infektiologie. Handbuch der Molekularen Medizin, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07865-5_9

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