Skip to main content

Verhornungsstörungen, hereditäre Epidermolysen und epidermale Fehlbildungen

  • Chapter
Histopathologie der Haut
  • 118 Accesses

Zusammenfassung

In diesem Kapitel sollen eine Reihe monogener Erkrankungen besprochen werden, bei denen genetische Ursachen ein spezifisches klinisches Krankheitsbild und eine bestimmte Histopathologie verursachen. Für die Diagnosefindung ist die Kenntnis der histopathologischen Veränderungen in vielen Fällen hilfreich, aber oft eben auch nur ein Baustein in der Diagnosefindung unter anderen. Dies gilt insbesondere für die große Gruppe der Verhornungsstörungen, die häufig ein relativ monomorphes histopathologisches Bild wie eine benigne epidermale Hyperproliferation aufweisen, ohne dass die Histologie alleine einen Rückschluss auf eine bestimmte Diagnose definitiv erlaubt. Die Verknüpfung von klinischem Bild und histologischem Substrat sind deshalb gerade bei Verhornungsstörungen von besonderer Wichtigkeit.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Anton-Lamprecht I, Hofbauer U (1972) Ultrastructural distinction of autosomal dominant ichthyosis vulgaris and X-linked recessive ichthyosis. Hum Genet 15: 261–264

    Article  CAS  Google Scholar 

  • Davies MG, Marks A, Dykes PJ, Reynolds D (1977) Epidermal ab- normalities in Refsum’s disease. Br J Dermatol 97: 401–406

    Article  PubMed  CAS  Google Scholar 

  • Paige DG, Emilian GG, Bouloux PM, Harper JI (1994) A clinical and genetic study of X-linked recessive ichthyosis and contiguous gene defects. Br J Dermatol 131: 622–629

    Article  PubMed  CAS  Google Scholar 

  • Traupe H, Happle R (1983) Clinical spectrum of steroid sulfatase deficiency: X-linked recessive ichthyosis, birth complications and cryptorchidism. Eur J Pediaatr 14o: 19–21

    Google Scholar 

  • Wells RS, Kerr CB (1966) The histology of ichthyosis. J Invest Dermatol 46: 530–535

    Google Scholar 

  • Buyse L, Graves C, Marks R, Wijeyseheru K, Alfaham M, Finlay (1993) Collodium baby dehydration: The danger of high transepidermal water loss. Br J Dermatol 129: 86–88

    Google Scholar 

  • Dale BA, Holbrook KA, Fleckman P, Kimball JR, Brumbaugh S, Sybert VP (1990) Heterogeneity in harlequin ichthyosis, an inborn error of epidermal keratinization. J Invest Dermatol 94: 6–18

    Article  PubMed  CAS  Google Scholar 

  • Fischer J, Fanie A, Bonadisar B et al. (2000) Two new loci for autosomal recessive ichthyosis on chromosome 3p21 and 19p12-q12 and evidence for further genetic heterogeneity. Am J Hum Genet 66: 904–913

    Google Scholar 

  • Hohl D, Aeschlimann D, Huber M (1998) In vitro and rapid in situ transglutaminase assays for congenital ichthyoses–a comparative study. J Invest Dermatol z: 268–271

    Google Scholar 

  • Huber M, Rettler I, Bernasconi K et al. (1995) Mutations of keratinocyte transglutaminase in lamellar ichthyosis. Science 267: 525–528

    Article  PubMed  CAS  Google Scholar 

  • Kolde G, Happle R, Traupe H (1985) Autosomal dominant lamellar ichthyosis: Ultrastructural characteristics of a new type of lamellar ichthyosis. Arch Dermatol Res 278: 1–5

    Google Scholar 

  • Parmentier L, Lakhdar H, Blanchet-Bardon C, Marchaud S, Dubertret L, Weissenbach J (1996) Mapping of a second locus for lamellar ichthyosis to chromosome 2q33–35. Hum Mol Genet 5: 555–559

