Zusammenfassung
Kutane Adnextumoren mit duktaler Differenzierung unterteilt man üblicherweise in Tumoren mit apokriner und ekkriner Differenzierung. Die morphologische Unterscheidung ist nicht immer eindeutig, weil die Drüsenausführungsgänge apokriner und ekkriner Adnextumoren morphologisch häufig nicht unterscheibar sind. Das klassische morphologische Merkmal für Adnextumoren mit apokriner Differenzierung, die so genannte „Dekapitationsekretion“, kann man gelegentlich auch bei Adnextumoren mit ekkriner Differenzierung beobachten. Deshalb gibt es noch immer Debatten über die Histogenese einiger dieser kutanen Adnextumoren mit duktaler Differenzierung. Der Großteil der apokrinen Adnextumoren ist gutartig, und nur selten wurden bösartige Varianten beschrieben. Maligne apokrine Adnextumoren weisen ein breites morphologisches Spektrum auf, wodurch manchmal eine eindeutige histologische Klassifikation erschwert wird (Tabelle 31.1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Ansai S, Koseki S, Hozumi Y, Kondo S (1995) An immunohistochemical study of lysozyme, CD-15 (Leu Mi), and gross cystic disease fluid protein-15 in various skin tumors. Assessment of the specificity and sensitivity of markers of apocrine differentiation. Am J Dermatopathol 17: 249–255
Gianotti R, Coggi A, Alessi E (1998) Cutaneous apocrine mixed tumor: Derived from the apocrine duct of the folliculosebaceous-apocrine unit? Am J Dermatopathol 20: 323–325
Mazoujian G, Pinkus GS, Haagensen DE Jr (1984) Extra-mammary Paget’s disease–evidence for an apocrine origin. An immunoperoxidase study of gross cystic disease fluid protein-15, carcinoembryonic antigen, and keratin proteins. Am J Surg Pathol 8: 43–50
Ohnishi T, Watanabe S (1997) Histogenesis of mixed tumor of the skin, apocrine type: Immunohisto chemical study of keratin expression. Am J Dermatopathol 19: 456–461
Requena L, Kiryu H, Ackerman AB (1998) Neoplasms with apocrine differentiation. Lippincott-Raven, Philadelphia
Ando K, Hashikawa Y, Nakashima M, Nakayama A, Ohashi M (1991) Pure apocrine nevus: a study of light microscopic and immunohistochemical features of a rare tumor. Am J Dermatopathol 13: 71–76
Herrmann JJ, Eramo LR (1995) Congenital apocrine hamartoma: An unusual clinical variant of organoid nevus with apocrine differentiation. Pediatr Dermatol 12: 248–251
Neill JS, Park HK (1993) Apocrine nevus: Light microscopic, immunohistochemical and ultrastructural studies of a case. J Cutan Pathol 20: 79–83
Rabens SF, Naness JI, Gottlieb BF (1976) Apocrine gland organic hamartoma (apocrine nevus). Arch Dermatol 112: 520–522
Vakilzadeh F, Happle R, Peters P, Macher E (1976) Fokale dermale Hypoplasie mit apokrinen Naevi und streifenförmiger Anomalie der Knochen. Arch Dermatol Res 256: 189–195
Müller-Hess S, Delacretaz J (1973) Trichoepitheliom mit Strukturen eines apocrinen Adenoms. Dermatologica 146: 170–176
Okun MR, Finn R, Blumental G (1980) Apocrine adenoma 31 versus apocrine carcinoma. Report of two cases. J Am Acad Dermatol 2: 322–326
Warkel RL, Helwig EB (1978) Apocrine gland adenoma and adenocarcinoma of the axilla. Arch Dermatol 114: 198–203
Camisa C (1980) Accessory breast on the posterior thigh of a man. J Am Acad Dermatol 3: 467–469
Hrabovszky T, Schneider I, Zombai E (1995) Axilläre akzessorische Brustdrüse. Hautarzt 46: 576–578
Toumbis-loannou E, Cohen PR (1994) Familial polythelia. J Am Acad Dermatol 30: 667–668
Weinberg SK, Motulsky AG (1976) Aberrant axillary breast tissue: A report of a family with six affected women in two generations. Clin Genet 10: 325–328
Lynde CW, McLean DI, Wood WS (1984) Tumors of cerumi-nous glands. J Am Acad Dermatol u: 841–847
Michel RG, Woodard BH, Shelburne JD, Bossen EH (1978) Ceruminous gland adenocarcinoma: A light and electron microscopic study. Cancer 41: 545–553
Neldner KH (1968) Ceruminoma. Arch Dermatol 98: 344–348
Wetli CV, Pardo V, Millard M, Gerston K (1972) Tumors of ceruminous glands. Cancer 29: 169–178
Brownstein MH, Phelps RG, Magnin PH (1985) Papillary adenoma of the nipple: Analysis of fifteen new cases. J Am Acad Dermatol 12: 707–715
Hödl S, Kerl H, Kresbach H (1978) Krankheiten im Bereich der Mamille. Hautarzt 29: 548–549
Marsch WC, Nürnberger F (1979) Das Mamillenadenom. Z Hautkr 54: 1067–1072
Montemarano AD, Sau P, James WD (1995) Superficial papillary adenomatosis of the nipple: A case report and review of the literature. J Am Acad Dermatol 33: 871–875
Smith NP, Wilson Jones E (1977) Erosive adenomatosis of the nipple. Clin Exp Dermatol 2: 79–84
Requena L, Sanchez Yus E, Santa Cruz DJ (1992) Apocrine type of cutaneous mixed tumor with follicular and sebaceous differentiation. Am J Dermatopathol 14: 186–194
