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Entzündliche Dermatosen der dermoepidermalen Junktion (Interface-Dermatitis)

  • L. El Shabrawi-Caelen
  • H.-P. Soyer

Zusammenfassung

Unter einer Interface-Dermatitis versteht man eine entzündliche Dermatose, bei der die dermoepidermale Junktionszone verwaschen und daher histologisch nicht mehr einwandfrei von der papillären Dermis abzugrenzen ist. Diese Veränderungen werden durch ein lymphozytäres Entzündungsinfiltrat hervorgerufen, das reich an T-Lymphozyten ist und zum zytotoxischen Schaden und zur Apoptose von Keratinozyten führt. Apoptotische Keratinozyten verlieren den Zellkontakt zueinander und sind histologisch als abgerundete, homogen eosinophile, anukleäre oder pyknotische Zellen erkennbar. Finden sie ihren Weg in die papilläre Dermis, so bezeichnet man sie als „Civatte bodies“, „cytoid bodies“ oder „Kolloid bodies“. Ein wichtiges Phänomen der Interface-Dermatitis ist die vakuoläre Degeneration (hydropische Degeneration), bei der der Schaden der basalen Keratinozyten zur intrazellulären Vakuolisierung und Odembildung führt. Die vakuoläre Degeneration kann mitunter so prominent sein, dass sie Anlass zur Spaltbildung an der Junktionszone ist.

Synonym

Lichen planus (engl.) Polymyositis (Dermatomyositis ohne Hautbeteiligung) „Lilakrankheit“ benigne lichenoide Keratose „lichen planus-like keratosis“ Erythema multiforme Pityriasis lichenoides et varioliformis acuta PLEVA Morbus Mucha-Habermann Para-psoriasis guttata Weißfleckenkrankheit 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • L. El Shabrawi-Caelen
  • H.-P. Soyer

There are no affiliations available

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