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Bindegewebetumoren der Haut

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Book cover Histopathologie der Haut

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Zusammenfassung

Bindegewebetumoren der Haut entstehen aus den Zellen des dermalen, periadnexalen, perivaskulären, subkutanen und faszialen Bindegewebes. Sie sind überwiegend in der Dermis lokalisiert und können das subkutane Fettgewebe involvieren. Die Beteiligung von tiefer gelegenen Strukturen, beispielsweise der Faszie, kommt in Ausnahmefällen vor. Dermal gelegene Tumoren sind prognostisch günstiger als subkutane Pendants.

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Literatur

  • Caux C, Vanbervliet B, Massacrier C et al. (1996) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 184: 695–706

    Article  PubMed  CAS  Google Scholar 

  • Fletcher CDM (1998) Myofibroblastic tumors: An Update. Verh Dtsch Ges Pathol 82: 75–82

    PubMed  CAS  Google Scholar 

  • Gabbiani G (1996) The cellular derivation and the life span of the myofibroblast. Path Res Pract 192: 708–711

    Article  PubMed  CAS  Google Scholar 

  • Mentzel T, Katenkamp D (1998) Myofibroblastäre Tumoren. Pathologe 19: 176–186

    Article  PubMed  CAS  Google Scholar 

  • Weiss SW, Nickoloff BJ (1993) CD34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 17: 10391045

    Google Scholar 

  • Cramer HJ, Kahlert G (1968) Über Bindegewebsnaevi. Hautarzt 19: 251–256

    PubMed  CAS  Google Scholar 

  • Schorr WF, Opitz JM, Reyes CN (1972) The connective tissue nevus-ostiopoikilosis syndrome. Arch Dermatol 106: 208–214

    Article  PubMed  CAS  Google Scholar 

  • Uitto J, Santa-Cruz DJ, Eisen AZ (1980) Connective tissue nevi of the skin. J Am Acad Dermatol 3: 441–461

    Article  PubMed  CAS  Google Scholar 

  • Enzinger FM, Weiss S (eds) (1994) Benign fibrous tissue tumors. In: Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 187–191

    Google Scholar 

  • Kahn HJ, Hanna WM (1995) „Aberrant elastic“ in elastofibroma: An immunohistological and ultrastructural study. Ultrastruct Pathol 19: 45–50

    Google Scholar 

  • Ruelas-Villavicencio AL, Aponte-Paredes PS, Ortiz-Hidalgo C (1999) CD34 expression in elastofibroma: Clinicopathological, histochemical, and immunohistochemical study in four cases. Abstract Rev Invest Clin 51: 11–16

    Google Scholar 

  • Schepel JA, Wille J, Seldenrijk CA, van Ramshorst B (1998) Elastofibroma: A familial occurrence. Eur J Surg 164: 557–558

    Google Scholar 

  • Nemeth AJ, Penneys NS (1989) Factor XIIIa is expressed by fibroblasts in fibrovascular tumors. J Cutan Pathol 16: 266–271

    Article  PubMed  CAS  Google Scholar 

  • Pack S, Turner ML, Zhuang Z et al. (1998) Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the MEN1 gene. J Invest Dermatol no: 438 440

    Google Scholar 

  • Roach ES, Gomez MR Northrup H (1998) Tuberous Sclerosis Complex Consensus Conference: Revised clinical diagnostic criteria. J Child Neurol 13: 624–628

    Google Scholar 

  • Yamamoto T, Katajama I, Nishioka K (1996) Fibropapule multiplex of the nose: A variant of Cowden’s disease? Dermatology 192: 379–381

    Article  PubMed  CAS  Google Scholar 

  • Cerio R, Rao BK, Spaull J, Wilson Jones E (1989) An immunohistochemical study of fibrous papule of the nose. J Cutan Pathol 16: 194–198

    Article  PubMed  CAS  Google Scholar 

  • Tope WD, Sangueza OP (1994) Rhinophymas fibrous variant. Histopathology and immunohistochemistry. Am J Dermatop atho l 16: 307–310

