Advertisement

Merkel-Zellkarzinom

Zusammenfassung

Merkel-Zellkarzinome sind neuroendokrin differenzierte Karzinome der Haut, deren Histogenese umstritten ist. Als Ursprungszelle werden die Merkel-Zellen der interfollikulären Epidermis und des Haarfollikels diskutiert, aber auch pluripotente, stammzellenähnliche Keratinozyten der Epidermis und der Adnexe.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Johansson L, Tennvall J, Akerman M (199o) Immunohistochemical examination of 25 cases of Merkel cell carcinoma: A comparison with small cell carcinoma of the lung and esophagus, and a review of the literature. Acta Pathol Microbiol Immunol Scand 98: 741–752Google Scholar
  2. Leonard JH, Leonard P, Kearsley JH (1993) Chromosomes 1, u, and 13 are frequently involved in karyotypic abnormalities in metastatic Merkel cell carcinoma. Cancer Genet Cytogenet 67: 65–7oPubMedCrossRefGoogle Scholar
  3. Moll R, Osborn M, Hartschuh W, Moll I, Mahrle G, Weber K (1986) Variability of expression and arrangement of cytokeratin and neurofilaments in cutaneous neuroendocrine carcinomas ( Merkel cell tumors ): Immunocytochemical and biochemical analysis of twelve cases. Ultrastruct Pathol 10: 473–495Google Scholar
  4. Moll R, Moll I, Gould VE (1997) Neuroendocrine Merkel cells of the skin and their neoplasms. In: Lechago J, Gould VE (eds) Bloodworth’s Endocrine Pathology. Williams & Wilkins, Baltimore, pp 641–661Google Scholar
  5. Ratner D, Nelson BR, Brown MD, Johnson TM (1993) Merkel cell carcinoma. J Am Acad Dermatol 29: 143–156PubMedCrossRefGoogle Scholar
  6. Silva E, Mackay B (1981) Neuroendocrine (Merkel cell) carcinomas of the skin: An ultrastructural study of nine cases. Ultrastruct Pathol 2: 1–9Google Scholar
  7. Toker C (1972) Trabecular carcinoma of the skin. Arch Dermatol 105: 107–110PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • I. Moll

There are no affiliations available

Personalised recommendations