    Google Scholar 

  • Raghunath M, Hennies HC, Velten F, Wiebe K, Steinert PM, Reis A, Traupe H (1998) A novel in situ method for the detection of deficient transglutaminase activity in the skin. Arch Dermatol Res 290: 621–627

    Article  PubMed  CAS  Google Scholar 

  • Traupe H (1989) The ichthyoses.A guide to clinical diagosis, genetic counseling, and therapy. Springer, Berlin Heidelberg New York Tokyo, pp 103–138

    Google Scholar 

  • Joh GY, Traupe H, Metze D et al. (1997) A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma. J Invest Dermatol 108: 357–361

    Article  PubMed  CAS  Google Scholar 

  • Rothnagel JA (1996) The role of keratin mutations in disorders of the skin. Curr Opin Dermatol 3: 127–136

    Google Scholar 

  • Rothnagel JA, Traupe H, Wojcik S et al. (1994) Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens. Nat Genet 7: 485–490

    Article  PubMed  CAS  Google Scholar 

  • Traupe H, Kolde G, Hamm H, Happle R (1986) Ichthyosis bullosa of Siemens: A unique type of epidermolytic hyperkeratosis. J Am Acad Dermatol 14: 1000–1005

    Google Scholar 

  • Traupe H (1989) The ichthyoses. A guide to clinical diagnosis, genetic counseling, and therapy. Springer, Berlin Heidelberg New York Toyko, pp 139–153

    Google Scholar 

  • Braverman N, Lin P, Moebius FF et al. (1999) Mutations in the gene encoding 3-beta-hydroxysteroid-delta 8, delta 7isomerase cause X-linked dominant Conradi-Hünermann syndrome. Nat Genet 22: 291–294

    Article  PubMed  CAS  Google Scholar 

  • Broughton BC, Steingrimmsdottir H, Weber CH, Lehmann AR (1994) Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy. Nat Genet 7: 189–194

    Google Scholar 

  • Chavanas S, Bodemer C, Rochat A et al. (2000) Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 25: 141–142

    Article  PubMed  CAS  Google Scholar 

  • Fartasch M, Williams ML, Elias PM (1994) Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: Differentiation from other infantile erythrodermas and pathogenic implications. Arch Derm 135: 823–832

    Google Scholar 

  • De-Laurenzi V, Rogers GR, Hamrock DJ et al. (1996) SjoegrenLarsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene. Nat Genet 12: 52–57

    Google Scholar 

  • Elias PM, Williams ML (1989) Neutral lipid storage disease with ichthyosis, defective lamellar body, content and intracellular dispersion. Arch Dermatol 121: 1000–1008

    Article  Google Scholar 

  • Hamm H, Meinecke P, Traupe H (1991) Further delineation of the ichthyosis follicularis, atrichia, and photophobia syndrome. Eur J Pediatr 15o: 627–629

    Article  Google Scholar 

  • Happle R (1979) X-linked dominant chondrodysplasia punctata. Review of literature and report of a case. Hum Genet 53: 65–73

    Google Scholar 

  • Has C, Bruckner-Tuderman LB, Müller D, Floeth M, Folkers E, Donnai D, Traupe H (moo) The Conradi-HünermannHapple syndrome (CDPX2) and emopamil binding protein: Novel mutations, and somatic and gonadal mosaicism. Hum Mol Genet 9: 1951-1955

    Google Scholar 

  • Kolde G, Happle R (1984) Histologic and ultrastructural features of the ichthyotic skin in X-linked dominant chondrodysplasia punctata. Acta Dermatol Venereol (Stockh) 64: 389–394

    Google Scholar 

  • Rebora A, Crovato F (1987) PIBI(D)S syndrome–trichothiodystrophy with xeroderma pigmentosum (group D) mutation. J Am Acad Dermatol 16: 940–947

    Article  PubMed  CAS  Google Scholar 

  • Feinstein A, Friedman J, Schewach-Millet M (1998) Pachyonychia congenita. J Am Acad Dermatol 19: 705–711 Fischer J, Bouadjar B, Heilig R, Fizames C, Prud’homme JF