    Google Scholar 

  • Ferenczy A, Richart RM, Wrigt TC (1991) Pearly penile papules: Absence of human papilloma virus DNA by polymerase chain reaction. Obstet Gynecol 78: 118–122

    Google Scholar 

  • O’Neil CA, Hansen RC (1995) Pearly penile papules on the shaft–letter. Arch Dermatol 131: 491–492

    Article  PubMed  Google Scholar 

  • Perrin C, Baran R (1994) Invaginated fibrokeratoma with matrix differentiation: A new histological variant of acquired fibrokeratoma. Br J Dermatol 130: 654–657

    Google Scholar 

  • Spitalny AD, Lavery LA (1992) Acquired fibrokeratoma of the heel. J Foot Surg 31: 509–511

    PubMed  CAS  Google Scholar 

  • Cribier B, Gambini C, RaineroM, Grosshans E (1995) Multi-nucleate cell angiohistiocytoma. A review and report of four cases. Acta Dermatol Venereol 75: 337–339

    Google Scholar 

  • Smolle J, Auboeck L, Gogg-Retzer I, Soyer HP, Kerl H (1989) Multinucleate cell angiohistiocytoma: A clinicopathological, immunohistochemical and ultrastructural study. Br J Dermatol 121: 113–121

    Google Scholar 

  • Banik R, Lubach D (1987) Skin tags: Localization and frequencies according to sex and age. Dermatologica 174: 180–183

    Google Scholar 

  • Eads TJ, Chuang TY, Fabre VC, Farmer ER, Hood AF (1996) The utility of submitting fibroepithelial polyps for histological examination. Arch Dermatol 132: 1459–1462

    Article  PubMed  CAS  Google Scholar 

  • Morgan MB, Howard HG, Everett MA (1997) Epithelial induction in dermatofibroma: A role for the epidermal growth factor ( EGF) receptor. Am J Dermatopathol 19: 35–40

    Google Scholar 

  • Nestle FO, Nickoloff VI, Burg G (1995) Dermatofibroma: An abortive immunoreactive process mediated by dermal dendritic cells? Dermatology 190: 265–268

    Article  PubMed  CAS  Google Scholar 

  • Glusac EJ, Barr RJ, Everett MA, Pitha J, Santa Cruz DJ (1994)

    Google Scholar 

  • Epithelioid cell histiocytoma. Am J Surg Pathol 18: 583–590 Junkins-Hopkins JM, Johnson WC (1998) Desmoplastic

    Google Scholar 

  • fibroblastoma. J Cutan Pathol 25: 450–454

    Google Scholar 

  • Zelger BG, Zelger B (1998) Dermatofibrome. Ein klinisch-pathologisches Klassifikationsschema. Pathologe 19: 412–419

    Google Scholar 

  • Zelger BW, Steiner H, Kutzner H (1996) Clear cell dermatofibroma. Am J Surg Pathol 20: 483–491

    Article  PubMed  CAS  Google Scholar 

  • Zelger BG, Zelger B (1998) Dermatofibrome. Ein klinisch-pathologisches Klassifikationsschema. Pathologe 19: 412–419

    Google Scholar 

  • Calonje E, Fletcher CDM (1993) New entities in soft tissue tumors. Pathologica 85: 1–15

    PubMed  CAS  Google Scholar 

  • Calonje E, Mentzel T, Fletcher CDM (1994) Cellular benign fibrous histiocytoma. Am J Surg Pathol 18: 668–676

    Article  PubMed  CAS  Google Scholar 

  • Sass U, André J, Noel CH et al. (1994) Tumeur plexiforme fibrohistiocytaire. Ann Dermatol Venereol 121: 109–112

    PubMed  CAS  Google Scholar 

  • Fletcher CDM (1998) Myofibroblastic tumors: An Update. Verh Dtsch Ges Pathol 82: 75–82

