Synovial Tumors

  • F. Vanhoenacker
  • J. W. M. Van Goethem
  • J. E. Vandevenne
  • M. Shahabpour


The synovial membrane is derived from embryonic mesenchyme and lines nonarticular areas in synovial joints, bursae and tendon sheaths Cells of the synovial membrane regulate the exchange of substances between blood and synovial fluid, and they synthesize hyaluronate, which is a major component of the synovial fluid [1]. The appearance of the synovial membrane varies considerably, depending on local mechanical factors and the nature of the underlying tissue. For instance, in high-pressure joints the synovium is flat and acellular, whereas in low-pressure joints it resembles cuboidal or columnar epithelium [20].


Synovial Sarcoma Giant Cell Tumor Tendon Sheath Ganglion Cyst Synovial Cyst 
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  1. 1.
    Barland P, Novokoff AB, Hamerman D (1962) Electron microscopy of the human synovial membrane. J Cell Biol 14:207PubMedCrossRefGoogle Scholar
  2. 2.
    Blacksin MF, Siegel JR, Benevenia J, Aisner SC (1997) Synovial sarcoma: frequency of nonaggressive MR characteristics. J Comput Assist Tomogr 21:785–789PubMedCrossRefGoogle Scholar
  3. 3.
    Bravo SM, Winalski CS, Weissman BN (1996) Pigmented villonodular synovitis. Radiol Clin North Am 34:311–326PubMedGoogle Scholar
  4. 4.
    Bui-Mansfield LT, Youngberg RA (1997) Intraarticular ganglia of the knee: prevalence, presentation, etiology, and management. AJR Am J Roentgenol 168:123–127PubMedCrossRefGoogle Scholar
  5. 5.
    Carrillo R, el-Naggar AK, Rodriguez-Peralto JL, Batsakis JG (1992) Synovial sarcoma of the tongue: case report and review of the literature. J Oral Maxillofac Surg 50:904–906PubMedCrossRefGoogle Scholar
  6. 6.
    Carstens HP, Howell RS (1979) Malignant giant cell tumor of tendon sheath. Virchows Arch [A] 382:237–243CrossRefGoogle Scholar
  7. 7.
    De Beuckeleer L, De Schepper A, De Belder F, Van Goethem J, Marques MC, Broeckx J, Verstraete K, Vermaut F (1997) Magnetic resonance imaging of localized giant cell tumour of the tendon sheath (MRI of localized GCTTS). Eur Radiol 7:198–201PubMedCrossRefGoogle Scholar
  8. 8.
    De Schepper AM, Degryse HR, Ramon FA, Van Marck EA (1992) Magnetic resonance imaging of extraabdominal desmoid tumors. J Belge Radiol 75:91–98PubMedGoogle Scholar
  9. 9.
    Enzinger FM, Weiss SW (1995) Synovial sarcoma In: Enzinger FM, Weiss SW (eds) Soft tissue tumors, 3 rd edn. Mosby, St Louis, pp 735–786Google Scholar
  10. 10.
    Flandry F, Hughston JC, McCann SB, et al (1994) Diagnostic features of diffuse pigmented villonodular synovitis of the knee. Clin Orthop 298:212–220PubMedGoogle Scholar
  11. 11.
    Hodler J, Yu JS, Steinert HC, Resnick D (1995) MR Imaging versus alternative imaging techniques. Magn Reson Imaging Clin N Am 3:591–608PubMedGoogle Scholar
  12. 12.
    Jaffe HL, Lichtenstein L, Sutro CJ (1941) Pigmented villonodular synovitis, bursitis, and tenosynovitis: a discussion of the synovial and bursal equivalents of the tenosynovial lesions commonly denoted as xanthoma, xanthogranuloma, giant cell tumor or myeloplaxoma of the tendon sheath, with some consideration of the tendon sheath lesion itself. Arch Pathol 31:731Google Scholar
  13. 13.
    Jelinek JS, Kransdorf MJ, Utz JA, Berrey BH, Thomson JD, Heekin RD, Radowich MS (1989) Imaging of pigmented villonodular synovitis with emphasis on MR imaging. AJR Am J Roentgenol 152:337–342PubMedCrossRefGoogle Scholar
  14. 14.
    Jergesen HE, Mankin HJ, Schiller AL (1978) Diffuse pigmented villonodular synovitis of the knee mimicking primary bone neoplasm. J Bone Joint Surg [Am] 60:825–829Google Scholar
  15. 15.
    Jones BC, Sundaram M, Kransdorf MJ (1993) Synovial sarcoma: MR imaging findings in 34 patients. AIR Am J Roentgenol 161:827–830CrossRefGoogle Scholar
  16. 16.
    Kaplan PA, Williams SM (1987) Mucocutaneous and peripheral soft-tissue hemangiomas: MR imaging. Radiology 163:163–166PubMedGoogle Scholar
  17. 17.
    Kindblom LG, Gunterberg G (1978) Pigmented villonodular synovitis involving bone Case report. J Bone Joint Surg [Am] 60:830–832Google Scholar
  18. 18.
    Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Konishi J (1996) Periosteal ganglion of the tibia Skelet Radiol 25:381–383CrossRefGoogle Scholar
  19. 19.
    Kransdorf MJ (1995) Malignant soft-tissue tumors in a large referral population: distribution of diagnosis by age, sex and location. AJR Am J Roentgenol 164:129–134PubMedCrossRefGoogle Scholar
  20. 20.
    Lever JD, Ford EHR (1958) Histological, histochemical and electron microscopic observations on synovial membrane. Anat Rec 132:525PubMedCrossRefGoogle Scholar