    Google Scholar 

  • Weissenbach J (1998) Genetic linkage of Meleda disease to chromosome 8qter. Eur J Hum Genet 6: 542–547 Greither A (1977) Erbliche Palmoplantarkeratosen. Hautarzt 28: 395–403

    Google Scholar 

  • Guerriero C, Albanesi C, Girolomoni G, De Simone C, Capizzi R (2000) Huriez syndrome: Case report with a detailed analysis of skin dendritic cells. Br J Dermatol 143: 1091–1096

    Google Scholar 

  • Hamm H, Happle R, Butterfass T, Traupe H (1988) Epidermolytic palmplantar keratoderma of Vörner: is it the most frequent type of hereditary palmplantar keratoderma? Dermatologica 177: 138–145

    Article  PubMed  CAS  Google Scholar 

  • Hamm H, Traupe H, Bröcker EB, Schubert H, Kolde G (1996) The scleroatrophic syndrome of Huriez: A cancer-prone genodermatosis. Br J Dermatol 134: 512–518

    Google Scholar 

  • Hennies HC, Zehender D, Kunze J, Küster W, Reis A (1994) Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma. Hum Genet 94: 649–654

    Google Scholar 

  • Hennies HC, Küster W, Mischke D, Reis A (1995) Localization of a locus for the striated form of palmoplantar keratoderma to chromosome 18q near the desmosomal cadherin gene cluster. Hum Mol Genet 4: 1015–1020

    Google Scholar 

  • Küster W, Becker A (1992) Indication for the identity of palmoplantar keratoderma type Unna-Thost with type Vörner. Thost’s family revisited no years later. Acta Dermatol Venereol 72: 120–122

    Google Scholar 

  • Laass MW, Hennies HC, Preis S, Stevens HP, Jung M, Leigh IM, Wienker TF, Reis A (1997) Localisation of a gene for Papillon-Lefevre syndrome to chromosome 11g14-q21 by homozygosity mapping. Hum Genet loi: 376–382

    Google Scholar 

  • Lucker GP, van de Kerkhof PC, Steijlen PM (1994) The hereditary palmoplantar keratoses: An updated review and classification. Br J Dermatol 131: 1–14

    Google Scholar 

  • Maestrini E, Monaco AP, McGrath JA et al. (1996) A molecular defect in loricrin, the major component of the corni-Lied cell envelope, underlies Vohwinkel’s syndrome. Nat Genet 13: 70–77

    Article  PubMed  CAS  Google Scholar 

  • Nazarro V, Blanchet-Bardon C, Mimoz C, Revuz J, Puissant C (1988) Papillon-Lefevre syndrome. Ultrastructural study and successful treatment with acitretin. Arch Dermatol 124: 533–539

    Google Scholar 

  • Reis A, Hennies HC, Langbein L et al. (1994) Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Nat Genet 6: 174–179

    Google Scholar 

  • Salomon T, Hrnjica M, Schnyder UW et al. (1988) Vier Fälle von Richner-Hanhart-Syndrom (Tyrosinämie Typ II) mit neurologischer Symptomatologie in einer jugoslawischen Familie. Hautarzt 39: 149–154

    Google Scholar 

  • Stevens HP, Kelslell DP, Bryant SP et al. (1996) Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the keratodermas. Arch Dermatol 132: 640–651

    Google Scholar 

  • Smith FJ, Gorden LD, Rugg EL et al. (1997) Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex. J Invest Dermatol 108: 220–223

    Article  PubMed  CAS  Google Scholar 

  • Toomes C, James J, Wood AJ et al. (1999) Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. Nat Genet 23: 421–424

    Google Scholar 

  • Aberdam D, Galliano MF, Vailly J et al. (1994) Herlitz’s junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (LAMININ-5). Nat Genet 6: 299-304