    PubMed  CAS  Google Scholar 

  • Kamino H, Reddy VB, Gero M, Greco MA (1992) Dermatomyofibroma. A benign cutaneous, plaque-like proliferation of fibroblasts and myofibroblasts in young adults. J Cutan Pathol 19: 85–93

    Google Scholar 

  • Kutzner H (1998) Perivaskuläre Myome: ein neues Konzept „myofibroblastärer“ Tumoren mit perivaskulärer myoider Differenzierung. Verh Dtsch Ges Pathol 82: 301–308

    PubMed  CAS  Google Scholar 

  • Kutzner H, Hügel H, Rütten A, Braun M (1993) Erworbenes gutartiges Myofibrom der Haut ( Adultes Myofibrom ). Hautarzt 44: 561–568

    Google Scholar 

  • Mentzel T, Katenkamp D (1998) Myofibroblastäre Tumoren. Pathologe 19: 176–186

    Article  PubMed  CAS  Google Scholar 

  • Mentzel T, Calonje E, Fletcher CDM (1993) Dermatomyofibroma: Additional observations on a distinctive cutaneous myofibroblastic tumor with emphasis on differential diagnosis. Br J Dermatol 129: 69–73

    Google Scholar 

  • Dal Cin P, Sciot R, De Smet L, van den Berge H (1998) Translocation 2;11 in a fibroma of tendon sheath. Histopathology 32: 433–435

    Article  Google Scholar 

  • Eckert F, Schauch B (1992) Das Sehnenscheidenfibrom. Ein Fallbericht mit immunhistochemischen Untersuchungen. Hautarzt 43: 92–96

    Google Scholar 

  • Maluf HM, DeYong BR, Swanson PE, Wick MR (1995) Fibroma and giant cell tumor of the tendon sheath: A comparative histological and immunohistological study. Mod Pathol 8: 155–159

    Google Scholar 

  • Sciot R, Samson I, van den Berge H, van Damme B, Dal-Cin P (1999) Collagenous fibroma (desmoplastic fibroma): Genetic link with fibroma of tendon sheath? Mod Pathol 12: 565–568

    PubMed  CAS  Google Scholar 

  • Goldblum JR, Tuthill RJ (1997) CD34 and factor XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma. Am J Dermatopathol 19: 147–153

    Article  PubMed  CAS  Google Scholar 

  • Kosanke U (1999) Ergebnisse der Therapie des Dermatofibrosarcoma protuberans mit Hilfe der mikrographisch kontrollierten Chirurgie. Medizinische Dissertation, Klinik für Dermatologie/Charité, Humboldt-Universität zu Berlin

    Google Scholar 

  • Kutzner H (1993) Expression of human progenitor cell antigen CD34 (HPCA-i) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalinfixed, paraffin-embedded tissue. Am J Acad Dermatol 28: 613–617

    Article  CAS  Google Scholar 

  • Zelger B, Sidoroff A, Stanzi U et al. (1994) Deep penetrating dermatofibroma versus dermatofibrosarcoma protuberans. Am J Surg Pathol 18: 677–686

    Article  PubMed  CAS  Google Scholar 

  • Ding J, Hashimoto H, Sugimoto T, Tsuneyoshi M, Enjoji M (1990) Bednar tumor (pigmented dermatofibrosarcoma protuberans). Acta Pathol Jpn 40: 744–754

    PubMed  CAS  Google Scholar 

  • Goodland JR, Mentzel T, Fletcher CDM (1995) Low grade fibromyxoid sarcoma: A clinicpathological analysis of eleven new cases in support of a distinct entity. Histopathology 26: 229–237

    Google Scholar 

  • Orlandi A, Bianchi L, Spagnoli LG (1998) Myxoid dermatofibrosarcoma protuberans: Morphological, ultrastructural and immunohistochemical features. J Cutan Pathol 25: 386–393