  21. 21.
    Levien LJ, Benn CA (1998) Adventitial cystic disease: a unifying hypothesis. J Vasc Surg 28:193–205PubMedCrossRefGoogle Scholar
  22. 22.
    Llauger J, Palmer J, Roson N, Cremades R, Bague S (1999) Pigmented villonodular synovitis and giant cell tumors of the tendon sheath: radiologic and pathologic features. AJR Am J Roentgenol 172:1087–1091PubMedCrossRefGoogle Scholar
  23. 23.
    Lois JF, Fischer HJ, Mirra JM, Gomes AS (1986) Angiography of histopathologic variants of synovial sarcoma. Acta Radiol Diagn 27:449–454Google Scholar
  24. 24.
    Malghem J, Vande Berg B, Lebon CH, Maldague B (1993) Les kystes muco d’extension atypique In: Chevrot A, Kahn MF, Morvan G (eds) Imagerie des parties molles de l’appareil locomoteur. Sauramps Medical, Montpellier, pp 107–115Google Scholar
  25. 25.
    Malghem J, Vande berg BC, Lebon C, Lecouvet FE, Maldague BE (1998) Ganglion cysts of the knee: articular communication revealed by delayed radiography and CT after arthrography. AJR Am J Roentgenol 170:1579–1583PubMedCrossRefGoogle Scholar
  26. 26.
    Martinoli C, Bianchi S, Derchi LE (1999) Tendon and nerve sonography. Radiol Clin North Am 37:691–711PubMedCrossRefGoogle Scholar
  27. 27.
    Milchgrub S, Ghandur-Mnaymneh L, Dorfman HD, Albores-Saavedra J (1993) Synovial sarcoma with extensive osteoid and bone formation. Am J Surg Pathol 17:357–363PubMedCrossRefGoogle Scholar
  28. 28.
    Morton MJ, Berquist TH, McLeod RA, Unni KK, Sim FH (1991) MR imaging of synovial sarcoma. AJR Am J Roentgenol 156:337–340PubMedCrossRefGoogle Scholar
  29. 29.
    Murphey MD, Kransdorf MJ, Smith SE (1999) Imaging of soft tissue neoplasms in the adult: malignant tumors. Semin Musculoskeletal Radiol 1:39–58CrossRefGoogle Scholar
  30. 30.
    Myers BW, Masi AT (1980) Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiologic study of 166 cases and literature review. Medicine (Baltimore) 59:223–238Google Scholar
  31. 31.
    Nucci F, Artico M, Santoro A, Bardella L, Delfini R, Bosco S, Palma L (1990) Intraneural synovial cyst of the peroneal nerve: report of two cases and review of the literature. Neurosurgery 26:339–344PubMedCrossRefGoogle Scholar
  32. 32.
    O’Keeffe LJ, Ramsden RT, Birzgalis AR (1993) Primary synovial sarcoma of the middle ear. J Laryngol Otol 107:1070–1072PubMedGoogle Scholar
  33. 33.
    Ptasznik R (1999) Ultrasound in acute and chronic knee injury. Radiol Clin North Am 37:797–830PubMedCrossRefGoogle Scholar
  34. 34.
    Reilly KE, Stern PJ, Dale JA (1999) Recurrent giant cell tumors of the tendon sheath. J Hand Surg 24:1298–1302CrossRefGoogle Scholar
  35. 35.
    Sanchez Reyes JM, Alcaraz Mexia M, Quinones Tapia D, Aramburu JA (1997) Extensively calcified synovial sarcoma. Skeletal Radiol 26:671–673PubMedCrossRefGoogle Scholar
  36. 36.
    Shaw GR, Lais CJ (1993) Fatal intravascular synovial sarcoma in a 31-year-old woman. Hum Pathol 24:809–810PubMedCrossRefGoogle Scholar
  37. 37.
    Spielmann A, Janzen DL, O’Connell JX, Munk PL (1997) Intraneural synovial sarcoma. Skeletal Radiol 26:677–681PubMedCrossRefGoogle Scholar
  38. 38.
    Steiner E, Steinbach LS, Schnarkowski P, Tirman PF, Genant HK (1996) Ganglia and cysts around joints. Radiol Clin North Am 34:395–425PubMedGoogle Scholar
  39. 39.
    Ushijima M, Hashimoto H, Tsuneyoshi M, Enjoji M (1986) Giant cell tumor of the tendon sheath (nodular tenosynovitis) A study of 207 cases to compare the large joint group with the common digit group. Cancer 57:875–884PubMedCrossRefGoogle Scholar
  40. 40.
    Vandevenne JE, Vanhoenacker F, Hauben E, De Schepper AM (1997) Nosologie des kystes para-articulaires. In: Bard H, Drapé JL, Goutallier D, Laredo JD (eds) Le genou traumatique et dégéneratif Sauramps Médical, Montpellier, pp 293–303Google Scholar
  41. 41.
    Vanhoenacker FM, Vandevenne JE, De Schepper AM, De Leersnijder J (2000) Regarding “Adventitial cystic disease: a unifying hypothesis” Letter to the editor. J Vasc Surg 31:621–622PubMedCrossRefGoogle Scholar
  42. 42.
    Van Holsbeeck M, Introcaso JH (1991) Sonography of bursae In: Van Holsbeeck M, Introcaso JH (eds). Musculoskeletal ultrasound, Mosby Year Book, St Louis, pp 91–121Google Scholar
  43. 43.
    Wang SC, Chhem RK, Cardinal E, Cho KH (1999) Joint Sonography. Radiol Clin North Am 37:653–668PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • F. Vanhoenacker
  • J. W. M. Van Goethem
  • J. E. Vandevenne
  • M. Shahabpour

There are no affiliations available

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