    Google Scholar 

  • Christiano AM, Anhalt G, Gibbons S, Bauer EA, Uitto J (1994) Premature termination codons in the type VII collagen gene (COL7A1) and severe, mutilating recessive dystrophic epidermolysis bullosa. Genomics 2: 160–168

    Article  Google Scholar 

  • Coulombe PA, Hutton ME, Letai A, Hebert A, Palier AS, Fuchs E (1991) Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analyses. Cell 66: 1301–1311

    Google Scholar 

  • Fine JD, Eady RA, Bauer EA et al. (2000) Revised classification system for inherited epidermolysis bullosa: Report of the Second International Consensus Meeting on diagnosis and classification of epidermolysis bullosa. J Am Acad Dermatol 42: 1051–1066

    Google Scholar 

  • Fuchs E, Coulombe PA (1992) Of mice and men: Genetic skin diseases of keratin. Cell 69: 899–902

    Google Scholar 

  • Hammami-Hauasli N, Schumann H, Raghunath M, Kilgus 0, Luthi U, Luger T, Bruckner-Tuderman L (1998) Some, but not all, glycine substitution mutations in COL7A1 result in intracellular accumulation of collagen VII, loss of anchoring fibrils, and skin blistering. J Biol Chem 173: 19228–19234

    Article  Google Scholar 

  • Hovnanian A, Rochat A, Bodermer C et al. (1997) Characterization of 18 new mutations in COL7A1 in recessive dystrophic epidermolysis bullosa provides evidence for distinct molecular mechanisms underlying defective anchoring fibril formation. Am J Hum Genet 61: 599–610

    Google Scholar 

  • Jonkman MF, de Jong MC, Heeres K et al. (1996) Generalized atrophic benign epidermolysis bullosa. Either 18o-kd bullous pemphigoid antigen or laminin-5 deficiency. Arch Dermatol 132: 145–150

    Article  PubMed  CAS  Google Scholar 

  • McGrath JA, Gatalica B, Christiano AM et al. (1995) Mutations in the 18o-kD bullous pemphigoid antigen (BPAG2), in atrophic benign epidermolysis bullosa. Nat Genet 11: 83–86

    Article  PubMed  CAS  Google Scholar 

  • Pulkkinen L, Rouan F, Bruckner-Tuderman L et al. (1998) Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: Missense versus nonsense. Am J Hum Genet 63: 1376–1387

    Google Scholar 

  • Schumann H, Hammami-Hauasli N, Pulkkinen L et al. (1997) Three novel homozygous point mutations and a new polymorphism in the COL17A1 gene: Relation to biological and clinical phenotypes of junctional epidermolysis bullosa. Am J Hum Genet 60: 1344–1353

    Google Scholar 

  • Smith FJ, Eady RA, Leigh IM et al. (1996) Plectin deficiency results in muscular dystrophy with epidermolysis bullosa. Nat Genet 13: 450–457

    Google Scholar 

  • Uttam J, Hutton E, Coulombe PA et al. (1996) The genetic basis of epidermolysis bullosa simplex with mottled pigmentation. Proc Natl Acad Sci U S A 93: 9079–9084

    Google Scholar 

  • Vidal F, Aberdam D, Miguel C et al. (1995) Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet 1o: 229–234

    Google Scholar 

  • Winberg JO, Hammami-Hauasli N, Nilssen O et al. (1997) Modulation of disease severity of dystrophic epidermolysis bullosa by a splice site mutation in combination with a missense mutations in the COL7A1 gene. Hum Mol Genet 6: 1125–1135

    Article  PubMed  CAS  Google Scholar 

  • Chernosky ME (1986) Porokeratosis. Arch Dermatol 122: 896–870

    Article  Google Scholar 

  • Ito M, Fujiwara H, Maruyama T et al. (1991) Morphogenesis of the cornoid lamella: Histochemical, immunohistochemical, and ultrastructural study of porokeratosis. J Cutan Pathol 18: 247–256

    Google Scholar 

  • Kutzner H, Rütten A, Hügel H (1996) Peppered pattern of cornoid lamellation: A clue to porokeratosis. Dermatopathology: Practical and Conceptual 2: 55–56