    Google Scholar 

  • Calonje E, Fletcher CDM (1996) Myoid differentiation in dermatofibrosarcoma protuberans and its fibrosarcomatous variant: Clinicopathologic analysis in 5 cases. J Cutan Pathol 23: 30–36

    Article  PubMed  CAS  Google Scholar 

  • Sanz-Trelles A, Ayala-Carbonero A, Rodrigo-Fernandez I, Weil-Lara B (1998) Leiomyomatous nodules and bundles of vascular origin in the fibrosarcomatous variant of dermatofibrosarcoma protuberans. J Cutan Pathol 25: 44–49

    Article  PubMed  CAS  Google Scholar 

  • Fletcher CDM (1998) Recent developments in soft tissue tumors. Verh Dtsch Ges Pathol 82: 33–46

    PubMed  CAS  Google Scholar 

  • Silverman JS, Tamsen A (1998) A cutaneous case of giant cell angiofibroma occurring with dermatofibrosarcoma protuberans and showing bimodal CD34+ fibroblastic and FXIIIa+ histiocytic immunophenotype. J Cut Pathol 26: 265–270

    Article  Google Scholar 

  • Mentzel T, Katenkamp D, Fletcher CDM (1996) Low malignancy myxofibrosarcoma versus low malignancy fibromyxoid sarcoma. Distinct entities with similar names but different clinical course. Pathologe 17: 116–121

    Google Scholar 

  • de Saint-Aubain-Somerhausen N, Rubin BP, Fletcher CD (1999) Myxoid solitary fibrous tumor: A study of seven cases with emphasis on differential diagnosis. Mod Pathol 12: 463–471

    Google Scholar 

  • Eyden BP, Christensen L, Tagore V, Harris M (1992) Myofibrosarcoma of subcutaneous soft tissue of the cheek. J Submicrosc Cytol 24: 307–313

    CAS  Google Scholar 

  • Mentzel T, Dry S, Katenkamp D, Fletcher CDM (1998) Low-grade myofibroblastic sarcoma. Am J Surg Pathol 22: 1228–1238

    Article  PubMed  CAS  Google Scholar 

  • Fish FS (1996) Soft tissue sarcomas in dermatology. Dermatol Surg 22: 268–273

    PubMed  CAS  Google Scholar 

  • Hollowood K, Fletcher CDM (1995) Malignant fibrous histiocytoma: Morphologic pattern or pathologic entity? Semin Diagn Pathol 12: 210–220

    PubMed  CAS  Google Scholar 

  • Lazova R, Moynes R, May D, Scott G (1997) LN-2 (CD74) a marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer 79: 2115–2124

    Article  PubMed  CAS  Google Scholar 

  • Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, Fletcher CDM (1996) Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol 20: 391–405

    Article  PubMed  CAS  Google Scholar 

  • Ehrlich HP, Desmoulière A, Diegelmann RF et al. (1994) Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 145: 105–113

    PubMed  CAS  Google Scholar 

  • Lee TY, Chin GS, Kim WJ; Chau D, Gittes GK, Longaker MT (1999) Expression of transforming growth factor beta 1, 2, and 3 proteins in keloids. Ann Plast Surg 43: 179 - i84

    PubMed  CAS  Google Scholar 

  • Goodlad JR, Fletcher CDM (1990) Intradermal variant of nodular „fasciitis“. Histopathology 17: 569–571

    Article  PubMed  CAS  Google Scholar 

  • Kiryu H, Takeshita H, Hori Y (1997) Proliferative Fasciitis. Am J Dermatopathol 19: 396–399

    Article  PubMed  CAS  Google Scholar 

  • Lai FM-M, Lam WY (1993) Nodular fasciitis of the dermis. J Cutan Pathol 20: 66–69

    Article  PubMed  CAS  Google Scholar 

  • Price SK, Kahn LB, Saxe N (1993) Dermal and intravascular fasciitis. Am J Dermatopathol 15: 539–543

    Article  PubMed  CAS  Google Scholar 

  • Samaratunga H, Earle J, O’Loughlin B (1996) Nodular fasciitis and related pseudosarcomatous lesions of soft tissue. Aust N Z J Surg 66: 22–25

    Article  PubMed  CAS  Google Scholar 

  • Enzinger FM, Weiss S (eds) (1994) Benign soft tissue tumors of uncertain type. In: Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 1053–1054

    Google Scholar 

  • Hernandez-Lugo AM, Domínguez-Cherit J, Vega-Memije ME (1999) Digital mucoid cyst: The ganglion type. Int J Dermatol 38: 531–538

    Google Scholar 

  • Enzinger FM, Weiss S (eds) (1994) Benign soft tissue tumors of uncertain type. In: Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 1051–1052

    Google Scholar 

  • Wilk M, Schmoeckel C (1994) Cutaneous focal mucinosis–a histopathological and immunohistochemical analysis of n cases. J Cutan Pathol 21: 446–452

    Article  PubMed  CAS  Google Scholar 

  • Calonje E, Guerin D, McCormick D, Fletcher CDM (1999) Superficial angiomyxoma: Clinicopathological analysis of a series of distinctive but poorly recognized cutaneous tumors with tendency for recurrence Am J Surg Pathol 23: 910–917

    CAS  Google Scholar 

  • Carney JA, Headington JT, Daniel Su WP (1986) Cutaneous myxomas. Arch Dermatol 122: 790–798

    Article  PubMed  CAS  Google Scholar 

  • Wilk M, Schmoeckel C, Kaiser HW, Hepple R Kreysel HW (1995) Cutaneous angiomyxoma: A benign neoplasm distinct from cutaneous focal mucinosis. J Am Acad Dermatol 33: 352–355

    Google Scholar 

  • Cooper PH (1992) Fibrous proliferations of infancy and childhood. J Cutan Pathol 19: 257–67

    Article  PubMed  CAS  Google Scholar 

  • Gabbiani G, Majno G (1972) Dupuytren’s contracture: Fibroblast contraction? Am J Pathol 66: 131–146

    PubMed  CAS  Google Scholar 

  • Häyry P, Reitamo JJ, Tötterman S, Hopfner-Hallikainen D, Sivula A (1982) The desmoid tumor. II. Am J Clin Pathol 77: 674–680

    Google Scholar 

  • Hügel H (1991) Die plaqueförmige dermale Fibromatose. Hautarzt 42: 223–226

    PubMed  Google Scholar 

  • Hügel H, Allen PW (1995) Fibromatosen und andere fibroblastisch/myofibroblastisch differenzierte Bindegewebstumoren aus der Sicht des Dermatologen. Z Hautkr 70: 717–724

    Google Scholar 

  • Jennins TA, Duray PH, Collins FS, Sabetta J, Enzinger FM (1984) Infantile myofibromatosis. Evidence for an autosomal-dominant disorder. Am J Surg Pathol 18: 529–538

    Google Scholar 

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Authors
  1. H. Audring
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  2. W. Sterry
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Editors and Affiliations

  1. Universitätsklinik für Dermatologie und Venerologie, Karl-Franzens-Universität Graz, Auenbruggerplatz 8, A-8036, Graz, Österreich

    Helmut Kerl  & Lorenzo Cerroni  & 

  2. Universitäts-Hautklinik, Eberhard-Karls-Universität Tübingen, Liebermeisterstraße 25, D-72076, Tübingen, Deutschland

    Claus Garbe

  3. Klinik für Dermatologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Deutschland

    Helmut H. Wolff

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Audring, H., Sterry, W. (2003). Bindegewebetumoren der Haut. In: Kerl, H., Garbe, C., Cerroni, L., Wolff, H.H. (eds) Histopathologie der Haut. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07784-9_34

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  • DOI: https://doi.org/10.1007/978-3-662-07784-9_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07785-6

  • Online ISBN: 978-3-662-07784-9

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