Wilk M, Klesper D, Uerlich M, Biwer E, Wimheuer R (1994) Chondroides Syringom. Immunohistologische Hinweise für eine myoepitheliale Differenzierung. Hautarzt 45: 324–329
Zumdick M, Milde P, Ruzicka T, Hölzle E (1995) Apokriner kutaner Mischtumor mit follikulärer Differenzierung. Hautarzt 46: 481–484
Karnbach C, Neuber K, Diaz-Cascajo C, Steinkraus V (1998) Syringocystadenoma papilliferum und Trichoblastom innerhalb eines Naevus sebaceus. Hautarzt 49: 654–656
Mammino JJ,Vidmar DA (1991) Syringocystadenoma papilliferum. Int J Dermatol 30: 763–766
Mensing H, Jaenner M (1981) Naevus sebaceus Jadassohn und Syringocystadenoma papilliferum. Epitheliale Hamartombildungen der Haut. Hautarzt 32: 130–135
Pullmann H, Pfeiff B (1985) Syringocystadenoma papilliferum als Differentialdiagnose eines Unterlippenkarzinoms. Z Hautkr 60: 348–355
Vanatta PR, Bangert JL, Freeman RG (1985) Syringocystadenoma papilliferum. A plasmacytotropic tumor. Am J Surg Pathol 9: 678–683
Toribio J, Zulaica A, Peteiro C (1987) Tubular apocrine adenoma. J Cutan Pathol 14: 114–117
Ceballos PI, Penneys NS, Acosta R (1990) Aggressive digital papillary adenocarcinoma. J Am Acad Dermatol 23: 331–334
Duke WH, Sherrod TT, Lupton GP (2000) Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). Am J Surg Pathol 24: 775–784
Kao GF, Helwig EB, Graham JH (1987) Aggressive digital papillary adenoma and adenocarcinoma. A clinico-pathological study of 57 patients, with histo chemical, immunopathological, and ultrastructural observations. J Cutan Pathol 14: 129–146
Dhawan SS, Nanda VS, Grekin S, Rabinovitz HS (1990) Apocrine adenocarcinoma: Case report and review of the literature. J Dermatol Surg Oncol 16: 468–470
Kuno Y, Numata T, Kanzaki T (1999) Adenocarcinoma with signet ring cells of the axilla showing apocrine features: A case report. Am J Dermatopathol 21: 37–41
Nishikawa Y, Tokusashi Y, Saito Y, Ogawa K, Miyokawa N, Katagiri M (1994) A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. Am J Surg Pathol 18: 832–836
Stout AP, Cooley SGE (1951) Carcinoma of sweat glands. Cancer 4: 521–536
Warkel RL, Helwig EB (1978) Apocrine gland adenoma and adenocarcinoma of the axilla. Arch Dermatol 114: 198–203
Armitage NC, Jass JR, Richman PI, Thomson JP, Phillips RK (1989) Paget’s disease of the anus: A clinicopathological study. Br J Surg 76: 60–63
Goldblum JR, Hart WR (1998) Perianal Paget’s disease: A histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. Am J Surg Pathol 22: 170–179
Lautier R, Achtelik WV, Wolff HH (1990) Immunhistochemische Untersuchungen beim mammären und extramammären Morbus Paget weisen auf eine apokrine Differenzierung. Z Hautkr 65: 571–574
Neumann R (1986) Extramammärer Morbus Paget–assozi- iert mit einem Magenkarzinom. Hautarzt 37: 568–570
Urabe A, Matsukuma A, Shimizu N, Nishimura M, Wada H, Hori Y (1990) Extramammary Paget’s disease: Comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. J Cutan Pathol 17: 257–265
Bates AW, Baithun SI (1998) Atypical mixed tumor of the skin: Histologic, immunohistochemical, and ultrastructural features in three cases and a review of the criteria for malignancy. Am J Dermatopathol zo: 35–40
Ishimura E, Iwamoto H, Kobashi Y, Yamabe H, Ichijima K (1983) Malignant chondroid syringoma. Report of a case with widespread metastasis and review of pertinent literature. Cancer 52: 1966–1973
Metzler G, Schaumburg-Lever G, Hornstein O, Rassner G (1996) Malignant chondroid syringoma: Immunohistopathology. Am J Dermatopathol 18: 83–89
Trown K, Heenan PJ (1994) Malignant mixed tumor of the skin (malignant chondroid syringoma). Pathology 26: 237–243
Antley CA, Carney M, Smoller BR (1999) Microcystic adnexal carcinoma arising in the setting of previous radiation therapy. J Cutan Pathol 26: 48–50
Carroll P, Goldstein GD, Brown CW Jr (2000) Metastatic microcystic adnexal carcinoma in an immunocompromised patient. Dermatol Surg 26: 531–534
Friedman PM, Friedman RH, Jiang SB, Nouri K, Amonette R, Robins P (1999) Microcystic adnexal carcinoma: Collaborative series review and update. J Am Acad Dermatol 41: 225–231
Goldstein DJ, Barr RJ, Santa Cruz DJ (1982) Microcystic adnexal carcinoma: A distinct clinicopathologic entity. Cancer 50: 566–572
Rank C, Bastian BC, Pistner H, Bröcker EB, Hamm H (1996) Das mikrozystische Adnexkarzinom der Haut. Hautarzt 47: 284–288
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kaddu, S., Soyer, HP., Kerl, H. (2003). Adnextumoren mit apokriner Differenzierung. In: Kerl, H., Garbe, C., Cerroni, L., Wolff, H.H. (eds) Histopathologie der Haut. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07784-9_31
Download citation
DOI: https://doi.org/10.1007/978-3-662-07784-9_31
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-07785-6
Online ISBN: 978-3-662-07784-9
eBook Packages: Springer Book Archive