    Google Scholar 

  • Magee JW, MCCalmont HT, LeBoit PE (1994) Overexpression of p53 tumor suppressor protein in porokeratosis. Arch Dermatol 130: 187–190

    Article  PubMed  CAS  Google Scholar 

  • Mikhail GR, Wertheimer FW (1968) Clinical variants of porokeratosis ( Mibelli ). Arch Dermatol 98: 124–131

    Google Scholar 

  • Neumann RA, Knobler RM, Metze D, Jurecka W (1988) Disseminated superficial porokeratosis and immunosuppression. Br J Dermatol 119: 375–380

    Google Scholar 

  • Otsuka F, Shima A, Ishibashi Y (1989) Porokeratosis as a pre-malignant condition of the skin. Cytologic demonstration of abnormal DNA ploidy in cells of the epidermis. Cancer 63: 891–896

    Google Scholar 

  • Wade TR, Ackerman AB (1980) Cornoid lamellation. A his- tologic reaction pattern. Am J Dermatopathol 2: 5–15

    Google Scholar 

  • Altman J, Mehregan AH (1971) Inflammatory linear ver- rucous epidermal nevus. Arch Dermatol 104: 385–389

    Google Scholar 

  • Ito M, Shimizu N, Fujiwara H, Maruyama T, Tezuka M (1991) Histopathogenesis of inflammatory linear verrucous epidermal naevus: Histochemistry, immunohistochemistry and ultrastructure. Arch Dermatol Res 283: 491–499

    Google Scholar 

  • Welch ML, Smith KJ, Skelton HG (1993) Immunohistochemical features in inflammatory linear verrucous epidermal nevi suggest a distinctive pattern of clonal dysregulation of growth. J Am Acad Dermatol 29: 242–248

    Article  PubMed  CAS  Google Scholar 

  • Böhm M, Luger TA, Metze D (1999) Urethelkarzinomassoziierte Akanthosis nigricans - symptomatische Therapie mit Calcipotriol. Hautarzt 50: 593–596

    Google Scholar 

  • Brown J, Winkelmann RK (1968) Acanthosis nigricans: A study of 90 cases. Medicine (Baltimore) 47: 33–51

    Google Scholar 

  • Brubaker MM, Levan NE, Collipp PJ (1965) Acanthosis nigricans and congenital total lipodystrophy. Arch Dermatol 91: 320–326

    Article  Google Scholar 

  • Hall JM, Moreland A, Cox GJ, Wade TR (1988) Oral Acanthosis nigricans: Report of a case and comparison of oral and cutaneous pathology. Am J Dermatopathol 1o: 68–73

    Google Scholar 

  • Schwarz RA (1994) Acanthosis nigricans. J Am Acad Dermatol 31: 1–19

    Article  Google Scholar 

  • Hamilton D, Tavofogi V, Shafer JC, Hambrick GW Jr (1980) Confluent and reticulated papillomatosis of Gougerot und Carteaud. Its relation to other papillomatoses. J Am Acad Dermatol 2: 401–410

    Google Scholar 

  • Kretzschmar L,Metze D,Vehring KH,Bonsmann G (1996) Papillomatosis confluens et reticularis. Hautarzt 47: 209–213

    Article  Google Scholar 

  • Lee SH, Choi EH, Lee WS, Kang WH, Bang D (1991) Confluent and reticulated papillomatosis: A clinical, histopathological and electron microscopicy study. J Dermatol 18: 725–730

    Google Scholar 

  • Panja RK (1977) Acrokeratosis verruciformis (Hopf)–a clinical entity? Br J Dermatol 96: 643–652

    Article  PubMed  CAS  Google Scholar 

  • Schueller WA (1972) Acrokeratosis verruciformis of Hopf. Arch Dermatol 106: 81–83

