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Krankheiten mit subepidermaler Blasenbildung

  • M. Megahed

Zusammenfassung

Die Epidermis ist mit der darunter liegenden Dermis durch eine hochkomplizierte Basalmembranzone (BMZ) verbunden. Diese Zone ist lichtmikroskopisch als PAS-positive Linie zu erkennen, ultrastrukturell zeigen sich vier Komponenten (Abb. 14.1):

Synonym

arzneiinduziertes Lyell-Syndrom 

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Literatur

  1. Gammon WR, Kowalewski C, Chorzelski TP, Kumar V, Briggaman RA, Beutner EH (1990) Direct immunofluorescence studies of sodium chloride-separated skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. J Am Acad Dermatol 22: 664–670PubMedCrossRefGoogle Scholar
  2. Megahed M (1996) Histologie subepidermaler bullöser Dermatosen. 47. Verh Dtsch Ges Path 80: 223–228Google Scholar
  3. Megahed M, Scharffetter-Kochanek K (1994) Epidermolysis bullosa acquisita successful treatment with colchicine. Arch Dermatol Res 286: 35–40PubMedCrossRefGoogle Scholar
  4. Woo dley DT, Briggaman RA, O’Keefe EJ, Inman AO, Queen L, Gammon WR (1984) Identification of the skin basement membrane autoantigen in epidermolysis bullosa acquisita. N Engl J Med 310: 1007–1013Google Scholar
  5. Woodley DT, Burgeson RE, Lunstrom G, Bruckner-Tuderman L, Reese MJ, Briggaman RA (1988) Epidermolysis bullosa acquisita antigen is the globular carboxyGoogle Scholar
  6. Ackerman AB, Chongchitnant N, Sanchez J et al. (1997) Histologic diagnosis of inflammatory skin diseases. 2nd edn. Williams & Wilkins, BaltimoreGoogle Scholar
  7. Diaz LA, Ratrie H III, Saunders WS, Futamura S, Squiquera HL, Anhalt GJ, Giudice GJ (1990) Isolation of a human epidermal cDNA corresponding to the 180 KD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. J Clin Invest 86: 1088–1094Google Scholar
  8. Gammon WR (1991) Bullous pemphigoid. In: Jordon RE (ed) Immunologic diseases of the skin. Appleton & Lange, Norwalk, pp 293–302Google Scholar
  9. Gammon WR, Kowalewski C, Chorzelski TP, Kumar V, Briggaman RA, Beutner EH (1990) Direct immunofluorescenceGoogle Scholar
  10. studies of sodium chloride-separated skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. J Am Acad Dermatol 22: 664–67oGoogle Scholar
  11. Giudice GJ, Emery DJ, Diaz LA (1992) Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP 180. J Invest Dermatol 99: 243–250PubMedCrossRefGoogle Scholar
  12. Labib RS, Anhalt GJ, Patel HP, Mutasim DF, Diaz LA (1986) Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 136: 1231–1235PubMedGoogle Scholar
  13. Megahed M (1996) Histologie subepidermaler bullöser Dermatosen. 47. Verh Dtsch Ges Path 8o: 223–228Google Scholar
  14. Müller S, Klaus-Kovtun V, Stanley JR (1989) A 23o-kD basic protein is the major bullous pemphigoid antigen. J Invest Dermatol 92: 33–38CrossRefGoogle Scholar
  15. Artik S, Schmiedeb erg Sv, Schuppe HC, Ruzicka T, Megahed M (1998) Herpes gestationis. Zr Hautkr 73: 701–703Google Scholar
  16. Ghohestani R, Nicolas JF, Kanitakis J, Bedane C, Faure M, Claudy A (1996) Pemphigoid gestationis with autoantibodies exclusively directed to the 230-kDa bullous pemphigoid antigen. Br J Dermatol 134: 603–604PubMedCrossRefGoogle Scholar
  17. Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA (1993) Bullous pemphigoid and herpes gestationis auto-antibodies recognize a common non-collagenous site on the BP 180 ectodomain. J Immunol 151: 5742–5750PubMedGoogle Scholar
  18. Holmes RC, Black MM, Jurecka W et al. (1983) Clues to the aetiology and pathogenesis of herpes gestationis. Br J Dermatol 109: 131–139PubMedCrossRefGoogle Scholar
  19. Shornick JK (1987) Herpes gestationis. J Am Acad Dermatol 17: 539–556PubMedCrossRefGoogle Scholar
  20. Shornick JK (1992) Fetal risks in herpes gestationis. J Am Acad Dermatol 26: 63–68PubMedCrossRefGoogle Scholar
  21. Shornick JK, Stastny P, Gilliam JN (1983) Paternal histocompatibility ( HLA) antigens and maternal anti-HLA antibodies in herpes gestationis. J Invest Dermatol 81: 407–409Google Scholar
  22. Allen CM, Camisa C, Grimwood R (1987) Lichen planus pemphigoides: Report of a case with oral lesions. Oral Surg Oral Med Oral Pathol 63: 184–188Google Scholar
  23. Borrego Hernando L, Vanaclocha Sebastian F, Hergueta Sanchez J, Ortiz Romero P, Iglesias Diez L (1992) Lichen planus pemphigoides in a 10-year-old girl. J Am Acad Dermatol 26: 124–125CrossRefGoogle Scholar
  24. Bouloc A, Vignon-Pennamen MD, Caux F et al. (1998) Lichen planus pemphigoides is a heterogeneous disease: A report of five cases studied by immunoelectron microscopy. Br J Dermatol 138: 972–980Google Scholar
  25. Kaposi M (1892) Lichen ruber pemphigoides. Arch Dermatol Syphilol (Berl) 24: 343–346Google Scholar
  26. Murphy GM, Cronin E (1989) Lichen planus pemphigoides. Clin Exp Dermatol 14: 322–324PubMedCrossRefGoogle Scholar
  27. Sobel S, Miller R, Shatin H (1976) Lichen planus pemphigoides. Immunofluorescence findings. Arch DermatolGoogle Scholar
  28. 112:.
  29. Tamada Y, Yokochi K, Nitta Y, Ikeya T, Hara K, Owaribe K (1995) Lichen planus pemphigoides: Identification of 18o kd hemidesmosome antigen. J Am Acad Dermatol 32: 883–887PubMedCrossRefGoogle Scholar
  30. Willsteed E, Bhogal BS, Das AK, Wojnarowska F, Black MM, McKee PH (1991) Lichen planus pemphigoides: A clinico-pathological study of nine cases. Histopathology 19: 147–154Google Scholar
  31. Zillikens D, Caux F, Mascaro JM et al. (1999) Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16 A domain of BP180. J InvestGoogle Scholar
  32. Dermatol 113: 117–121Google Scholar
  33. Ahmed AR, Kurgis BS, Rogers RS (1991) Cicatricial pemphigoid. J Am Acad Dermatol 24: 987–1001PubMedCrossRefGoogle Scholar
  34. Balding SD, Prost C, Diaz LA, Bernard P, Bedane C,Aberdam D, Giudice GJ (1996) Cicatricial pemphigoid autoantibodies react with multiple sites on the BP18o extracellular domain. J Invest Dermatol 106: 141–146Google Scholar
  35. Chan LS, Majmudar AA, Tran HH et al. (1997) Laminin-6 and laminin-5 are recognized by autoantibodies in a subset of cicatricial pemphigoid. J Invest Dermatol 6: 848853Google Scholar
  36. Kirtschig G, Marinkovich MP, Burgeson RE, Yancey KB (1995) Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5. J Invest Dermatol 105: 543–548PubMedCrossRefGoogle Scholar
  37. Niimi Y, Zhu XJ, Bystryn JC (1992) Identification of cicatri- cial pemphigoid antigens. Arch Dermatol 128: 54–57PubMedCrossRefGoogle Scholar
  38. Straßburg M, Megahed M (2000) Gingivo-parodontale Manifestationen systemischer Erkrankungen. In: Mutschelknauß R (Hrsg) Lehrbuch der klinischen Parodontologie. Quintessenz, Berlin, S 149–167Google Scholar
  39. Tyagi S, Bhol K, Natarajan K, Livir-Rallatos C, Foster CS, Ahmed AR (1996) Ocular cicatricial pemphigoid antigen: Partial sequence and biochemical characterization. Proc Natl Acad Sci USA 93: 14714–14719Google Scholar
  40. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3: 797–801PubMedCrossRefGoogle Scholar
  41. Dieterich W, Laag E, Bruckner-Tuderman L et al. (1999) Antibodies to tissue transglutaminase as serologic markers in patients with dermatitis herpetiformis. J Invest Dermatol 113: 133–136PubMedCrossRefGoogle Scholar
  42. Katz SI (1993) Dermatitis herpetiformis In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds) Dermatology in general medicine, 4th edn. McGraw Hill, New York, pp 636–641Google Scholar
  43. Megahed M (1996) Histologie subepidermaler bullöser Dermatosen. Verb Dtsch Ges Path 8o: 223–228Google Scholar
  44. Reunala T (1998) Dermatitis herpetiformis: coeliac disease of the skin. Ann Med 3o: 416–418CrossRefGoogle Scholar
  45. Spurkland A, Ingvarsson G, Falk ES, Knutsen I, Sollid LM, Thorsby E (1997) Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers. Tissue Antigens 49: 29–34PubMedCrossRefGoogle Scholar
  46. Chorzelski TP, Jablonska S, Maciejowska E (1991) Linear IgA bullous dermatosis of adults. Clin Dermatol 3: 383392Google Scholar
  47. Dmochowski M, Hashimoto T, Bhogal BS, Black MM, Zone JJ, Nishikawa T (1993) Immunoblotting studies of linear IgA disease. J Dermatol Sci 3: 194–20oCrossRefGoogle Scholar
  48. Ghohestani RF, Nicolas JF, Kanitakis J, ClaudyA (1997) Linear IgA bullous dermatosis with IgA antibodies exclusively directed against the 18o-or 230 kDa epidermal antigens. J Invest Dermatol 6: 854–858Google Scholar
  49. Megahed M (1996) Histologie subepidermaler bullöser Dermatosen. Verh Dtsch Ges Path 8o: 223–228Google Scholar
  50. Megahed M, Goerz G, Lenard HG, Plewig G (1991) Lineare IgA Dermatose des Kindesalter. Monatsschr Kinderheilkd 9: 636–638Google Scholar
  51. Motoki K, Megahed M, LaForgia S, Uitto J (1996) Cloning and chromosomal mapping of mouse ladinin, a novel cutaneous basement membrane zone component. Genomics 39: 323–330CrossRefGoogle Scholar
  52. Schneck B, Termeer C, Mockenhaupt M, Augustin M, Schöpf E (1999) IgA-Lineare Dermatose im Erwachsenenalter mit klinischen Zeichen eines Stevens-Johnson-Syndrom. Hautarzt 4: 288–291CrossRefGoogle Scholar
  53. Willsteed E, Bhogal BS, Black MM, McKee P, Wojnarowska F (199o) Use of 1 M NaCl split skin in the indirect immunofluorescence of the linear IgA bullous dermatoses. J Cutan Patho117: 144–148Google Scholar
  54. Wojnarowska F, Whitehead P, Leigh IM, Bhogal BS, Black MM (1991) Identification of the target antigen in chronic bullous disease of childhood and linear IgA disease of adults. Br J Dermatol 2: 157–162CrossRefGoogle Scholar
  55. Zambruno G, Manca V, Kanitakis J, Cozzani E, Nicolas JF, Giannetti A (1994) Linear IgA bullous dermatosis with autoantibodies to a 290 kd antigen of anchoring fibrils. J Am Acad Dermatol 31: 884–888PubMedCrossRefGoogle Scholar
  56. Zone JJ, Taylor TB, Meyer LJ, Petersen MJ (1998) The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 18o kDa bullous pemphigoid antigen, BPAg2. J Invest Dermatol 3:Google Scholar
  57. Barton DD, Fine JD, Gammon WR, Sams WM Jr (1986) Bulbous systemic lupus erythematosus: An unusual clinical course and detectable circulating autoantibodies to the epidermolysis bullosa acquisita antigen. J Am Acad Dermatol 15: 369–373Google Scholar
  58. Camisa C, Sharma HM (1983) Vesiculobullous systemic lupus erythematosus. Report of two cases and a review of the literature. J Am Acad Dermatol 9: 924–933Google Scholar
  59. Gammon WR, Kowalewski C, Chorzelski TP, Kumar V, Briggaman RA, Beutner EH (199o) Direct immunofluorescence studies of sodium chloride-separated skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita. J Am Acad Dermatol 22: 664–670Google Scholar
  60. Gammon WR, Woodley DT, Dole KC, Briggaman RA (1985) Evidence that anti-basement membrane zone antibodies in bullous eruption of systemic lupus erythematosus recognize epidermolysis bullosa acquisita autoantigen. J Invest Dermatol 6: 472–476CrossRefGoogle Scholar
  61. Olansky AJ, Briggaman RA, Gammon WR, Kelly TF, Sams WM Jr (1982) Bullous systemic lupus erythematosus. J Am Acad Dermatol 7: 511–520PubMedCrossRefGoogle Scholar
  62. Ackerman AB, Chongchitnant N, Sanchez J et al. (1997) Histologic diagnosis of inflammatory skin diseases, znd edn. Williams & Wilkins, BaltimoreGoogle Scholar
  63. Fritsch C, von Schmiedeberg S, Lehmann P (1998) Porphyria cutanea tarda. Hautarzt 49: 870–882PubMedCrossRefGoogle Scholar
  64. Goerz G, Fritsch C, Bolsen B (1996) Porphyrien aus dermatologischer Sicht. In: Macher E, Kolde G, Bröcker EB (Hrsg) Jahrbuch der Dermatologie. Stoffwechsel und Haut. Biermann, Zülpich, S 75–99Google Scholar
  65. Megahed M (1996) Histologie subepidermaler bullöser Dermatosen. Verh Dtsch Ges Path 8o: 223–228Google Scholar
  66. Lyell A (1956) Toxic epidermal necrolysis: An eruption re- sembling scaling of the skin. Br J Dermatol 68: 355–361PubMedCrossRefGoogle Scholar
  67. Roujeau JC, Chosidow O, Saiag P, Guillaume JC (1990) Toxic epidermal necrolysis ( Lyell syndrome ). Am Acad Dermatol 23: 1039–1058Google Scholar
  68. Schöpf E, Mockenhaupt B, Razany B (1993) Schwere Arzneimittelexantheme: Toxisch Epidermale Nekrolyse, Stevens-Johnson-Syndrom. In: Braun-Falco O, Plewig G, Meurer M (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie, Bd 13. Springer, Berlin Heidelberg New York Tokyo, S 251–256CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2003

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  • M. Megahed

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