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Entzündliche Dermatosen der dermoepidermalen Junktion (Interface-Dermatitis)

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Book cover Histopathologie der Haut

Zusammenfassung

Unter einer Interface-Dermatitis versteht man eine entzündliche Dermatose, bei der die dermoepidermale Junktionszone verwaschen und daher histologisch nicht mehr einwandfrei von der papillären Dermis abzugrenzen ist. Diese Veränderungen werden durch ein lymphozytäres Entzündungsinfiltrat hervorgerufen, das reich an T-Lymphozyten ist und zum zytotoxischen Schaden und zur Apoptose von Keratinozyten führt. Apoptotische Keratinozyten verlieren den Zellkontakt zueinander und sind histologisch als abgerundete, homogen eosinophile, anukleäre oder pyknotische Zellen erkennbar. Finden sie ihren Weg in die papilläre Dermis, so bezeichnet man sie als „Civatte bodies“, „cytoid bodies“ oder „Kolloid bodies“. Ein wichtiges Phänomen der Interface-Dermatitis ist die vakuoläre Degeneration (hydropische Degeneration), bei der der Schaden der basalen Keratinozyten zur intrazellulären Vakuolisierung und Odembildung führt. Die vakuoläre Degeneration kann mitunter so prominent sein, dass sie Anlass zur Spaltbildung an der Junktionszone ist.

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Authors
  1. L. El Shabrawi-Caelen
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  2. H.-P. Soyer
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Editor information

Editors and Affiliations

  1. Universitätsklinik für Dermatologie und Venerologie, Karl-Franzens-Universität Graz, Auenbruggerplatz 8, A-8036, Graz, Österreich

    Helmut Kerl  & Lorenzo Cerroni  & 

  2. Universitäts-Hautklinik, Eberhard-Karls-Universität Tübingen, Liebermeisterstraße 25, D-72076, Tübingen, Deutschland

    Claus Garbe

  3. Klinik für Dermatologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Deutschland

    Helmut H. Wolff

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© 2003 Springer-Verlag Berlin Heidelberg

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El Shabrawi-Caelen, L., Soyer, HP. (2003). Entzündliche Dermatosen der dermoepidermalen Junktion (Interface-Dermatitis). In: Kerl, H., Garbe, C., Cerroni, L., Wolff, H.H. (eds) Histopathologie der Haut. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07784-9_8

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  • DOI: https://doi.org/10.1007/978-3-662-07784-9_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07785-6

  • Online ISBN: 978-3-662-07784-9

  • eBook Packages: Springer Book Archive

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