    Article  PubMed  CAS  Google Scholar 

  • Balus L, Donati P, Amantea A, Breathnach AS (1988) Multiple minute digitate hyperkeratosis. J Am Acad Dermatol 18: 431–426

    Article  PubMed  CAS  Google Scholar 

  • Coleman R, Malone M, Handfield-Jones S (1994) Waxy keratoses of childhood. Clin Exp Dermatol 9:173–176 Nedwich JA, Sullivan JJ (1987) Disseminated spiked hyperkeratosis. Int J Dermatol 26: 358–361

    Google Scholar 

  • Paul C, Fermand J-P, Flageul B et al. (1995) Hyperkeratotic spicules and monoclonal gammopathy. J Am Acad Dermatol 33: 346-351

    Google Scholar 

  • Shuttleworth D, Graham-Brown RAC, Hutchinson PE (1985) Minute aggregate keratoses–a report of three cases. Clin Exp Dermatol to: 566–571

    Google Scholar 

  • Rebora A, Crovato F (1984) The spectrum of Dowling-Degos disease. Br J Dermatol 110: 627–630

    Article  PubMed  CAS  Google Scholar 

  • Schiller M, Kütting B, Luger T, Metze D (1999) Umschriebene retikuläre Hyperpigmentierungen–ein weites klinisches Spektrum. Hautarzt 50: 580–585

    Google Scholar 

  • Flegel H (1958) Hyperkeratosis lenticularis perstans. Hautarzt 9: 362–364

    Google Scholar 

  • Pearson LH, Smith JG, Chalker DK (1987) Hyperkeratosis lenticularis perstans ( Flegel’s disease ): Case report and literature review. J Am Acad Dermatol 16: 190–195

    Google Scholar 

  • Metze D, Lübke D, Luger T (2000) Hyperkeratosis lenticularis perstans (M. Flegel) - Eine komplexe Differenzierungsstörung der Epidermis mit therapeutischem Ansprechen auf ein synthetisches Vitamin-D3 Derivat. Hautarzt 51: 31–35

    Google Scholar 

  • Drachtman RA, Alter BP (1992) Dyskeratosis congenita: Clinical and genetic heterogeneity. Am J Ped Hematol/ Onco114: 297–304

    Google Scholar 

  • Marghescu S, Braun-Falco 0 (1965) Über die kongenitalen Poikilodermien ( Ein analytischer Versuch ). Dermatol Wochenschr 151: 9–19

    Google Scholar 

  • Pickenäcker A, Hildebrand A, Schmid M, Otte H-G, Metze D (1998) Poikilodermie mit warzigen Hyperkeratosen. Hautarzt 49: 586–590

    Article  PubMed  Google Scholar 

  • Katz SI, Penneys NS (1971) Sebaceous gland papules in anhidrotic ectodermal dysplasia. Arch Dermatol 103: 507–509

    Article  PubMed  CAS  Google Scholar 

  • Lamartine J, Essenfelder GM, Kibar Z et al. (2000) Mutations in GJB6 cause hidrotic epidermal dysplasia. Nat Genet 26: 142–144

    Article  PubMed  CAS  Google Scholar 

  • Lambert WC, Bilinski DL (1983) Diagnostic pitfalls in anhidrotic ectodermal dysplasia: Indications for palmar skin biopsy. Cutis 31: 182–187

    Google Scholar 

  • Reddy BSN, Chandra S, Jha PK, Singh G (1978) Anhidrotic ectodermal dysplasia. Int J Dermatol 17: 129–141

    Article  Google Scholar 

  • Solomon LM, Fretzin D, Pruzansky S (1970) Pilosebaceous dysplasia in the oral-facial-digital syndrome. Arch Dermatol 102: 598–602

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Traupe, H., Metze, D. (2003). Verhornungsstörungen, hereditäre Epidermolysen und epidermale Fehlbildungen. In: Kerl, H., Garbe, C., Cerroni, L., Wolff, H.H. (eds) Histopathologie der Haut. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07784-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07784-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07785-6

  • Online ISBN: 978-3-662-07784-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics