Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Alterung und zelluläre Immunität

  • Chapter
Hautalterung

  • 72 Accesses

Zusammenfassung

Altern ist ein mehrstufiges, facettenreiches, zeitabhängiges Phänomen, das durch die abnehmende Fähigkeit eines Organismus, auf exogenen und endogenen Stress durch physikalische, biologische oder chemische Agentien adäquat zu reagieren, gekennzeichnet ist (Hart u. Daniel 1980).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Bancherau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245–252

    Article  Google Scholar 

  • Buchanan JP, Peters CA, Rasmussen CJ, Rothstein G (1996) Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging. Exp Gerontol 31: 135–144

    Google Scholar 

  • Chopra RK, Nagel JE, Chrest FJ, Adler WH (1987) Impaired phorbol ester and calcium ionophore induced proliferation of Tcells from old humans. Clin Exp Immunol 70: 456–62

    PubMed  CAS  Google Scholar 

  • Dalziel KL (1991) Aspects of cutaneous ageing. Clin Exp Dermatol 16: 315–323

    Article  PubMed  CAS  Google Scholar 

  • Delo VA, Dawes L,Jackson R (1981) Density of Langerhans cells (LC) in normal vs. chronic actinically damaged skin (CADS) of humans.J Invest Dermatol 330–331

    Google Scholar 

  • Elmets CA (1995) Ultraviolet radiation and antigen presentation. In: Krutmann J, Elmets CA (eds) Photoimmunology. Blackwell, Oxford, pp 42–54

    Google Scholar 

  • Erkeller-Yuksel FM, Deneys V,Yuksel B, Hannet I, Hulstaert F, Hamilton C et al. (1992) Age-re-lated changes in human blood lymphocyte subpopulations.J Pediatr 120: 216–22

    CAS  Google Scholar 

  • Ershler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty.Annu Rev Med 51: 245–270

    CAS  Google Scholar 

  • Garg M, LuoW, Kaplan AM, Bondada S (1994) Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice. Infect Immun 64: 4456–4462

    Google Scholar 

  • Ghersetich I, Lotti T (1994) Alpha-Interferon cream restores decreased levels of Langerhans/indeterminate (CD1 a+) cells in aged and PUVA-treated skin. Skin Pharmacol 7: 118–120

    Article  PubMed  CAS  Google Scholar 

  • Gilchrest BA, Szabo G, Flynn E, Goldwyn RM (1983) Chronologic and actinically induced aging in human facial skin.1 Invest Dermatol (Suppl) 80: 81–85

    Google Scholar 

  • Hanna MG, Nettesheim P,Ogden L,Makinodan T (1967) Reduced immune potential of aged mice:Significance of morphologic changes in lymphatic tissues.Proc Soc Exp Biol Med 125: 882–886

    Google Scholar 

  • Hart RW, Daniel FB (1980) Genetic stability in-vitro and in-vivo. Advances in Pathobiology 7: 123–141

    PubMed  CAS  Google Scholar 

  • Hulstaert F, Hannet I, Deneys V, Munhyeshuli V, ReichertT,de Bruyere M,Strauss K (1994) Age-related changes in human blood lymphocyte subpopulations. Clin Immunol Immunopathol 70: 152–158

    Article  CAS  Google Scholar 

  • Kondo S (2000) The role of cytokines in photoaging.J Dermatol Sci (Suppl) 23: 30–36

    Article  Google Scholar 

  • Legge JS, Austin CM (1968) Antigen localization and the immune response as a function of age. Aust J Exp Biol Med Sci 46: 361–65

    Article  PubMed  CAS  Google Scholar 

  • Lesourd BM, Meaume S (1994) Cell mediated immunity changes in ageing, relative importance of cell subpopulation switches and of nutritional factors. Immunol Lett 40: 235–42

    Article  PubMed  CAS  Google Scholar 

  • Maletto BA, Gruppi A, Moron G, Pistoresipalencia MC (1996) Age-associated changes in lymphoid and antigen-presenting cell functions in mice immunized with Trypanosoma cruzi antigens. Mech Ageing Dev 88: 39–47

    Article  PubMed  CAS  Google Scholar 

  • Medzhitov RM, Janeway CA (1997) Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9: 4–9

    Article  PubMed  CAS  Google Scholar 

  • Meunier L,Voorhees JJ, Cooper KD (1996) In vivo retinoic acid modulates expression of the class II major histocompatibility complex and function of antigen-presenting macrophages and keratinocytes in ultraviolet-exposed human skin.J Invest Dermatol 106 (5): 1042–1046

    CAS  Google Scholar 

  • Miller C,Kelsoe G, Han S (1994) Lack of B7–2 expression in the germinal centers of aged mice. Aging: Immunol Infect Dis 5: 249–257

    Google Scholar 

  • Nagel JE, Chopra RK, Chrest FJ, McCoy MT, Schneider EL, Holbrook NJ, Adler WH (1988) Decreased proliferation, interleukin 2 synthesis,and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.J Clin Invest 81: 1096–1102

    CAS  Google Scholar 

  • Neale R, Russell A, Muller HK, Green A (1997) Sun exposure, sunscreen and their effects on epidermal Langerhans cells. Photchem-Photobiol 66 (2): 260–264

    Article  CAS  Google Scholar 

  • Pawelec G, Solana R, Remarque E, Mariani E (1998) Impact of aging on innate immunity. J Leukoc Biol 64: 703–712

    PubMed  CAS  Google Scholar 

  • Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C et al. (2002) T cells and ageing, January 2002 update. Front Biosci 7: 56–183

    Google Scholar 

  • Pietschmann P, Hahn P, Kudlacek S, Thomas R, Peterlik M (2000) Surface markers and transendothelial migration of dendritic cells from elderly subjects. Exp Geront 35: 213–224

    Article  CAS  Google Scholar 

  • Sato H, Dobashi M (1998) The distribution, immune complex trapping ability and morphology of follicular dendritic cells in popliteal lymph nodes of aged rats. Histol and Histopathol 13: 99–108

    CAS  Google Scholar 

  • Song L, Kim YH, Chopra RK, Proust JJ, Nagel JE, Nordin AA, Adler WH (1993) Age-related effects in T cell activation and proliferation. Exp Gerontol 28: 313–321

    Article  PubMed  CAS  Google Scholar 

  • Steger MM, Maczek C, Grubeck-Loebenstein B (1996) Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin Exp Immunol 105: 544–550

    Article  PubMed  CAS  Google Scholar 

  • Steger MM, Maczek C, Grubeck-Loebenstein B (1997) Peripheral blood dendritic cells rein- duce proliferation in in vitro aged T cell populations. Mech Ageing Dev 93: 125–130

    Article  PubMed  CAS  Google Scholar 

  • Szakal AK, Kurowski Taylor J, Smith JP, Kosco MH, Burton GF,Tew JJ. (1990) Kinetics of germinal center development in lymph nodes of young and aging immune mice. Anat Rec 227: 475–485

    CAS  Google Scholar 

  • Thiers BH, Maize JC, Spicer SS, Cantor AB (1984) The effect of aging and chronic sun exposure on human Langerhans cell populations.] Invest Dermatol 82: 223–226

    CAS  Google Scholar 

  • Tortorella C, Loria MP, Piazzolla G,Schulzekoops H, Lipsky PE,Jirillo E,Antonaci S (1997) Age-related impairment of T-cell proliferative responses related to the decline of CD28+T cell subsets. Arch Gerontol Geriat 26: 55–70

    CAS  Google Scholar 

  • Toyoda M, Bhawan J (1997) Ultrastructural evidence for the participation of Langerhans cells in cutaneous photoaging processes: a quantitative comparative study.J Dermatol Sci 14: 87–100

    CAS  Google Scholar 

  • Vetricka V,Tlaskalova-Hogenova H, Pospisil M (1985) Impaired antigen-presenting function of macrophages from aged mice. Immunol Invest 14: 105–114

    Article  Google Scholar 

  • Wick G, Grubeck-Loebenstein B (1997) The aging immune system: primary and secondary alterations of immune reactivity in the elderly. Exp Gerontol 32: 401–413

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. M. Grewe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Grewe, M. (2003). Alterung und zelluläre Immunität. In: Hautalterung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07736-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07736-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07737-5

  • Online ISBN: 978-3-662-07736-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation