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Immunsystem und Infektiologie pp 87–105Cite as

Immunsystem Haut

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Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 4))

Zusammenfassung

Bei der immunologischen Auseinandersetzung des Organismus mit der Umwelt kommt der inneren bzw. äußeren Körperoberfläche eine besondere Rolle zu. In Analogie zum MALT (mucosa-associated lymphoid tissue) entwickelte Streilein [1983] das Konzept des SALT (skin-associated lymphoid tissue oder Haut-assoziiertes lymphoides Gewebe). Diese SALT bestehen u.a. aus antigenpräsentierenden Langerhans-Zellen, Zytokin-produzierenden Keratinozyten, epidermotropen T-Zellen und drai-nierenden peripheren Lymphknoten (Abb. 2.1.1).

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Literatur

  • Aberer W, Schuler G, Stingl G, Honigsmann H, Wolff K (1981) Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 76:202–210

    Article  PubMed  CAS  Google Scholar 

  • Abernathy Carver KJ, Sampson HA, Picker LJ, Leung DY (1995) Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. J Clin Invest 95:913–918

    Article  Google Scholar 

  • Ansel JC, Brown JR, Payan DG, Brown MA (1993) Substance P selectively activates TNF-alpha gene expression in murine mast cells. J Immunol 150:4478–4485

    PubMed  CAS  Google Scholar 

  • Antoniades HN, Galanopoulos T, Neville Golden J, Kiritsy CP, Lynch SE (1991) Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts. Proc Natl Acad Sci USA 88:565–569

    Article  PubMed  CAS  Google Scholar 

  • Aubock J, Romani N, Grubauer G, Fritsch P (1986) HLA-DR expression on keratinocytes is a common feature of diseased skin. Br J Dermatol 114:465–472

    Article  PubMed  CAS  Google Scholar 

  • Barber LD, Parham P (1993) Peptide binding to major histocompatibility complex molecules. Annu Rev Cell Biol 9:163–206

    Article  PubMed  CAS  Google Scholar 

  • Barnard JA, Graves Deal R, Pittelkow MR, DuBois R, Cook P, Ramsey GW, Bishop PR, Damstrup L, Coffey RJ (1994) Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. J Biol Chem 269, 22817–22822

    PubMed  CAS  Google Scholar 

  • Beilke MA (1989) Vascular endothelium in immunology and infectious disease. Rev Infect Dis 11:273–283

    Article  PubMed  CAS  Google Scholar 

  • Benyon RC (1989) The human skin mast cell. Clin Exp Allergy 19:375–387

    Article  PubMed  CAS  Google Scholar 

  • Berg DJ, Leach MW, Kuhn R, Rajewsky K, Muller W, Davidson NJ, Rennick D (1995) Interleukin 10 but not interleu-kin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182:99–108

    Article  PubMed  CAS  Google Scholar 

  • Berman B, Chen VL, France DS, Dotz WI, Petroni G (1983) Anatomical mapping of epidermal Langerhans cell densities in adults. Br J Dermatol 109:553–558

    Article  PubMed  CAS  Google Scholar 

  • Bienenstock, Tomioka M, Stead R, Ernst P, Jordana M, Gauldie J, Dolovich J, Denburg J (1987) Mast cell involvement in various inflammatory processes. Am Rev Respir Dis 135:S5–S8

    Google Scholar 

  • Birbeck MS, Breathnach AS, Everall JD (1961) An electron microscope study of basal melanocytes and high-level clear cells (Langerhans cells) in vitiligo. J Invest Dermatol 37:51

    Google Scholar 

  • Boehncke WH, Dressel D, Zollner TM, Kaufmann R (1996) Pulling the trigger on psoriasis [letter]. Nature 379:777

    Article  PubMed  CAS  Google Scholar 

  • Boismenu R, Havran WL (1994) Modulation of epithelial cell growth by intraepithelial gamma delta T cells. Science 266:1253–1255

    Article  PubMed  CAS  Google Scholar 

  • Bos JD, Zonneveld I, Das PK, Krieg SR, Loos CM van der, Kapsenberg ML (1987) The skin immune system (SIS): distribution and immunophenotype of lymphocyte sub-populations in normal human skin. J Invest Dermatol 88:569–573

    Article  PubMed  CAS  Google Scholar 

  • Bos JD, Teunissen MB, Cairo I, Krieg SR, Kapsenberg ML, Das PK, Borst J (1990) T-cell receptor gamma delta bearing cells in normal human skin. J Invest Dermatol 94:37–42

    Article  PubMed  CAS  Google Scholar 

  • Bos JD, Boer OJ de, Tibosch E, Das PK, Pals ST (1993) Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin. Arch Dermatol Res 285:179–183

    Article  PubMed  CAS  Google Scholar 

  • Boxman I, Lowik C, Aarden L, Ponec M (1993) Modulation of 11–6 production and Il-1 activity by keratinocyte-fibro-blast interaction. J Invest Dermatol 101:316–324

    Article  PubMed  CAS  Google Scholar 

  • Braathen LR, Thorsby E (1980) Studies on human epidermal Langerhans cells. I. Allo-activating and antigen-presenting capacity. Scand J Immunol 11:401–408

    Article  PubMed  CAS  Google Scholar 

  • Bradley LM, Croft M, Swain SL (1993) T-cell memory: new perspectives. Immunol Today 14:197–199

    Article  PubMed  CAS  Google Scholar 

  • Brain SD, Williams TJ (1988) Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature 335:73–75

    Article  PubMed  CAS  Google Scholar 

  • Brasch J, Sterry W (1992) Expression of adhesion molecules in early allergic patch test reactions. Dermatology 185:12–17

    Article  PubMed  CAS  Google Scholar 

  • Brown LF, Yeo KT, Berse B, Yeo TK, Senger DR, Dvorak HF, Water L van de (1992) Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176:1375–1379

    Article  PubMed  CAS  Google Scholar 

  • Brown LF, Ulbricht SM, Berse B, Jackman RW, Matsueda G, Tognazzi KA, Manseau EJ, Dvorak HF, Water L van de (1995) Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. J Immunol 154:2801–2807

    PubMed  CAS  Google Scholar 

  • Cerio R, Griffiths CE, Cooper KD, Nickoloff BJ, Headington JT (1989) Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin. Br J Dermatol 121:421–431

    Article  PubMed  CAS  Google Scholar 

  • Chaker MB, Tharp MD, Bergstresser PR (1984) Rodent epidermal Langerhans cells demonstrate greater histochemi-cal specificity for ADP than for ATP and AMP. J Invest Dermatol 82:496–500

    Article  PubMed  CAS  Google Scholar 

  • Chedid M, Rubin JS, Csaky KG, Aaronson SA (1994) Regulation of keratinocyte growth factor gene expression by in-terleukin 1. J Biol Chem 269:10753–10757

    PubMed  CAS  Google Scholar 

  • Coffey RJ Jr, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR (1987) Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature 328:817–820

    Article  PubMed  CAS  Google Scholar 

  • Cumberbatch M, Gould SJ, Peters SW, Kimber I, Cumber-batch M, Peters SW, Gould SJ, Kimber I (1991) MHC class II expression by Langerhans’ cells and lymph node dendritic cells: possible evidence for maturation of Langerhans’ cells following contact sensitization. Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells: comparison with epidermal Langerhans cells. Immunology 74:414–419

    PubMed  CAS  Google Scholar 

  • Cumberbatch M, Peters SW, Gould SJ, Kimber I (1992) Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells: comparison with epidermal Langerhans cells. Immunol Lett 32:105–110

    Article  PubMed  CAS  Google Scholar 

  • De Kossodo S, Cruz PD Jr, Dougherty I, Thompson P, Silva Valdez M, Beutler B (1995) Expression of the tumor necrosis factor gene by dermal fibroblasts in response to ultraviolet irradiation or lipopolysaccharide. J Invest Dermatol 104:318–322

    Article  PubMed  Google Scholar 

  • Detmar M, Brown LF, Claffey KP, Yeo KT, Kocher O, Jack-man RW, Berse B, Dvorak HF (1994) Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 180:1141–1146

    Article  PubMed  CAS  Google Scholar 

  • Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM (1993) 11–10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 151:1224–1234

    PubMed  CAS  Google Scholar 

  • Dupuy P, Heslan M, Fraitag S, Hercend T, Dubertret L, Ba-got M (1990) T-cell receptor-gamma/delta bearing lymphocytes in normal and inflammatory human skin. J Invest Dermatol 94:764–768

    Article  PubMed  CAS  Google Scholar 

  • Eedy DJ (1993) Neuropeptides in skin. Br J Dermatol 128:597–605

    Article  PubMed  CAS  Google Scholar 

  • Enk AH, Katz SI (1992) Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 89:1398–13402

    Article  PubMed  CAS  Google Scholar 

  • Enk AH, Angeloni VL, Udey MC, Katz SI (1993) An essential role for Langerhans cell-derived Il-l beta in the initiation of primary immune responses in skin. J Immunol 150:3698–3704

    PubMed  CAS  Google Scholar 

  • Enk CD, Sredni D, Blauvelt A, Katz SI (1995) Induction of 11–10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J Immunol 154:4851–4856

    PubMed  CAS  Google Scholar 

  • Ferguson TA, Dube P, Griffith TS (1994) Regulation of contact hypersensitivity by interleukin 10. J Exp Med 179:1597–1604

    Article  PubMed  CAS  Google Scholar 

  • Foster CA, Yokozeki H, Rappersberger K, Koning F, Volc Platzer B, Rieger A, Coligan JE, Wolff K, Stingl G (1990) Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor. J Exp Med 171:997–1013

    Article  PubMed  CAS  Google Scholar 

  • Gauchat JF, Henchoz S, Mazzei G, Aubry JP, Brunner T, Bla-sey H, Life P, Talabot D, Flores Romo L, Thompson J, et al. (1993) Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365:340–343

    Article  PubMed  CAS  Google Scholar 

  • Glick AB, Kulkami AB, Tennenbaum T, Hennings H, Flanders KC, O’Reilly M, Sporn MB, Karlsson S, Yuspa SH (1993) Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyper-proliferation and a high risk for malignant conversion. Proc Natl Acad Sci USA 90:6076–6080

    Article  PubMed  CAS  Google Scholar 

  • Griffiths CE, Railan D, Gallatin WM, Cooper KD (1995) The ICAM-3/LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4+-T cells. Br J Dermatol 133:823–829

    Article  PubMed  CAS  Google Scholar 

  • Grossman RM, Krueger J, Yourish D, Granelli Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB (1989) Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 86:6367–6371

    Article  PubMed  CAS  Google Scholar 

  • Groves RW, Mizutani H, Kieffer JD, Kupper TS (1995) Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci USA 92:11874–11878

    Article  PubMed  CAS  Google Scholar 

  • Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J (1988) Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 107:1611–1619

    Article  PubMed  CAS  Google Scholar 

  • Hanau D, Fabre M, Schmitt DA, Stampf JL, Garaud JC, Bie-ber T, Grosshans E, Benezra C, Cazenave JP (1987) Human epidermal Langerhans cells internalize by receptor-mediated endocytosis T6 (CD1 „NA1/34“) surface antigen. Birbeck granules are involved in the intracellular traffic of the T6 antigen. J Invest Dermatol 89:172–177

    Article  PubMed  CAS  Google Scholar 

  • Hancock GE, Kaplan G, Cohn ZA (1988) Keratinocyte growth regulation by the products of immune cells. J Exp Med 168:1395–1402

    Article  PubMed  CAS  Google Scholar 

  • Harder J, Bartels J, Christophers E, Schröder J-M (1997) A peptide antibiotic from normal human skin. Nature 387:861

    Article  PubMed  CAS  Google Scholar 

  • Hauser C, Katz SI (1988) Activation and expansion of hapten- and protein-specific T helper cells from nonsensitiz-ed mice. Proc Natl Acad Sci USA 85:5625–5628

    Article  PubMed  CAS  Google Scholar 

  • Hauser C, Snapper CM, Ohara J, Paul WE, Katz SI (1989) T helper cells grown with hapten-modified cultured Langerhans’ cells produce interleukin 4 and stimulate IgE production by B cells. Eur J Immunol 19:245–251

    Article  PubMed  CAS  Google Scholar 

  • Heine H, Forster FJ (1975) Histophysiology of mast cells in skin and other organs. Arch Dermatol Res 253:225–228

    Article  PubMed  CAS  Google Scholar 

  • Hemler ME (1990) VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol 8:365–400

    Article  PubMed  CAS  Google Scholar 

  • Herman A, Kappler JW, Marrack P, Pullen AM (1991) Super-antigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol 9:745–772

    Article  PubMed  CAS  Google Scholar 

  • Heufler C, Topar G, Grasseger A, Stanzl U, Koch F, Romani N, Namen AE, Schuler G (1993) Interleukin 7 is produced by murine and human keratinocytes. J Exp Med 178:1109–1114

    Article  PubMed  CAS  Google Scholar 

  • Hilliges M, Wang L, Johansson O (1995) Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J Invest Dermatol 104:134–137

    Article  PubMed  CAS  Google Scholar 

  • Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahi-na A, Granstein RD (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363:159–163

    Article  PubMed  CAS  Google Scholar 

  • Howard M, O’Garra A (1992) Biological properties of interleukin 10. Immunol Today 13:198–200

    Article  PubMed  CAS  Google Scholar 

  • Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O’Garra A, Murphy KM (1993) Development of TH1 CD4+-T cells through 11–12 produced by Listeria-induced macrophages [see comments]. Science 260:547–549

    Article  PubMed  CAS  Google Scholar 

  • Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11–25

    Article  PubMed  CAS  Google Scholar 

  • Inaba K, Steinman RM (1987) Monoclonal antibodies to LFA-1 and to CD4 inhibit the mixed leukocyte reaction after the antigen-dependent clustering of dendritic cells and T lymphocytes. J Exp Med 165:1403–1417

    Article  PubMed  CAS  Google Scholar 

  • Inaba K, Witmer Pack M, Inaba M, Hathcock KS, Sakuta H, Azuma M, Yagita H, Okumura K, Linsley PS, Ikehara S et al. (1994) The tissue distribution of the B7–2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 180:1849–1860

    Article  PubMed  CAS  Google Scholar 

  • Kaplan G, Luster AD, Hancock G, Cohn ZA (1987) The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med 166:1098–1108

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann R, Mielke V, Reimann J, Klein CE, Sterry W (1993) Cellular and molecular composition of human skin in long-term xenografts on SCID mice. Exp Dermatol 2:209–216

    Article  PubMed  CAS  Google Scholar 

  • Kishimoto T, Akira S, Taga T (1992) Interleukin-6 and its receptor: a paradigm for cytokines. Science 258:593–597

    Article  PubMed  CAS  Google Scholar 

  • Knight SC (1984) Veiled cells “dendritic cells” of the peripheral lymph. Immunobiology 168:349–361

    Article  PubMed  CAS  Google Scholar 

  • Kock A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC, Luger TA (1990) Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609–1614

    Article  PubMed  CAS  Google Scholar 

  • Kojima T, Cromie MA, Fisher GJ, Voorhees JJ, Elder JT (1993) GRO-alpha mRNA is selectively overexpressed in psoriatic epidermis and is reduced by cyclosporin A in vivo, but not in cultured keratinocytes. J Invest Dermatol 101:767–772

    Article  PubMed  CAS  Google Scholar 

  • Kripke ML, Munn CG, Jeevan A, Tang JM, Bucana C (1990) Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J Immunol 145:2833–2838

    PubMed  CAS  Google Scholar 

  • Kubin M, Kamoun M, Trinchieri G (1994) Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med 180:211–222

    Article  PubMed  CAS  Google Scholar 

  • Kupper TS (1990) Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest 86:1783–1789

    Article  PubMed  CAS  Google Scholar 

  • Kupper TS, Groves RW (1995) The interleukin-1 axis and cutaneous inflammation. J Invest Dermatol 105:62s–66s

    Article  Google Scholar 

  • Langerhans P (1868) Über die Nerven der menschlichen Haut. Virchows Arch 44:325

    Article  Google Scholar 

  • Lappin MB, Kimber I, Norval M (1996) The role of dendritic cells in cutaneous immunity. Arch Dermatol Res 288:109–121

    Article  PubMed  CAS  Google Scholar 

  • Lenz A, Heine M, Schuler G, Romani N (1993) Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization. J Clin Invest 92:2587–2596

    Article  PubMed  CAS  Google Scholar 

  • Lester MR, Hofer MF, Gately M, Trumble A, Leung DY (1995) Down-regulating effects of 11–4 and 11–10 on the IFN-gamma response in atopic dermatitis. J Immunol 154:6174–6181

    PubMed  CAS  Google Scholar 

  • Leung DY, Travers JB, Giorno R, Norris DA, Skinner R, Aelion J, Kazemi LV, Kim MH, Trumble AE, Kotb M et al. (1995b) Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis. J Clin Invest 96:2106–2112

    Article  PubMed  CAS  Google Scholar 

  • Leung DY, Gately M, Trumble A, Ferguson Darnell B, Schlie-vert PM, Picker LJ (1995a) Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 181:747–753

    Article  PubMed  CAS  Google Scholar 

  • Leung DY, Travers JB, Giorno R, Norris DA, Skinner R, Aelion J, Kazemi LV, Kim MH, Trumble AE, Kotb M et al. (1995b) Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis. J Clin Invest 96:2106–2112

    Article  PubMed  CAS  Google Scholar 

  • Lotti T, Hautmann G, Panconesi E (1995) Neuropeptides in skin. J Am Acad Dermatol, 33:482–496

    Article  PubMed  CAS  Google Scholar 

  • Lowman MA, Benyon RC, Church MK (1988) Characterization of neuropeptide-induced histamine release from human dispersed skin mast cells. Br Pharmacol, 95:121–130

    Article  CAS  Google Scholar 

  • Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O, Lee DC (1993) TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell, 73:263–278

    Article  PubMed  CAS  Google Scholar 

  • Luster AD, Greenberg SM, Leder P (1995) The IP-10 chemo-kine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J Exp Med 182:219–231

    Article  PubMed  CAS  Google Scholar 

  • Ma J, Wang JH, Guo YJ, Sy MS, Bigby M (1994) In vivo treatment with anti-ICAM-1 and anti-LFA-1 antibodies inhibits contact sensitization-induced migration of epidermal Langerhans cells to regional lymph nodes. Cell Immunol 158:389–399

    Article  PubMed  CAS  Google Scholar 

  • Makgoba MW, Sanders ME, Shaw S (1989) The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition. Immunol Today 10:417–422

    Article  PubMed  CAS  Google Scholar 

  • Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL, Dunn AR (1993) Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73:249–261

    Article  PubMed  CAS  Google Scholar 

  • Marikovsky M, Lavi S, Pinkas Kramarski R, Karunagaran D, Liu N, Wen D, Yarden Y (1995) ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene 10:1403–1411

    PubMed  CAS  Google Scholar 

  • Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, Stingl G (1995) The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol 154:6285–6290

    PubMed  CAS  Google Scholar 

  • Meunier L, Gonzalez Ramos A, Cooper KD (1993) Heterogeneous populations of class II MHC+ cells in human dermal cell suspensions. Identification of a small subset responsible for potent dermal antigen-presenting cell activity with features analogous to Langerhans cells. J Immunol 151:4067–4080

    PubMed  CAS  Google Scholar 

  • Michie CA, Davis T, Leung DY, Travers JB, Norris DA, Lester MR, Hofer MF, M Gately, Trumble A, Leung DY (1996) Atopic dermatitis and staphylococcal superantigens [letter]. The role of superantigens in skin disease Down-regulating effects of 11–4 and 11–10 on the IFN-gamma response in atopic dermatitis. Lancet 347:324

    Article  PubMed  CAS  Google Scholar 

  • Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM, Aaronson SA (1992) Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 89:246–250

    Article  PubMed  CAS  Google Scholar 

  • Mizutani H, Roswit W, Hemperly J, Lawley T, Compton C, Swerlick R, Kupper TS (1994) Human dermal microvascular endothelial cells express the 140-kD isoform of neural cell adhesion molecule. Biochem Biophys Res Commun 203:686–693

    Article  PubMed  CAS  Google Scholar 

  • Mohamadzadeh M, Takashima A, Dougherty I, Knop J, Bergstresser PR, Cruz PD Jr (1995) Ultraviolet B radiation up-regulates the expression of 11–15 in human skin. J Immunol 155:4492–4496

    PubMed  CAS  Google Scholar 

  • Moll H (1993) Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis. Immunol Today 14:383–387

    Article  PubMed  CAS  Google Scholar 

  • Morrissey PJ, Goodwin RG, Nordan RP, Anderson D, Grab-stein KH, Cosman D, Sims J, Lupton S, Acres B, Reed SG (1989) Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells. J Exp Med 169:707–716

    Article  PubMed  CAS  Google Scholar 

  • Muller G, Saloga J, Germann T, Bellinghausen I, Mohamadzadeh M, Knop J, Enk AH (1994) Identification and induction of human keratinocyte-derived 11–12. J Clin Invest 94:1799–1805

    Article  PubMed  CAS  Google Scholar 

  • Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S (1988) Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature, 333:571–573

    Article  PubMed  CAS  Google Scholar 

  • Nathan C, Sporn M (1991) Cytokines in context. J Cell Biol 113:981–986

    Article  PubMed  CAS  Google Scholar 

  • Naukkarinen A, Harvima I, Paukkonen K, Aalto ML, Hors-manheimo M (1993) Immunohistochemical analysis of sensory nerves and neuropeptides, and their contacts with mast cells in developing and mature psoriatic lesions. Arch Dermatol Res 285:341–346

    Article  PubMed  CAS  Google Scholar 

  • Nestle FO, Zheng XG, Thompson CB, Turka LA, Nickoloff BJ (1993) Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol 151:6535–6645

    PubMed  CAS  Google Scholar 

  • O’Keefe EJ, Chiu ML, Payne RE Jr. (1988) Stimulation of growth of keratinocytes by basic fibroblast growth factor. J Invest Dermatol 90:767–769

    Article  PubMed  Google Scholar 

  • Perussia B, Chan SH, D’Andrea A, Tsuji K, Santoli D, Pospi-sil M, Young D, Wolf SF, Trinchieri G (1992) Natural killer (NK) cell stimulatory factor or 11–12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+; T lymphocytes, and NK cells. J Immunol 149:3495–34502

    PubMed  CAS  Google Scholar 

  • Picker LJ, Treer JR, Ferguson Darnell B, Collins PA, Bergstresser PR, Terstappen LW (1993) Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol 150:1122–1136

    PubMed  CAS  Google Scholar 

  • Picker LJ, Michie SA, Rott LS, Butcher EC (1990) A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 136:1053–1068

    PubMed  CAS  Google Scholar 

  • Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC (1991) ELAM-1 is an adhesion molecule for skin-homing T cells [see comments]. Nature 349:796–799

    Article  PubMed  CAS  Google Scholar 

  • Piguet PF, Grau GE, Hauser C, Vassalli P (1991) Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions. J Exp Med 173:673–679

    Article  PubMed  CAS  Google Scholar 

  • Pincelli C, Sevignani C, Manfredini R, Grande A, Fantini F, Bracci Laudiero L, Aloe L, Ferrari S, Cossarizza A, Gian-netti A (1994) Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes. J Invest Dermatol 103:13–18

    Article  PubMed  CAS  Google Scholar 

  • Pober JS, T Collins, Gimbrone MA Jr, Libby P, Reiss CS (1986) Inducible expression of class II major histocompatibility complex antigens and the immunogenicity of vascular endothelium. Transplantation 41:141–146

    Article  PubMed  CAS  Google Scholar 

  • Proksch E, Brasch J, Sterry W (1996) Integrity of the permeability barrier regulates epidermal Langerhans cell density. Br J Dermatol 134:630–638

    Article  PubMed  CAS  Google Scholar 

  • Rattis FM, Peguet Navarro J, Staquet MJ, Dezutter Dam-buyant C, Courtellemont P, Redziniak G, Schmitt D (1996) Expression and function of B7–1 (CD80) and B7–2 (CD86) on human epidermal Langerhans cells. Eur J Immunol 26:449–453

    Article  PubMed  CAS  Google Scholar 

  • Ristow HJ, Messmer TO (1988) Basic fibroblast growth factor and insulin-like growth factor I are strong mitogens for cultured mouse keratinocytes. J Cell Physiol 137:277–284

    Article  PubMed  CAS  Google Scholar 

  • Rivas JM, Ullrich SE (1992) Systemic suppression of de-layed-type hypersensitivity by supernatants from UV-ir-radiated keratinocytes. An essential role for keratinocyte-derived 11–10. J Immunol 149:3865–3871

    PubMed  CAS  Google Scholar 

  • Röcken M, Muller KM, Saurat JH, Muller I, Louis JA, Cerot-tini JC, Hauser C (1992) Central role for TCR/CD3 ligation in the differentiation of CD4+-T cells toward A Thl or Th2 functional phenotype. J Immunol 148:47–54

    PubMed  Google Scholar 

  • Rohde D, Schluter Wigger W, Mielke V, Driesch P von den, Gaudecker B von, Sterry W (1992) Infiltration of both T cells and neutrophils in the skin is accompanied by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1): an immunohistochemical and ultrastructural study. J Invest Dermatol 98:794–799

    Article  PubMed  CAS  Google Scholar 

  • Romani N, Koide S, Crowley M, Witmer Pack M, Livingstone AM, Fathman CG, Inaba K, Steinman RM (1989) Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 169:1169–1178

    Article  PubMed  CAS  Google Scholar 

  • Rowden G (1981) The Langerhans cell. Crit Rev Immunol 3:95–180

    PubMed  CAS  Google Scholar 

  • Sallusto F, Cella M, Danieli C, Lanzavecchia A (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregula-tion by cytokines and bacterial products [see comments]. J Exp Med 182:389–400

    Article  PubMed  CAS  Google Scholar 

  • Santamaria Babi LF, Moser R, Perez Soler MT, Picker LJ, Blaser K, Hauser C (1995) Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 154:1543–1550

    Google Scholar 

  • Schall TJ, Bacon KB (1994) Chemokines, leukocyte trafficking, and inflammation. Curr Opin Immunol 6:865–873

    Article  PubMed  CAS  Google Scholar 

  • Schauer E, Trautinger F, Kock A, Schwarz A, Bhardwaj R, Simon M, Ansel JC, Schwarz T, Luger TA (1994) Proopio-melanocortin-derived peptides are synthesized and released by human keratinocytes. J Clin Invest 93:2258–2262

    Article  PubMed  CAS  Google Scholar 

  • Schroder JM (1995) Cytokine networks in the skin. J Invest Dermatol 105:20S–24S

    Article  Google Scholar 

  • Schuler G, Thurner B, Romani N (1997) Dendritic cells: from ignored cells to major players in t cell mediated immunity. Int Arch Allergy Immunol 112:317–322

    Article  PubMed  CAS  Google Scholar 

  • Schwarz A, Grabbe S, Riemann H, Aragane Y, Simon M, Manon S, Andrade S, Luger TA, Zlotnik A, Schwarz T (1994) In vivo effects of interleukin-10 on contact hypersensitivity and delayed-type hypersensitivity reactions. J Invest Dermatol 103:211–216

    Article  PubMed  CAS  Google Scholar 

  • Schwarzenberger K, Udey MC (1996) Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J Invest Dermatol 106:553–558

    Article  PubMed  CAS  Google Scholar 

  • Seino K, Azuma M, Bashuda H, Fukao K, Yagita H, Okumu-ra K (1995) CD86 (B70/B7–2) on endothelial cells co-stimulates allogeneic CD4+-T cells. Int Immunol 7:1331–1337

    Article  PubMed  CAS  Google Scholar 

  • Sellheyer K, Bickenbach JR, Rothnagel JA, Bundman D, Longley MA, Krieg T, Roche NS, Roberts AB, Roop DR (1993) Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc Natl Acad Sci USA 90:5237–5241

    Article  PubMed  CAS  Google Scholar 

  • Shimada S, Caughman SW, Sharrow SO, Stephany D, Katz SI (1987) Enhanced antigen-presenting capacity of cultured Langerhans’ cells is associated with markedly increased expression of Ia antigen. J Immunol 139:2551–2555

    PubMed  CAS  Google Scholar 

  • Sibilia M, Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234–238

    Article  PubMed  CAS  Google Scholar 

  • Sinigaglia F (1994) The molecular basis of metal recognition by T cells. J Invest Dermatol 102:398–401

    Article  PubMed  CAS  Google Scholar 

  • Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434

    Article  PubMed  CAS  Google Scholar 

  • Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314

    Article  PubMed  CAS  Google Scholar 

  • Springer TA, Lasky LA (1991) Cell adhesion. Sticky sugars for selectins [news]. Nature 349:196–197

    Article  PubMed  CAS  Google Scholar 

  • Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296

    Article  PubMed  CAS  Google Scholar 

  • Sterry W, Bruhn S, Kunne N, Lichtenberg B, Weber Matthie-sen K, Brasch J, Mielke V (1990) Dominance of memory over naive T cells in contact dermatitis is due to differential tissue immigration. Br J Dermatol 123:59–64

    Article  PubMed  CAS  Google Scholar 

  • Stingl G, Gazze Stingl LA, Aberer W, Wolff K (1981) Antigen presentation by murine epidermal langerhans cells and its alteration by ultraviolet B light. J Immunol 127:1707–1713

    PubMed  CAS  Google Scholar 

  • Stingl G, Katz SI, Clement L, Green I, Shevach EM (1978) Immunologic functions of la-bearing epidermal Langerhans cells. J Immunol 121:2005–2013

    PubMed  CAS  Google Scholar 

  • Streilein JW (1978) Lymphocyte traffic, T-cell malignancies and the skin. J Invest Dermatol 71:167–171

    Article  PubMed  CAS  Google Scholar 

  • Streilein JW (1983) Skin-associated lymphoid tissues (SALT): origins and functions. J Invest Dermatol 80:12s–16s

    Article  Google Scholar 

  • Streilein JW, Grammer SF, Yoshikawa T, Demidem A, Ver-meer M (1990) Functional dichotomy between Langerhans cells that present antigen to naive and to memory/ effector T lymphocytes. Immunol Rev 117:159–183

    Article  PubMed  CAS  Google Scholar 

  • Swerlick RA, Lee KH, Wick TM, Lawley TJ (1992) Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. J Immunol 148:78–83

    PubMed  CAS  Google Scholar 

  • Symington FW (1989) Lymphotoxin, tumor necrosis factor, and gamma interferon are cytostatic for normal human keratinocytes. J Invest Dermatol 92:798–805

    Article  PubMed  CAS  Google Scholar 

  • Takahashi S, Hashimoto K (1985) Derivation of Langerhans cell granules from cytomembrane. J Invest Dermatol 84:469–471

    Article  PubMed  CAS  Google Scholar 

  • Takashima A, Edelbaum D, Kitajima T, Shadduck RK, Gilmore GL, Xu S, Taylor RS, Bergstresser PR, Ariizumi K (1995) Colony-stimulating factor-1 secreted by fibroblasts promotes the growth of dendritic cell lines (XS series) derived from murine epidermis. J Immunol 154:5128–5135

    PubMed  CAS  Google Scholar 

  • Tanaka T, Danno K, Ikai K, Imamura S (1988) Effects of substance P and substance K on the growth of cultured keratinocytes. J Invest Dermatol 90:399–401

    Article  PubMed  CAS  Google Scholar 

  • Tanaka Y, Adams DH, Shaw S (1993) Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes. Immunol Today 14:111–115

    Article  PubMed  CAS  Google Scholar 

  • Tang A, Amagai M, Granger LG, Stanley JR, Udey MC (1993) Adhesion of epidermal Langerhans cells to kerati-nocytes mediated by E-cadherin. Nature 361:82–85

    Article  PubMed  CAS  Google Scholar 

  • Thiers BH, Maize JC, Spicer SS, Cantor AB (1984) The effect of aging and chronic sun exposure on human Langerhans cell populations. J Invest Dermatol 82:223–226

    Article  PubMed  CAS  Google Scholar 

  • Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC et al. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant pheno-type. Science 269:230–234

    Article  PubMed  CAS  Google Scholar 

  • Toews GB, Bergstresser PR, Streilein JW (1980) Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124:445–453

    PubMed  CAS  Google Scholar 

  • Tron VA, Coughlin MD, Jang DE, Stanisz J, Sauder DN (1990) Expression and modulation of nerve growth factor in murine keratinocytes (PAM 212). J Clin Invest 85:1085–1089

    Article  PubMed  CAS  Google Scholar 

  • Valdimarsson H, Sigmundsdottir H, Jonsdottir I (1997) Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin? Clin Exp Immunol 1:21–24

    Google Scholar 

  • Waelti ER, Inaebnit SP, Rast HP, Hunziker T, Limat A, Braa-then LR, Wiesmann U (1992) Co-culture of human keratinocytes on post-mitotic human dermal fibroblast feeder cells: production of large amounts of interleukin 6. J Invest Dermatol 98:805–808

    Article  PubMed  CAS  Google Scholar 

  • Weber Matthiesen K, Sterry W (1990) Organization of the monocyte/macrophage system of normal human skin [see comments]. J Invest Dermatol 95:83–89

    Article  Google Scholar 

  • Weelden H van, Putte SC van der, Toonstra J, Leun JC van der (1990) UVA-induced tumours in pigmented hairless mice and the carcinogenic risks of tanning with UVA. Arch Dermatol Res 282:289–294

    Article  PubMed  Google Scholar 

  • Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH (1989) Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol 109:877–889

    Article  PubMed  CAS  Google Scholar 

  • Werner S, Peters KG, Longaker MT, Fuller Pace F, Banda MJ, Williams LT (1992) Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci USA 89:6896–6900

    Article  PubMed  CAS  Google Scholar 

  • Wiesner Menzel L, Schulz B, Vakilzadeh F, Czarnetzki BM (1981) Electron microscopical evidence for a direct contact between nerve fibres and mast cells. Acta Derm Ve-nereol 61:465–469

    Google Scholar 

  • Wilkinson PC, Liew FY (1995) Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255–1259

    Article  PubMed  CAS  Google Scholar 

  • Witmer Pack MD, Olivier W, Valinsky J, Schuler G, Stein-man RM (1987) Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med 166:1484–1498

    Article  Google Scholar 

  • Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR (1992) Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90:482–487

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Marcus Schmitt-Egenolf
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  2. Wolfram Sterry
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Schmitt-Egenolf, M., Sterry, W. (1999). Immunsystem Haut. In: Ganten, D., Ruckpaul, K. (eds) Immunsystem und Infektiologie. Handbuch der Molekularen Medizin, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07865-5_3

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